{"id":5369,"date":"2026-05-26T11:20:56","date_gmt":"2026-05-26T11:20:56","guid":{"rendered":"https:\/\/laexome.com\/systematic-evidence-for-collagen-peptides\/"},"modified":"2026-09-23T08:10:14","modified_gmt":"2026-09-23T08:10:14","slug":"systematic-evidence-for-collagen-peptides","status":"publish","type":"post","link":"https:\/\/laexome.com\/ko\/systematic-evidence-for-collagen-peptides\/","title":{"rendered":"\ucf5c\ub77c\uac90 \ud3a9\ud0c0\uc774\ub4dc\uc5d0 \ub300\ud55c \uccb4\uacc4\uc801 \uadfc\uac70"},"content":{"rendered":"

Pu et al. (2023) \u2014 26\uac74\uc758 RCT\uc5d0 \ub300\ud55c \uccb4\uacc4\uc801 \ubb38\ud5cc\uace0\ucc30 \ubc0f \uba54\ud0c0\ubd84\uc11d<\/h3>\n
\n

1. \uc11c\ub860<\/h2>\n
\n\uc678\ubd80 \ud658\uacbd\uc5d0 \ub178\ucd9c\ub418\ub294 \uc778\uccb4 \ucd5c\ub300 \uae30\uad00\uc778 \ud53c\ubd80\ub294 \ub178\ud654 \uacfc\uc815\uc5d0\uc11c \ub0b4\uc778\uc131 \uc694\uc778\uacfc \uc678\uc778\uc131 \uc694\uc778\uc758 \uc601\ud5a5\uc744 \ubaa8\ub450 \ubc1b\ub294\ub2e4 [1<\/a>].
\n\ud53c\ubd80 \ub178\ud654\ub294 \ud0c8\uc218, \ud53c\ubd80 \ud0c4\ub825 \uc800\ud558, \uc8fc\ub984 \ubc1c\uc0dd\uc744 \ud2b9\uc9d5\uc73c\ub85c \ud55c\ub2e4 [2<\/a>].
\n\ubbf8\uc6a9\uc5d0 \ub300\ud55c \uae30\uc900\uc774 \uc810\ucc28 \ub192\uc544\uc9c0\uba74\uc11c \ud53c\ubd80 \ub178\ud654\ub294 \uc0c1\ub2f9\ud55c \uad00\uc2ec\uc744 \ubc1b\uc544 \uc654\ub2e4.
\n\ub610\ud55c \ub9ce\uc740 \uad6d\uac00\uac00 \uace0\ub839\uc0ac\ud68c\ub85c \uc9c4\uc785\ud568\uc5d0 \ub530\ub77c \ud53c\ubd80 \ub178\ud654\uac00 \ubbf8\uce58\ub294 \uc2ec\ub9ac\uc0ac\ud68c\uc801 \uc601\ud5a5 \ub54c\ubb38\uc5d0 \ud6a8\uacfc\uc801\uc778 \uc911\uc7ac\uc5d0 \ub300\ud55c \ud544\uc694\uc131\uc774 \uc99d\uac00\ud558\uace0 \uc788\ub2e4 [3<\/a>].
\n\uc774\ub7ec\ud55c \ub9e5\ub77d\uc5d0\uc11c \ucd5c\uadfc \uba87 \ub144\uac04 \ubcf4\ucda9\uc81c\ub85c\uc11c \ub274\ud2b8\ub77c\uc288\ud2f0\uceec\uc758 \uc0ac\uc6a9\uc774 \uc99d\uac00\ud558\uace0 \uc788\ub2e4 [4<\/a>].\n<\/div>\n
\n\ucf5c\ub77c\uac90\uc740 \ub2e4\uc591\ud55c \uacb0\ud569\uc870\uc9c1\uc758 \uc8fc\uc694 \ub2e8\ubc31\uc9c8 \uad6c\uc870\uc774\uba70, \uc778\uccb4 \ud53c\ubd80 \uac74\uc870\uc911\ub7c9\uc758 80%\ub97c \ucc28\uc9c0\ud55c\ub2e4 [5<\/a>].
\n\ucf5c\ub77c\uac90\uc740 \ub9e4 \uc138 \ubc88\uc9f8 \uc794\uae30\ub9c8\ub2e4 glycine\uc774 \ubc18\ubcf5\ub418\uace0, \ub098\uba38\uc9c0 \uc794\uae30\uc5d0\ub294 \ud2b9\ud788 proline\uacfc hydroxyproline\uc774 \uc874\uc7ac\ud568\uc73c\ub85c\uc368 \ud615\uc131\ub418\ub294 \uc0bc\uc911 \ub098\uc120 \uad6c\uc870\ub97c \ud2b9\uc9d5\uc73c\ub85c \ud55c\ub2e4 [6<\/a>].<\/p>\n

\uc138\ud3ec\uc678\uae30\uc9c8\uc5d0\uc11c \uac00\uc7a5 \ud48d\ubd80\ud55c \uc131\ubd84\uc778 \ucf5c\ub77c\uac90\uc740 \uae30\uacc4\uc801 \uc9c0\uc9c0\ub97c \uc81c\uacf5\ud558\uace0 \uc870\uc9c1 \ubc1c\ub2ec\uc744 \uc720\ub3c4\ud55c\ub2e4 [7<\/a>].\n<\/div>\n

<\/div>\n
\n\ub178\ud654\ub294 \ucf5c\ub77c\uac90\uc758 \ubc88\uc5ed \ud6c4 \uac00\uacf5\uc5d0 \uad00\uc5ec\ud558\ub294 \ud6a8\uc18c\uc758 \uac10\uc18c\ub97c \uc720\ubc1c\ud558\uc5ec, \ucf5c\ub77c\uac90\uc744 \ud569\uc131\ud558\ub294 \uc12c\uc720\uc544\uc138\ud3ec\uc758 \uc218\uc640 \ud53c\ubd80\uc5d0 \ud608\uc561\uc744 \uacf5\uae09\ud558\ub294 \ud608\uad00\uc758 \uc218\ub97c \uac10\uc18c\uc2dc\ud0a8\ub2e4 [8<\/a>].
\n\uc5f0\ub839 \uc99d\uac00\uc5d0 \ub530\ub978 \ud53c\ubd80 \ud488\uc9c8 \uc800\ud558\ub294 \ucf5c\ub77c\uac90 \ud569\uc131 \uac10\uc18c\uc640 \ud53c\ubd80 \ud608\uad00\uc131 \uac10\uc18c\ub97c \ud2b9\uc9d5\uc73c\ub85c \ud558\uba70, \uc774\ub294 \ud0c4\ub825 \uc800\ud558\uc640 \uc8fc\ub984 \ud615\uc131\uc73c\ub85c \uc774\uc5b4\uc9c4\ub2e4 [9<\/a>].
\n\uc774\ub7ec\ud55c \ubcc0\ud654\ub294 \uc12c\uc720\uc544\uc138\ud3ec \ud65c\uc131\uc758 \uc800\ud558\uc640 \ud53c\ubd80 \ub0b4 \ud608\uad00 \uc218 \uac10\uc18c\uc5d0 \uae30\uc778\ud55c\ub2e4 [10<\/a>].
\n\ub530\ub77c\uc11c \ud53c\ubd80\ub294 \ub098\uc774\uac00 \ub4e4\uba74\uc11c \ud0c8\uc218, \ud0c4\ub825 \uc800\ud558, \ud45c\ud53c \ub450\uaed8 \uac10\uc18c\uc640 \uac19\uc740 \ud1f4\ud589\uc131 \ubcc0\ud654\ub97c \uacaa\ub294\ub2e4 [11<\/a>].
\n\ub2e4\uc591\ud55c \uc601\uc591\uc18c\uc640 \ubcf4\ucda9\uc81c\uac00 \ud53c\ubd80 \uac74\uac15\uc744 \uac1c\uc120\ud558\uace0 \uc80a\uc740 \ud53c\ubd80 \uc678\uad00\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ub41c\ub2e4 [12<\/a>].
\n\uc774\ub7ec\ud55c \ubc29\ubc95\uc5d0\ub294 \uad6d\uc18c \ud06c\ub9bc, \uc8fc\uc0ac\ud615 \ud544\ub7ec, \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc81c\uac00 \ud3ec\ud568\ub41c\ub2e4.
\n\uad6d\uc18c \ud06c\ub9bc\uc740 \uc131\ubd84 \uc911 \ud558\ub098\ub85c \ucf5c\ub77c\uac90\uc744 \ud568\uc720\ud558\uba70, \ud53c\ubd80 \uc218\ubd84\ub3c4\uc640 \ud0c4\ud0c4\ud568\uc744 \ub192\uc774\ub3c4\ub85d \uc124\uacc4\ub41c\ub2e4 [13<\/a>].
\n\uadf8\ub7ec\ub098 \uad6d\uc18c \ud06c\ub9bc\uc740 \ud53c\ubd80 \uce68\ud22c \ub2a5\ub825\uc774 \uc81c\ud55c\uc801\uc774\ubbc0\ub85c \ud6a8\uacfc\uac00 \uac10\uc18c\ud560 \uc218 \uc788\ub2e4 [13<\/a>].
\n\ud788\uc54c\ub8e8\ub860\uc0b0 \ud544\ub7ec\uc640 \uac19\uc740 \uc8fc\uc0ac\ud615 \ud544\ub7ec\ub294 \ucf5c\ub77c\uac90 \uc0dd\uc131\uc744 \uc790\uadf9\ud558\uace0 \ud53c\ubd80\ub97c \ubcfc\ub968\uac10 \uc788\uac8c \ub9cc\ub4e4\uc5b4 \uc989\uac01\uc801\uc778 \ud6a8\uacfc\ub97c \uc81c\uacf5\ud55c\ub2e4 [14<\/a>].
\n\uadf8\ub7ec\ub098 \ube44\uc6a9\uc774 \ub192\uc744 \uc218 \uc788\uc73c\uba70 \uba4d, \ubd80\uae30, \uac10\uc5fc\uacfc \uac19\uc740 \uc774\uc0c1\ubc18\uc751 \uc704\ud5d8\uc774 \ub530\ub978\ub2e4 [14<\/a>].
\n\ubc18\uba74, \ud2b9\ud788 \uac00\uc218\ubd84\ud574 \ucf5c\ub77c\uac90 \ud3a9\ud0c0\uc774\ub4dc\ub97c \ud568\uc720\ud55c \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc81c\ub294 \ub2e4\ub978 \ucf5c\ub77c\uac90 \uae30\ubc18 \ubc29\ubc95\uacfc \ube44\uad50\ud574 \uc548\uc804\ud558\uace0 \ube44\uc6a9 \ud6a8\uc728\uc801\uc778 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4.
\n\ub610\ud55c \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc81c\ub294 \uacbd\uad6c \uc12d\ucde8\uac00 \uac00\ub2a5\ud574 \uc77c\uc0c1\uc0dd\ud65c\uc5d0 \uc27d\uac8c \ud3ec\ud568\ud560 \uc218 \uc788\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4 [15<\/a>].\n<\/div>\n
<\/div>\n
\n\uc774\ub7ec\ud55c \ubcf4\ucda9\uc81c \uc911 \uac00\uc218\ubd84\ud574 \ucf5c\ub77c\uac90(HC)\uc740 \uac00\uc7a5 \ub110\ub9ac \uc0ac\uc6a9\ub418\uba70 \uc720\ub9dd\ud55c \ud53c\ubd80 \ud56d\ub178\ud654 \ub274\ud2b8\ub77c\uc288\ud2f0\uceec\uc774\ub2e4 [16<\/a>].
\n\ub2e4\ub978 \uc5f0\uad6c\uc5d0\uc11c\ub294 HC\ub97c \uacbd\uad6c \uc12d\ucde8\ud55c \uc9c0 1\uc2dc\uac04 \ud6c4 alanine\u2013hydroxyproline\u2013glycine \ubc0f serine\u2013hydroxyproline\u2013glycine\uc774 \uc0ac\ub78c\uc758 \ud608\uc561\uc5d0\uc11c \uac80\ucd9c\ub420 \uc218 \uc788\uc74c\uc774 \ubcf4\uace0\ub418\uc5c8\uc73c\uba70 [17<\/a>,18<\/a>] \ud53c\ubd80\uc5d0\ub3c4 \ucd95\uc801\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4 [19<\/a>].<\/p>\n<\/div>\n
<\/div>\n
\n\ucd5c\uadfc \uc5f0\uad6c\uc5d0\uc11c\ub294 HC\uac00 \ud53c\ubd80 \uc218\ubd84\ub3c4\uc640 \ud0c4\ub825\uc744 \uac1c\uc120\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4 [16<\/a>].
\n\uadf8\ub7ec\ub098 \ubaa8\ub4e0 HC \uacf5\uae09\uc6d0\uc774 \ub3d9\uc77c\ud55c \ud6a8\ub2a5\uc744 \ub098\ud0c0\ub0b4\ub294 \uac83\uc740 \uc544\ub2c8\ub2e4.
\n\ub3d9\uc77c\ud55c \uc6a9\ub7c9\uacfc \ud22c\uc5ec \uae30\uac04\uc774\ub77c\ub3c4 \ud2b9\uc815 \uacf5\uae09\uc6d0\uc758 \ucf5c\ub77c\uac90\uc774 \ub2e4\ub978 \uacf5\uae09\uc6d0\ubcf4\ub2e4 \ub354 \ud6a8\uacfc\uc801\uc77c \uc218 \uc788\ub2e4 [20<\/a>].
\n\ub530\ub77c\uc11c \ud53c\ubd80 \ub178\ud654\uc5d0 \ub300\ud55c HC\uc758 \uc801\uc808\ud55c \uacf5\uae09\uc6d0\uacfc \uce58\ub8cc \uae30\uac04\uc744 \uaddc\uba85\ud558\uae30 \uc704\ud55c \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.\n<\/div>\n
<\/div>\n
\n\uc804 \uc138\uacc4\uc801\uc73c\ub85c \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc81c\uc5d0 \uad00\ud55c \uc784\uc0c1\uc5f0\uad6c\uac00 \uc99d\uac00\ud558\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0 \uadf8 \uacb0\uacfc\ub97c \uccb4\uacc4\uc801 \ubb38\ud5cc\uace0\ucc30\uacfc \uba54\ud0c0\ubd84\uc11d\uc73c\ub85c \uc885\ud569\ud560 \ud544\uc694\uac00 \uc788\ub2e4.
\n\uc774\uc5d0 \ubcf8 \uccb4\uacc4\uc801 \ubb38\ud5cc\uace0\ucc30 \ubc0f \uba54\ud0c0\ubd84\uc11d\uc5d0\uc11c\ub294 \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc774 \ud53c\ubd80 \uc218\ubd84\ub3c4\uc640 \ud0c4\ub825\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc870\uc0ac\ud558\uc600\ub2e4.\n<\/div>\n
<\/div>\n<\/section>\n
\n

2. \uc7ac\ub8cc \ubc0f \ubc29\ubc95<\/h2>\n
\n

2.1. \uac80\uc0c9 \uc804\ub7b5, \ud3ec\ud568 \uae30\uc900 \ubc0f \uc81c\uc678 \uae30\uc900<\/h3>\n
\n\uc81c\ud55c \uc870\uac74 \uc5c6\uc774 Medical Subject Headings\uc758 \ub2e4\uc74c \uac80\uc0c9\uc5b4\ub97c \uc0ac\uc6a9\ud558\uc5ec Embase, PubMed \ubc0f Cochrane Library \ub370\uc774\ud130\ubca0\uc774\uc2a4\uc5d0\uc11c \ubb38\ud5cc \uac80\uc0c9\uc744 \uc218\ud589\ud558\uc600\ub2e4: (collagen OR hydrolyzed collagen) AND (anti-aging).
\n2022\ub144 12\uc6d4 \uc774\uc804\uc5d0 \ucd9c\ud310\ub41c \uad00\ub828 \uc5f0\uad6c\ub97c \ud655\uc778\ud558\uc600\ub2e4.
\n\ub2e4\uc74c \uae30\uc900\uc744 \ucda9\uc871\ud558\ub294 \uc5f0\uad6c\ub97c \ud3ec\ud568\ud558\uc600\ub2e4: (1) \ubb34\uc791\uc704 \uc784\uc0c1\uc2dc\ud5d8(RCT) \uc124\uacc4\ub97c \uc801\uc6a9\ud55c \uc5f0\uad6c, (2) \uac74\uac15\ud55c \uc131\uc778(18\uc138 \uc774\uc0c1)\uc744 \ud3ec\ud568\ud55c \uc5f0\uad6c, (3) HC\ub97c \ud22c\uc5ec\ubc1b\uc740 \ub300\uc0c1\uc790\ub97c \ud3ec\ud568\ud55c \uc5f0\uad6c, (4) \uc601\uc5b4\ub85c \uc791\uc131\ub41c \uc804\ubb38 \ub17c\ubb38.
\n\ub2e4\uc74c \uc5f0\uad6c\ub294 \uc81c\uc678\ud558\uc600\ub2e4: (1) \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc81c\uc640 \ub2e4\ub978 \ubcf4\ucda9\uc81c\uc758 \ubcd1\uc6a9 \ud6a8\uacfc\ub97c \ud3c9\uac00\ud55c \uc5f0\uad6c \ub610\ub294 (2) \uc601\uc5b4\ub85c \uc791\uc131\ub418\uc9c0 \uc54a\uc740 RCT.
\n\ub17c\ubb38 \ub0b4 \uadf8\ub798\ud504\uc758 \uc6d0\uc790\ub8cc\ub294 WebPlotDigitizer\ub97c \uc0ac\uc6a9\ud558\uc5ec \ucd94\ucd9c\ud558\uc600\ub2e4 [21<\/a>].\n<\/div>\n<\/section>\n
\n

2.2. \ub370\uc774\ud130 \ucd94\ucd9c<\/h3>\n
\n\ub450 \uba85\uc758 \ub3c5\ub9bd\uc801\uc778 \uac80\ud1a0\uc790(S-YP, CC)\uac00 \ud3ec\ud568 \uc5f0\uad6c\uc758 \uae30\ubcf8 \uc815\ubcf4\ub97c \ucd94\ucd9c\ud558\uc600\ub2e4.
\n\ucd94\ucd9c\ud55c \uc815\ubcf4\ub294 \uc5f0\uad6c \uba54\ud0c0\ub370\uc774\ud130(\uc989, \uc81c1\uc800\uc790, \ucd9c\ud310\uc5f0\ub3c4, \uc5f0\uad6c \uc124\uacc4), \uc5f0\uad6c \ud45c\ubcf8 \uc815\ubcf4(\uc989, \ud658\uc790 \uc218, \uc131\ubcc4, \ud3c9\uade0 \uc5f0\ub839, \uce58\ub8cc\uad70 \ubc0f \uc704\uc57d\uad70\uc758 \uae30\uc800 \ud2b9\uc131), \uc911\uc7ac(\uc989, \ucf5c\ub77c\uac90 \ubcf4\ucda9\uc81c\uc758 \uc6a9\ub7c9 \ubc0f \ud615\ud0dc), \uacb0\uacfc(\uc989, \uc218\ubd84\ub3c4 \ubc0f \ud0c4\ub825)\ub97c \ud3ec\ud568\ud558\uc600\ub2e4.
\n\uc5f0\uc18d\ud615 \uacb0\uacfc\ub294 \ud3c9\uade0 \u00b1 \ud45c\uc900\ud3b8\ucc28(SD)\ub85c, \uc774\uc0b0\ud615 \ub370\uc774\ud130\ub294 \ubc31\ubd84\uc728\ub85c \uc81c\uc2dc\ud558\uc600\ub2e4.\n<\/div>\n<\/section>\n
\n

2.3. \ud1b5\uacc4 \ubd84\uc11d, \ubbfc\uac10\ub3c4 \ubd84\uc11d \ubc0f \ube44\ub6a4\ub9bc \ud3c9\uac00<\/h3>\n
\n\ud655\uc778\ub41c \uc5f0\uad6c\uc758 SD\uc640 \ud3c9\uade0 \ucc28\uc774\ub97c \uacc4\uc0b0\ud558\uae30 \uc704\ud574 \ub79c\ub364\ud6a8\uacfc \ubaa8\ud615\uc744 \uc0ac\uc6a9\ud558\uc600\ub2e4.\u00a0p<\/span>\u00a0\uac12\uc774 <0.05\uc774\uba74 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud55c \uac83\uc73c\ub85c \ud310\ub2e8\ud558\uc600\ub2e4. \ud3ec\ud568 \uc5f0\uad6c \uac04 \uc774\uc9c8\uc131 \uc218\uc900\uc740 Hedge\u2019s I2<\/sup>\u00a0\uac80\uc815\uc744 \uc0ac\uc6a9\ud558\uc5ec \ud3c9\uac00\ud558\uc600\uace0, \uac01 \ud3ec\ud568 \uc5f0\uad6c\uc5d0 \ub300\ud574 \ud3ec\ub9ac\uc2a4\ud2b8 \ud50c\ub86f\uc744 \uc0dd\uc131\ud558\uc600\ub2e4.
\n\ub610\ud55c I2<\/sup>\u00a0\u2265 50%\ub294 \ub192\uc740 \uc774\uc9c8\uc131\uc744 \uc758\ubbf8\ud558\uc600\ub2e4 [22<\/a>].
\n\uc804\uccb4 \ud6a8\uacfc \uac80\uc815 \uacb0\uacfc\ub294 z\uac12\uc73c\ub85c \ubcf4\uace0\ud558\uc600\uc73c\uba70, \uc774\ub97c \ud1b5\ud574 95% \uc2e0\ub8b0\uad6c\uac04(CI)\uc744 \ucd94\ub860\ud558\uc600\ub2e4.
\n\uc7a0\uc7ac\uc801\uc73c\ub85c \uc601\ud5a5\ub825\uc774 \ud070 \uc5f0\uad6c\uc758 \ud6a8\uacfc\ub97c \ubc30\uc81c\ud558\uae30 \uc704\ud574 \ubbfc\uac10\ub3c4 \ubd84\uc11d\uc744 \uc218\ud589\ud558\uc600\ub2e4.
\n\uac01 \uc5f0\uad6c\ub294 Cochrane Handbook for Systematic Reviews of Interventions\uc5d0 \ub530\ub77c \ubd84\ub958\ud558\uc600\ub2e4 [23<\/a>].
\nCochrane \ube44\ub6a4\ub9bc \uc704\ud5d8(RoB) 2.0 \ub3c4\uad6c\ub97c \uc0ac\uc6a9\ud558\uc5ec \ud3ec\ud568\ub41c RCT\uc758 \ube44\ub6a4\ub9bc \uc704\ud5d8\uc744 \ud3c9\uac00\ud558\uc600\ub2e4.
\n\uc120\ud0dd, \uc218\ud589, \uac80\ucd9c, \ud0c8\ub77d \ubc0f \ubcf4\uace0 \ube44\ub6a4\ub9bc\uc758 5\uac1c \uc601\uc5ed\uc744 \ud3c9\uac00\ud558\uc600\ub2e4 [24<\/a>].
\n\ubcf8 \uba54\ud0c0\ubd84\uc11d\uc758 \ubaa8\ub4e0 \uacb0\uacfc\ub294 RevMan \uc18c\ud504\ud2b8\uc6e8\uc5b4(\ubc84\uc804 5.4)\ub97c \uc0ac\uc6a9\ud558\uc5ec \ubd84\uc11d\ud558\uc600\ub2e4.\n<\/div>\n<\/section>\n<\/section>\n
<\/div>\n
\n

3. \uacb0\uacfc<\/h2>\n
\n

3.1. \uc5f0\uad6c \uacb0\uacfc \ubc0f \uc5f0\uad6c \ud2b9\uc131<\/h3>\n
\n\uadf8\ub9bc 1<\/a>\u00a0\uc740 Preferred Reporting Items for Systematic Reviews and Meta-Analyses \uc9c0\uce68\uc5d0 \ub530\ub77c \uc218\ud589\ub41c \ubb38\ud5cc \uac80\uc0c9 \uacfc\uc815\uc758 \ud750\ub984\ub3c4\ub97c \ubcf4\uc5ec\uc900\ub2e4 [25<\/a>].
\n\ucd08\uae30 \uac80\uc0c9\uc5d0\uc11c 1,135\uac74\uc758 \uc5f0\uad6c\ub97c \ud655\uc778\ud558\uc600\ub2e4.
\n\uc911\ubcf5 \ubb38\ud5cc\uc744 \uc81c\uac70\ud558\uace0 \uad00\ub828 \ub17c\ubb38\uc758 \uc81c\ubaa9 \ub610\ub294 \ucd08\ub85d\uc744 \uc120\ubcc4\ud55c \ud6c4, \ub0a8\uc740 37\uac74\uc758 \uc5f0\uad6c\uc5d0 \ub300\ud574 \uc804\ubb38\uc744 \ud3c9\uac00\ud558\uc600\ub2e4.
\n\uc774 \uc911 26\ud3b8\uc758 \ub17c\ubb38\uc774 \ubcf8 \uccb4\uacc4\uc801 \ubb38\ud5cc\uace0\ucc30 \ubc0f \uba54\ud0c0\ubd84\uc11d\uc5d0 \ud3ec\ud568\ub418\uc5c8\ub2e4.\n<\/div>\n
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\uadf8\ub9bc 1.<\/b>\u00a0PRISMA \uc9c0\uce68\uc5d0 \ub530\ub978 \uccb4\uacc4\uc801 \ubb38\ud5cc\uace0\ucc30 \ubc0f \uba54\ud0c0\ubd84\uc11d\uc758 \ud750\ub984\ub3c4.<\/em><\/div>\n<\/section>\n<\/section>\n
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3.2. \uc5f0\uad6c \ud2b9\uc131<\/h3>\n
\n\ucd1d 1,721\uba85\uc758 \ud658\uc790\ub97c \ud3ec\ud568\ud55c 26\uac74\uc758 RCT\uac00 \ubcf8 \uba54\ud0c0\ubd84\uc11d\uc5d0 \ud3ec\ud568\ub418\uc5c8\ub2e4.
\n\ud3ec\ud568 \uc5f0\uad6c\uc5d0\uc11c HC \ubcf4\ucda9 \uae30\uac04\uc740 2\uc8fc\uc5d0\uc11c 12\uc8fc\uc600\ub2e4.
\n\ud3ec\ud568\ub41c RCT \uc911 14\uac74\uc740 \uc5b4\ub958 \uc720\ub798 \ucf5c\ub77c\uac90, 1\uac74\uc740 \uc18c \uc720\ub798 \ucf5c\ub77c\uac90, 1\uac74\uc740 \ub2ed \uc720\ub798 \ucf5c\ub77c\uac90, 2\uac74\uc740 \ub3fc\uc9c0 \uc720\ub798 \ucf5c\ub77c\uac90\uc744 \ub2e4\ub8e8\uc5c8\uc73c\uba70, 9\uac74\uc740 \ucf5c\ub77c\uac90 \uacf5\uae09\uc6d0\uc5d0 \ub300\ud55c \uc815\ubcf4\uac00 \uc5c6\uc5c8\ub2e4.
\n\ud3ec\ud568\ub41c RCT\uc758 \uc5f0\uad6c \ud2b9\uc131\uc740\u00a0\ud45c 1<\/a>.\n<\/div>\n
\n\ud53c\ubd80 \uc218\ubd84\ub3c4 \uce21\uc815\uc5d0\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ucf54\ub974\ub124\uc624\ubbf8\ud130(corneometer)\ub77c\ub294 \ube44\uce68\uc2b5\uc801 \uae30\uae30\uac00 \uc0ac\uc6a9\ub41c\ub2e4.
\n\uc774 \uae30\uae30\ub294 \ud53c\ubd80 \ud45c\uba74\uc5d0 \uace0\uc8fc\ud30c \uc804\ub958\ub97c \uac00\ud574 \ucd5c\uc0c1\uce35\uc5d0 \uc874\uc7ac\ud558\ub294 \uc218\ubd84\uc758 \uc591\uc744 \uce21\uc815\ud558\uba70, \uacb0\uacfc\ub294 \ucf54\ub974\ub124\uc624\uba54\ud2b8\ub9ac \ub2e8\uc704\ub85c \ud45c\uc2dc\ub41c\ub2e4.
\n\ucf54\ub974\ub124\uc624\ubbf8\ud130\ub294 \ud53c\ubd80 \uc218\ubd84 \uc7a5\ubcbd\uc5d0 \ub300\ud55c \uc720\uc6a9\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud568\uc73c\ub85c\uc368 \uad6d\uc18c \uc81c\ud488\uc758 \ud6a8\uacfc\ub97c \ud3c9\uac00\ud558\uace0 \uc804\ubc18\uc801\uc778 \ud53c\ubd80 \uac74\uac15\uc744 \ud3c9\uac00\ud558\ub294 \ub370 \ub110\ub9ac \uc0ac\uc6a9\ub41c\ub2e4.
\n\ub530\ub77c\uc11c \ud53c\ubd80 \uc218\ubd84\ub3c4\ub97c \uce21\uc815\ud558\uace0 \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc758 \ud6a8\ub2a5\uc744 \ud3c9\uac00\ud558\ub294 \ub370 \uc720\uc6a9\ud55c \ub3c4\uad6c\ub85c \uac04\uc8fc\ub41c\ub2e4 [18<\/a>,26<\/a>,27<\/a>,28<\/a>,29<\/a>,30<\/a>,31<\/a>,32<\/a>,33<\/a>].<\/p>\n

\ud55c\ud3b8 \ud53c\ubd80 \ud0c4\ub825\uc740 \ud53c\ubd80 \uac74\uac15\uc5d0 \ub300\ud55c \uc720\uc6a9\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud558\ub294 \ube44\uce68\uc2b5\uc801 \ubc29\ubc95\uc778 \ucee4\ud1a0\uba54\ud2b8\ub9ac(cutometry)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4.
\n\uc774 \ubc29\ubc95\uc740 \ud53c\ubd80\uc758 \uc791\uc740 \ubd80\uc704\uc5d0 \uc870\uc808\ub41c \uc74c\uc555\uc744 \uac00\ud558\uace0 \uadf8\uc5d0 \ub530\ub978 \ubcc0\ud615\uc744 \uce21\uc815\ud558\uba70, \uc774 \ubcc0\ud615\uc740 \ud53c\ubd80 \ud0c4\ub825\uacfc \uc9c1\uc811\uc801\uc778 \ube44\ub840 \uad00\uacc4\uac00 \uc788\ub2e4.
\n\ucee4\ud1a0\uba54\ud2b8\ub9ac\ub294 \uc5f0\uad6c \ubc0f \uc784\uc0c1 \ud658\uacbd\uc5d0\uc11c \ud53c\ubd80 \ud0c4\ub825 \uc218\uc900\uc744 \ud3c9\uac00\ud558\uace0 \uc2dc\uac04\uc5d0 \ub530\ub978 \ud53c\ubd80 \ubcc0\ud654\ub97c \ubaa8\ub2c8\ud130\ub9c1\ud558\ub294 \ub370 \ub110\ub9ac \uc0ac\uc6a9\ub41c\ub2e4.
\n\uc804\ubc18\uc801\uc73c\ub85c \ud53c\ubd80 \uac74\uac15\uc744 \ud3c9\uac00\ud558\ub294 \uc548\uc804\ud558\uace0 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \ubc29\ubc95\uc774\ub2e4.\n<\/p><\/div>\n

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\ud45c 1.<\/b>
\n\ud3ec\ud568 \uc5f0\uad6c \ub300\uc0c1\uc790\uc758 \ud2b9\uc131.<\/div>\n