{"id":5391,"date":"2026-05-26T09:42:40","date_gmt":"2026-05-26T09:42:40","guid":{"rendered":"https:\/\/laexome.com\/collagen-tripeptides-improve-skin-hydration-elasticity\/"},"modified":"2026-09-23T10:28:49","modified_gmt":"2026-09-23T10:28:49","slug":"collagen-tripeptides-improve-skin-hydration-elasticity","status":"publish","type":"post","link":"https:\/\/laexome.com\/ko\/collagen-tripeptides-improve-skin-hydration-elasticity\/","title":{"rendered":"Collagen Tripeptides\uac00 \ud53c\ubd80 \uc218\ubd84\uacfc \ud0c4\ub825 \uac1c\uc120\uc5d0 \ubbf8\uce58\ub294 \ud6a8\uacfc"},"content":{"rendered":"<h3>\ucf5c\ub77c\uac90 \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc\uac00 \ud53c\ubd80\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5<\/h3>\n<p><strong>\uc11c\ub860:<\/strong> \ucf5c\ub77c\uac90\uc740 \ub2e4\uc591\ud55c \ud615\ud0dc\ub85c \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488\uc758 \uae30\ub2a5\uc131 \uc131\ubd84\uc73c\ub85c \ub110\ub9ac \uc0ac\uc6a9\ub418\uace0 \uc788\uc9c0\ub9cc, \ucf5c\ub77c\uac90 \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc(CTP)\uc758 \uacbd\uad6c \uc12d\ucde8\uac00 \uc778\uac04\uc758 \ud53c\ubd80\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc740 \uc544\uc9c1 \uba85\ud655\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc9c0\uae08\uae4c\uc9c0 \ubcf4\uace0\ub41c CTP\uc758 \uae0d\uc815\uc801\uc778 \uacb0\uacfc \ub300\ubd80\ubd84\uc740 \uae30\uc0c1 \uc870\uac74\uc758 \uc601\ud5a5\uc744 \uace0\ub824\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc911\ub144 \uc5ec\uc131\uc758 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ub300\ud55c CTP\uc758 \ud6a8\uacfc\ub97c \ud3c9\uac00\ud558\uace0, \uae30\ud6c4 \ubcc0\ud654\uc758 \uc601\ud5a5\uc744 \ubcf4\uc815\ud558\uc5ec \ubd84\uc11d\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\uc7ac\ub8cc \ubc0f \ubc29\ubc95:<\/strong> 40\uc138\uc5d0\uc11c 60\uc138 \uc0ac\uc774\uc758 \uc5ec\uc131 84\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc744 \uc2e4\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4. \ucc38\uac00\uc790\ub4e4\uc740 \ubb34\uc791\uc704\ub85c \ubc30\uc815\ub418\uc5b4 12\uc8fc \ub3d9\uc548 \ub9e4\uc77c \uc704\uc57d \ub610\ub294 1,000 mg\uc758 CTP\ub97c \uc12d\ucde8\ud558\uc600\uc2b5\ub2c8\ub2e4. CTP\ub294 \ube44\ubcd1\uc6d0\uc131 <em>Bacillus<\/em> \uc18d \uc138\uade0\uc5d0\uc11c \uc720\ub798\ud55c collagenase\ub97c \uc774\uc6a9\ud55c \ubd84\ud574 \ubc29\ubc95\uc744 \ud1b5\ud574 <em>Nile Tilapia<\/em>\uc758 \ud53c\ubd80\ub85c\ubd80\ud130 \uc81c\uc870\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \uc218\ubd84\ub3c4, \uc8fc\ub984 \ubc0f \ud0c4\ub825\uc740 \uc5f0\uad6c \uc2dc\uc791 \uc2dc\uc810\uacfc 6\uc8fc \ubc0f 12\uc8fc \ud6c4\uc5d0 \ud3c9\uac00\ud558\uc600\uc73c\uba70, \uc9c0\uc5ed \uae30\uc0c1\uccad\uc758 \uae30\uc0c1 \ub370\uc774\ud130\ub97c \ud65c\uc6a9\ud558\uc5ec \ud3c9\uac00 \uae30\uac04 \uc911 \uc628\ub3c4, \uc2b5\ub3c4 \ubc0f ultraviolet A \ub178\ucd9c\uc758 \uc601\ud5a5\uc744 \ubcf4\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\uacb0\uacfc:<\/strong> 82\uba85\uc758 \ucc38\uac00\uc790 \uc911 74\uba85\uc774 \ubd80\uc791\uc6a9 \uc5c6\uc774 \uc2dc\ud5d8\uc744 \uc644\ub8cc\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub300\uc870\uad70\uacfc \ube44\uad50\ud588\uc744 \ub54c, 12\uc8fc \ud6c4 CTP\uad70\uc5d0\uc11c \uacbd\ud53c \uc218\ubd84 \uc190\uc2e4(trans-epidermal water loss)\uc774 \ub354 \ud06c\uac8c \uac10\uc18c\ud558\uc600\uc2b5\ub2c8\ub2e4(<em>P<\/em> < 0.05). 12\uc8fc \uc2dc\uc810\uc5d0\uc11c \ud574\ub2f9 \uc9c0\uc5ed\uc758 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud55c \ud6c4\uc5d0\ub3c4 \ub450 \uadf8\ub8f9 \uac04 TEWL \ucc28\uc774\ub294 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uac8c \uc720\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4(\uc2b5\ub3c4 \ubc0f \uc628\ub3c4 \ubcf4\uc815, <em>P<\/em> = 0.024; UVA \ubcf4\uc815, <em>P<\/em> = 0.032; \uc628\ub3c4, \uace0\uc628 \ubc0f ultraviolet A \ubcf4\uc815, <em>P<\/em> = 0.031). \ud53c\ubd80 \uc218\ubd84\ub3c4 \uce21\uba74\uc5d0\uc11c\ub3c4 \ub300\uc870\uad70\ubcf4\ub2e4 CTP\uad70\uc5d0\uc11c \ub354 \ud070 \uac1c\uc120\uc774 \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud558\uc704 \uadf8\ub8f9 \ubd84\uc11d\uc5d0\uc11c\ub294 50\uc138 \ubbf8\ub9cc\uc758 \ud53c\ud5d8\uc790\uac00 12\uc8fc \ub3d9\uc548 CTP\ub97c \uc12d\ucde8\ud55c \ud6c4 \uc8fc\uad00\uc801 \ud53c\ubd80 \uac1c\uc120 \uc124\ubb38\uc9c0\uc758 \ucd1d\uc810\uacfc \uc218\ubd84 \ud56d\ubaa9\uc5d0\uc11c \uc720\uc758\ud55c \uac1c\uc120\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. CTP \uc12d\ucde8\uc5d0 \ub300\ud55c \ub0b4\uc57d\uc131\uc740 \uc591\ud638\ud558\uc600\uc73c\uba70, \ub450 \uadf8\ub8f9 \ubaa8\ub450\uc5d0\uc11c \uc8fc\ubaa9\ud560 \ub9cc\ud55c \ubd80\uc791\uc6a9\uc740 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\uace0\ucc30:<\/strong> \ubcf8 \uc5f0\uad6c \uacb0\uacfc\ub294 <em>Nile Tilapia<\/em>\uc758 \ud53c\ubd80\uc5d0\uc11c \uc720\ub798\ud55c CTP(<em>Oreochromis niloticus<\/em>)\ub97c \uacbd\uad6c \uc12d\ucde8\ud558\ub294 \uac83\uc774 \uc591\ud638\ud55c \ub0b4\uc57d\uc131\uc744 \ubcf4\uc774\uba70, \uc911\ub144 \uc5ec\uc131\uc758 \ud53c\ubd80 \uc218\ubd84 \uc190\uc2e4 \uac10\uc18c\uc5d0 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\uc784\uc0c1\uc2dc\ud5d8 \ub4f1\ub85d:<\/strong> <a href=\"http:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener\">www.clinicaltrials.gov\/<\/a>, \uc2dd\ubcc4\ubc88\ud638: <a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03505684\" target=\"_blank\" rel=\"noopener\">NCT03505684<\/a>.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\ud0a4\uc6cc\ub4dc:<\/strong> \ucf5c\ub77c\uac90 \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc, \ud53c\ubd80 \uc218\ubd84\ub3c4, \ud53c\ubd80 \ud0c4\ub825, \ud53c\ubd80 \uc8fc\ub984, \uc911\ub144 \uc5ec\uc131, \uae30\ud6c4 \ubcc0\ud654<\/p>\n<h2><\/h2>\n<h2>\uc11c\ub860<\/h2>\n<p>\uc790\uc5f0\uc801\uc778 \ub178\ud654 \uacfc\uc815\uc5d0\uc11c \ud53c\ubd80\uc758 \uc5d8\ub77c\uc2a4\ud2f4 \uc12c\uc720\uc640 \ucf5c\ub77c\uac90\uc740 \uac10\uc18c\ud558\uba70, \uc774\ub294 \uacb0\uad6d \ud53c\ubd80 \ub178\ud654, \uc794\uc8fc\ub984 \ubc0f \uae4a\uc740 \uc8fc\ub984\uc73c\ub85c \uc774\uc5b4\uc9d1\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B1\" target=\"_blank\" rel=\"noopener\">1<\/a>). \ud45c\ud53c\uc640 \uc9c4\ud53c \ub0b4 glycosaminoglycans(GAGs)\uc758 \uc591 \uc5ed\uc2dc \ub098\uc774\uac00 \ub4e4\uc218\ub85d \uac10\uc18c\ud558\uc5ec \ud53c\ubd80\uac00 \uc218\ubd84\uc744 \uc720\uc9c0\ud558\ub294 \ub2a5\ub825\uc774 \uc800\ud558\ub418\uace0 \ud53c\ubd80 \uac74\uc870\uac00 \uc99d\uac00\ud569\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B2\" target=\"_blank\" rel=\"noopener\">2<\/a>). \ucf5c\ub77c\uac90\uc740 \uc9c4\ud53c extracellular matrix(ECM)\uc758 \uc8fc\uc694 \uad6c\uc870\uc801 \uad6c\uc131 \uc131\ubd84\uc73c\ub85c, \uc815\uc0c1\uc801\uc778 \uc778\uac04 \ud53c\ubd80 \uc9c4\ud53c \uac74\uc870 \uc911\ub7c9\uc758 70% \uc774\uc0c1\uc744 \ucc28\uc9c0\ud569\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B3\" target=\"_blank\" rel=\"noopener\">3<\/a>).<\/p>\n<p>\uc0dd\ubb3c\ud559\uc801 \ud65c\uc131 \ud654\ud569\ubb3c\uc758 \uacbd\uad6c \uc12d\ucde8\uac00 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uc5f0\uad6c \uacb0\uacfc\ub4e4\uc740 \ud53c\ubd80 \uac74\uac15\uc5d0 \ub3c4\uc6c0\uc744 \uc8fc\ub294 \uc601\uc591 \ubcf4\ucda9\uc81c\uc758 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc84c\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B4\" target=\"_blank\" rel=\"noopener\">4<\/a>). \uc608\ub97c \ub4e4\uc5b4, \ud56d\uc0b0\ud654 \ud2b9\uc131\uc744 \uac00\uc9c4 \uc77c\ubd80 \uac74\uac15\ubcf4\uc870\uc2dd\ud488\uc740 2\ucc28 \uc804\ub2ec\uc790\ub97c \ud1b5\ud574 \ud53c\ubd80\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ub294 \uc18c\ud654 \uacfc\uc815\uc5d0\uc11c \uc704\uc7a5\uad00\uc744 \ud1b5\uacfc\ud558\uace0 \uc7a5 \uc7a5\ubcbd\uc744 \ub118\uc5b4 \ud608\ub958\ub97c \ud1b5\ud574 \uc7a0\uc7ac\uc801\uc73c\ub85c \ud65c\uc131 \uc0c1\ud0dc\ub85c \ud53c\ubd80\uc5d0 \ub3c4\ub2ec\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc0dd\ub9ac\ud65c\uc131 \ud654\ud569\ubb3c\uc744 \ud3ec\ud568\ud55c \ud608\uc561\uc740 \ud45c\ud53c, \uc9c4\ud53c, \ud53c\ud558 \uc9c0\ubc29 \ubc0f \ud53c\uc9c0\ub97c \ud3ec\ud568\ud55c \ud53c\ubd80\uc640 \ubaa8\ub4e0 \ud53c\ubd80 \uad6c\ud68d\uc5d0 \uc9c0\uc18d\uc801\uc73c\ub85c \uc601\uc591\ubd84\uc744 \uacf5\uae09\ud569\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B5\" target=\"_blank\" rel=\"noopener\">5<\/a>). \uc774\ub7ec\ud55c \ud654\ud569\ubb3c \uc911 \ucf5c\ub77c\uac90\uc740 \uc0dd\ubb3c\ud559\uc801\u00b7\uae30\ub2a5\uc801 \ud2b9\uc131\uc73c\ub85c \uc778\ud574 \uc2dd\ud488, \ud654\uc7a5\ud488 \ubc0f \uc81c\uc57d \uc0b0\uc5c5\uc5d0\uc11c \ub110\ub9ac \uc0ac\uc6a9\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B6\" target=\"_blank\" rel=\"noopener\">6<\/a>). \ud2b9\ud788 \ud574\uc591 \uc5b4\ub958\uc5d0\uc11c \uc720\ub798\ud55c \ucf5c\ub77c\uac90 \ud3a9\ud0c0\uc774\ub4dc\ub294 \uace0\ud608\uc555(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B7\" target=\"_blank\" rel=\"noopener\">7<\/a>), \uadfc\uc721 \uc190\uc0c1(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B8\" target=\"_blank\" rel=\"noopener\">8<\/a>), \uc9c0\uc9c8 \ubc0f \ud608\ub2f9 \uc870\uc808(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B7\" target=\"_blank\" rel=\"noopener\">7<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B9\" target=\"_blank\" rel=\"noopener\">9<\/a>), \uacfc\uccb4\uc911\uc778 \uc0ac\ub78c\uc758 \uccb4\uc911 \uad00\ub9ac(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B10\" target=\"_blank\" rel=\"noopener\">10<\/a>)\uc5d0 \uc720\uc6a9\ud55c \uac74\uac15\ubcf4\uc870\uc2dd\ud488\uc73c\ub85c \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ucf5c\ub77c\uac90\uc740 (Gly-X-Y)n \ud615\ud0dc\uc758 \uc0bc\uc911 \ub098\uc120 \uad6c\uc870\ub97c \uac00\uc9c0\uba70, X\uc640 Y\ub294 \ub300\ubd80\ubd84 proline(Pro)\uacfc hydroxyproline(Hyp)\uc73c\ub85c \uad6c\uc131\ub429\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B11\" target=\"_blank\" rel=\"noopener\">11<\/a>). \uc12d\ucde8 \ud6c4 Gly-Pro-Hyp\ub294 \uc7a5 \uc0c1\ud53c\uc5d0 \uacb0\ud569\ub41c aminopeptidase N\uc758 \uc194\uac00\uc7a5\uc790\ub9ac\ub9c9\uc5d0 \uc758\ud574 \ubd80\ubd84\uc801\uc73c\ub85c \uac00\uc218\ubd84\ud574\ub418\uc5b4 Gly\uac00 \uc81c\uac70\ub429\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B12\" target=\"_blank\" rel=\"noopener\">12<\/a>). \uc774\ud6c4 \ucf5c\ub77c\uac90 \uc720\ub798 \ud3a9\ud0c0\uc774\ub4dc\uc758 \uc8fc\uc694 \ud65c\uc131 \uc131\ubd84\uc778 Pro-Hyp\ub294 H+-coupled oligopeptide transporter(PEPT-1)\ub97c \ud1b5\ud574 \uc18c\uc7a5 \uc0c1\ud53c\uc138\ud3ec\ub85c \uc6b4\ubc18\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B13\" target=\"_blank\" rel=\"noopener\">13<\/a>). \uace0\ubd84\uc790 \ucf5c\ub77c\uac90 \ud3a9\ud0c0\uc774\ub4dc\uc640 \ube44\uad50\ud588\uc744 \ub54c, \uc800\ubd84\uc790 \ucf5c\ub77c\uac90 \uac00\uc218\ubd84\ud574\ubb3c \ub610\ub294 \ucf5c\ub77c\uac90 \ud2b8\ub9ac\ud3a9\ud0c0\uc774\ub4dc(CTP)\ub97c \uacbd\uad6c \uc12d\ucde8\ud55c \ud6c4 \ud608\uc7a5 \ub0b4 Gly-Pro-Hyp \ub18d\ub3c4\uac00 \ub354 \ub192\uac8c \uac80\ucd9c\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B14\" target=\"_blank\" rel=\"noopener\">14<\/a>). \ub610\ud55c \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c\ub294 Gly-Pro-Hyp\uc640 Pro-Hyp\uac00 \uc704\uc0b0 \ubc0f \ud6a8\uc18c, pancreatin \ub610\ub294 \ud608\uc7a5 peptidase\uc5d0 \uc758\ud574 \ubd84\ud574\ub418\uc9c0 \uc54a\uace0 \uc704\uc7a5\uc561\uacfc \ud608\uc7a5 \ub0b4\uc5d0\uc11c \uc548\uc815\uc801\uc73c\ub85c \uc720\uc9c0\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B14\" target=\"_blank\" rel=\"noopener\">14<\/a>). \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 Gly-Pro-Hyp\uc640 Pro-Hyp\uc758 \ud6a8\uc18c\uc801 \uc548\uc815\uc131\uacfc \uc7a5 \ud22c\uacfc\uc131\uc73c\ub85c \uc778\ud574 CTP\uc758 \uacbd\uad6c \uc12d\ucde8\uac00 \uc0dd\ub9ac\ud65c\uc131 \ud3a9\ud0c0\uc774\ub4dc\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \uc12d\ucde8\ud558\ub294 \ubc29\ubc95\uc774 \ub420 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4.<\/p>\n<p>CTP\uc758 \ud6a8\ub2a5\uc5d0 \uad00\ud55c \uadfc\uac70\ub294 \uc9c0\uc18d\uc801\uc73c\ub85c \ucd95\uc801\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ucd5c\uadfc\uc758 \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc5d0\uc11c \uc800\ubd84\uc790 \ucf5c\ub77c\uac90 \ud3a9\ud0c0\uc774\ub4dc(LMWCP)\uc758 \uacbd\uad6c \uc12d\ucde8\ub294 \uc911\ub144 \uc5ec\uc131\uc758 \ud53c\ubd80 \uc218\ubd84\ub3c4, \ud0c4\ub825 \ubc0f \uc8fc\ub984\uc744 \uac1c\uc120\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>). \uadf8\ub7ec\ub098 \ub2e4\uc591\ud55c \ud53c\ubd80 \ud2b9\uc131\uc744 \uce21\uc815\ud558\uc5ec \ud3c9\uac00\ud55c LMWCP\uc758 \ud6a8\uacfc\ub294 \uc2dc\ud5d8 \ub2f9\uc2dc\uc758 \uc628\ub3c4, \uc2b5\ub3c4 \ubc0f ultraviolet A(UVA)\uc758 \uc601\ud5a5\uc744 \uace0\ub824\ud558\uc9c0 \uc54a\uc740 \uc0c1\ud0dc\uc5d0\uc11c \ubd84\uc11d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uae30\ud6c4 \uc694\uc778\uc774 \uc804\ubc18\uc801\uc778 \ud53c\ubd80 \uc0c1\ud0dc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4\ub294 \uc810\uc744 \uace0\ub824\ud558\uba74, \ud53c\ud5d8\uc790\uac00 \uc2dc\ud5d8\uc744 \ubc1b\uc740 \uc9c0\uc5ed\uacfc \uacc4\uc808\uc758 \uc628\ub3c4, \uc2b5\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud55c \ud6c4 \ud53c\ubd80 \uc9c0\ud45c\ub97c \ubd84\uc11d\ud558\uc5ec CTP\uac00 \ud53c\ubd80 \uac74\uac15\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ud3c9\uac00\ud558\ub294 \uac83\uc774 \uc801\uc808\ud569\ub2c8\ub2e4. \ubcf8 \ubb34\uc791\uc704 \uc774\uc911\ub9f9\uac80 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c\ub294 \uae30\uc0c1 \uc870\uac74\uc744 \ubcf4\uc815\ud55c \ud6c4\uc5d0\ub3c4 <em>Nile Tilapia<\/em> \uc5b4\ud53c\uc5d0\uc11c \uc720\ub798\ud55c CTP\uc758 \uacbd\uad6c \ud22c\uc5ec\uac00 \uc911\ub144 \uc5ec\uc131\uc758 \ud53c\ubd80 \uc0c1\ud0dc\ub97c \uac1c\uc120\ud560 \uc218 \uc788\ub294\uc9c0\ub97c \ud3c9\uac00\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\uc7ac\ub8cc \ubc0f \ubc29\ubc95<\/h2>\n<h3>\uc5f0\uad6c \uc124\uacc4 \ubc0f \uc724\ub9ac\uc801 \uace0\ub824\uc0ac\ud56d<\/h3>\n<p>\ubcf8 \uc5f0\uad6c\ub294 \ubb34\uc791\uc704, \uc704\uc57d \ub300\uc870, \uc774\uc911\ub9f9\uac80 \uc784\uc0c1\uc2dc\ud5d8\uc73c\ub85c \uc124\uacc4\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \ud53c\ud5d8\uc790\ub294 \uc5f0\uad6c \ucc38\uc5ec \uc804\uc5d0 \uc5f0\uad6c \ucc38\uc5ec\uc5d0 \ub300\ud55c \uc0ac\uc804 \ub3d9\uc758\ub97c \uc81c\uacf5\ud558\uc600\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 Declaration of Helsinki\uc5d0 \ub530\ub77c \uc218\ud589\ub418\uc5c8\uc73c\uba70, \uc5f0\uad6c \ud504\ub85c\ud1a0\ucf5c\uc740 Pusan National University Yangsan Hospital\uc758 Institutional Review Board \uc724\ub9ac\uc704\uc6d0\ud68c\uc758 \uc2b9\uc778\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4(IRB No. 02-2017-033, 2017\ub144 11\uc6d4 6\uc77c). \ubcf8 \uc784\uc0c1\uc2dc\ud5d8\uc740 <a href=\"http:\/\/www.clinicaltrials.gov\/\" target=\"_blank\" rel=\"noopener\">ClinicalTrials.gov<\/a>\uc5d0 \ub4f1\ub85d\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03505684\" target=\"_blank\" rel=\"noopener\">NCT03505684<\/a>, 2018\ub144 4\uc6d4 23\uc77c).<\/p>\n<h3>\uc5f0\uad6c \ucc38\uc5ec\uc790<\/h3>\n<p>\uc678\uad00\uc0c1 \uac74\uac15\ud55c \uc9c0\uc6d0\uc790\ub4e4\uc740 \ub300\ud55c\ubbfc\uad6d \uc591\uc0b0\uc2dc\uc5d0 \uc704\uce58\ud55c 3\ucc28 \uc758\ub8cc\uae30\uad00\uc758 \uad11\uace0\ub97c \ud1b5\ud574 \ubaa8\uc9d1\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \ucc38\uc5ec \ub300\uc0c1\uc740 40\uc138\uc5d0\uc11c 60\uc138 \uc0ac\uc774\uc774\uba70 Tewameter\ub97c \uc774\uc6a9\ud574 \uce21\uc815\ud55c \uacbd\ud53c \uc218\ubd84 \uc190\uc2e4(TEWL) \uc810\uc218\uac00 \u22654\uc778 \uc0ac\ub78c\uc73c\ub85c \uc120\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc9c0\uc6d0\uc790\ub4e4\uc740 \ub4f1\ub85d \uc804 4\uc8fc \ub3d9\uc548 \uc0ac\uc6a9\ud558\ub358 \uac83\uacfc \ub3d9\uc77c\ud55c \uc2a4\ud0a8\ucf00\uc5b4 \uc81c\ud488(\uc678\uc6a9 \uc81c\ud488 \ubc0f \uacbd\uad6c \ubcf4\ucda9\uc81c)\uc744 \uacc4\uc18d \uc0ac\uc6a9\ud574\uc57c \ud588\uc73c\uba70, 12\uc8fc\uac04\uc758 \uc5f0\uad6c \uae30\uac04 \ub3d9\uc548 \ub2e4\ub978 \ud53c\ubd80 \uad00\ub9ac \uc2dc\uc220\uc744 \ubc1b\uc544\uc11c\ub294 \uc548 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc8fc\uc694 \uc81c\uc678 \uae30\uc900\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4. \ub4f1\ub85d \uc804 3\uac1c\uc6d4 \uc774\ub0b4\uc5d0 retinoids, steroids \ubc0f \uae30\ud0c0 \ud638\ub974\ubaac \uc81c\ud488\uc744 \ud3ec\ud568\ud558\uc5ec \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ubcc0\ud654\ub97c \uc904 \uc218 \uc788\ub294 \uc57d\ubb3c\uc774\ub098 \ubcf4\ucda9\uc81c\ub97c \uc0ac\uc6a9\ud55c \uacbd\uc6b0, \ud2b9\uc815 \uc131\ubd84\uc774\ub098 \ud587\ube5b\uc5d0 \ub300\ud55c \ud53c\ubd80 \uacfc\ubbfc\uc99d \ub610\ub294 \uc54c\ub808\ub974\uae30 \ubc18\uc751 \ubcd1\ub825\uc774 \uc788\ub294 \uacbd\uc6b0, \uc774\uc804 6\uac1c\uc6d4 \uc774\ub0b4\uc5d0 \ud53c\ubd80 \uac1c\uc120 \uc2dc\uc220\uc744 \ubc1b\uc740 \uacbd\uc6b0, \uc54c\ucf54\uc62c \ub0a8\uc6a9, \ub4f1\ub85d \uc804 3\uac1c\uc6d4 \uc774\ub0b4\uc758 \uae08\uc5f0, \uc870\uc808\ub418\uc9c0 \uc54a\ub294 \ud608\uc555\u00b7\ud608\ub2f9 \ub610\ub294 \uc704\uc7a5\uad00 \uc99d\uc0c1, aspartate aminotransferase(AST) \ub610\ub294 alanine aminotransferase(ALT) \ud608\uccad \uc218\uce58 >80 mg\/dL, creatinine(Cr) \uc218\uce58 >1.5 mg\/dL, \uc784\uc2e0 \ub610\ub294 \uc218\uc720 \uc911\uc778 \uacbd\uc6b0, \uc5f0\uad6c \uc131\ubd84\uc5d0 \ub300\ud55c \uc54c\ub808\ub974\uae30\uac00 \uc788\ub294 \uacbd\uc6b0, \uadf8\ub9ac\uace0 \uc5f0\uad6c \uae30\uac04 \uc911 \uac70\uc8fc\uc9c0\ub97c \uc774\uc804\ud560 \uacc4\ud68d\uc774 \uc788\ub294 \uacbd\uc6b0\uc785\ub2c8\ub2e4. \ub610\ud55c \uc548\uc804\uc0c1\uc758 \uc774\uc720\ub85c \uc5f0\uad6c \uc2dc\uc791 \uc804 6\uac1c\uc6d4 \uc774\ub0b4\uc5d0 \uc2ec\ud608\uad00 \uc9c8\ud658 \ub610\ub294 \uc554 \uc9c4\ub2e8\uc744 \ubc1b\uc740 \uc9c0\uc6d0\uc790\ub3c4 \uc81c\uc678\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub2e4\uc74c \uae30\uc900\uc5d0 \ud574\ub2f9\ud558\ub294 \uacbd\uc6b0 \ud53c\ud5d8\uc790\ub294 \uc5f0\uad6c\uc5d0\uc11c \ud0c8\ub77d\ud558\uac70\ub098 \ucc38\uc5ec\ub97c \uc911\ub2e8\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ub418\uc5c8\uc73c\uba70 per protocol \ubd84\uc11d\uc5d0\uc11c \uc81c\uc678\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc2dc\ud5d8 \uc81c\ud488 \ub610\ub294 \uc704\uc57d\uc744 \uc5f0\uc18d 5\uc77c \ub3d9\uc548 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\uc740 \uacbd\uc6b0, \ucd94\uc801 \ud3c9\uac00\uc5d0 \ucc38\uc11d\ud558\uc9c0 \uc54a\uc740 \uacbd\uc6b0, \uc21c\uc751\ub3c4\uac00 \ub0ae\uc740 \uacbd\uc6b0(<80%), \uacfc\ub3c4\ud55c \uc74c\uc8fc \ub610\ub294 \ud587\ube5b \ub178\ucd9c, \uc5f0\uad6c \uae30\uac04 \uc911 \ub2e4\ub978 \uc9c0\uc5ed\uc73c\ub85c \uc774\uc8fc\ud55c \uacbd\uc6b0\uc785\ub2c8\ub2e4. \uc21c\uc751\ub3c4\ub294 \ub9e4 \ubc29\ubb38 \uc2dc \ub0a8\uc544 \uc788\ub294 \ucea1\uc290 \uc218\ub97c \ud655\uc778\ud558\uc5ec \ud3c9\uac00\ud558\uc600\uc2b5\ub2c8\ub2e4. 11\uba85\uc758 \ucc38\uac00\uc790\uac00 \uc81c\uc678 \uae30\uc900\uc5d0 \ud574\ub2f9\ud558\uc600\uc73c\uba70, 3\uba85\uc740 \uc5f0\uad6c \ucc38\uc5ec\ub97c \uac70\ubd80\ud558\uc600\uc2b5\ub2c8\ub2e4.\n\n\n<h3>\ubb34\uc791\uc704 \ubc30\uc815<\/h3>\n<p>\uc2a4\ud06c\ub9ac\ub2dd\uc744 \uc704\ud574 \ucd1d 98\uba85\uc758 \ucc38\uac00\uc790\ub97c \ubaa8\uc9d1\ud558\uc600\uc73c\uba70, \uae30\ucd08 \uce21\uc815\uc744 \uc644\ub8cc\ud55c \ud6c4 \ucd5c\uc885\uc801\uc73c\ub85c 84\uba85(85.7%)\uc774 \uc5f0\uad6c\uc5d0 \ub4f1\ub85d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ucc38\uac00\uc790\ub4e4\uc740 \ubb34\uc791\uc704 \ubc88\ud638\ub97c \uc774\uc6a9\ud55c \ube14\ub85d \ubb34\uc791\uc704 \ubc30\uc815\uc744 \ud1b5\ud574 CTP \uc911\uc7ac\uad70(IG) \ub610\ub294 \uc704\uc57d \ub300\uc870\uad70(CG)\uc5d0 \ubb34\uc791\uc704\ub85c \ubc30\uc815\ub418\uc5c8\uc73c\uba70, \ub4f1\ub85d \uc2dc \uc2dd\ubcc4\ubc88\ud638\uac00 \ubd80\uc5ec\ub418\uc5c8\uc2b5\ub2c8\ub2e4. IG(<em>n<\/em> = 42)\ub294 \ud558\ub8e8 1,000 mg\uc758 CTP \ubcf4\ucda9\uc81c(\ucea1\uc290\ub2f9 250 mg)\ub97c \uc12d\ucde8\ud558\uc600\uc2b5\ub2c8\ub2e4. CG(<em>n<\/em> = 42)\ub294 \uc704\uc57d\uc744 \uc12d\ucde8\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#F1\" target=\"_blank\" rel=\"noopener\">\uadf8\ub9bc 1<\/a>). \ubb34\uc791\uc704 \ubc30\uc815 \ucf54\ub4dc\ub294 \ud1b5\uacc4 \uc804\ubb38\uac00\uac00 nQuery Advisor 7.0\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc0dd\uc131\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \ucc38\uc5ec \uc801\uaca9 \uc5ec\ubd80\ub97c \uacb0\uc815\ud558\uace0 \uce21\uc815\uc744 \uc218\ud589\ud558\ub294 \ub2f4\ub2f9\uc790\ub4e4\uc740 \uc804\uccb4 \uc5f0\uad6c \uacfc\uc815 \ub3d9\uc548 \ubb34\uc791\uc704 \ubc30\uc815 \uacb0\uacfc\ub97c \uc54c \uc218 \uc5c6\ub3c4\ub85d \ud558\uc600\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \ucc38\uac00\uc790\ub294 \ucd1d 4\ud68c \uc5f0\uad6c\uc13c\ud130\ub97c \ubc29\ubb38\ud558\ub3c4\ub85d \ud558\uc600\uc2b5\ub2c8\ub2e4(\ubc29\ubb38 1: \uc2a4\ud06c\ub9ac\ub2dd, \ubc29\ubb38 2: \ubb34\uc791\uc704 \ubc30\uc815 \ubc0f \ubcf4\ucda9\uc81c \uc12d\ucde8 \uc2dc\uc791, \ubc29\ubb38 3: \uc911\uc7ac \uc2dc\uc791 6\uc8fc \ud6c4, \ubc29\ubb38 4: 12\uc8fc \ud6c4).<\/p>\n<p><strong>\uadf8\ub9bc 1<\/strong><\/p>\n<section id=\"s2\">\n<section id=\"sec5\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-3092 size-full\" src=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001.jpg\" alt=\"\" width=\"767\" height=\"523\" srcset=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001.jpg 767w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001-300x205.jpg 300w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001-600x409.jpg 600w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><\/p>\n<p class=\"isSelectedEnd\"><em>CONSORT \ud750\ub984\ub3c4.<\/em><\/p>\n<h3>\uc2dc\ud5d8 \uc81c\ud488 \ubc0f \uc704\uc57d<\/h3>\n<p class=\"isSelectedEnd\">CTP\ub294 \ube44\ubcd1\uc6d0\uc131 <em>Bacillus<\/em> \uc18d \uc138\uade0\uc5d0\uc11c \uc720\ub798\ud55c collagenase\ub97c \uc774\uc6a9\ud55c \ubd84\ud574 \ubc29\ubc95\uc744 \ud1b5\ud574 Nile Tilapia(<em>Oreochromis niloticus<\/em>)\uc758 \ud53c\ubd80\uc5d0\uc11c \uc81c\uc870\ub418\uc5c8\uc2b5\ub2c8\ub2e4(Collagen-Tripep20S; Amicogen Inc., Jinju, Gyeongsangnam-do, South Korea). \uc804\uccb4 CTP\uc758 \ud3c9\uade0 \ubd84\uc790\ub7c9\uc740 500 Da\uc600\uc73c\uba70, CTP \ud568\ub7c9\uc740 20%\uc774\uace0 \uadf8\uc911 3.2%\uac00 Gly\u2013Pro\u2013Hyp\ub85c \uad6c\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Gly\u2013Pro\u2013Hyp\ub294 <em>in vivo<\/em>\uc5d0\uc11c \uc548\uc815\uc131\uacfc \uc0dd\uccb4\uc774\uc6a9\ub960\uc774 \uc785\uc99d\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B14\" target=\"_blank\" rel=\"noopener\">14<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>). \ub610\ud55c \uc0dd\uc950\uc5d0\uc11c \uc720\uc804\uc790 \ubc0f \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \uc99d\uac00\ub97c \ud1b5\ud574 \ud53c\ubd80 \uc218\ubd84 \uac1c\uc120 \ud6a8\uacfc\uac00 \uc870\uc9c1\ud559\uc801\uc73c\ub85c \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B16\" target=\"_blank\" rel=\"noopener\">16<\/a>). \ud53c\ud5d8\uc790\uc5d0\uac8c \ud22c\uc5ec\ud55c CTP\uc758 \uc6a9\ub7c9\uc740 \uc774\uc804 \ub3d9\ubb3c \uc5f0\uad6c \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \uacb0\uc815\ub418\uc5c8\uc73c\uba70, \ud574\ub2f9 \uc5f0\uad6c\uc5d0\uc11c \uc0dd\uc950\uc5d0\uac8c \ub9e4\uc77c CTP(333 mg\/kg)\ub97c \ud22c\uc5ec\ud55c \uacb0\uacfc \ubd80\uc791\uc6a9 \uc5c6\uc774 \ud53c\ubd80 \uc218\ubd84\ub3c4\uc640 \uc8fc\ub984\uc774 \uc720\uc758\ud558\uac8c \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B17\" target=\"_blank\" rel=\"noopener\">17<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B18\" target=\"_blank\" rel=\"noopener\">18<\/a>). \ub530\ub77c\uc11c \uc131\uc778 \uac74\uac15 \uc9c0\uc6d0\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uce58\ub8cc\uc81c\uc758 \ucd08\uae30 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \ucd5c\ub300 \uc548\uc804 \uc2dc\uc791 \uc6a9\ub7c9\uc744 \ucd94\uc815\ud558\uae30 \uc704\ud55c \uac00\uc774\ub4dc\ub77c\uc778\uc5d0 \ub530\ub77c \ud3c9\uade0 \uccb4\uc911 60 kg\uc778 \uc131\uc778\uc5d0\uac8c 1,000 mg\uc758 collagen hydrolysate\uac00 \uc801\uc808\ud55c \uac83\uc73c\ub85c \ud310\ub2e8\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B19\" target=\"_blank\" rel=\"noopener\">19<\/a>). \ub610\ud55c \ubcf8 \uc5f0\uad6c\uc640 \uc720\uc0ac\ud55c \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud53c\ud5d8\uc790\uc5d0\uac8c \ud558\ub8e8 1.0~3.0 g\uc758 \uc6a9\ub7c9\uc774 \ud22c\uc5ec\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B20\" target=\"_blank\" rel=\"noopener\">20<\/a>\u2013<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B22\" target=\"_blank\" rel=\"noopener\">22<\/a>). IG \ud53c\ud5d8\uc790\ub4e4\uc740 12\uc8fc \ub3d9\uc548 \uc544\uce68\uacfc \uc800\ub141\uc5d0 \uac01\uac01 CTP 2\ucea1\uc290(\ucea1\uc290\ub2f9 250 mg)\uc744 \ud558\ub8e8 \ub450 \ucc28\ub840 \uc12d\ucde8\ud558\uc600\uc73c\uba70, \ud558\ub8e8 \ucd1d 4\ucea1\uc290\uc744 \ubcf5\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. CG \ud53c\ud5d8\uc790\uc5d0\uac8c\ub294 \ub3d9\uc77c\ud55c \ud504\ub85c\ud1a0\ucf5c\uacfc \uae30\uac04\uc73c\ub85c \uc704\uc57d\uc774 \uc81c\uacf5\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc704\uc57d\uc740 maltodextrin 170 mg(68.2%)\uacfc dextrin 80 mg(31.8%)\uc73c\ub85c \uad6c\uc131\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub2f9\uc0ac\uc758 \uc608\ube44 \uc5f0\uad6c\uc5d0\uc11c\ub294 tripeptide\uc758 \ud608\uc7a5 \uc5ed\uac00 \uc218\uc900\uacfc \uc81c\ud488\uc758 kinetics\uac00 \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B14\" target=\"_blank\" rel=\"noopener\">14<\/a>).<\/p>\n<h3>\uc720\ud6a8\uc131 \uce21\uc815<\/h3>\n<p class=\"isSelectedEnd\">\uac01 \ubc29\ubb38 \uc2dc \ud53c\ubd80 \ud2b9\uc131\uc744 \ud3c9\uac00\ud558\uae30 \uc804\uc5d0 \ucc38\uac00\uc790\ub4e4\uc740 \uc628\ub3c4(23 \u00b1 1\u00b0C)\uc640 \uc2b5\ub3c4(45 \u00b1 5%)\uac00 \uc870\uc808\ub41c \ub3d9\uc77c\ud55c \uacf5\uac04\uc5d0\uc11c 30\ubd84 \ub3d9\uc548 \uba38\ubb3c\ub800\uc2b5\ub2c8\ub2e4. 1\ucc28 \uc720\ud6a8\uc131 \ubcc0\uc218\ub294 CTP \ub610\ub294 \uc704\uc57d \uc12d\ucde8 \ud6c4 6\uc8fc \ubc0f 12\uc8fc \uc2dc\uc810\uc5d0\uc11c \uae30\ucd08\uce58 \ub300\ube44 TEWL\uc758 \ubcc0\ud654\uc600\uc2b5\ub2c8\ub2e4. 2\ucc28 \ud3c9\uac00 \ubcc0\uc218\ub85c\ub294 \ud53c\ubd80 \uc218\ubd84\ub3c4, \ud0c4\ub825, \uc8fc\ub984 \ubc0f \ucc38\uac00\uc790\uc758 \uc790\uac00\ud3c9\uac00\uac00 \ud3ec\ud568\ub418\uc5c8\uc73c\uba70, \uac01 \ubc29\ubb38 \uc2dc \ud3c9\uac00\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<h4>\ud53c\ubd80 \uacbd\ud53c \uc218\ubd84 \uc190\uc2e4<\/h4>\n<p class=\"isSelectedEnd\">\uc8fc\uad00\uc808\uc640\uc5d0\uc11c \uc804\ubc29 10 cm \ubd80\uc704\uc758 \ud53c\ubd80\ub97c \ub300\uc0c1\uc73c\ub85c evaporimeter(Tewameter TM300; Courage + Khazaha Electronic GmbH, K\u00f6ln, Germany)\ub97c \uc0ac\uc6a9\ud558\uc5ec 3\ud68c \uce21\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B23\" target=\"_blank\" rel=\"noopener\">23<\/a>). \ubd84\uc11d\uc5d0\ub294 \ud3c9\uade0\uac12\uc774 \uc0ac\uc6a9\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<h4>\ud53c\ubd80 \uc218\ubd84\ub3c4<\/h4>\n<p class=\"isSelectedEnd\">\ud45c\ud53c\uc758 \uc678\uce35\uc778 \uac01\uc9c8\uce35(stratum corneum)\uc758 \uc218\ubd84\ub3c4\ub294 corneometer(Corneometer CM 825; Courage + Khazaha Electronic GmbH, K\u00f6ln, Germany)\ub97c \uc774\uc6a9\ud558\uc5ec \uc774\ub9c8 \ubd80\uc704\uc5d0\uc11c \uc815\uc804\uc6a9\ub7c9 \ubc29\uc2dd\uc73c\ub85c \uce21\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B24\" target=\"_blank\" rel=\"noopener\">24<\/a>). \uac01 \uce21\uc815 \uc2dc\uc810\ub9c8\ub2e4 \uc774\ub9c8\uc758 \uc2dc\ud5d8 \ubd80\uc704 \ub0b4 \uc11c\ub85c \ub2e4\ub978 \uc704\uce58\uc5d0\uc11c \ucd5c\uc18c 5\ud68c \uce21\uc815\ud55c \ud6c4, \ucd5c\ub300\uac12\uacfc \ucd5c\uc18c\uac12\uc744 \uc81c\uc678\ud55c 3\uac1c \uce21\uc815\uac12\uc758 \ud3c9\uade0\uc744 \ubd84\uc11d\uc5d0 \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h4>\ud53c\ubd80 \ud0c4\ub825<\/h4>\n<p class=\"isSelectedEnd\">\ud53c\ubd80 \ud0c4\ub825\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574 cutometer(Cutometer MPA 580; Courage + Khazaha Electronic GmbH, K\u00f6ln, Germany)\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B24\" target=\"_blank\" rel=\"noopener\">24<\/a>). \uac01 \uce21\uc815 \uc2dc \uc2dc\ud5d8 \ubd80\uc704\uc778 \uc804\uc644\uc758 \uc11c\ub85c \ub2e4\ub978 3\uac1c \uc9c0\uc810\uc5d0\uc11c \ud53c\ubd80 \ud0c4\ub825\uc744 \ud3c9\uac00\ud558\uace0 \uadf8 \uac12\uc744 \ud3c9\uade0\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h4>\ud53c\ubd80 \uc8fc\ub984<\/h4>\n<p class=\"isSelectedEnd\">\ud53c\ubd80 \uc8fc\ub984 \uce21\uc815\uc740 visiometer(Skin-Visiometer SV 600; Courage + Khazaka electronic GmbH, K\u00f6ln, Germany)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc591\ucabd \ub208\uac00\uc758 crow&#8217;s-feet \ubd80\uc704\uc5d0\uc11c \ud3c9\uac00\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B25\" target=\"_blank\" rel=\"noopener\">25<\/a>). \uc2dc\uac01\uc801 \ub4f1\uae09\uc740 blinded dermatologist\uac00 global photodamage scoring system\uc758 \ucc99\ub3c4\uc5d0 \ub530\ub77c \ud3c9\uac00\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B25\" target=\"_blank\" rel=\"noopener\">25<\/a>).<\/p>\n<h4>\uc124\ubb38\uc9c0<\/h4>\n<p class=\"isSelectedEnd\">6\uc8fc \ubc0f 12\uc8fc \ud6c4, \uc5f0\uad6c \ud53c\ud5d8\uc790\ub4e4\uc740 \uc124\ubb38\uc9c0\ub97c \uc791\uc131\ud558\uace0 \uc2dc\uac04 \uacbd\uacfc\uc5d0 \ub530\ub978 \ud53c\ubd80 \ud2b9\uc131 \uac1c\uc120\uc5d0 \ub300\ud55c \uc790\uc2e0\uc758 \uc778\uc2dd\uc744 \uc8fc\uad00\uc801\uc73c\ub85c \ud3c9\uac00\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc751\ub2f5\uc740 5\uc810 Likert scale\uc744 \uae30\uc900\uc73c\ub85c \ud558\uc600\uc2b5\ub2c8\ub2e4(1, \ub9e4\uc6b0 \uc545\ud654\ub428; 2, \uc545\ud654\ub428; 3, \ubcc0\ud654 \uc5c6\uc74c; 4, \uac1c\uc120\ub428; 5, \ub9e4\uc6b0 \uac1c\uc120\ub428). \ub610\ud55c \uc5f0\uad6c \ubcf4\ucda9\uc81c\uc640 \uad00\ub828\ub41c \ubd88\ucf8c\ud55c \uacbd\ud5d8\uc774 \uc788\ub294 \uacbd\uc6b0 \uc774\ub97c \ud568\uaed8 \ubcf4\uace0\ud558\ub3c4\ub85d \ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h3>\uc548\uc804\uc131 \ud3c9\uac00<\/h3>\n<p class=\"isSelectedEnd\">\ud608\uc555\uacfc \uc2ec\ubc15\uc218\ub294 10\ubd84\uac04 \ud734\uc2dd \ud6c4 \uc549\uc740 \uc790\uc138\uc5d0\uc11c BP-203 RV II \uc7a5\ube44(Colin Corp., Aichi, Japan)\ub97c \uc0ac\uc6a9\ud558\uc5ec 3\ud68c \uce21\uc815\ud558\uc600\uc73c\uba70, \ud3c9\uade0\uac12\uc744 \uae30\ub85d\ud558\uc600\uc2b5\ub2c8\ub2e4. \uccb4\uc911\uacfc \uc2e0\uc7a5\uc740 \ub514\uc9c0\ud138 \uccb4\uc911\uacc4 \ubc0f stadiometer(BSM370; Biospace Co. Ltd., Seoul, South Korea)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ud558\uc600\uace0, \ud658\uc790\ub4e4\uc740 \uc2e0\ubc1c\uc744 \ubc97\uace0 \uac00\ubcbc\uc6b4 \uac00\uc6b4\uc744 \ucc29\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. 4\uc2dc\uac04 \uae08\uc2dd \ud6c4 \uc5f0\uad6c \uc2dc\uc791 \uc2dc\uc810\uacfc \uc5f0\uad6c \uc2dc\uc791 \ud6c4 6\uc8fc \ubc0f 12\uc8fc\uc5d0 \ud608\uc561 \uac80\uccb4\ub97c \ucc44\ucde8\ud558\uc600\uc2b5\ub2c8\ub2e4. \ud608\uccad AST, ALT, total bilirubin, glucose \ubc0f Cr\uc740 TBA200FR biochemical analyzer(Toshiba Co. Ltd., Tokyo, Japan)\ub97c \uc0ac\uc6a9\ud558\uc5ec \uce21\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \uc804 \uae30\uac04 \ub3d9\uc548 \uae30\ud0c0 \ubaa8\ub4e0 \uc774\uc0c1\ubc18\uc751 \ub610\ub294 \uc608\uc0c1\ud558\uc9c0 \ubabb\ud55c \uc54c\ub808\ub974\uae30 \ubc18\uc751\uc5d0 \ub300\ud55c \ubcf4\uace0\ub3c4 \uc218\uc9d1\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h3>\uae30\ud6c4 \ub370\uc774\ud130<\/h3>\n<p class=\"isSelectedEnd\">\uc804\uccb4 \uc5f0\uad6c \uae30\uac04\uc778 1\uc6d4\ubd80\ud130 10\uc6d4\uae4c\uc9c0 \ubaa8\ub4e0 \ucc38\uac00\uc790\uac00 \uac70\uc8fc\ud55c \uc9c0\uc5ed\uc778 Kyungsang province\uc640 Busan\uc758 \uc628\ub3c4, \uc2b5\ub3c4 \ubc0f UVA \ub370\uc774\ud130\ub294 \uc9c0\uc5ed \uae30\uc0c1\uccad\uc73c\ub85c\ubd80\ud130 \uc218\uc9d1\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h3>\ud1b5\uacc4 \ubd84\uc11d<\/h3>\n<p class=\"isSelectedEnd\">\ud45c\ubcf8 \ud06c\uae30 \uacc4\uc0b0\uc5d0\ub294 nQuery Advisor software version 7.0(Cork, Ireland)\uc744 \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc758 \ud45c\ubcf8 \ud06c\uae30\ub294 CTP \ubcf4\ucda9\uc81c\uac00 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ud3c9\uac00\ud55c Choi et al.(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B21\" target=\"_blank\" rel=\"noopener\">21<\/a>)\uc758 \uc5f0\uad6c\ub97c \ubc14\ud0d5\uc73c\ub85c \uc0b0\ucd9c\ud558\uc600\uc2b5\ub2c8\ub2e4. 1\ucc28 \uacb0\uacfc \ubcc0\uc218\uc758 \ud45c\uc900\ud3b8\ucc28\ub97c 5.0, alpha error\ub97c 5%\ub85c \uac00\uc815\ud588\uc744 \ub54c \ud3c9\uade0 TEWL \uc218\uce58\uc5d0\uc11c 3.53\uc758 \ucc28\uc774\ub97c \uac80\ucd9c\ud558\uae30 \uc704\ud55c 80%\uc758 \uac80\uc815\ub825\uc744 \ud655\ubcf4\ud558\ub824\uba74 \uadf8\ub8f9\ub2f9 34\uba85\uc758 \ud53c\ud5d8\uc790\uac00 \ud544\uc694\ud55c \uac83\uc73c\ub85c \ucd94\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ud6c4 20%\uc758 \uc911\ub3c4 \ud0c8\ub77d \uac00\ub2a5\uc131\uc744 \uace0\ub824\ud558\uc5ec \uadf8\ub8f9\ub2f9 42\uba85\uc73c\ub85c \ud45c\ubcf8 \ud06c\uae30\ub97c \uc870\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub450 \uadf8\ub8f9 \uac04 \uacb0\uacfc \ube44\uad50\ub97c \uc704\ud55c \uc8fc\uc694 \ubd84\uc11d\uc73c\ub85c intent to treat(ITT)\ub97c \uc0ac\uc6a9\ud558\uc600\uc73c\uba70, \uacb0\uce21\uce58\ub294 multiple imputation \ubc29\uc2dd\uc73c\ub85c \ubcf4\uc644\ud558\uc600\uc2b5\ub2c8\ub2e4(<em>n<\/em> = 84). \ubcf4\ucda9\uc81c\uc758 \uc720\ud6a8\uc131\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574 per-protocol(PP) \ubd84\uc11d\ub3c4 \uc2e4\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4(<em>n<\/em> = 71). \uc815\uaddc\uc131 \uac00\uc815\uc744 \uac80\uc815\ud558\uae30 \uc704\ud574 Shapiro\u2013Wilk&#8217;s test\ub97c \uc2dc\ud589\ud558\uc600\uc2b5\ub2c8\ub2e4. \uae30\ucd08 \ud2b9\uc131\uacfc \uc2dc\ud5d8 6\uc8fc \ubc0f 12\uc8fc \uc2dc\uc810\uc758 \ubcc0\ud654\uc5d0 \ub300\ud55c \uadf8\ub8f9 \uac04 \ube44\uad50\uc5d0\uc11c\ub294 \uc5f0\uc18d\ud615 \ubcc0\uc218\uc5d0 two-sample <em>t<\/em>-test\ub97c \uc0ac\uc6a9\ud558\uc600\uc73c\uba70, \ube44\uc815\uaddc \ubd84\ud3ec\ub97c \ubcf4\uc774\ub294 \ubcc0\uc218\uc5d0\ub294 Mann-Whitney&#8217;s U test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \ubc94\uc8fc\ud615 \ubcc0\uc218\uc5d0\ub294 Chi-square test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \uadf8\ub8f9 \ub0b4 \ube44\uad50\uc5d0\uc11c\ub294 \uc5f0\uc18d\ud615 \ubcc0\uc218\uc5d0 paired <em>t<\/em>-test\ub97c \uc0ac\uc6a9\ud558\uc600\uc73c\uba70, \ube44\uc815\uaddc \ubd84\ud3ec\ub97c \ubcf4\uc774\ub294 \ubcc0\uc218\uc5d0\ub294 Wilcoxon signed rank test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc5f0\ub839\uc744 \uae30\uc900\uc73c\ub85c \ud558\uc704 \uadf8\ub8f9 \ubd84\uc11d\uc744 \uc2e4\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4. \uce21\uc815\uc77c\uc758 \uc628\ub3c4, \uc2b5\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud55c \ud6c4 \uacb0\uacfc\uc758 \uadf8\ub8f9 \uac04 \ucc28\uc774\ub97c \ube44\uad50\ud558\uae30 \uc704\ud574 repeated measures analysis of covariance\ub97c \uc2e4\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4. <em>P<\/em> < 0.05\ub97c \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud55c \uac83\uc73c\ub85c \uac04\uc8fc\ud558\uc600\uc2b5\ub2c8\ub2e4. \ubd84\uc11d\uc5d0\ub294 SPSS Statistics for Windows Version 22.0(IBM Corp., Armonk, NY)\uc744 \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\uacb0\uacfc<\/h2>\n<h3>CONSORT(Consolidated Standards of Reporting Trials) \ud750\ub984\ub3c4 \ubc0f \ud53c\ud5d8\uc790\uc758 \uae30\ucd08 \ud2b9\uc131<\/h3>\n<p class=\"isSelectedEnd\">\ub300\uc870 \uc911\uc7ac \uc2dc\ud5d8\uc5d0\uc11c \ud53c\ud5d8\uc790\uc758 \uc9c4\ud589 \uacfc\uc815\uc740 CONSORT \ud615\uc2dd\uc758 \ub3c4\ud45c\ub85c \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B26\" target=\"_blank\" rel=\"noopener\">26<\/a>)(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#F1\" target=\"_blank\" rel=\"noopener\">\uadf8\ub9bc 1<\/a>). 40~60\uc138\uc758 \ud53c\ud5d8\uc790 84\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \ud1b5\uacc4 \ubd84\uc11d\uc744 \uc2e4\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4. IG(<em>n<\/em> = 42)\uc758 \ud3c9\uade0 \uc5f0\ub839\uc740 48.0 \u00b1 5.9\uc138\uc600\uc73c\uba70, CG(<em>n<\/em> = 42)\uc758 \ud3c9\uade0 \uc5f0\ub839\uc740 49.9 \u00b1 6.5\uc138\uc600\uc2b5\ub2c8\ub2e4. IG\uc758 4\uba85\uacfc CG\uc758 3\uba85\uc740 \uc2dc\ud5d8\uacfc \uad00\ub828\uc774 \uc5c6\ub294 \uac1c\uc778\uc801\uc778 \uc774\uc720\ub85c \ub3d9\uc758\ub97c \ucca0\ud68c\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub610\ud55c 3\uba85\uc758 \ud53c\ud5d8\uc790(IG 2\uba85, CG 1\uba85)\ub294 \ud504\ub85c\ud1a0\ucf5c \uc704\ubc18\uc73c\ub85c \uc81c\uc678\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 10\uba85\uc758 \ucc38\uac00\uc790 \ud2b9\uc131\uc740 \uc5f0\uad6c\ub97c \uc644\ub8cc\ud55c \ub2e4\ub978 \ucc38\uac00\uc790\ub4e4\uacfc \uc720\uc0ac\ud558\uc600\uc2b5\ub2c8\ub2e4. IG\uc640 CG \ubaa8\ub450\uc5d0\uc11c \uc21c\uc751\ub3c4\ub294 88%\ub97c \ucd08\uacfc\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub530\ub77c\uc11c ITT population\uacfc PP population\uc740 \uac01\uac01 84\uba85\uacfc 71\uba85\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \uc2dc\uc791 \uc2dc \uc5f0\ub839, \uccb4\uc911, \uc74c\uc8fc \ubc0f \ud761\uc5f0\uc5d0 \ub300\ud574 \uadf8\ub8f9 \uac04 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud55c \ucc28\uc774\ub294 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#T1\" target=\"_blank\" rel=\"noopener\">\ud45c 1<\/a>). \uc774\uc911\ub9f9\uac80 \uc870\uac74\uc740 \uc5f0\uad6c \uc804 \uae30\uac04 \ub3d9\uc548 \uc798 \uc720\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p>CG, \uc704\uc57d \ub300\uc870\uad70; IG, collagen tripeptide \uc911\uc7ac\uad70. \uc74c\uc8fc\ub294 \ud3c9\uade0\uc801\uc73c\ub85c \ud55c \ubc88\uc5d0 5\uc794 \uc774\uc0c1\uc744 \uc8fc 2\ud68c \uc774\uc0c1 \uc12d\ucde8\ud558\ub294 \uac83\uc73c\ub85c \uc815\uc758\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub370\uc774\ud130\ub294 \ud3c9\uade0 \u00b1 \ud45c\uc900\ud3b8\ucc28 \ub610\ub294 \uc218(%)\ub85c \uc81c\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc815\uaddc\uc131 \uac00\uc815 \uac80\uc815\uc5d0\ub294 Shapiro\u2013Wilk&#8217;s test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\ub839\uacfc \uccb4\uc911\uc5d0\ub294 Mann\u2013Whitney&#8217;s U test, \uc2e0\uc7a5\uc5d0\ub294 two-sample t-test, \uc74c\uc8fc\uc5d0\ub294 Chi-square test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<\/section>\n<\/section>\n<table style=\"width: 100%; border-collapse: collapse; font-family: 'Lora', serif; color: #222;\">\n<caption style=\"caption-side: top; text-align: left; padding-bottom: 10px;\"><strong>Table 1.<\/strong>Baseline characteristics of the study subjects.<\/caption>\n<thead>\n<tr>\n<th style=\"border-top: 1px solid #333; border-bottom: 1px solid #333; padding: 12px; text-align: left;\" rowspan=\"2\"><\/th>\n<th style=\"border-top: 1px solid #333; border-bottom: 1px solid #333; padding: 12px; text-align: center;\" colspan=\"3\">Intention to treat population<\/th>\n<th style=\"border-top: 1px solid #333; border-bottom: 1px solid #333; padding: 12px; text-align: center;\" colspan=\"3\">Per protocol population<\/th>\n<\/tr>\n<tr>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">CG (<em>n<\/em> = 41)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">IG (<em>n<\/em> = 41)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\"><em>P<\/em><\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">CG (<em>n<\/em> = 38)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">IG (<em>n<\/em> = 36)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\"><em>P<\/em><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Age (years)<\/td>\n<td style=\"padding: 12px; text-align: center;\">49.9 \u00b1 6.5<\/td>\n<td style=\"padding: 12px; text-align: center;\">48.0 \u00b1 5.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.176<\/td>\n<td style=\"padding: 12px; text-align: center;\">49.5 \u00b1 6.4<\/td>\n<td style=\"padding: 12px; text-align: center;\">47.9 \u00b1 6.0<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.303<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Weight (kg)<\/td>\n<td style=\"padding: 12px; text-align: center;\">56.7 \u00b1 6.8<\/td>\n<td style=\"padding: 12px; text-align: center;\">57.4 \u00b1 8.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.813<\/td>\n<td style=\"padding: 12px; text-align: center;\">56.4 \u00b1 7.0<\/td>\n<td style=\"padding: 12px; text-align: center;\">57.1 \u00b1 9.2<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.864<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Height (cm)<\/td>\n<td style=\"padding: 12px; text-align: center;\">157.9 \u00b1 5.7<\/td>\n<td style=\"padding: 12px; text-align: center;\">157.6 \u00b1 4.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.807<\/td>\n<td style=\"padding: 12px; text-align: center;\">158.1 \u00b1 5.7<\/td>\n<td style=\"padding: 12px; text-align: center;\">157.5 \u00b1 4.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.614<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Alcohol drinking (%)<\/td>\n<td style=\"padding: 12px; text-align: center;\">2 (4.8)<\/td>\n<td style=\"padding: 12px; text-align: center;\">4 (9.8)<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.396<\/td>\n<td style=\"padding: 12px; text-align: center;\">2 (5.3)<\/td>\n<td style=\"padding: 12px; text-align: center;\">3 (8.3)<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.599<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left; border-bottom: 1px solid #333;\">Smoker (%)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">\u2013<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">\u2013<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p class=\"isSelectedEnd\">CG, \uc704\uc57d \ub300\uc870\uad70; IG, collagen tripeptide \uc911\uc7ac\uad70. \uc74c\uc8fc\ub294 \ud3c9\uade0\uc801\uc73c\ub85c \ud55c \ubc88\uc5d0 5\uc794 \uc774\uc0c1\uc744 \uc8fc 2\ud68c \uc774\uc0c1 \uc12d\ucde8\ud558\ub294 \uac83\uc73c\ub85c \uc815\uc758\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub370\uc774\ud130\ub294 \ud3c9\uade0 \u00b1 \ud45c\uc900\ud3b8\ucc28 \ub610\ub294 \uc218(%)\ub85c \uc81c\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc815\uaddc\uc131 \uac00\uc815 \uac80\uc815\uc5d0\ub294 Shapiro\u2013Wilk&#8217;s test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\ub839\uacfc \uccb4\uc911\uc5d0\ub294 Mann\u2013Whitney&#8217;s U test, \uc2e0\uc7a5\uc5d0\ub294 two-sample t-test, \uc74c\uc8fc\uc5d0\ub294 Chi-square test\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h3>\ud53c\ubd80 \ud2b9\uc131\uc758 \ubcc0\ud654<\/h3>\n<h4>\ud53c\ubd80 \uc9c0\ud45c<\/h4>\n<p>\uc2dc\ud5d8 6\uc8fc \ubc0f 12\uc8fc \ud6c4, \ub450 \uadf8\ub8f9 \ubaa8\ub450\uc5d0\uc11c \uc218\ubd84 \uc190\uc2e4\uc774 \uac10\uc18c\ud558\uc600\uc73c\uba70, TEWL\uc758 \uac10\uc18c \ud3ed\uc740 CG\ubcf4\ub2e4 IG\uc5d0\uc11c \ub354 \ud06c\uac8c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#T2\" target=\"_blank\" rel=\"noopener\">\ud45c 2<\/a>). 12\uc8fc \uc2dc\uc810\uc5d0\uc11c \ud574\ub2f9 \uc9c0\uc5ed\uc758 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud55c \ud6c4\uc5d0\ub3c4 \ub450 \uadf8\ub8f9 \uac04 TEWL \ucc28\uc774\ub294 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uac8c \uc720\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4(\uc2b5\ub3c4 \ubc0f \uc628\ub3c4 \ubcf4\uc815, <em>P<\/em> = 0.024; UVA \ubcf4\uc815, <em>P<\/em> = 0.032; \uc628\ub3c4, \uace0\uc628 \ubc0f ultraviolet A \ubcf4\uc815, <em>P<\/em> = 0.031)(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#F2\" target=\"_blank\" rel=\"noopener\">\uadf8\ub9bc 2<\/a>). \ud53c\ubd80 \uc218\ubd84\ub3c4 \uce21\uba74\uc5d0\uc11c\ub294 CG\ubcf4\ub2e4 IG\uc5d0\uc11c \ub354 \ud070 \uac1c\uc120\uc774 \ud655\uc778\ub418\uc5c8\uc73c\ub098, \ub450 \uadf8\ub8f9 \uac04 \uae30\ucd08\uce58 \ub300\ube44 \ubcc0\ud654\ub7c9\uc758 \ucc28\uc774\ub294 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#F2\" target=\"_blank\" rel=\"noopener\">\uadf8\ub9bc 2<\/a>). \ud574\ub2f9 \uc9c0\uc5ed\uc758 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud55c \ud6c4, CG\uc640 IG \ubaa8\ub450\uc5d0\uc11c 50\uc138 \uc774\uc0c1 \ud53c\ud5d8\uc790\uc758 TEWL\uc5d0 \uc720\uc758\ud55c \ucc28\uc774\uac00 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#T3\" target=\"_blank\" rel=\"noopener\">\ud45c 3<\/a>).<\/p>\n<style>\n.responsive-study-table {<br \/>    width: 100%;<br \/>    overflow-x: auto;<br \/>    -webkit-overflow-scrolling: touch;<br \/>    margin: 20px 0;<br \/>}<\/p>\n<p>.responsive-study-table table {<br \/>    width: 100%;<br \/>    min-width: 1200px;<br \/>    border-collapse: collapse;<br \/>    font-family: 'Lora', serif;<br \/>    color: #222;<br \/>}<\/p>\n<p>.responsive-study-table th,<br \/>.responsive-study-table td {<br \/>    padding: 10px 12px;<br \/>    border-bottom: 1px solid #d9d9d9;<br \/>    vertical-align: middle;<br \/>}<\/p>\n<p>.responsive-study-table thead th {<br \/>    text-align: center;<br \/>    font-weight: 700;<br \/>    border-top: 1px solid #333;<br \/>    border-bottom: 1px solid #333;<br \/>}<\/p>\n<p>.responsive-study-table tbody td {<br \/>    text-align: center;<br \/>}<\/p>\n<p>.responsive-study-table tbody td:first-child {<br \/>    text-align: left;<br \/>}<\/p>\n<p>.section-row td {<br \/>    font-weight: 700;<br \/>    text-align: left !important;<br \/>    background: #f7f7f7;<br \/>    border-top: 1px solid #333;<br \/>}<\/p>\n<p>@media screen and (max-width: 767px) {<br \/>    .responsive-study-table table {<br \/>        font-size: 12px;<br \/>        min-width: 1000px;<br \/>    }<\/p>\n<p>    .responsive-study-table th,<br \/>    .responsive-study-table td {<br \/>        padding: 7px 8px;<br \/>    }<br \/>}<br \/><\/style>\n<div class=\"responsive-study-table\">\n<table>\n<thead>\n<tr>\n<th rowspan=\"2\">Variable<\/th>\n<th colspan=\"2\">Observed values<\/th>\n<th colspan=\"7\">Changes from baseline<\/th>\n<\/tr>\n<tr>\n<th>IG (<em>n<\/em> = 14)<\/th>\n<th>CG (<em>n<\/em> = 19)<\/th>\n<th>IG (<em>n<\/em> = 14)<\/th>\n<th><em>P<\/em><sup>a,b<\/sup><\/th>\n<th>CG (<em>n<\/em> = 19)<\/th>\n<th><em>P<\/em><sup>a,b<\/sup><\/th>\n<th><em>P<\/em><sup>c,d<\/sup><\/th>\n<th><em>P<\/em><sup>e<\/sup><\/th>\n<th><em>P<\/em><sup>f<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody><!-- Transepidermal water loss --><\/p>\n<tr class=\"section-row\">\n<td colspan=\"10\">Transepidermal water loss (g\/m<sup>2<\/sup>\/h)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>6.60 \u00b1 2.64<\/td>\n<td>5.54 \u00b1 1.61<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>4.53 \u00b1 1.25<\/td>\n<td>3.97 \u00b1 0.97<\/td>\n<td>\u22122.07 \u00b1 2.20<\/td>\n<td>0.003<sup>a<\/sup><\/td>\n<td>\u22121.57 \u00b1 2.19<\/td>\n<td>0.002<sup>a<\/sup><\/td>\n<td>0.413<sup>c<\/sup><\/td>\n<td>0.152<\/td>\n<td>0.294<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>5.39 \u00b1 1.87<\/td>\n<td>5.16 \u00b1 1.12<\/td>\n<td>\u22121.21 \u00b1 2.00<\/td>\n<td>0.056<sup>a<\/sup><\/td>\n<td>\u22120.39 \u00b1 1.89<\/td>\n<td>0.657<sup>a<\/sup><\/td>\n<td>0.209<sup>c<\/sup><\/td>\n<td>0.034<\/td>\n<td>0.040<\/td>\n<\/tr>\n<p><!-- Skin hydration --><\/p>\n<tr class=\"section-row\">\n<td colspan=\"10\">Skin hydration (A.U.)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>192.39 \u00b1 24.09<\/td>\n<td>195.89 \u00b1 25.70<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>203.90 \u00b1 21.82<\/td>\n<td>192.92 \u00b1 27.34<\/td>\n<td>11.50 \u00b1 19.57<\/td>\n<td>0.047<sup>b<\/sup><\/td>\n<td>\u22122.97 \u00b1 21.56<\/td>\n<td>0.555<sup>b<\/sup><\/td>\n<td>0.057<sup>d<\/sup><\/td>\n<td>0.043<\/td>\n<td>0.046<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>212.55 \u00b1 19.33<\/td>\n<td>212.42 \u00b1 16.51<\/td>\n<td>20.16 \u00b1 21.55<\/td>\n<td>0.004<sup>b<\/sup><\/td>\n<td>16.53 \u00b1 22.70<\/td>\n<td>0.005<sup>b<\/sup><\/td>\n<td>0.646<sup>d<\/sup><\/td>\n<td>0.622<\/td>\n<td>0.639<\/td>\n<\/tr>\n<p><!-- Skin elasticity --><\/p>\n<tr class=\"section-row\">\n<td colspan=\"10\">Skin elasticity (mm)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>0.40 \u00b1 0.11<\/td>\n<td>0.39 \u00b1 0.10<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>0.38 \u00b1 0.12<\/td>\n<td>0.37 \u00b1 0.09<\/td>\n<td>\u22120.03 \u00b1 0.13<\/td>\n<td>0.485<sup>b<\/sup><\/td>\n<td>\u22120.03 \u00b1 0.07<\/td>\n<td>0.124<sup>b<\/sup><\/td>\n<td>0.986<sup>d<\/sup><\/td>\n<td>0.931<\/td>\n<td>0.720<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>0.35 \u00b1 0.11<\/td>\n<td>0.37 \u00b1 0.10<\/td>\n<td>\u22120.05 \u00b1 0.10<\/td>\n<td>0.079<sup>b<\/sup><\/td>\n<td>\u22120.02 \u00b1 0.07<\/td>\n<td>0.208<sup>b<\/sup><\/td>\n<td>0.316<sup>d<\/sup><\/td>\n<td>0.316<\/td>\n<td>0.330<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>Values are presented as mean \u00b1 SD.<\/p>\n<p>aPaired t-test.<br \/>\nbTwo-sample t-test.<br \/>\ncRepeated measures ANCOVA (adjusted for temperature and humidity).<br \/>\ndANCOVA (adjusted for ultraviolet A).<br \/>\neANCOVA (adjusted for temperature, high temperature, and ultraviolet A).<\/p>\n<h5 class=\"obj_head\">Figure 2.<\/h5>\n<p><img decoding=\"async\" class=\"alignnone wp-image-3093 size-full\" src=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002.jpg\" alt=\"\" width=\"630\" height=\"1019\" srcset=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002.jpg 630w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002-185x300.jpg 185w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002-600x970.jpg 600w\" sizes=\"(max-width: 630px) 100vw, 630px\" \/><\/p>\n<p><em>Changes in skin parameters in individuals receiving collagen tripeptide or placebo.\u00a0<strong>(A)<\/strong>\u00a0Changes in transepidermal water loss (TEWL).\u00a0<strong>(B)<\/strong>\u00a0Changes in skin hydration. *P\u00a0< 0.05, **P\u00a0< 0.01 by paired\u00a0t-test comparisons with baseline values.\u00a0P\u00a0< 0.05 by two-sample\u00a0t-test comparisons between values in the intervention group and the control group.<\/em><\/p>\n<p>\u00a0<\/p>\n<style>\n.study-table-wrap {<br \/>    width: 100%;<br \/>    overflow-x: auto;<br \/>    -webkit-overflow-scrolling: touch;<br \/>    margin: 24px 0;<br \/>}<\/p>\n<p>.study-table {<br \/>    width: 100%;<br \/>    min-width: 1200px;<br \/>    border-collapse: collapse;<br \/>    font-family: 'Lora', serif;<br \/>    color: #222;<br \/>    line-height: 1.45;<br \/>}<\/p>\n<p>.study-table th,<br \/>.study-table td {<br \/>    padding: 10px 12px;<br \/>    border-bottom: 1px solid #dcdcdc;<br \/>    vertical-align: middle;<br \/>}<\/p>\n<p>.study-table thead th {<br \/>    text-align: center;<br \/>    font-weight: 700;<br \/>    border-top: 1px solid #333;<br \/>    border-bottom: 1px solid #333;<br \/>}<\/p>\n<p>.study-table tbody td {<br \/>    text-align: center;<br \/>}<\/p>\n<p>.study-table tbody td:first-child {<br \/>    text-align: left;<br \/>    white-space: nowrap;<br \/>}<\/p>\n<p>.study-section td {<br \/>    background: #f7f7f7;<br \/>    font-weight: 700;<br \/>    text-align: left !important;<br \/>    border-top: 1px solid #333;<br \/>}<\/p>\n<p>@media screen and (max-width: 767px) {<br \/>    .study-table {<br \/>        font-size: 12px;<br \/>        min-width: 1050px;<br \/>    }<\/p>\n<p>    .study-table th,<br \/>    .study-table td {<br \/>        padding: 7px 8px;<br \/>    }<br \/>}<br \/><\/style>\n<div class=\"study-table-wrap\">\n<table class=\"study-table\">\n<thead>\n<tr>\n<th rowspan=\"2\">Variable<\/th>\n<th colspan=\"2\">Observed values<\/th>\n<th colspan=\"7\">Changes from baseline<\/th>\n<\/tr>\n<tr>\n<th>IG (<em>n<\/em> = 14)<\/th>\n<th>CG (<em>n<\/em> = 19)<\/th>\n<th>IG (<em>n<\/em> = 14)<\/th>\n<th><em>P<\/em><sup>a,b<\/sup><\/th>\n<th>CG (<em>n<\/em> = 19)<\/th>\n<th><em>P<\/em><sup>a,b<\/sup><\/th>\n<th><em>P<\/em><sup>c,d<\/sup><\/th>\n<th><em>P<\/em><sup>e<\/sup><\/th>\n<th><em>P<\/em><sup>f<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody><!-- Transepidermal water loss --><\/p>\n<tr class=\"study-section\">\n<td colspan=\"10\">Transepidermal water loss (g\/m<sup>2<\/sup>\/h)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>6.60 \u00b1 2.64<\/td>\n<td>5.54 \u00b1 1.61<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>4.53 \u00b1 1.25<\/td>\n<td>3.97 \u00b1 0.97<\/td>\n<td>\u22122.07 \u00b1 2.20<\/td>\n<td>0.003<sup>a<\/sup><\/td>\n<td>\u22121.57 \u00b1 2.19<\/td>\n<td>0.002<sup>a<\/sup><\/td>\n<td>0.413<sup>c<\/sup><\/td>\n<td>0.152<\/td>\n<td>0.294<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>5.39 \u00b1 1.87<\/td>\n<td>5.16 \u00b1 1.12<\/td>\n<td>\u22121.21 \u00b1 2.00<\/td>\n<td>0.056<sup>a<\/sup><\/td>\n<td>\u22120.39 \u00b1 1.89<\/td>\n<td>0.657<sup>a<\/sup><\/td>\n<td>0.209<sup>c<\/sup><\/td>\n<td>0.034<\/td>\n<td>0.040<\/td>\n<\/tr>\n<p><!-- Skin hydration --><\/p>\n<tr class=\"study-section\">\n<td colspan=\"10\">Skin hydration (A.U.)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>192.39 \u00b1 24.09<\/td>\n<td>195.89 \u00b1 25.70<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>203.90 \u00b1 21.82<\/td>\n<td>192.92 \u00b1 27.34<\/td>\n<td>11.50 \u00b1 19.57<\/td>\n<td>0.047<sup>b<\/sup><\/td>\n<td>\u22122.97 \u00b1 21.56<\/td>\n<td>0.555<sup>b<\/sup><\/td>\n<td>0.057<sup>d<\/sup><\/td>\n<td>0.043<\/td>\n<td>0.046<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>212.55 \u00b1 19.33<\/td>\n<td>212.42 \u00b1 16.51<\/td>\n<td>20.16 \u00b1 21.55<\/td>\n<td>0.004<sup>b<\/sup><\/td>\n<td>16.53 \u00b1 22.70<\/td>\n<td>0.005<sup>b<\/sup><\/td>\n<td>0.646<sup>d<\/sup><\/td>\n<td>0.622<\/td>\n<td>0.639<\/td>\n<\/tr>\n<p><!-- Skin elasticity --><\/p>\n<tr class=\"study-section\">\n<td colspan=\"10\">Skin elasticity (mm)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>0.40 \u00b1 0.11<\/td>\n<td>0.39 \u00b1 0.10<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>0.38 \u00b1 0.12<\/td>\n<td>0.37 \u00b1 0.09<\/td>\n<td>\u22120.03 \u00b1 0.13<\/td>\n<td>0.485<sup>b<\/sup><\/td>\n<td>\u22120.03 \u00b1 0.07<\/td>\n<td>0.124<sup>b<\/sup><\/td>\n<td>0.986<sup>d<\/sup><\/td>\n<td>0.931<\/td>\n<td>0.720<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>0.35 \u00b1 0.11<\/td>\n<td>0.37 \u00b1 0.10<\/td>\n<td>\u22120.05 \u00b1 0.10<\/td>\n<td>0.079<sup>b<\/sup><\/td>\n<td>\u22120.02 \u00b1 0.07<\/td>\n<td>0.208<sup>b<\/sup><\/td>\n<td>0.316<sup>d<\/sup><\/td>\n<td>0.316<\/td>\n<td>0.330<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<h4>\ucc38\uac00\uc790\uc758 \uc790\uac00\ud3c9\uac00<\/h4>\n<p>\ub450 \uadf8\ub8f9\uc758 \ud53c\ud5d8\uc790 \ubaa8\ub450 \uc2dc\uac04\uc774 \uc9c0\ub0a8\uc5d0 \ub530\ub77c \ud53c\ubd80 \uc0c1\ud0dc\uac00 \ub2e4\uc18c \uac1c\uc120\ub418\uc5c8\ub2e4\uace0 \ubcf4\uace0\ud558\uc600\uc73c\ub098, \uadf8\ub8f9 \uac04 \uc720\uc758\ud55c \ucc28\uc774\ub294 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#T4\" target=\"_blank\" rel=\"noopener\">\ud45c 4<\/a>). \ub610\ud55c 12\uc8fc \ub3d9\uc548 \ubcf4\ucda9\uc81c\ub97c \uacbd\uad6c \uc12d\ucde8\ud55c \ud6c4 \ubd88\ucf8c\ud55c \ud53c\ubd80 \uac10\uac01\uc740 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#T4\" target=\"_blank\" rel=\"noopener\">\ud45c 4<\/a>). \uadf8\ub7ec\ub098 \ud558\uc704 \uadf8\ub8f9 \ubd84\uc11d\uc5d0\uc11c\ub294 50\uc138 \ubbf8\ub9cc\uc758 \ud53c\ud5d8\uc790\uac00 12\uc8fc \ub3d9\uc548 CTP\ub97c \uc12d\ucde8\ud55c \ud6c4 \uc8fc\uad00\uc801 \ud53c\ubd80 \uac1c\uc120 \uc124\ubb38\uc9c0\uc758 \ucd1d\uc810\uacfc \uc218\ubd84 \ud56d\ubaa9\uc5d0\uc11c \uc720\uc758\ud55c \uac1c\uc120\uc744 \ubcf4\uc600\uc73c\uba70(<em>P<\/em> < 0.05, data not shown), 50\uc138 \uc774\uc0c1\uc758 \ud53c\ud5d8\uc790\ub294 CTP\ub97c 6\uc8fc \ub3d9\uc548 \uc12d\ucde8\ud55c \ud6c4 \ub300\uc870\uad70\uacfc \ube44\uad50\ud558\uc5ec \ud53c\ubd80 \ub2f9\uae40\uc774 \uc720\uc758\ud558\uac8c \uac1c\uc120\ub418\uc5c8\ub2e4\uace0 \ubcf4\uace0\ud558\uc600\uc2b5\ub2c8\ub2e4(<em>P<\/em> < 0.05, data not shown).\n\n\u00a0\n\n\n\n<style>\n.skin-study-table-wrap {<br \/>    width: 100%;<br \/>    overflow-x: auto;<br \/>    -webkit-overflow-scrolling: touch;<br \/>    margin: 24px 0;<br \/>}<\/p>\n<p>.skin-study-table {<br \/>    width: 100%;<br \/>    min-width: 1150px;<br \/>    border-collapse: collapse;<br \/>    font-family: &#8216;Lora&#8217;, serif;<br \/>    color: #222;<br \/>    line-height: 1.45;<br \/>}<\/p>\n<p>.skin-study-table th,<br \/>.skin-study-table td {<br \/>    padding: 10px 12px;<br \/>    border-bottom: 1px solid #dddddd;<br \/>    vertical-align: middle;<br \/>}<\/p>\n<p>.skin-study-table thead th {<br \/>    text-align: center;<br \/>    font-weight: 700;<br \/>    border-top: 1px solid #333;<br \/>    border-bottom: 1px solid #333;<br \/>}<\/p>\n<p>.skin-study-table tbody td {<br \/>    text-align: center;<br \/>}<\/p>\n<p>.skin-study-table tbody td:first-child {<br \/>    text-align: left;<br \/>    white-space: nowrap;<br \/>    font-weight: 500;<br \/>}<\/p>\n<p>@media screen and (max-width: 767px) {<\/p>\n<p>    .skin-study-table {<br \/>        font-size: 12px;<br \/>        min-width: 1000px;<br \/>    }<\/p>\n<p>    .skin-study-table th,<br \/>    .skin-study-table td {<br \/>        padding: 7px 8px;<br \/>    }<br \/>}<br \/><\/style>\n<div class=\"skin-study-table-wrap\">\n<table class=\"skin-study-table\">\n<thead>\n<tr>\n<th rowspan=\"2\">Variable<\/th>\n<th colspan=\"4\">Intervention group (<em>n<\/em> = 36)<\/th>\n<th colspan=\"6\">Control group (<em>n<\/em> = 38)<\/th>\n<\/tr>\n<tr>\n<th>6 week<\/th>\n<th>12 week<\/th>\n<th>\u0394<\/th>\n<th>P<sup>a<\/sup><\/th>\n<th>6 week<\/th>\n<th>12 week<\/th>\n<th>\u0394<\/th>\n<th>P<sup>a<\/sup><\/th>\n<th>P<sup>b<\/sup><\/th>\n<th>P<sup>c<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Total score<\/td>\n<td>35.22 \u00b1 3.4<\/td>\n<td>35.75 \u00b1 3.6<\/td>\n<td>0.53 \u00b1 2.7<\/td>\n<td>0.256<\/td>\n<td>34.87 \u00b1 4.1<\/td>\n<td>35.45 \u00b1 4.4<\/td>\n<td>0.58 \u00b1 4.8<\/td>\n<td>0.461<\/td>\n<td>0.748<\/td>\n<td>0.719<\/td>\n<\/tr>\n<tr>\n<td>Hydration<\/td>\n<td>3.42 \u00b1 0.6<\/td>\n<td>3.50 \u00b1 0.6<\/td>\n<td>0.08 \u00b1 0.6<\/td>\n<td>0.373<\/td>\n<td>3.37 \u00b1 0.6<\/td>\n<td>3.50 \u00b1 0.7<\/td>\n<td>0.13 \u00b1 0.8<\/td>\n<td>0.303<\/td>\n<td>1.000<\/td>\n<td>0.969<\/td>\n<\/tr>\n<tr>\n<td>Smoothness<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>3.53 \u00b1 0.6<\/td>\n<td>0.17 \u00b1 0.6<\/td>\n<td>0.083<\/td>\n<td>3.34 \u00b1 0.7<\/td>\n<td>3.53 \u00b1 0.7<\/td>\n<td>0.18 \u00b1 0.8<\/td>\n<td>0.147<\/td>\n<td>0.992<\/td>\n<td>0.911<\/td>\n<\/tr>\n<tr>\n<td>Roughness<\/td>\n<td>3.28 \u00b1 0.6<\/td>\n<td>3.47 \u00b1 0.7<\/td>\n<td>0.19 \u00b1 0.6<\/td>\n<td>0.070<\/td>\n<td>3.42 \u00b1 0.6<\/td>\n<td>3.47 \u00b1 0.7<\/td>\n<td>0.05 \u00b1 0.9<\/td>\n<td>0.711<\/td>\n<td>0.993<\/td>\n<td>0.959<\/td>\n<\/tr>\n<tr>\n<td>Glowing<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>0.00 \u00b1 0.5<\/td>\n<td>1.000<\/td>\n<td>3.26 \u00b1 0.7<\/td>\n<td>3.32 \u00b1 0.7<\/td>\n<td>0.05 \u00b1 0.7<\/td>\n<td>0.644<\/td>\n<td>0.766<\/td>\n<td>0.843<\/td>\n<\/tr>\n<tr>\n<td>Elasticity<\/td>\n<td>3.39 \u00b1 0.6<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>\u22120.03 \u00b1 0.5<\/td>\n<td>0.744<\/td>\n<td>3.34 \u00b1 0.6<\/td>\n<td>3.32 \u00b1 0.7<\/td>\n<td>\u22120.03 \u00b1 0.8<\/td>\n<td>0.845<\/td>\n<td>0.749<\/td>\n<td>0.756<\/td>\n<\/tr>\n<tr>\n<td>Wrinkles<\/td>\n<td>3.31 \u00b1 0.5<\/td>\n<td>3.25 \u00b1 0.4<\/td>\n<td>\u22120.06 \u00b1 0.5<\/td>\n<td>0.487<\/td>\n<td>3.16 \u00b1 0.5<\/td>\n<td>3.29 \u00b1 0.6<\/td>\n<td>0.13 \u00b1 0.6<\/td>\n<td>0.169<\/td>\n<td>0.739<\/td>\n<td>0.914<\/td>\n<\/tr>\n<tr>\n<td>Itching<\/td>\n<td>2.97 \u00b1 0.3<\/td>\n<td>2.97 \u00b1 0.6<\/td>\n<td>0.00 \u00b1 0.6<\/td>\n<td>1.000<\/td>\n<td>2.97 \u00b1 0.4<\/td>\n<td>2.97 \u00b1 0.6<\/td>\n<td>0.00 \u00b1 0.8<\/td>\n<td>1.000<\/td>\n<td>0.992<\/td>\n<td>0.923<\/td>\n<\/tr>\n<tr>\n<td>Aching<\/td>\n<td>3.00 \u00b1 0.0<\/td>\n<td>3.00 \u00b1 0.0<\/td>\n<td>0.00 \u00b1 0.0<\/td>\n<td>\u2013<\/td>\n<td>3.00 \u00b1 0.4<\/td>\n<td>2.95 \u00b1 0.4<\/td>\n<td>\u22120.05 \u00b1 0.6<\/td>\n<td>0.571<\/td>\n<td>0.422<\/td>\n<td>0.382<\/td>\n<\/tr>\n<tr>\n<td>Burning<\/td>\n<td>2.94 \u00b1 0.3<\/td>\n<td>3.00 \u00b1 0.2<\/td>\n<td>0.06 \u00b1 0.2<\/td>\n<td>0.160<\/td>\n<td>3.00 \u00b1 0.4<\/td>\n<td>3.03 \u00b1 0.4<\/td>\n<td>0.03 \u00b1 0.6<\/td>\n<td>0.785<\/td>\n<td>0.746<\/td>\n<td>0.827<\/td>\n<\/tr>\n<tr>\n<td>Stinging<\/td>\n<td>2.97 \u00b1 0.4<\/td>\n<td>3.00 \u00b1 0.4<\/td>\n<td>0.03 \u00b1 0.3<\/td>\n<td>0.571<\/td>\n<td>2.89 \u00b1 0.3<\/td>\n<td>2.92 \u00b1 0.4<\/td>\n<td>0.03 \u00b1 0.5<\/td>\n<td>0.734<\/td>\n<td>0.383<\/td>\n<td>0.366<\/td>\n<\/tr>\n<tr>\n<td>Tightness<\/td>\n<td>3.22 \u00b1 0.6<\/td>\n<td>3.31 \u00b1 0.5<\/td>\n<td>0.08 \u00b1 0.4<\/td>\n<td>0.263<\/td>\n<td>3.11 \u00b1 0.5<\/td>\n<td>3.16 \u00b1 0.6<\/td>\n<td>0.05 \u00b1 0.6<\/td>\n<td>0.600<\/td>\n<td>0.282<\/td>\n<td>0.300<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\uac12\uc740 \ud3c9\uade0 \u00b1 SD\ub85c \uc81c\uc2dc\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p>a Paired t-test.<br \/>\nb 6\uc8fc\uc640 12\uc8fc \uc0ac\uc774\uc758 \ubcc0\ud654\ub97c \ube44\uad50\ud55c two-sample t-test.<br \/>\nc Repeated measures ANCOVA(\uc628\ub3c4, \uc2b5\ub3c4 \ubc0f ultraviolet A \ubcf4\uc815).<\/p>\n<h3>\uc548\uc804\uc131<\/h3>\n<p>\ub300\ubd80\ubd84\uc758 \ud53c\ud5d8\uc790\ub294 \uc774\uc0c1 \uc99d\uc0c1 \uc5c6\uc774 \uc5f0\uad6c \ud504\ub85c\ud1a0\ucf5c\uc744 \uc644\ub8cc\ud558\uc600\uc2b5\ub2c8\ub2e4. CG\uc758 \ud53c\ud5d8\uc790 1\uba85\uc774 \uad6c\uac15 \uac74\uc870\ub97c \ud638\uc18c\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc774 \uc99d\uc0c1\uc774 CTP \uc12d\ucde8\uc640 \uad00\ub828\uc774 \uc5c6\ub294 \uac83\uc73c\ub85c\ub294 \ud310\ub2e8\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub450 \uadf8\ub8f9 \ubaa8\ub450\uc5d0\uc11c \uac04 \ud6a8\uc18c, creatinine \ubc0f glucose \uc218\uce58\uc758 \uc784\uc0c1\uc801\uc73c\ub85c \uc720\uc758\ud55c \ubcc0\ud654\ub294 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \uae30\uac04 \ub3d9\uc548 \uc774\ub7ec\ud55c \uc9c0\ud45c\uc5d0\uc11c \uadf8\ub8f9 \uac04 \ucc28\uc774\ub3c4 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\uace0\ucc30<\/h2>\n<p>CTP\ub294 \uc624\ub7ab\ub3d9\uc548 \ud53c\ubd80 \ub178\ud654 \ubc29\uc9c0\ub97c \uc704\ud55c \uac00\uc7a5 \ub110\ub9ac \uc0ac\uc6a9\ub418\ub294 \ubcf4\ucda9\uc81c \uc911 \ud558\ub098\uc600\uc9c0\ub9cc, \uc778\uac04\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \ud6a8\uacfc\uc5d0 \ub300\ud55c \uadfc\uac70\ub294 \uc544\uc9c1 \ucda9\ubd84\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ubcf8 \uc784\uc0c1\uc2dc\ud5d8\uc740 \ub2e4\uc591\ud55c \ud53c\ubd80 \uc9c0\ud45c\uc5d0 \ub300\ud55c CTP\uc758 \uc720\ud6a8\uc131, \uc548\uc804\uc131 \ubc0f \ub0b4\uc57d\uc131\uc744 \ud655\uc778\ud558\ub294 \uac83\uc744 \ubaa9\uc801\uc73c\ub85c \ud558\uc600\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c \uacb0\uacfc, \uc911\ub144 \uc5ec\uc131\uc774 12\uc8fc \ub3d9\uc548 \ub9e4\uc77c 1,000 mg\uc758 CTP\ub97c \uacbd\uad6c \uc12d\ucde8\ud588\uc744 \ub54c TEWL\uc774 \uac10\uc18c\ud558\uc600\uc73c\uba70, \uc804\ubc18\uc801\uc73c\ub85c \uc591\ud638\ud55c \ub0b4\uc57d\uc131\uc744 \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \ud53c\ubd80 \uc0c1\ud0dc\ub294 \uc5f0\ub839, \uc131\ubcc4 \ubc0f \uce21\uc815 \ubd80\uc704\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc0dd\ud65c\uc2b5\uad00\uacfc \ud53c\ubd80 \uc0dd\ub9ac \ub4f1 \uc5ec\ub7ec \uc694\uc778\uc758 \uc870\ud569\uc5d0 \uc758\ud574 \uacb0\uc815\ub429\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B27\" target=\"_blank\" rel=\"noopener\">27<\/a>). \ud53c\ubd80\uc758 \ubcf4\uc2b5 \ud2b9\uc131\uacfc UV \ub178\ucd9c\uc740 \uac74\uc870\ud55c \uac00\uc744 \ubc0f \uaca8\uc6b8\ubcf4\ub2e4 \ubd04\uacfc \uc5ec\ub984\uc5d0 \ub354 \ub192\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B28\" target=\"_blank\" rel=\"noopener\">28<\/a>). UVA\ub294 \ud53c\ubd80 \uae4a\uc219\uc774 \uce68\ud22c\ud558\uc5ec \ud608\uad00 \ubc0f \uc9c4\ud53c \ub0b4 \uc138\ud3ec \uce68\uc724\uc5d0 \uc190\uc0c1\uc744 \uc904 \uc218 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B29\" target=\"_blank\" rel=\"noopener\">29<\/a>\u2013<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B31\" target=\"_blank\" rel=\"noopener\">31<\/a>). \ub530\ub77c\uc11c \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \ud53c\ud5d8\uc790\ub4e4\uc758 CTP \uc12d\ucde8 \ud6a8\uacfc\ub97c \ubcf4\ub2e4 \uad6c\uccb4\uc801\uc73c\ub85c \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc678\ubd80 \uae30\uc0c1 \uc694\uc778\uc744 \ubcf4\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc2dc\ud5d8 \uae30\uac04 \ub3d9\uc548 \ucc38\uac00\uc790\ub4e4\uc774 \uac70\uc8fc\ud55c \uc9c0\uc5ed\uc758 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud55c \ud6c4\uc5d0\ub3c4 \ub450 \uadf8\ub8f9 \uac04 TEWL \ucc28\uc774\ub294 \uc720\uc758\ud558\uac8c \uc720\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ub178\ud654\ub294 \ud53c\ubd80 \ub450\uaed8\uc640 \uc0c1\ud53c\uc138\ud3ec \uc218\uc758 \uac10\uc18c\uc640 \uad00\ub828\uc774 \uc788\uc73c\uba70, \ub3d9\uc2dc\uc5d0 stromal collagen\ub3c4 \uac10\uc18c\ud569\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B2\" target=\"_blank\" rel=\"noopener\">2<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B3\" target=\"_blank\" rel=\"noopener\">3<\/a>). \uc80a\uc740 \uc5ec\uc131\uacfc \ube44\uad50\ud588\uc744 \ub54c \uc911\ub144 \uc5ec\uc131\uc5d0\uc11c\ub294 estrogen \uacb0\ud54d\uc774 \ud45c\ud53c\uc5d0 \uc9c1\uc811\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uc5b4 \ud53c\ubd80 \ub178\ud654 \uacfc\uc815\uc774 \ub354\uc6b1 \uc2ec\ud654\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B32\" target=\"_blank\" rel=\"noopener\">32<\/a>). \ub610\ud55c \ud654\uc7a5\ud488 \ubc0f \ubbf8\uc6a9 \uc2dc\uc220\uc5d0 \ub300\ud55c \uc9c0\ucd9c \uc99d\uac00\uc5d0\uc11c \ub098\ud0c0\ub098\ub4ef\uc774 \ub9ce\uc740 \uc911\ub144 \uc5ec\uc131\uc740 \uc5bc\uad74 \uc678\ubaa8\uc640 \ub208\uc5d0 \ubcf4\uc774\ub294 \ub178\ud654 \ud604\uc0c1\uc5d0 \ub192\uc740 \uad00\uc2ec\uc744 \uac00\uc9c0\uace0 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B33\" target=\"_blank\" rel=\"noopener\">33<\/a>). \uc774\ub7ec\ud55c \ub9e5\ub77d\uc5d0\uc11c \ubcf8 \uc5f0\uad6c\ub294 \ub0a8\uc131\uc774\ub098 \uc80a\uc740 \uc5ec\uc131\uc5d0 \ube44\ud574 collagen treatment\uc758 \ud61c\ud0dd\uc744 \ub354 \ud06c\uac8c \ubc1b\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\ub294 \uc911\ub144 \uc5ec\uc131\uc744 \ub300\uc0c1\uc73c\ub85c \ud558\uc600\ub2e4\ub294 \uc810\uc5d0\uc11c \uc784\uc0c1\uc801 \uc758\ubbf8\uac00 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ud53c\ubd80 \uae30\ub2a5\uc5d0\uc11c collagen\uc758 \ud6a8\ub2a5\uc774 \ub098\ud0c0\ub098\ub294 \uc0dd\ubb3c\ud559\uc801 \uae30\uc804\uc740 \uc9c4\ud53c\uc5d0\uc11c\uc758 \uc791\uc6a9\uc73c\ub85c \uc124\uba85\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B34\" target=\"_blank\" rel=\"noopener\">34<\/a>). \uadf8\ub7ec\ub098 collagen\uc740 \ud070 \ubd84\uc790\uc774\uba70 \uc704\uc7a5\uad00\uc5d0\uc11c \uc0dd\ub9ac\ud65c\uc131 \ud615\ud0dc\ub85c \uc27d\uac8c \ubd84\ud574\ub418\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0, \ud45c\uc801 \uc870\uc9c1\uc5d0 \ub3c4\ub2ec\ud558\uc5ec \ub2e4\uc591\ud55c \uc0dd\ub9ac\uc801 \uae30\ub2a5\uc5d0 \ucc38\uc5ec\ud560 \uc218 \uc788\ub3c4\ub85d \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ub192\uc774\ub294 \uac83\uc740 \uc784\uc0c1\uc801\uc73c\ub85c \uc5b4\ub824\uc6b4 \uacfc\uc81c\uc785\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B35\" target=\"_blank\" rel=\"noopener\">35<\/a>). \uc774\uac83\uc774 \ubc14\ub85c collagen\uc774 \ud53c\ubd80 \uac74\uac15 \ubcf4\ucda9\uc81c\uc5d0 \uac00\uc7a5 \ud754\ud788 \uc0ac\uc6a9\ub418\ub294 \uc131\ubd84 \uc911 \ud558\ub098\uc784\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ud53c\ubd80\uc5d0 \ubbf8\uce58\ub294 \ud6a8\uacfc\uc5d0 \uad00\ud55c \uadfc\uac70\uac00 \uc0c1\ub300\uc801\uc73c\ub85c \ubd80\uc871\ud55c \uc774\uc720\uc785\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B4\" target=\"_blank\" rel=\"noopener\">4<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B21\" target=\"_blank\" rel=\"noopener\">21<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B36\" target=\"_blank\" rel=\"noopener\">36<\/a>). \ud53c\ubd80\uc5d0 \ub300\ud55c collagen\uc758 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \ub192\uc774\uae30 \uc704\ud574 LMWCP\uc758 \uc81c\uc870\uac00 \uc810\ucc28 \uc99d\uac00\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ub354 \uc791\uc740 peptide\ub294 \uc704\uc7a5\uad00 \ubc0f \ud608\uc7a5 \ud6a8\uc18c\uc758 \uc791\uc6a9\uc5d0 \ub354 \uc798 \uacac\ub514\uace0 \uc7a5 \uc0c1\ud53c\uc138\ud3ec\ub9c9\uc744 \ud1b5\uacfc\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc608\uc0c1\ub429\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>).<\/p>\n<p>\ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ub41c CTP\uc5d0\ub294 3.2%\uc758 Gly-Pro-Hyp\uac00 \ud3ec\ud568\ub418\uc5b4 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774 \uc11c\uc5f4\uc740 collagen \uc720\ub798 peptide\uc758 \uc8fc\uc694 \ud65c\uc131 \uc131\ubd84\uc785\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B37\" target=\"_blank\" rel=\"noopener\">37<\/a>). \uc57d\ub9ac\ud559\uc801 \uc0dd\uccb4\uc774\uc6a9\ub960 \uc5f0\uad6c\uc5d0\uc11c\ub294 Gly-Pro-Hyp\uc5d0\uc11c \uc720\ub798\ud55c Pro-Hyp dipeptide\uac00 \uacbd\uad6c \ud22c\uc5ec \ud6c4 \uc218 \uc2dc\uac04 \ub3d9\uc548 \uc778\uac04 \ud608\ub958\uc5d0\uc11c \ub192\uc740 \ub18d\ub3c4\ub85c \uc874\uc7ac\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B35\" target=\"_blank\" rel=\"noopener\">35<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B38\" target=\"_blank\" rel=\"noopener\">38<\/a>). \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c\ub294 14C\ub85c \ud45c\uc9c0\ub41c Pro-Hyp\uac00 \uc12d\ucde8 \ud6c4 \ud53c\ubd80\uc640 \ubf08 \uc870\uc9c1\uc5d0 \ube60\ub974\uac8c \ub3c4\ub2ec\ud558\ub294 \uac83\uc774 \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B39\" target=\"_blank\" rel=\"noopener\">39<\/a>). \ubcf4\ub2e4 \ucd5c\uadfc\uc758 \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c\ub294 \uacbd\uad6c \ud22c\uc5ec\ub41c collagen peptide\uac00 Pro-Hyp\uc758 \ud761\uc218\ub97c \ud1b5\ud574 UVB \uc720\ubc1c \ud53c\ubd80 \ub178\ud654\ub97c \ubc29\uc9c0\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B40\" target=\"_blank\" rel=\"noopener\">40<\/a>). \ub610\ud55c \ud55c \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\ub294 collagen hydrolysate \uc12d\ucde8 \ud6c4 \uc18c\ubcc0\uc5d0\uc11c Pro-Hyp\uac00 \ud655\uc778\ub418\uc5c8\uc73c\uba70, \uc774\ub294 \uc774\ub7ec\ud55c \ud615\ud0dc\uc758 collagen peptide\uac00 \ud608\ub958 \ub0b4 peptidase\uc5d0 \ub300\ud574 \uc0c1\ub300\uc801\uc73c\ub85c \uc548\uc815\uc801\uc774\uace0 \uc800\ud56d\uc131\uc744 \uac00\uc9c0\uba70 \ud53c\ubd80 \uc870\uc9c1\uae4c\uc9c0 \ub3c4\ub2ec\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B13\" target=\"_blank\" rel=\"noopener\">13<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B41\" target=\"_blank\" rel=\"noopener\">41<\/a>). \ub610\ud55c \ud53c\ubd80 \uc9c4\ud53c fibroblast\uc5d0\uc11c Pro-Hyp\uc758 \uc0dd\ub9ac\uc801 \uae30\ub2a5\uc744 \uc870\uc0ac\ud55c \uc77c\ubd80 <em>in vitro<\/em> \uc5f0\uad6c\uc5d0\uc11c\ub294 Pro-Hyp\uac00 \uc138\ud3ec \uc99d\uc2dd \ud65c\uc131\uc744 \uc99d\uac00\uc2dc\ud0a4\uace0 \uc9c4\ud53c fibroblast\uc758 chemotaxis\ub97c \ucd09\uc9c4\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B34\" target=\"_blank\" rel=\"noopener\">34<\/a>). \ub610\ud55c Pro-Hyp\ub294 \uc9c4\ud53c fibroblast\uc5d0\uc11c hyaluronic acid\uc758 \uc0dd\uc131\uc744 \ucd09\uc9c4\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B42\" target=\"_blank\" rel=\"noopener\">42<\/a>). \uc774\ub7ec\ud55c Pro-Hyp\uc758 \uc0dd\ub9ac\uc801 \uc5ed\ud560\uc740 \ud53c\ubd80 \uac74\uac15 \uc720\uc9c0\uc5d0 \uc788\uc5b4 collagen hydrolysate\uc758 \ud6a8\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0a4\ub294 \ub370 \uc911\uc694\ud569\ub2c8\ub2e4. \ud604\uc7ac \uacbd\uad6c collagen \uc12d\ucde8 \ud6c4 \ud3c9\uac00\ub41c \ud53c\ubd80 \uc0c1\ud0dc\uc5d0\uc11c \ub098\ud0c0\ub09c \uc720\uc775\ud55c \uacb0\uacfc\ub294 CTP\uc5d0 \ud3ec\ud568\ub41c Gly-Pro-Hyp\uc640 Pro-Hyp\uac00 \ud6a8\uacfc\uc801\uc73c\ub85c \ud761\uc218\ub418\uace0 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \ub098\ud0c0\ub0bc \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n<p>CTP\uc5d0 \uad00\ud55c \ub300\ubd80\ubd84\uc758 \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\ub294 CTP \ubcf4\ucda9 \ud6c4 \uc804\ubc18\uc801\uc778 \ud53c\ubd80 \uc9c8\uac10\uc774 \uac1c\uc120\ub418\ub294 \uae0d\uc815\uc801\uc778 \uacb0\uacfc\ub97c \ubcf4\uace0\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B4\" target=\"_blank\" rel=\"noopener\">4<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B36\" target=\"_blank\" rel=\"noopener\">36<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B43\" target=\"_blank\" rel=\"noopener\">43<\/a>\u2013<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B45\" target=\"_blank\" rel=\"noopener\">45<\/a>). \uadf8\ub7ec\ub098 \uc774\ub7ec\ud55c \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ub41c collagen \ubcf4\ucda9\uc81c\uc5d0\ub294 \ube44\ud0c0\ubbfc\uc774\ub098 \ubbf8\ub124\ub784\uc744 \ud568\uc720\ud55c antioxidants \ub4f1 collagen \uc0dd\uc131\uc744 \ucd09\uc9c4\ud558\uac70\ub098 \ubd84\ud574\ub97c \uc5b5\uc81c\ud558\ub294 \ub2e4\ub978 \uc131\ubd84\ub4e4\ub3c4 \ud3ec\ud568\ub418\uc5b4 \uc788\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B46\" target=\"_blank\" rel=\"noopener\">46<\/a>). \ub530\ub77c\uc11c \ud53c\ubd80 \ud0c4\ub825\uc758 \uc99d\uac00\ub294 collagen bioactive peptide\uc758 \uc874\uc7ac\ubfd0\ub9cc \uc544\ub2c8\ub77c antioxidants \ud63c\ud569\ubb3c\uc758 \uc601\ud5a5\uc5d0\uc11c\ub3c4 \ube44\ub86f\ub418\uc5c8\uc744 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc131\ubd84\ub4e4\uc758 \uc720\uc775\ud55c \ud2b9\uc131\uc740 \uc774\ubbf8 \uc798 \uc54c\ub824\uc838 \uc788\uace0 \uad11\ubc94\uc704\ud558\uac8c \uc5f0\uad6c\ub418\uc5b4 \uc654\uae30 \ub54c\ubb38\uc5d0(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B47\" target=\"_blank\" rel=\"noopener\">47<\/a>), \uc774\uc804 \uc5f0\uad6c \uacb0\uacfc\ub9cc\uc73c\ub85c\ub294 CTP \uc790\uccb4\uac00 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \uae0d\uc815\uc801\uc778 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294\uc9c0, \uadf8\ub9ac\uace0 \uadf8 \uac1c\uc120 \uc815\ub3c4\uac00 \uc5b4\ub290 \uc815\ub3c4\uc778\uc9c0 \uba85\ud655\ud788 \ud310\ub2e8\ud558\uae30 \uc5b4\ub835\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 CTP \uc790\uccb4\uac00 \ud53c\ubd80\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uad6c\uccb4\uc801\uc73c\ub85c \uc870\uc0ac\ud558\uae30 \uc704\ud574 \uc2dc\ud5d8\uad70\uc5d0 CTP\ub9cc \ud3ec\ud568\ub41c \ubcf4\ucda9\uc81c\ub97c \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ud55c CTP\uc758 \ud2b9\uc131\uacfc \uad00\ub828\ud558\uc5ec, \ucd5c\uadfc \uc218\ud589\ub41c \ud55c \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc740 \ubcf8 \uc5f0\uad6c\uc640 \ube44\uad50 \uac00\ub2a5\ud55c \uc5f0\uad6c\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>). \uc774 \uc2dc\ud5d8\uc5d0\uc11c\ub294 1,000 mg\uc758 LMWCP(3% Gly-Pro-Hyp\ub97c \ud3ec\ud568\ud558\uc5ec tripeptide \ud568\ub7c9 >15%)\uc640 100 mg\uc758 vitamin C\ub97c \ud22c\uc5ec\ubc1b\uc740 \uc2dc\ud5d8\uad70\uacfc 100 mg\uc758 vitamin C\ub9cc \ud22c\uc5ec\ubc1b\uc740 \uc704\uc57d\uad70\uc744 \ube44\uad50\ud558\uc600\uc2b5\ub2c8\ub2e4. \ud574\ub2f9 \uc5f0\uad6c\uc5d0\uc11c\ub294 40~60\uc138 \uc5ec\uc131\uc5d0\uc11c 12\uc8fc\uac04 LMWCP\ub97c \uacbd\uad6c \uc12d\ucde8\ud588\uc744 \ub54c \ud53c\ubd80 \uc218\ubd84\ub3c4, \ud0c4\ub825 \ubc0f \uc8fc\ub984\uc774 \uac1c\uc120\ub418\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc5f0\uad6c\uac00 2\uc6d4(\uc5f0\uad6c\uac00 \uc218\ud589\ub41c \uad6d\uac00\uc5d0\uc11c \uc2b5\ub3c4\uac00 \ub0ae\uace0 \uae30\uc628\uc774 \ub0ae\uc740 \uaca8\uc6b8)\ubd80\ud130 6\uc6d4(\uc2b5\ub3c4\uc640 \uae30\uc628\uc774 \ub192\uc740 \uc5ec\ub984)\uae4c\uc9c0 \uc9c4\ud589\ub418\uc5c8\ub2e4\ub294 \uc810\uc744 \uace0\ub824\ud558\uba74, \uc774\ub7ec\ud55c \uae0d\uc815\uc801 \uacb0\uacfc\ub294 \ucc38\uac00\uc790\uc758 \ud53c\ubd80 \ud2b9\uc131\uc744 \ud3c9\uac00\ud55c \uc2dc\uc810\uc758 \uc11c\ub85c \ub2e4\ub978 \uae30\uc0c1 \uc870\uac74\uc5d0\uc11c \ube44\ub86f\ub418\uc5c8\uc744 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \ud3c9\uac00 \uc804 \ucc38\uac00\uc790\ub97c \uc77c\uc815\ud55c \uc628\ub3c4(22\u201324\u00b0C)\uc640 \uc2b5\ub3c4(40\u201360%)\uc758 \uacf5\uac04\uc5d0\uc11c 30\ubd84 \ub3d9\uc548 \uba38\ubb3c\uac8c \ud558\uc5ec \ub300\uae30 \ud658\uacbd\uc774 \ud53c\ubd80 \uc9c8\uac10\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubc30\uc81c\ud558\ub824\uace0 \ud558\uc600\uc9c0\ub9cc, \ub450 \ud3c9\uac00 \uc2dc\uc810\uc758 \uc804\ubc18\uc801\uc778 \uae30\uc0c1 \uc870\uac74\uc774 \ucc38\uac00\uc790\uc758 \ud53c\ubd80 \uc0c1\ud0dc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\ucce4\uc744 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ud658\uacbd\uc758 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA\ub294 \ud53c\ubd80 \uc7a5\ubcbd \uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce69\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B31\" target=\"_blank\" rel=\"noopener\">31<\/a>). \uc800\uc628 \ubc0f \ub0ae\uc740 \uc2b5\ub3c4\uc640 \uac19\uc740 \uae30\ud6c4 \uc694\uc778\uc740 \ud53c\ubd80\uc758 \uc218\ubd84 \uc190\uc2e4\uc744 \uac00\uc18d\ud654\ud558\uace0 \ud53c\ubd80 \uac74\uc870 \ubc0f dermatitis\uc758 \uc704\ud5d8\uc744 \ub192\uc785\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B31\" target=\"_blank\" rel=\"noopener\">31<\/a>).<\/p>\n<p>\uc774\ub7ec\ud55c \uce21\uba74\uc5d0\uc11c \ud53c\ubd80 \uc9c8\uac10\uc758 \ubcc0\ud654\ub97c \ud3c9\uac00\ud558\ub294 \uc784\uc0c1 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc911\uc7ac\uac00 \uc218\ud589\ub41c \uc9c0\uc5ed\uc758 \uacc4\uc808\uc801 \ubcc0\ud654\ub97c \uc8fc\uc694 covariate factor\ub85c \ud3ec\ud568\ud574\uc57c \ud569\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uae30\uc0c1 \uc870\uac74\uc774 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubc30\uc81c\ud558\uae30 \uc704\ud574, 12\uc8fc\uac04 CTP\ub97c \uacbd\uad6c \uc12d\ucde8\ud55c \ud6c4 \ud53c\ubd80 \uc9c0\ud45c\uc758 \ubcc0\ud654\ub97c \ubd84\uc11d\ud560 \ub54c \uc5f0\uad6c \uae30\uac04 \ub3d9\uc548 \ucc38\uac00\uc790\ub4e4\uc774 \uac70\uc8fc\ud55c \uc9c0\uc5ed\uc758 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA\ub97c \ubcf4\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4. \ud3c9\uade0 \uc2b5\ub3c4, \uc628\ub3c4 \ubc0f UVA \ub370\uc774\ud130\ub294 \uc9c0\uc5ed \uae30\uc0c1\uccad\uc5d0\uc11c \uc218\uc9d1\ub418\uc5c8\uae30 \ub54c\ubb38\uc5d0 \ud658\uacbd \ub370\uc774\ud130\ub294 \uc2e0\ub8b0\uc131\uacfc \uc815\ud655\uc131\uc744 \uac16\ucd94\uace0 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uae30\uc0c1 \uc870\uac74 \ubcf4\uc815\uc740 \uc774\uc804 \uc5f0\uad6c \ucc38\uac00\uc790\ub4e4\uacfc \ube44\uad50\ud558\uc5ec \ubcf8 \uc5f0\uad6c \ucc38\uac00\uc790\uc5d0\uc11c \ud53c\ubd80 \uc9c0\ud45c\uc758 \uac1c\uc120 \uc815\ub3c4\uac00 \uc0c1\ub300\uc801\uc73c\ub85c \ub0ae\uac8c \ub098\ud0c0\ub09c \uc774\uc720\ub97c \ubd80\ubd84\uc801\uc73c\ub85c \uc124\uba85\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>). \ub610\ud55c \ubcf8 \uc5f0\uad6c\uc758 \uc704\uc57d\uad70\uc5d0\uc11c \ud53c\ubd80 \uc0c1\ud0dc\uac00 \uc720\uc758\ud558\uac8c \uac1c\uc120\ub41c \uac83\uc740 \uacc4\uc808\uc801 \ubcc0\ud654\uc5d0 \ub530\ub978 \uacb0\uacfc\uc77c \uac00\ub2a5\uc131\uc774 \uc788\ub2e4\uace0 \uac00\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c \uc774\uc804\uc5d0\ub3c4 CTP\uac00 \ud53c\ubd80 \uac74\uac15\uc5d0 \uae0d\uc815\uc801\uc778 \uacb0\uacfc\ub97c \ub098\ud0c0\ub0b8 \uc5ec\ub7ec \uc5f0\uad6c\uac00 \uc788\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B4\" target=\"_blank\" rel=\"noopener\">4<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B15\" target=\"_blank\" rel=\"noopener\">15<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B36\" target=\"_blank\" rel=\"noopener\">36<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B43\" target=\"_blank\" rel=\"noopener\">43<\/a>\u2013<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B45\" target=\"_blank\" rel=\"noopener\">45<\/a>). \uadf8\ub7ec\ub098 \uc774\uc804 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uae30\ud6c4 \uc694\uc778\uc744 \uace0\ub824\ud558\uc9c0 \uc54a\uc558\uc73c\uba70, \uc774\uac83\uc774 \ubcf8 \uc5f0\uad6c\uc640 \uc774\uc804 \uc5f0\uad6c\ub97c \uad6c\ubd84\ud558\ub294 \uc911\uc694\ud55c \ucc28\uc774\uc810\uc785\ub2c8\ub2e4.<\/p>\n<p>\uc8fc\ubcc0 \ud658\uacbd\uc758 \ub0ae\uc740 \uc628\ub3c4 \ubc0f\/\ub610\ub294 \ub192\uc740 \uc5fc\ubd84\uc73c\ub85c \uc778\ud574 \uc5b4\ub958\ub294 \uc721\uc0c1 \ub3d9\ubb3c \uc720\ub798 collagen peptide\uc640 \ube44\uad50\ud558\uc5ec \uc6b0\uc218\ud55c collagen \uacf5\uae09\uc6d0\uc774 \ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc5b4\ub958 \uc720\ub798 collagen\uc740 \uace0\uc720\ud55c \uc544\ubbf8\ub178\uc0b0 \uc870\uc131\uacfc \ubd84\uc790\uc801\u00b7\uc0dd\ubb3c\ud559\uc801 \ud2b9\uc131\uc744 \uac00\uc9c0\uba70, antioxidant, anti-skin aging \ubc0f anti-fat accumulating \ud65c\uc131\uc744 \ubcf4\uc785\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B10\" target=\"_blank\" rel=\"noopener\">10<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B36\" target=\"_blank\" rel=\"noopener\">36<\/a>, <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B48\" target=\"_blank\" rel=\"noopener\">48<\/a>). Ohara et al.(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B49\" target=\"_blank\" rel=\"noopener\">49<\/a>)\uc740 \uc11c\ub85c \ub2e4\ub978 type 1 collagen \uacf5\uae09\uc6d0(\uc5b4\ub958 \ubc0f \ub3fc\uc9c0 \uc720\ub798 gelatin hydrolysate)\uc5d0\uc11c \uc2dd\ud488 \uc720\ub798 gelatin hydrolysate peptide\ub97c \uc12d\ucde8\ud55c \ud6c4 \uc778\uac04 \ud608\uc561 \ub0b4 peptide\uc758 \uc591\uacfc \uad6c\uc870\ub97c \ube44\uad50\ud558\uc600\uc2b5\ub2c8\ub2e4. Free form Hyp\uc758 \uacbd\uc6b0 \uc5b4\ub958 gelatin hydrolysate\uac00 \ub3fc\uc9c0 gelatin hydrolysate\ubcf4\ub2e4 \ub354 \ub9ce\uc774 \ud761\uc218\ub418\uc5c8\uc73c\uba70, \uc774\ub294 \uc5b4\ub958 gelatin\uc5d0\uc11c \uc720\ub798\ud55c \uc800\ubd84\uc790 collagen\uc774 \uc0dd\uccb4\uc774\uc6a9\ub960 \ubc0f \ud53c\ubd80 \uac74\uac15 \uac1c\uc120 \uce21\uba74\uc5d0\uc11c \ub354 \uc6b0\uc218\ud560 \uac00\ub2a5\uc131\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \ub610\ud55c \ud3ec\uc720\ub958 \uae30\ubc18 collagen\uacfc \ube44\uad50\ud560 \ub54c, marine-based collagen\uc740 \uc9c8\ubcd1 \uc804\ud30c \uc704\ud5d8\uc774 \uc5c6\uace0, \uc885\uad50\uc801 \uc81c\uc57d\uc774 \uc801\uc73c\uba70, \ube44\uc6a9 \ud6a8\uc728\uc801\uc778 \uacf5\uc815, \ub0ae\uc740 \ubd84\uc790\ub7c9, \uc0dd\uccb4\uc801\ud569\uc131 \ubc0f \uc778\uccb4\uc5d0\uc11c\uc758 \uc6a9\uc774\ud55c \ud761\uc218 \ub4f1\uc758 \ud2b9\uc131\uc73c\ub85c \uc778\ud574 \ud65c\uc6a9\uc774 \ube60\ub974\uac8c \uc99d\uac00\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p>Bioactive peptide\uc758 \uc0dd\uccb4\uc774\uc6a9\ub960\uc744 \ub192\uc774\uae30 \uc704\ud574 \ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ud55c CTP\ub294 \ube44\ubcd1\uc6d0\uc131 <em>Bacillus<\/em> \uc18d \uc138\uade0\uc5d0\uc11c \uc720\ub798\ud55c collagenase\ub97c \uc774\uc6a9\ud55c \ubd84\ud574 \ubc29\ubc95\uc73c\ub85c Tilapia \uc5b4\ud53c\uc5d0\uc11c \uc81c\uc870\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub3d9\ubb3c \uc5f0\uad6c\uc5d0\uc11c CTP\uc758 Gly-Pro-Hyp\uc640 Pro-Hyp \uc131\ubd84\uc740 \uace0\ubd84\uc790 collagen peptide\uc5d0 \ube44\ud574 \uc950\uc5d0\uac8c \uacbd\uad6c \ud22c\uc5ec\ud55c \ud6c4 \ub354 \uc798 \ud761\uc218\ub418\uace0 \ub354 \ub192\uc740 \ud608\uc7a5 \ub18d\ub3c4\uc5d0 \ub3c4\ub2ec\ud558\uc600\uc2b5\ub2c8\ub2e4. Gly-Pro-Hyp\uc640 Pro-Hyp\ub294 \uc704\uc7a5\uc561\uacfc \uc950 \ud608\uc7a5\uc5d0\uc11c 2\uc2dc\uac04 \ub3d9\uc548 \uc548\uc815\uc801\uc73c\ub85c \uc720\uc9c0\ub418\uc5c8\uc73c\uba70, Gly-Pro-Hyp\ub294 \uc7a5 \uc138\ud3ec \ub2e8\uce35\uc744 \ud1b5\uacfc\ud558\uc5ec \uc6b4\ubc18\ub420 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B14\" target=\"_blank\" rel=\"noopener\">14<\/a>). \ub610\ud55c \ubcf4\ub2e4 \ucd5c\uadfc\uc758 \uc870\uc9c1\ud559\uc801 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc774 CTP \uc81c\ud488\uc758 \uacbd\uad6c \uc12d\ucde8\uac00 \ud53c\ubd80 \uc218\ubd84\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc0dd\uc950\uc5d0\uc11c biomarker \ubc1c\ud604\uc744 \ubd84\uc11d\ud558\uc600\uc2b5\ub2c8\ub2e4(<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7839319\/?utm_source=chatgpt.com#B28\" target=\"_blank\" rel=\"noopener\">28<\/a>). CTP \uc801\uc6a9 \ud6c4 \uc778\uac04 \uc9c4\ud53c fibroblast\uc5d0\uc11c ceramide kinase, hyaluronic acid, collagen 1A \ubc0f hyaluronan synthase-2(HAS2)\uc758 \ubc1c\ud604 \uc218\uc900\uc740 \uc99d\uac00\ud55c \ubc18\uba74, hyaluronidase-1(HYAL1)\uacfc CD44\uc758 \uc218\uc900\uc740 \uac10\uc18c\ud558\uc600\uc2b5\ub2c8\ub2e4. \ub610\ud55c TEWL, scratching behavior, HYAL1, tumor necrosis factor-alpha(TNF-\u03b1) \ubc0f interleukin-6(IL-6)\uc740 \uc720\uc758\ud558\uac8c \uac10\uc18c\ud558\uc600\uace0, \uc218\ubd84 \ud568\ub7c9 \ubc0f HAS2 \uc218\uc900\uc740 \uc99d\uac00\ud558\uc600\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uacb0\uacfc\ub294 \ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uc0ac\uc6a9\ub41c CTP \uc81c\ud488\uc774 \ud53c\ubd80 \uc218\ubd84\ub3c4\ub97c \ud5a5\uc0c1\uc2dc\ud0a4\uace0 \uc778\uac04\uc5d0\uc11c \ud53c\ubd80 \ubcf4\uc2b5 \uc131\ubd84\uc73c\ub85c\uc11c \uc7a0\uc7ac\ub825\uc744 \uac00\uc9c8 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4. \uc5b4\ub958\ub294 \ub192\uc740 \uc601\uc591\uac00\uc640 \ub0ae\uc740 \uc5f4\ub7c9 \uc12d\ucde8\ub77c\ub294 \uc7a5\uc810\uc73c\ub85c \uc778\ud574 \uc0dd\uc2dd \ubc0f \uc870\ub9ac \uc2dd\ud488 \ubaa8\ub450\uc5d0\uc11c \uc810\ucc28 \uc778\uae30 \uc788\ub294 \uc2dd\uc7ac\ub8cc\ub85c \uc790\ub9ac \uc7a1\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8 \uacb0\uacfc \ud604\uc7ac \ub9ce\uc740 \uc591\uc758 \uc5b4\ud53c\uac00 \ud3d0\uae30\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud658\uacbd\uc801 \uad00\uc810\uc5d0\uc11c\ub3c4 \uc5b4\ud53c\uc640 \uac19\uc740 \ubd80\uc0b0\ubb3c\uc744 \ubcf4\ub2e4 \ud6a8\uc728\uc801\uc73c\ub85c \ud65c\uc6a9\ud558\ub294 \uac83\uc740 \ubc14\ub78c\uc9c1\ud569\ub2c8\ub2e4.<\/p>\n<p>\ubcf8 \uc5f0\uad6c\uc5d0\ub294 \uba87 \uac00\uc9c0 \uc81c\ud55c\uc810\uc774 \uc788\uc2b5\ub2c8\ub2e4. \ubcf8 \uc5f0\uad6c\ub294 \ub2e8\uc77c \uae30\uad00\uc5d0\uc11c \uc218\ud589\ub418\uc5c8\uc73c\uba70 \uc5ec\uc131\ub9cc\uc744 \ub300\uc0c1\uc73c\ub85c \ud558\uc600\uae30 \ub54c\ubb38\uc5d0 \uc5f0\uad6c \uacb0\uacfc\ub97c \uc77c\ubc18\ud654\ud558\ub294 \ub370 \ud55c\uacc4\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ub610\ud55c \ud45c\ubcf8 \ud06c\uae30\uac00 \uc791\uace0 \uc5f0\uad6c \uae30\uac04\uc774 \uc9e7\uc558\uae30 \ub54c\ubb38\uc5d0 \ub450 \uadf8\ub8f9 \uac04 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ub300\ud55c collagen\uc758 \ud6a8\uacfc \ucc28\uc774\ub294 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uc600\uc74c\uc5d0\ub3c4 \uadf8 \uc815\ub3c4\ub294 \ud06c\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ub610\ud55c \ubcf8 \uc5f0\uad6c\uc5d0\uc11c \uace0\ub824\ud55c \ubaa8\ub4e0 \uc0ac\ud56d\uc744 \ubaa8\ub4e0 \uae30\ud6c4 \uc870\uac74\uc5d0 \ud655\ub300 \uc801\uc6a9\ud558\uae30\ub294 \uc5b4\ub824\uc6b8 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ub9c8\uc9c0\ub9c9\uc73c\ub85c \uc774\uc911\ub9f9\uac80 RCT\uc5d0\uc11c \ub450 \uadf8\ub8f9\uc5d0 \ub3d9\uc77c\ud55c \ud5a5, \uc0c9\uc0c1 \ubc0f \ub9db\uc744 \uc81c\uacf5\ud558\uae30 \uc704\ud574 collagen pill\uc744 \uc0ac\uc6a9\ud558\uc600\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 liquid collagen\uc740 \uace0\ud615 \ubcf4\ucda9\uc81c\ubcf4\ub2e4 \ud608\ub958\ub85c \ub354 \ube60\ub974\uace0 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ub418\uba70 \ub2e8\ubc31\uc9c8\uc758 \uc18c\ud654 \uc2dc\uac04\uc744 \ub2e8\ucd95\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ud55c\uacc4\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ubcf8 \uc5f0\uad6c\ub294 \ub2e4\uc74c\uacfc \uac19\uc740 \uac15\uc810\uc73c\ub85c \uc778\ud574 \uc0c1\ub2f9\ud55c \uac00\uce58\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uccab\uc9f8, \uc800\uc790\ub4e4\uc774 \uc544\ub294 \ud55c \ubcf8 \uc5f0\uad6c\ub294 \uc9c0\uc5ed \uae30\uc0c1\uccad\uc758 \uc815\ud655\ud55c \ub370\uc774\ud130\ub97c \uc0ac\uc6a9\ud558\uc5ec \uc5f0\uad6c \uae30\uac04 \ub3d9\uc548 \ud53c\ud5d8\uc790\uac00 \uac70\uc8fc\ud55c \uc9c0\uc5ed\uc758 \uae30\uc0c1 \uc870\uac74\uc744 \ubcf4\uc815\ud55c \ud6c4 CTP\uac00 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ubbf8\uce58\ub294 \ud6a8\ub2a5\uc744 \ud3c9\uac00\ud55c \ucd5c\ucd08\uc758 \uc784\uc0c1 \uc5f0\uad6c\uc785\ub2c8\ub2e4. \ub610\ud55c \ubcf8 \uc5f0\uad6c\ub294 \uc801\uc808\ud55c \ud3ec\ud568 \ubc0f \uc81c\uc678 \uae30\uc900\uc744 \uc801\uc6a9\ud558\uc5ec \uc5c4\uaca9\ud558\uac8c \uc218\ud589\ub41c \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ub354\ubd88\uc5b4 \ud53c\ubd80 \uc9c0\ud45c\ub294 \uc2e0\ub8b0\ud560 \uc218 \uc788\ub294 \uc815\ub7c9\uc801 \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud558\uc5ec \uac1d\uad00\uc801\uc73c\ub85c \uce21\uc815\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\uacb0\ub860\uc801\uc73c\ub85c, \ubcf8 \ubb34\uc791\uc704 \uc704\uc57d \ub300\uc870 \uc784\uc0c1\uc2dc\ud5d8\uc740 CTP \uc12d\ucde8\uac00 \uc591\ud638\ud55c \ub0b4\uc57d\uc131\uc744 \ubcf4\uc774\uba70 \uc911\ub144 \uc5ec\uc131\uc758 \uc218\ubd84 \uc190\uc2e4 \uac10\uc18c\uc5d0 \ub3c4\uc6c0\uc744 \uc904 \uc218 \uc788\uc74c\uc744 \ubcf4\uc5ec\uc90d\ub2c8\ub2e4. \ub610\ud55c \ubcf8 \uc5f0\uad6c \uacb0\uacfc\ub294 \ucc38\uac00\uc790\ub4e4\uc774 \uac70\uc8fc\ud55c \uc9c0\uc5ed\uc758 \uc628\ub3c4, \uc2b5\ub3c4 \ubc0f UVA\uc640 \uac19\uc740 \uae30\ud6c4 \ub370\uc774\ud130\uac00 \uc778\uac04\uc758 \ud53c\ubd80 \ud2b9\uc131\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc5d0 \ub300\ud55c \ucd08\uae30 \uadfc\uac70\ub97c \uc81c\uacf5\ud558\uba70, \ud2b9\ud788 \uc0ac\uacc4\uc808\uc774 \ub69c\ub837\ud55c \uc9c0\uc5ed\uc5d0\uc11c \ud5a5\ud6c4 \uc778\uac04 \ud53c\ubd80 \uac74\uac15\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1\uc2dc\ud5d8\uc744 \uc218\ud589\ud560 \ub54c \ud53c\ubd80 \uc911\uc7ac\uc5d0 \ubbf8\uce58\ub294 \uae30\uc0c1 \uc870\uac74\uc758 \uc601\ud5a5\uc744 \uace0\ub824\ud574\uc57c \ud568\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n<h2>\ub370\uc774\ud130 \uc774\uc6a9 \uac00\ub2a5\uc131 \uc131\uba85<\/h2>\n<p>\ubcf8 \ub17c\ubb38\uc758 \uacb0\ub860\uc744 \ub4b7\ubc1b\uce68\ud558\ub294 \uc6d0\uc2dc \ub370\uc774\ud130\ub294 \uacfc\ub3c4\ud55c \uc81c\ud55c \uc5c6\uc774 \uc800\uc790\ub4e4\uc774 \uc81c\uacf5\ud560 \uc608\uc815\uc785\ub2c8\ub2e4.<\/p>\n<h2>\uc724\ub9ac \uc131\uba85<\/h2>\n<p>\uc778\uac04 \ucc38\uac00\uc790\uac00 \ud3ec\ud568\ub41c \ubcf8 \uc5f0\uad6c\ub294 Pusan National University Yangsan Hospital\uc758 Institutional Review Board \uc724\ub9ac\uc704\uc6d0\ud68c\uc758 \uac80\ud1a0\uc640 \uc2b9\uc778\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \ud658\uc790\/\ucc38\uac00\uc790\ub4e4\uc740 \ubcf8 \uc5f0\uad6c \ucc38\uc5ec\ub97c \uc704\ud574 \uc11c\uba74 \ub3d9\uc758\uc11c\ub97c \uc81c\uacf5\ud558\uc600\uc2b5\ub2c8\ub2e4.<\/p>\n<h2>\uc800\uc790 \uae30\uc5ec<\/h2>\n<p>YJT, YLL, H-CK \ubc0f SYL\uc740 \uc5f0\uad6c\uc758 \uac1c\ub150\ud654\uc5d0 \uae30\uc5ec\ud558\uc600\uc2b5\ub2c8\ub2e4. DKS, AHK, JIK, YLL, H-CK \ubc0f SYL\uc740 \uc5f0\uad6c \ubc29\ubc95\ub860\uc744 \uc124\uacc4\ud558\uc600\uc2b5\ub2c8\ub2e4. YLL\uacfc SYL\uc740 \ucc38\uac00\uc790 \ubaa8\uc9d1 \ubc0f \ub370\uc774\ud130 \uc218\uc9d1 \uacfc\uc815\uc5d0\uc11c \uc801\uadf9\uc801\uc778 \uc5ed\ud560\uc744 \uc218\ud589\ud558\uc600\uc2b5\ub2c8\ub2e4. YJT\uc640 SYL\uc740 \uacb0\uacfc \uac80\uc99d\uc5d0 \uae30\uc5ec\ud558\uc600\uc2b5\ub2c8\ub2e4. DKS, AHK \ubc0f JIK\ub294 \ub370\uc774\ud130\uc758 formal analysis\ub97c \uc218\ud589\ud558\uc600\uc2b5\ub2c8\ub2e4. YJT\uc640 AHK\ub294 data curation\uc744 \uacf5\ub3d9\uc73c\ub85c \uc218\ud589\ud558\uc600\uc2b5\ub2c8\ub2e4. YJT, Y-WK \ubc0f SYL\uc740 \uc6d0\uace0 \ucd08\uc548\uc744 \uc791\uc131\ud558\uace0 \ucd5c\uc885 \ubb38\uc11c\ub97c \uac80\ud1a0\ud558\uc600\uc2b5\ub2c8\ub2e4. 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