{"id":5354,"date":"2026-05-26T11:20:56","date_gmt":"2026-05-26T11:20:56","guid":{"rendered":"https:\/\/laexome.com\/systematic-evidence-for-collagen-peptides\/"},"modified":"2026-08-21T09:21:33","modified_gmt":"2026-08-21T09:21:33","slug":"systematic-evidence-for-collagen-peptides","status":"publish","type":"post","link":"https:\/\/laexome.com\/zh-hans\/systematic-evidence-for-collagen-peptides\/","title":{"rendered":"\u80f6\u539f\u86cb\u767d\u80bd\u7684\u79d1\u5b66\u8bc1\u636e\uff1a\u7cfb\u7edf\u7814\u7a76\u89e3\u6790"},"content":{"rendered":"
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2023 \u5e74\u7814\u7a76\uff1a\u57fa\u4e8e 26 \u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u7cfb\u7edf\u7efc\u8ff0\u4e0e\u835f\u8403\u5206\u6790<\/p>\n

1. \u5f15\u8a00<\/h3>\n

\u76ae\u80a4\u662f\u4eba\u4f53\u6700\u5927\u7684\u5668\u5b98\uff0c\u4e5f\u662f\u76f4\u63a5\u66b4\u9732\u4e8e\u5916\u754c\u73af\u5883\u7684\u7ec4\u7ec7\u4e4b\u4e00\u3002\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u5185\u5728\u56e0\u7d20\u548c\u5916\u90e8\u73af\u5883\u56e0\u7d20<\/strong>\u90fd\u4f1a\u5f71\u54cd\u808c\u80a4\u72b6\u6001\u3002\u808c\u80a4\u8001\u5316\u901a\u5e38\u8868\u73b0\u4e3a\u6c34\u5206\u51cf\u5c11\u3001\u5f39\u6027\u4e0b\u964d\u4ee5\u53ca\u76b1\u7eb9\u51fa\u73b0\u3002\u968f\u7740\u4eba\u4eec\u5bf9\u808c\u80a4\u5e74\u8f7b\u72b6\u6001\u7684\u5173\u6ce8\u4e0d\u65ad\u589e\u52a0\uff0c\u5982\u4f55\u79d1\u5b66\u6539\u5584\u808c\u80a4\u8001\u5316\u95ee\u9898\u4e5f\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u5173\u6ce8\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u8fd1\u5e74\u6765\u4eba\u4eec\u5bf9\u8425\u517b\u7d20\u53ca\u81b3\u98df\u8865\u5145\u5242\u5728\u808c\u80a4\u5065\u5eb7\u65b9\u9762\u7684\u5e94\u7528\u4e5f\u65e5\u76ca\u91cd\u89c6\u3002<\/p>\n

\u80f6\u539f\u86cb\u767d<\/strong>\u662f\u4eba\u4f53\u7ed3\u7f14\u7ec4\u7ec7\u4e2d\u7684\u4e3b\u8981\u7ed3\u6784\u86cb\u767d\uff0c\u4e5f\u662f\u808c\u80a4\u7684\u91cd\u8981\u7ec4\u6210\u90e8\u5206\uff0c\u7ea6\u5360\u4eba\u4f53\u76ae\u80a4\u5e72\u91cd\u7684 80%\u3002\u80f6\u539f\u86cb\u767d\u5177\u6709\u72ec\u7279\u7684\u4e09\u80a1\u87ba\u65cb\u7ed3\u6784\uff0c\u5176\u4e2d\u7518\u6c28\u9178\u6bcf\u4e09\u4e2a\u6c28\u57fa\u9178\u6b8b\u57fa\u91cd\u590d\u51fa\u73b0\uff0c\u800c\u812f\u6c28\u9178\u548c\u7f9f\u812f\u6c28\u9178\u4e5f\u5360\u6709\u91cd\u8981\u6bd4\u4f8b\u3002\u4f5c\u4e3a\u7ec6\u80de\u5916\u57fa\u8d28\u4e2d\u6700\u4e30\u5bcc\u7684\u86cb\u767d\u8d28\u4e4b\u4e00\uff0c\u80f6\u539f\u86cb\u767d\u80fd\u591f\u4e3a\u808c\u80a4\u63d0\u4f9b\u7ed3\u6784\u652f\u6491\uff0c\u5e76\u53c2\u4e0e\u7ec4\u7ec7\u7684\u5f62\u6210\u4e0e\u7ef4\u6301\u3002<\/p>\n

\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u4e0e\u80f6\u539f\u86cb\u767d\u751f\u6210\u548c\u52a0\u5de5\u76f8\u5173\u7684\u9176\u6d3b\u6027\u4f1a\u9010\u6e10\u4e0b\u964d\uff0c\u540c\u65f6\u8d1f\u8d23\u5408\u6210\u80f6\u539f\u86cb\u767d\u7684\u6210\u7ea4\u7ef4\u7ec6\u80de<\/strong>\u6570\u91cf\u548c\u6d3b\u6027\u4e5f\u4f1a\u51cf\u5c11\uff0c\u76ae\u80a4\u4e2d\u7684\u8840\u7ba1\u4f9b\u5e94\u4e5f\u4f1a\u968f\u4e4b\u4e0b\u964d\u3002\u8fd9\u4e9b\u53d8\u5316\u4f1a\u5bfc\u81f4\u80f6\u539f\u86cb\u767d\u5408\u6210\u51cf\u5c11\uff0c\u4f7f\u808c\u80a4\u5f39\u6027\u4e0b\u964d\uff0c\u5e76\u9010\u6e10\u5f62\u6210\u76b1\u7eb9\u3002<\/p>\n

\u56e0\u6b64\uff0c\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u808c\u80a4\u53ef\u80fd\u51fa\u73b0\u4e00\u7cfb\u5217\u53d8\u5316\uff0c\u5305\u62ec\u6c34\u5206\u51cf\u5c11\u3001\u5f39\u6027\u4e0b\u964d\u4ee5\u53ca\u8868\u76ae\u539a\u5ea6\u964d\u4f4e<\/strong>\u3002\u4e3a\u4e86\u6539\u5584\u808c\u80a4\u72b6\u6001\u5e76\u5e2e\u52a9\u7ef4\u6301\u5e74\u8f7b\u7684\u808c\u80a4\u5916\u89c2\uff0c\u4eba\u4eec\u91c7\u7528\u4e86\u591a\u79cd\u8425\u517b\u548c\u62a4\u80a4\u65b9\u5f0f\uff0c\u5305\u62ec\u5916\u7528\u62a4\u80a4\u54c1\u3001\u6ce8\u5c04\u586b\u5145\u4ee5\u53ca\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u7b49\u3002<\/p>\n

\u542b\u6709\u80f6\u539f\u86cb\u767d\u7684\u5916\u7528\u62a4\u80a4\u4ea7\u54c1\u901a\u5e38\u7528\u4e8e\u5e2e\u52a9\u63d0\u5347\u808c\u80a4\u7684\u6c34\u6da6\u5ea6\u548c\u7d27\u81f4\u611f\uff0c\u4f46\u7531\u4e8e\u5916\u7528\u6210\u5206\u8fdb\u5165\u76ae\u80a4\u7684\u80fd\u529b\u6709\u9650\uff0c\u5176\u4f5c\u7528\u53ef\u80fd\u53d7\u5230\u4e00\u5b9a\u5f71\u54cd\u3002\u4ee5\u900f\u660e\u8d28\u9178\u4e3a\u4ee3\u8868\u7684\u6ce8\u5c04\u586b\u5145\u5242\uff0c\u5219\u53ef\u4ee5\u901a\u8fc7\u586b\u5145\u808c\u80a4\u3001\u523a\u6fc0\u80f6\u539f\u86cb\u767d\u751f\u6210\u6765\u5e26\u6765\u8f83\u4e3a\u5373\u65f6\u7684\u89c6\u89c9\u6548\u679c\uff0c\u4f46\u540c\u65f6\u53ef\u80fd\u5b58\u5728\u6210\u672c\u8f83\u9ad8\u4ee5\u53ca\u7600\u9752\u3001\u80bf\u80c0\u548c\u611f\u67d3\u7b49\u4e0d\u826f\u53cd\u5e94\u98ce\u9669\u3002<\/p>\n

\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\uff0c\u5c24\u5176\u662f\u542b\u6709\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u80bd\u7684\u4ea7\u54c1\uff0c\u88ab\u8ba4\u4e3a\u5177\u6709\u8f83\u597d\u7684\u5b89\u5168\u6027\u548c\u5e94\u7528\u4fbf\u5229\u6027<\/strong>\u3002\u7531\u4e8e\u53ef\u4ee5\u901a\u8fc7\u53e3\u670d\u65b9\u5f0f\u6444\u5165\uff0c\u4e5f\u66f4\u5bb9\u6613\u878d\u5165\u65e5\u5e38\u751f\u6d3b\u3002<\/p>\n

\u5728\u4f17\u591a\u76f8\u5173\u8865\u5145\u5242\u4e2d\uff0c\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/strong>Hydrolyzed Collagen<\/strong>\uff0c<\/strong>HC<\/strong>\uff09\u662f\u76ee\u524d\u8f83\u53d7\u5173\u6ce8\u7684\u808c\u80a4\u6297\u8870\u8001\u8425\u517b\u6210\u5206\u4e4b\u4e00\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u53e3\u670d\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u540e\uff0c\u90e8\u5206\u80f6\u539f\u86cb\u767d\u6765\u6e90\u7684\u5c0f\u5206\u5b50\u80bd\uff0c\u4f8b\u5982\u4e19\u6c28\u9178<\/strong>–<\/strong>\u7f9f\u812f\u6c28\u9178<\/strong>–<\/strong>\u7518\u6c28\u9178\uff08<\/strong>Ala-Hyp-Gly<\/strong>\uff09\u548c\u4e1d\u6c28\u9178<\/strong>–<\/strong>\u7f9f\u812f\u6c28\u9178<\/strong>–<\/strong>\u7518\u6c28\u9178\uff08<\/strong>Ser-Hyp-Gly<\/strong>\uff09<\/strong>\uff0c\u53ef\u5728\u7ea6 1 \u5c0f\u65f6\u540e\u5728\u4eba\u4f53\u8840\u6db2\u4e2d\u68c0\u6d4b\u5230\uff0c\u5e76\u53ef\u8fdb\u4e00\u6b65\u5230\u8fbe\u76ae\u80a4\u7ec4\u7ec7\u3002<\/p>\n

\u8fd1\u671f\u7814\u7a76\u663e\u793a\uff0c\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u6709\u52a9\u4e8e\u6539\u5584\u808c\u80a4\u6c34\u5206\u548c\u5f39\u6027<\/strong>\u3002\u4e0d\u8fc7\uff0c\u5e76\u975e\u6240\u6709\u6765\u6e90\u7684\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u90fd\u5177\u6709\u76f8\u540c\u7684\u6548\u679c\u3002\u5373\u4f7f\u6444\u5165\u5242\u91cf\u548c\u6301\u7eed\u65f6\u95f4\u76f8\u540c\uff0c\u4e0d\u540c\u6765\u6e90\u7684\u80f6\u539f\u86cb\u767d\u4e5f\u53ef\u80fd\u8868\u73b0\u51fa\u4e0d\u540c\u7684\u6548\u679c\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u8fdb\u4e00\u6b65\u7814\u7a76\u4e0d\u540c\u80f6\u539f\u86cb\u767d\u6765\u6e90\u53ca\u9002\u5b9c\u7684\u4f7f\u7528\u5468\u671f\uff0c\u4ee5\u4e86\u89e3\u5176\u5bf9\u808c\u80a4\u8001\u5316\u7684\u5f71\u54cd\u3002<\/p>\n

\u968f\u7740\u5168\u7403\u8303\u56f4\u5185\u5173\u4e8e\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u7684\u4e34\u5e8a\u7814\u7a76\u4e0d\u65ad\u589e\u52a0\uff0c\u6709\u5fc5\u8981\u901a\u8fc7\u7cfb\u7edf\u7efc\u8ff0\u548c\u835f\u8403\u5206\u6790<\/strong>\u5bf9\u73b0\u6709\u7814\u7a76\u7ed3\u679c\u8fdb\u884c\u7efc\u5408\u8bc4\u4f30\u3002\u56e0\u6b64\uff0c\u672c\u9879\u7cfb\u7edf\u7efc\u8ff0\u4e0e\u835f\u8403\u5206\u6790\u65e8\u5728\u8bc4\u4f30\u80f6\u539f\u86cb\u767d\u8865\u5145\u5bf9\u808c\u80a4\u6c34\u5206\u548c\u5f39\u6027\u7684\u5f71\u54cd<\/strong>\u3002<\/p>\n

2. \u6750\u6599\u4e0e\u65b9\u6cd5<\/h2>\n

2.1 \u6587\u732e\u68c0\u7d22\u3001\u7eb3\u5165\u4e0e\u6392\u9664\u6807\u51c6<\/h3>\n

\u7814\u7a76\u56e2\u961f\u5728 Embase<\/strong>\u3001<\/strong>PubMed <\/strong>\u548c<\/strong> Cochrane Library<\/strong> \u7b49\u533b\u5b66\u6587\u732e\u6570\u636e\u5e93\u4e2d\u8fdb\u884c\u7cfb\u7edf\u68c0\u7d22\uff0c\u5e76\u4f7f\u7528\u533b\u5b66\u4e3b\u9898\u8bcd\uff08Medical Subject Headings\uff0cMeSH\uff09\u53ca\u76f8\u5173\u5173\u952e\u8bcd\u8fdb\u884c\u68c0\u7d22\u3002\u68c0\u7d22\u5f0f\u4e3a\uff1a\uff08<\/strong>collagen OR hydrolyzed collagen<\/strong>\uff09<\/strong>AND<\/strong>\uff08<\/strong>anti-aging<\/strong>\uff09<\/strong><\/p>\n

\u68c0\u7d22\u8303\u56f4\u672a\u8bbe\u7f6e\u5176\u4ed6\u9650\u5236\uff0c\u5e76\u7eb3\u5165\u622a\u81f3 2022 <\/strong>\u5e74<\/strong> 12 <\/strong>\u6708<\/strong>\u53d1\u8868\u7684\u76f8\u5173\u7814\u7a76\u3002<\/p>\n

\u7b26\u5408\u4ee5\u4e0b\u6761\u4ef6\u7684\u7814\u7a76\u88ab\u7eb3\u5165\u5206\u6790\uff1a<\/p>\n

    \n
  1. \u91c7\u7528**\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09**\u8bbe\u8ba1\uff1b<\/li>\n
  2. \u7814\u7a76\u5bf9\u8c61\u4e3a\u5e74\u9f84 \u226518 <\/strong>\u5c81\u7684\u5065\u5eb7\u6210\u5e74\u4eba<\/strong>\uff1b<\/li>\n
  3. \u53d7\u8bd5\u8005\u63a5\u53d7**\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09**\u8865\u5145\uff1b<\/li>\n
  4. \u4e3a\u53ef\u83b7\u53d6\u5b8c\u6574\u5168\u6587\u7684\u82f1\u6587\u7814\u7a76\u3002<\/li>\n<\/ol>\n

    \u4ee5\u4e0b\u7814\u7a76\u88ab\u6392\u9664\uff1a<\/p>\n

      \n
    1. \u8bc4\u4f30\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u4e0e\u5176\u4ed6\u8865\u5145\u5242\u8054\u5408\u4f7f\u7528\u6548\u679c\u7684\u7814\u7a76\uff1b<\/li>\n
    2. \u975e\u82f1\u6587\u53d1\u8868\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002<\/li>\n<\/ol>\n

      \u5bf9\u4e8e\u90e8\u5206\u7814\u7a76\u4e2d\u4ec5\u4ee5\u56fe\u8868\u5f62\u5f0f\u5448\u73b0\u7684\u6570\u636e\uff0c\u7814\u7a76\u4eba\u5458\u4f7f\u7528 WebPlotDigitizer<\/strong> \u8f6f\u4ef6\u4ece\u56fe\u8868\u4e2d\u63d0\u53d6\u539f\u59cb\u6570\u636e\u3002<\/p>\n

      2.2 \u6570\u636e\u63d0\u53d6<\/h3>\n

      \u4e24\u540d\u72ec\u7acb\u7814\u7a76\u4eba\u5458\u5206\u522b\u63d0\u53d6\u7eb3\u5165\u7814\u7a76\u7684\u57fa\u672c\u4fe1\u606f\uff0c\u5305\u62ec\uff1a<\/p>\n

        \n
      • \u7814\u7a76\u4fe1\u606f<\/strong>\uff1a\u7b2c\u4e00\u4f5c\u8005\u3001\u53d1\u8868\u5e74\u4efd\u53ca\u7814\u7a76\u8bbe\u8ba1\uff1b<\/li>\n
      • \u53d7\u8bd5\u8005\u4fe1\u606f<\/strong>\uff1a\u53d7\u8bd5\u8005\u4eba\u6570\u3001\u6027\u522b\u3001\u5e73\u5747\u5e74\u9f84\uff0c\u4ee5\u53ca\u80f6\u539f\u86cb\u767d\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\u7684\u57fa\u7ebf\u7279\u5f81\uff1b<\/li>\n
      • \u5e72\u9884\u4fe1\u606f<\/strong>\uff1a\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u7684\u5242\u91cf\u53ca\u5f62\u5f0f\uff1b<\/li>\n
      • \u7814\u7a76\u7ed3\u679c<\/strong>\uff1a\u808c\u80a4\u6c34\u5206\u548c\u5f39\u6027\u7b49\u6307\u6807\u3002<\/li>\n<\/ul>\n

        \u8fde\u7eed\u6027\u6570\u636e\u4ee5\u5e73\u5747\u503c \u00b1 \u6807\u51c6\u5dee\uff08SD\uff09\u8868\u793a\uff0c\u5206\u7c7b\u6570\u636e\u5219\u4ee5\u767e\u5206\u6bd4\u8868\u793a\u3002<\/p>\n

        2.3 \u7edf\u8ba1\u5206\u6790\u3001\u654f\u611f\u6027\u5206\u6790\u4e0e\u504f\u501a\u8bc4\u4f30<\/h3>\n

        \u7814\u7a76\u91c7\u7528\u968f\u673a\u6548\u5e94\u6a21\u578b<\/strong>\u5bf9\u7eb3\u5165\u7814\u7a76\u7684\u6570\u636e\u8fdb\u884c\u7efc\u5408\u5206\u6790\uff0c\u5e76\u8ba1\u7b97\u76f8\u5173\u6307\u6807\u7684\u5e73\u5747\u5dee\u5f02\u3002p < 0.05<\/strong> \u88ab\u89c6\u4e3a\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002<\/p>\n

        \u7814\u7a76\u4eba\u5458\u901a\u8fc7 I\u00b2 <\/strong>\u7edf\u8ba1\u91cf<\/strong>\u8bc4\u4f30\u4e0d\u540c\u7814\u7a76\u4e4b\u95f4\u7684\u5f02\u8d28\u6027\uff0c\u5e76\u4e3a\u7eb3\u5165\u5206\u6790\u7684\u7814\u7a76\u751f\u6210\u68ee\u6797\u56fe\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0cI\u00b2 \u2265 50%<\/strong> \u8868\u793a\u7814\u7a76\u4e4b\u95f4\u5b58\u5728\u8f83\u9ad8\u7a0b\u5ea6\u7684\u5f02\u8d28\u6027\u3002<\/p>\n

        \u7814\u7a76\u540c\u65f6\u62a5\u544a\u4e86\u603b\u4f53\u6548\u5e94\u7684 z <\/strong>\u503c<\/strong>\uff0c\u5e76\u636e\u6b64\u8bc4\u4f30 95% <\/strong>\u7f6e\u4fe1\u533a\u95f4\uff08<\/strong>CI<\/strong>\uff09<\/strong>\u3002<\/p>\n

        \u6b64\u5916\uff0c\u7814\u7a76\u8fdb\u884c\u4e86\u654f\u611f\u6027\u5206\u6790<\/strong>\uff0c\u4ee5\u8bc4\u4f30\u4e2a\u522b\u7814\u7a76\u5bf9\u603b\u4f53\u7ed3\u679c\u7684\u6f5c\u5728\u5f71\u54cd\u3002\u6240\u6709\u7814\u7a76\u5747\u4f9d\u636e Cochrane <\/strong>\u7cfb\u7edf\u7efc\u8ff0\u5e72\u9884\u63aa\u65bd\u624b\u518c<\/strong>\u8fdb\u884c\u5206\u7c7b\uff0c\u5e76\u4f7f\u7528 Cochrane <\/strong>\u504f\u501a\u98ce\u9669\uff08<\/strong>Risk of Bias<\/strong>\uff0c<\/strong>RoB<\/strong>\uff09<\/strong>2.0 <\/strong>\u5de5\u5177<\/strong>\u8bc4\u4f30\u7eb3\u5165\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684\u504f\u501a\u98ce\u9669\u3002<\/p>\n

        \u504f\u501a\u8bc4\u4f30\u4e3b\u8981\u6db5\u76d6\u4e94\u4e2a\u65b9\u9762\uff1a<\/p>\n

          \n
        • \u9009\u62e9\u504f\u501a<\/li>\n
        • \u5b9e\u65bd\u504f\u501a<\/li>\n
        • \u6d4b\u91cf\u504f\u501a<\/li>\n
        • \u8131\u843d\u504f\u501a<\/li>\n
        • \u62a5\u544a\u504f\u501a<\/li>\n<\/ul>\n

          \u672c\u9879\u835f\u8403\u5206\u6790\u4e2d\u7684\u6240\u6709\u7ed3\u679c\u5747\u4f7f\u7528 RevMan 5.4<\/strong> \u8f6f\u4ef6\u8fdb\u884c\u7edf\u8ba1\u5206\u6790\u3002<\/p>\n

          3. \u7814\u7a76\u7ed3\u679c<\/h2>\n

          3.1 \u6587\u732e\u7b5b\u9009\u7ed3\u679c\u4e0e\u7814\u7a76\u6982\u51b5<\/h3>\n

          \u56fe 1 \u5c55\u793a\u4e86\u672c\u9879\u6587\u732e\u68c0\u7d22\u4e0e\u7b5b\u9009\u7684\u6d41\u7a0b\uff0c\u8be5\u6d41\u7a0b\u4f9d\u636e\u7cfb\u7edf\u7efc\u8ff0\u4e0e\u835f\u8403\u5206\u6790\u4f18\u5148\u62a5\u544a\u89c4\u8303\uff08PRISMA\uff09\u8fdb\u884c\u3002<\/p>\n

          \u7814\u7a76\u56e2\u961f\u5728\u521d\u6b65\u68c0\u7d22\u4e2d\u5171\u53d1\u73b0 1,135 <\/strong>\u9879\u76f8\u5173\u7814\u7a76<\/strong>\u3002\u5728\u53bb\u9664\u91cd\u590d\u6587\u732e\uff0c\u5e76\u5bf9\u76f8\u5173\u7814\u7a76\u7684\u6807\u9898\u548c\u6458\u8981\u8fdb\u884c\u7b5b\u9009\u540e\uff0c\u8fdb\u4e00\u6b65\u5bf9\u7b26\u5408\u6761\u4ef6\u7684 37 <\/strong>\u7bc7\u7814\u7a76\u5168\u6587<\/strong>\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n

          \u6700\u7ec8\uff0c\u5171\u6709 26 <\/strong>\u7bc7\u7814\u7a76<\/strong>\u7b26\u5408\u7eb3\u5165\u6807\u51c6\uff0c\u5e76\u88ab\u7eb3\u5165\u672c\u9879\u7cfb\u7edf\u7efc\u8ff0\u4e0e\u835f\u8403\u5206\u6790<\/strong>\u3002<\/p>\n<\/div>\n

          \n
          \"\"<\/div>\n
          \n

          \u56fe<\/em>1. <\/em>\u7cfb\u7edf\u7efc\u8ff0\u4e0e\u835f\u8403\u5206\u6790\u7684\u6587\u732e\u7b5b\u9009\u6d41\u7a0b\u56fe\uff08\u9075\u5faa<\/em> PRISMA <\/em>\u89c4\u8303\uff09<\/em><\/p>\n<\/div>\n<\/section>\n<\/section>\n

          \n
          <\/div>\n

          3.2 \u7814\u7a76\u7279\u5f81<\/h3>\n

          \u672c\u6b21\u835f\u8403\u5206\u6790\u5171\u7eb3\u5165 26 <\/strong>\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08<\/strong>RCT<\/strong>\uff09<\/strong>\uff0c\u6d89\u53ca 1,721 <\/strong>\u540d\u53d7\u8bd5\u8005<\/strong>\u3002\u7eb3\u5165\u7814\u7a76\u4e2d\uff0c\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09\u7684\u8865\u5145\u5468\u671f\u4e3a 2 <\/strong>\u81f3<\/strong> 12 <\/strong>\u5468<\/strong>\u3002<\/p>\n

          \u5728\u8fd9\u4e9b\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u6709 14 <\/strong>\u9879\u7814\u7a76<\/strong>\u91c7\u7528\u9c7c\u6e90\u80f6\u539f\u86cb\u767d\uff0c1 <\/strong>\u9879<\/strong>\u91c7\u7528\u725b\u6e90\u80f6\u539f\u86cb\u767d\uff0c1 <\/strong>\u9879<\/strong>\u91c7\u7528\u9e21\u6e90\u80f6\u539f\u86cb\u767d\uff0c2 <\/strong>\u9879<\/strong>\u91c7\u7528\u732a\u6e90\u80f6\u539f\u86cb\u767d\uff0c\u53e6\u6709 9 <\/strong>\u9879\u7814\u7a76\u672a\u660e\u786e\u8bf4\u660e\u80f6\u539f\u86cb\u767d\u7684\u6765\u6e90<\/strong>\u3002\u7eb3\u5165\u7814\u7a76\u7684\u5177\u4f53\u7279\u5f81\u89c1\u8868<\/strong> 1<\/strong>\u3002<\/p>\n

          \u808c\u80a4\u6c34\u5206\u7684\u6d4b\u91cf<\/h4>\n

          \u808c\u80a4\u6c34\u5206\u901a\u5e38\u91c7\u7528\u4e00\u79cd\u540d\u4e3a Corneometer\uff08\u89d2\u8d28\u5c42\u6c34\u5206\u6d4b\u8bd5\u4eea\uff09\u7684\u975e\u4fb5\u5165\u5f0f\u4eea\u5668\u8fdb\u884c\u6d4b\u91cf\u3002\u8be5\u4eea\u5668\u901a\u8fc7\u5411\u76ae\u80a4\u8868\u9762\u65bd\u52a0\u9ad8\u9891\u7535\u6d41\uff0c\u68c0\u6d4b\u76ae\u80a4\u6700\u5916\u5c42\u4e2d\u7684\u6c34\u5206\u542b\u91cf\uff0c\u5e76\u4ee5\u7279\u5b9a\u7684\u6d4b\u91cf\u5355\u4f4d\u8fdb\u884c\u91cf\u5316\u3002<\/p>\n

          Corneometer \u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u62a4\u80a4\u4ea7\u54c1\u529f\u6548\u8bc4\u4ef7\u548c\u808c\u80a4\u5065\u5eb7\u7814\u7a76\uff0c\u53ef\u7528\u4e8e\u4e86\u89e3\u76ae\u80a4\u7684\u6c34\u5206\u72b6\u6001\u4ee5\u53ca\u5c4f\u969c\u529f\u80fd\u3002\u56e0\u6b64\uff0c\u5b83\u4e5f\u662f\u8bc4\u4f30\u808c\u80a4\u6c34\u5206\u6c34\u5e73\u548c\u62a4\u80a4\u4ea7\u54c1\u4fdd\u6e7f\u6548\u679c\u7684\u91cd\u8981\u68c0\u6d4b\u5de5\u5177\u3002<\/p>\n

          \u808c\u80a4\u5f39\u6027\u7684\u6d4b\u91cf<\/h4>\n

          \u808c\u80a4\u5f39\u6027\u901a\u5e38\u91c7\u7528 Cutometry\uff08\u76ae\u80a4\u5f39\u6027\u6d4b\u8bd5\uff09\u8fdb\u884c\u6d4b\u91cf\uff0c\u8fd9\u662f\u4e00\u79cd\u975e\u4fb5\u5165\u5f0f\u7684\u808c\u80a4\u68c0\u6d4b\u65b9\u6cd5\u3002<\/p>\n

          \u6d4b\u8bd5\u65f6\uff0c\u4eea\u5668\u4f1a\u5728\u76ae\u80a4\u5c40\u90e8\u65bd\u52a0\u4e00\u5b9a\u7684\u8d1f\u538b\uff0c\u4f7f\u76ae\u80a4\u4ea7\u751f\u53ef\u63a7\u7684\u5f62\u53d8\uff0c\u5e76\u901a\u8fc7\u6d4b\u91cf\u76ae\u80a4\u7684\u5f62\u53d8\u7a0b\u5ea6\u6765\u8bc4\u4f30\u5176\u5f39\u6027\u3002\u901a\u5e38\u60c5\u51b5\u4e0b\uff0c\u76ae\u80a4\u5728\u8d1f\u538b\u4f5c\u7528\u4e0b\u7684\u5f62\u53d8\u53ca\u6062\u590d\u60c5\u51b5\u53ef\u4ee5\u53cd\u6620\u808c\u80a4\u7684\u5f39\u6027\u72b6\u6001\u3002<\/p>\n

          Cutometry \u5e7f\u6cdb\u5e94\u7528\u4e8e\u76ae\u80a4\u79d1\u5b66\u7814\u7a76\u548c\u4e34\u5e8a\u7814\u7a76\u4e2d\uff0c\u53ef\u7528\u4e8e\u8bc4\u4f30\u808c\u80a4\u5f39\u6027\uff0c\u5e76\u89c2\u5bdf\u4e00\u6bb5\u65f6\u95f4\u5185\u808c\u80a4\u72b6\u6001\u7684\u53d8\u5316\u3002\u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u662f\u4e00\u79cd\u8f83\u4e3a\u5b89\u5168\u3001\u53ef\u9760\u7684\u808c\u80a4\u5f39\u6027\u8bc4\u4f30\u65b9\u6cd5\u3002<\/p>\n

          \u8868<\/em>1. <\/em>\u7eb3\u5165\u7814\u7a76\u53d7\u8bd5\u8005\u7684\u57fa\u672c\u7279\u5f81<\/em><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
          \u4f5c\u8005\uff08\u5e74\u4efd\uff09<\/strong><\/td>\n\u5973\u6027<\/strong>\/<\/strong>\u7537\u6027<\/strong><\/td>\n\u5e74\u9f84\u8303\u56f4<\/strong><\/td>\n\u7814\u7a76\u65f6\u95f4<\/strong><\/p>\n

          \uff08\u5468\uff09<\/strong><\/td>\n

          		\u5e72\u9884\u63aa\u65bd<\/strong><\/p>\n

          \uff08\u6765\u6e90\uff09<\/strong><\/td>\n

          		\u63d0\u53d6\u7684\u7814\u7a76\u6307\u6807<\/strong><\/td>\n<\/tr>\n<\/thead>\n
          Proksch \u7b49\uff082014a\uff09<\/td>\n60\/0<\/td>\n35\u201355\u5c81<\/td>\n8\u300112<\/td>\n2.5 g HC \/ 5 g HC\uff08\u732a\u6e90\uff09<\/td>\n\u76ae\u80a4\u5f39\u6027 \/ \u6c34\u5206 \/ \u7ecf\u76ae\u6c34\u5206\u6d41\u5931\uff08TEWL\uff09\/ \u76b1\u7eb9<\/td>\n<\/tr>\n
          Proksch \u7b49\uff082014b\uff09<\/td>\n107\/0<\/td>\n45\u201365\u5c81<\/td>\n8\u300112<\/td>\n2.5 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u76b1\u7eb9 \/ \u76ae\u80a4\u6d3b\u68c0 \/ I\u578b\u524d\u80f6\u539f \/ \u5f39\u6027\u86cb\u767d \/ \u539f\u7ea4\u7ef4\u86cb\u767d<\/td>\n<\/tr>\n
          Yoon \u7b49\uff082014\uff09<\/td>\n44\/0<\/td>\n>44\u5c81<\/td>\n12<\/td>\n3 g HC\uff08\u9c7c\u6e90\uff09<\/td>\nI\u578b\u524d\u80f6\u539f \/ \u539f\u7ea4\u7ef4\u86cb\u767d1 \/ \u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u91761\u548c12 \/ \u76ae\u80a4\u6d3b\u68c0 \/ \u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272<\/td>\n<\/tr>\n
          Di Cerbo \u7b49\uff082014\uff09<\/td>\n30\/0<\/td>\n40\u201345\u5c81<\/td>\n4.5<\/td>\n372 mg HC<\/td>\n\u76ae\u80a4 pH \u503c \/ \u6c34\u5206 \/ \u76ae\u8102 \/ \u5f39\u6027 \/ \u80a4\u8272 \/ \u5f39\u6027\u86cb\u767d \/ \u5f39\u6027\u86cb\u767d\u91762 \/ \u7ea4\u8fde\u86cb\u767d \/ \u900f\u660e\u8d28\u9178 \/ \u7fb0\u57fa\u5316\u86cb\u767d<\/td>\n<\/tr>\n
          Choi \u7b49\uff082014\uff09<\/td>\n24\/8<\/td>\n30\u201348\u5c81<\/td>\n5<\/td>\n3 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u76ae\u80a4\u6c34\u5206 \/ \u5f39\u6027 \/ TEWL \/ \u7ea2\u6591 \/ \u6ee1\u610f\u5ea6\u95ee\u5377<\/td>\n<\/tr>\n
          Sugihara\u3001Inoue \u548c Wang\uff082015\uff09<\/td>\n53\/0<\/td>\n35\u201355\u5c81<\/td>\n8<\/td>\n2.5 g HC\uff08\u9c7c\u6e90\uff09<\/td>\n\u6c34\u5206 \/ \u5f39\u6027 \/ \u76b1\u7eb9<\/td>\n<\/tr>\n
          Campos \u7b49\uff082015\uff09<\/td>\n60\/0<\/td>\n40\u201350\u5c81<\/td>\n12<\/td>\n10 g HC<\/td>\n\u89d2\u8d28\u5c42\u6c34\u5206 \/ \u76ae\u80a4\u9ecf\u5f39\u6027 \/ \u771f\u76ae\u56de\u58f0\u5bc6\u5ea6 \/ \u9ad8\u6e05\u6444\u5f71<\/td>\n<\/tr>\n
          Asserin \u7b49\uff082015\uff09<\/td>\n134\/0<\/td>\n40\u201365\u5c81<\/td>\n8\u300112<\/td>\n10 g HC\uff08\u732a\u6e90\uff09\/ 10 g HC\uff08\u9c7c\u6e90\uff09<\/td>\n\u76ae\u80a4\u6c34\u5206 \/ TEWL \/ \u771f\u76ae\u5bc6\u5ea6 \/ \u771f\u76ae\u56de\u58f0\u5bc6\u5ea6 \/ \u771f\u76ae\u80f6\u539f\u86cb\u767d\u964d\u89e3<\/td>\n<\/tr>\n
          Inoue\u3001Sugihara \u548c Wang\uff082016\uff09<\/td>\n80\/0<\/td>\n35\u201355\u5c81<\/td>\n8<\/td>\n2.5 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u76ae\u80a4\u6c34\u5206 \/ \u5f39\u6027 \/ \u76b1\u7eb9<\/td>\n<\/tr>\n
          Genovese\u3001Corbo \u548c Sibilla\uff082017\uff09<\/td>\n111\/9<\/td>\n40\u201360\u5c81<\/td>\n12<\/td>\n5 g HC<\/td>\n\u5f39\u6027 \/ \u76ae\u80a4\u6d3b\u68c0 \/ \u4e3b\u89c2\u8bc4\u4ef7\u95ee\u5377<\/td>\n<\/tr>\n
          Koizumi \u7b49\uff082017\uff09<\/td>\n71\/0<\/td>\n30\u201360\u5c81<\/td>\n12<\/td>\n3 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u76b1\u7eb9 \/ \u6c34\u5206 \/ \u5f39\u6027 \/ \u8840\u6db2\u68c0\u6d4b<\/td>\n<\/tr>\n
          Czajka \u7b49\uff082018\uff09<\/td>\n120\/0<\/td>\n21\u201370\u5c81<\/td>\n12<\/td>\n4 g HC<\/td>\n\u5f39\u6027 \/ \u76ae\u80a4\u6d3b\u68c0 \/ \u81ea\u6211\u611f\u53d7\u95ee\u5377<\/td>\n<\/tr>\n
          Kim\uff082018\uff09<\/td>\n70\/0<\/td>\n40\u201360\u5c81<\/td>\n12<\/td>\n1000 mg \u80f6\u539f\u86cb\u767d\uff08\u9c7c\u6e90\uff09<\/td>\n\u76ae\u80a4\u6c34\u5206 \/ \u76b1\u7eb9 \/ \u5f39\u6027<\/td>\n<\/tr>\n
          Ito\u3001Seki \u548c Ueda\uff082018\uff09<\/td>\n17\/4<\/td>\n30\u201350\u5c81<\/td>\n8<\/td>\n10 g \u80f6\u539f\u86cb\u767d\u80bd\uff08\u9c7c\u6e90\uff09<\/td>\n\u5f39\u6027 \/ \u6c34\u5206 \/ TEWL \/ \u76ae\u80a4 pH \u503c \/ \u8272\u6591 \/ \u76b1\u7eb9 \/ \u6bdb\u5b54 \/ \u808c\u80a4\u7eb9\u7406 \/ \u5bc6\u5ea6 \/ \u80f6\u539f\u86cb\u767d\u8bc4\u5206 \/ \u751f\u957f\u6fc0\u7d20\uff08GH\uff09\/ \u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50-1\uff08IGF-1\uff09<\/td>\n<\/tr>\n
          Bolke \u7b49\uff082019\uff09<\/td>\n72\/0<\/td>\n>35\u5c81<\/td>\n12\u300116<\/td>\n2.5 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u6c34\u5206 \/ \u5f39\u6027 \/ \u76b1\u7eb9 \/ \u76ae\u80a4\u5bc6\u5ea6 \/ \u4e3b\u89c2\u8bc4\u4ef7\u95ee\u5377<\/td>\n<\/tr>\n
          Schwartz \u7b49\uff082019\uff09<\/td>\n113\/0<\/td>\n36\u201359\u5c81<\/td>\n12<\/td>\n0.6 g HC\uff08\u9e21\u6e90\uff09<\/td>\n\u7ea2\u6591 \/ \u6c34\u5206 \/ TEWL \/ \u5f39\u6027 \/ \u76b1\u7eb9 \/ \u771f\u76ae\u80f6\u539f\u86cb\u767d \/ \u4e3b\u89c2\u8bc4\u4ef7\u95ee\u5377<\/td>\n<\/tr>\n
          Zmitek \u7b49\uff082020\uff09<\/td>\n31\/0<\/td>\n40\u201365\u5c81<\/td>\n12<\/td>\n4 g HC\uff08\u9c7c\u6e90\uff09<\/td>\n\u771f\u76ae\u5bc6\u5ea6\u53ca\u539a\u5ea6 \/ \u9ecf\u5f39\u6027 \/ \u6c34\u5206 \/ TEWL \/ \u76b1\u7eb9 \/ \u808c\u80a4\u6c34\u5206 \/ \u771f\u76ae\u5fae\u7ed3\u6784<\/td>\n<\/tr>\n
          Laing \u7b49\uff082020\uff09<\/td>\n60\/0<\/td>\n40\u201370\u5c81<\/td>\n12<\/td>\n2.5 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u771f\u76ae\u80f6\u539f\u86cb\u767d\u964d\u89e3 \/ \u4e3b\u89c2\u8bc4\u4ef7\u95ee\u5377<\/td>\n<\/tr>\n
          Sangsuwan \u548c Asawanonda\uff082020\uff09<\/td>\n36\/0<\/td>\n50\u201360\u5c81<\/td>\n4\u30018<\/td>\n5 g HC<\/td>\n\u5f39\u6027<\/td>\n<\/tr>\n
          Nomoto \u548c Iizaka\uff082020\uff09<\/td>\n27\/12<\/td>\n>65\u5c81<\/td>\n8<\/td>\n12 g \u80f6\u539f\u86cb\u767d\u80bd<\/td>\n\u89d2\u8d28\u5c42\u6c34\u5206 \/ \u5f39\u6027<\/td>\n<\/tr>\n
          Ping\uff082020\uff09<\/td>\n50\/0<\/td>\n35\u201350\u5c81<\/td>\n8<\/td>\n5.5 g \u80f6\u539f\u86cb\u767d\uff08\u9c7c\u6e90\uff09<\/td>\n\u76ae\u80a4\u6c34\u5206 \/ \u4eae\u5ea6 \/ \u808c\u80a4\u7eb9\u7406 \/ \u9c7c\u5c3e\u7eb9 \/ \u80f6\u539f\u86cb\u767d\u542b\u91cf<\/td>\n<\/tr>\n
          Evans\uff082020\uff09<\/td>\n50\/0<\/td>\n45\u201360\u5c81<\/td>\n12<\/td>\n10 g HC\uff08\u9c7c\u6e90\uff09<\/td>\n\u76b1\u7eb9 \/ \u5f39\u6027 \/ \u81ea\u6211\u8bc4\u4ef7\u7684\u808c\u80a4\u5916\u89c2<\/td>\n<\/tr>\n
          Tak\uff082021\uff09<\/td>\n84\/0<\/td>\n40\u201360\u5c81<\/td>\n12<\/td>\n1000 mg \u80f6\u539f\u86cb\u767d\u4e09\u80bd<\/td>\n\u6c34\u5206 \/ \u5f39\u6027 \/ \u76b1\u7eb9<\/td>\n<\/tr>\n
          Miyanaga\uff082021\uff09<\/td>\n99\/0<\/td>\n35\u201350\u5c81<\/td>\n12<\/td>\n1 g HC \/ 5 g HC<\/td>\n\u76ae\u80a4\u542b\u6c34\u91cf \/ TEWL \/ \u5f39\u6027 \/ \u539a\u5ea6<\/td>\n<\/tr>\n
          Jung\uff082021\uff09<\/td>\n25\/25<\/td>\n35\u201360\u5c81<\/td>\n12<\/td>\n1000 mg \u80f6\u539f\u86cb\u767d\uff08\u9c7c\u6e90\uff09<\/td>\n\u76ae\u80a4\u6c34\u5206 \/ TEWL \/ \u808c\u80a4\u7eb9\u7406 \/ \u67d4\u97e7\u6027<\/td>\n<\/tr>\n
          Bianchi\uff082022\uff09<\/td>\n52\/0<\/td>\n40\u201360\u5c81<\/td>\n8<\/td>\n5 g HC<\/td>\n\u76ae\u80a4\u6c34\u6da6\u5ea6 \/ \u5f39\u6027 \/ \u76b1\u7eb9\u6df1\u5ea6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

           <\/p>\n

           <\/p>\n

          3.3 \u835f\u8403\u5206\u6790\u7ed3\u679c<\/h3>\n

          3.3.1 \u7eb3\u5165\u7814\u7a76\u7684\u7efc\u5408\u5206\u6790<\/h4>\n

          \u5728\u8fdb\u884c\u6700\u7ec8\u7684\u835f\u8403\u5206\u6790\u524d\uff0c\u90e8\u5206\u7814\u7a76\u56e0\u7f3a\u5c11\u5173\u952e\u6570\u636e\u6216\u4e0d\u7b26\u5408\u9884\u8bbe\u5206\u6790\u6761\u4ef6\u800c\u88ab\u6392\u9664\u3002<\/p>\n

          Campos\u3001Czajka\u3001Genovese \u548c Sangsuwan \u7684\u7814\u7a76\u672a\u6d4b\u91cf\u808c\u80a4\u6c34\u5206<\/strong>\uff0c\u800c\u808c\u80a4\u6c34\u5206\u662f\u672c\u7814\u7a76\u91cd\u70b9\u5173\u6ce8\u7684\u6307\u6807\u4e4b\u4e00\uff0c\u56e0\u6b64\u672a\u7eb3\u5165\u6c34\u5206\u76f8\u5173\u5206\u6790\u3002<\/p>\n

          Asserin \u7684\u7814\u7a76\u672a\u6d4b\u91cf\u808c\u80a4\u5f39\u6027<\/strong>\uff0c\u56e0\u6b64\u65e0\u6cd5\u7528\u4e8e\u8bc4\u4f30\u80f6\u539f\u86cb\u767d\u8865\u5145\u5bf9\u808c\u80a4\u5f39\u6027\u7684\u5f71\u54cd\u3002<\/p>\n

          Bianchi \u548c Ping \u7684\u7814\u7a76\u7531\u4e8e\u7f3a\u5c11\u5b89\u6170\u5242\u7ec4\u7684\u6807\u51c6\u5dee\u6570\u636e<\/strong>\uff0c\u65e0\u6cd5\u6ee1\u8db3\u7edf\u8ba1\u5206\u6790\u6240\u9700\u7684\u6570\u636e\u8981\u6c42\uff0c\u56e0\u6b64\u88ab\u6392\u9664\u3002<\/p>\n

          Laing \u7684\u7814\u7a76\u672a\u63d0\u4f9b\u8db3\u591f\u7684\u808c\u80a4\u6c34\u5206\u548c\u5f39\u6027\u76f4\u63a5\u6d4b\u91cf\u6570\u636e\uff0c\u4ec5\u63d0\u4f9b\u663e\u5fae\u89c2\u5bdf\u7ed3\u679c\u53ca\u95ee\u5377\u6570\u636e\uff0c\u65e0\u6cd5\u6ee1\u8db3\u672c\u7814\u7a76\u5bf9\u4e3b\u8981\u89c2\u5bdf\u6307\u6807\u7684\u5206\u6790\u8981\u6c42\u3002<\/p>\n

          \u6b64\u5916\uff0cProksch \u7684\u7814\u7a76\u7f3a\u5c11\u5b89\u6170\u5242\u7ec4\u6570\u636e<\/strong>\uff0c\u56e0\u6b64\u65e0\u6cd5\u4e0e\u80f6\u539f\u86cb\u767d\u5e72\u9884\u7ec4\u8fdb\u884c\u6709\u6548\u6bd4\u8f83\u3002<\/p>\n

          \u56e0\u6b64\uff0c\u4e0a\u8ff0\u7814\u7a76\u5747\u672a\u6ee1\u8db3\u672c\u6b21\u835f\u8403\u5206\u6790\u9884\u8bbe\u7684\u6570\u636e\u7eb3\u5165\u6807\u51c6\u3002<\/p>\n

          \u5728\u6700\u7ec8\u7eb3\u5165\u5206\u6790\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u6839\u636e\u80f6\u539f\u86cb\u767d\u8865\u5145\u60c5\u51b5\u4ee5\u53ca\u808c\u80a4\u6c34\u5206\u6216\u5f39\u6027<\/strong>\u7b49\u6307\u6807\uff0c\u5c06\u53d7\u8bd5\u8005\u5206\u4e3a\u80f6\u539f\u86cb\u767d\u7ec4\u548c\u5b89\u6170\u5242\u7ec4\uff0c\u5e76\u5bf9\u76f8\u5173\u6570\u636e\u8fdb\u884c\u7efc\u5408\u5206\u6790\u3002<\/p>\n

          \u808c\u80a4\u6c34\u5206<\/h3>\n

          \u5171\u6709 18 <\/strong>\u9879\u7814\u7a76<\/strong>\u7684\u6570\u636e\u88ab\u7528\u4e8e\u5206\u6790\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09\u5bf9\u808c\u80a4\u6c34\u5206\u7684\u5f71\u54cd\uff0c\u5176\u6807\u51c6\u5316\u5e73\u5747\u5dee\uff08SMD<\/strong>\uff09\u7ed3\u679c\u89c1\u56fe 2\u3002<\/p>\n

          \u7efc\u5408\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cHC \u8865\u5145\u7684\u603b\u4f53\u6548\u5e94\u91cf\u4e3a 0.63<\/strong>\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff1a0.38\u20130.88<\/strong>\uff09\uff0c\u8868\u660e\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\uff0c\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u8865\u5145\u4e0e\u808c\u80a4\u6c34\u5206\u7684\u663e\u8457\u6539\u5584\u76f8\u5173<\/strong>\u3002<\/p>\n

          \u7edf\u8ba1\u7ed3\u679c\u4e3a\uff1az = 4.94<\/strong>\uff0c<\/strong>p < 0.00001<\/strong><\/p>\n

          \u808c\u80a4\u5f39\u6027<\/h3>\n

          \u5171\u6709 19 <\/strong>\u9879\u7814\u7a76<\/strong>\u7684\u6570\u636e\u88ab\u7528\u4e8e\u5206\u6790 HC \u5bf9\u808c\u80a4\u5f39\u6027\u7684\u5f71\u54cd\uff0c\u76f8\u5173\u835f\u8403\u5206\u6790\u68ee\u6797\u56fe\u89c1\u56fe 3\u3002<\/p>\n

          \u7efc\u5408\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0cHC \u8865\u5145\u7684\u603b\u4f53\u6548\u5e94\u91cf\u4e3a 0.72<\/strong>\uff0895% \u7f6e\u4fe1\u533a\u95f4\uff1a0.40\u20131.03<\/strong>\uff09\u3002<\/p>\n

          \u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u8865\u5145\u4e0e\u808c\u80a4\u5f39\u6027\u7684\u663e\u8457\u6539\u5584\u76f8\u5173<\/strong>\u3002<\/p>\n

          \u7edf\u8ba1\u7ed3\u679c\u4e3a\uff1az = 4.49<\/strong>\uff0c<\/strong>p < 0.00001<\/strong><\/p>\n

          \n

          \"\"<\/p>\n

          \n

          \u56fe<\/em><\/strong> 2. <\/em><\/strong>\u7eb3\u5165\u7814\u7a76\u4e2d\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em><\/strong>HC<\/em><\/strong>\uff09\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u808c\u80a4\u6c34\u5206\u53d8\u5316\u7684\u835f\u8403\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/strong><\/p>\n

          \"\"<\/p>\n

          \n

          \u56fe<\/em><\/strong> 3. <\/em><\/strong>\u7eb3\u5165\u7814\u7a76\u4e2d\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em><\/strong>HC<\/em><\/strong>\uff09\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u808c\u80a4\u5f39\u6027\u53d8\u5316\u7684\u835f\u8403\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/strong><\/p>\n

          3.3.2 <\/strong>\u4e9a\u7ec4\u5206\u6790<\/strong><\/p>\n

          \u7b80\u5355\u6765\u8bf4\uff0c\u4e9a\u7ec4\u5206\u6790\u662f\u5c06\u7814\u7a76\u8fdb\u4e00\u6b65\u6309\u7167\u80f6\u539f\u86cb\u767d\u6765\u6e90\u548c\u8865\u5145\u65f6\u95f4\u8fdb\u884c\u5206\u7c7b\u6bd4\u8f83\uff0c\u4ee5\u4e86\u89e3\u4e0d\u540c\u6765\u6e90\u53ca\u4e0d\u540c\u4f7f\u7528\u5468\u671f\u662f\u5426\u4f1a\u5f71\u54cd\u6700\u7ec8\u7ed3\u679c\u3002<\/p>\n

          \u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u6709\u591a\u79cd\u5f62\u5f0f\uff0c\u5305\u62ec\u51dd\u80f6\u3001\u6db2\u4f53\u548c\u80f6\u56ca\u7b49\u3002\u6839\u636e\u6765\u6e90\u4e0d\u540c\uff0c\u6240\u4f7f\u7528\u7684\u80f6\u539f\u86cb\u767d\u4e5f\u6709\u6240\u5dee\u5f02\uff0c\u5e38\u89c1\u6765\u6e90\u5305\u62ec\u9c7c\u6e90\u3001\u732a\u6e90\u3001\u9e21\u6e90\u548c\u725b\u6e90\u80f6\u539f\u86cb\u767d<\/strong>\u3002<\/p>\n

          \u7814\u7a76\u56e2\u961f\u8fdb\u4e00\u6b65\u8fdb\u884c\u4e86\u4e9a\u7ec4\u5206\u6790<\/strong>\uff0c\u5206\u522b\u8bc4\u4f30\u4e0d\u540c\u6765\u6e90\u7684\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09\u4ee5\u53ca\u4e0d\u540c\u8865\u5145\u65f6\u95f4\u5bf9\u808c\u80a4\u6c34\u5206\u7684\u5f71\u54cd\u3002<\/p>\n

          \u7ed3\u679c\u663e\u793a\uff0c\u6765\u6e90\u4e8e\u9c7c\u3001\u725b\u3001\u9e21\u3001\u732a\u4ee5\u53ca\u6765\u6e90\u4e0d\u660e<\/strong>\u7684\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\uff0c\u5747\u4e0e\u808c\u80a4\u6c34\u5206\u7684\u663e\u8457\u6539\u5584\u76f8\u5173\uff08p < 0.00001<\/strong>\uff09\uff0c\u5177\u4f53\u7ed3\u679c\u89c1\u56fe 4\u3002<\/p>\n

          \u5728\u4e0d\u540c\u6765\u6e90\u7684\u80f6\u539f\u86cb\u767d\u4e2d\uff0c\u9e21\u6e90\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u5bf9\u808c\u80a4\u6c34\u5206\u7684\u5f71\u54cd\u6700\u5f31<\/strong>\uff0c\u5176\u6548\u5e94\u91cf\u4e3a \u22120.03<\/strong>\uff0895% CI\uff1a\u22120.40\u20130.34\uff09\u3002<\/p>\n

          \u7814\u7a76\u56e2\u961f\u540c\u65f6\u5bf9\u4e0d\u540c\u8865\u5145\u5468\u671f\u8fdb\u884c\u4e86\u4e9a\u7ec4\u5206\u6790\uff0c\u5206\u522b\u8003\u5bdf\u4e86 2<\/strong>\u3001<\/strong>4<\/strong>\u3001<\/strong>6<\/strong>\u3001<\/strong>8 <\/strong>\u548c<\/strong> 12 <\/strong>\u5468<\/strong>\u7684\u8865\u5145\u6548\u679c\u3002<\/p>\n

          \u68ee\u6797\u56fe\u5206\u6790\u663e\u793a\uff0c\u8865\u5145 **4 \u5468\uff08p = 0.002\uff09\u30016 \u5468\uff08p = 0.04\uff09\u30018 \u5468\uff08p < 0.00001\uff09\u548c 12 \u5468\uff08p = 0.001\uff09**\u65f6\uff0cHC \u5bf9\u808c\u80a4\u6c34\u5206\u7684\u5f71\u54cd\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u5177\u4f53\u7ed3\u679c\u89c1\u56fe 5\u3002<\/p>\n

          \u6b64\u5916\uff0c\u4e0e\u77ed\u671f\u8865\u5145\uff08<8 <\/strong>\u5468<\/strong>\uff09\u76f8\u6bd4\uff0c\u957f\u671f\u8865\u5145\uff08>8 <\/strong>\u5468<\/strong>\uff09\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u7684\u6548\u679c\u66f4\u4e3a\u660e\u663e\uff1a<\/p>\n

            \n
          • \u957f\u671f\u8865\u5145\uff08>8 \u5468\uff09\uff1a\u6548\u5e94\u91cf 0.59\uff0895% CI\uff1a0.35\u20130.83\uff09<\/li>\n
          • \u77ed\u671f\u8865\u5145\uff08<8 \u5468\uff09\uff1a\u6548\u5e94\u91cf 0.39\uff0895% CI\uff1a0.15\u20130.63\uff09<\/li>\n<\/ul>\n

            \u76f8\u5173\u7ed3\u679c\u89c1\u56fe 6\u3002<\/p>\n

            \n
            \"\"<\/div>\n
            \n
            \n

            \u56fe<\/em> 4. <\/em>\u4e0d\u540c\u6765\u6e90\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em>HC<\/em>\uff09\u8865\u5145\u5bf9\u808c\u80a4\u6c34\u5206\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/p>\n

            \u56fe\u4e2d\u6bd4\u8f83\u4e86\u9c7c\u6e90\u3001\u725b\u6e90\u3001\u9e21\u6e90\u3001\u732a\u6e90\u53ca\u6765\u6e90\u4e0d\u660e\u7684\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u8865\u5145\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u7684\u808c\u80a4\u6c34\u5206\u53d8\u5316\u3002<\/em><\/p>\n<\/div>\n

            \n
            \"\"<\/div>\n
            \n
            \n
            \n
            \n

            \u56fe<\/em> 5. <\/em>\u4e0d\u540c\u8865\u5145\u5468\u671f\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em>HC<\/em>\uff09\u5bf9\u808c\u80a4\u6c34\u5206\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/p>\n

            \u672c\u56fe\u6bd4\u8f83\u4e862<\/strong><\/em>\u3001<\/em><\/strong>4<\/em><\/strong>\u3001<\/em><\/strong>6<\/em><\/strong>\u3001<\/em><\/strong>8 <\/em><\/strong>\u548c<\/em><\/strong> 12 <\/em><\/strong>\u5468<\/em><\/strong>\u8865\u5145\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC<\/em>\uff09\u540e\uff0c\u808c\u80a4\u6c34\u5206\u76f8\u5173\u6307\u6807\u7684\u53d8\u5316\u3002<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n

            \n
            \"\"<\/div>\n
            \n
            \n
            \n
            \n

            \u56fe<\/em><\/strong> 6. <\/em><\/strong>\u957f\u671f\u4e0e\u77ed\u671f\u8865\u5145\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em><\/strong>HC<\/em><\/strong>\uff09\u5bf9\u808c\u80a4\u6c34\u5206\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/strong><\/p>\n

            \u5176\u4e2d\uff1a<\/em><\/p>\n

              \n
            • \u957f\u671f\u8865\u5145\uff1a<\/em><\/strong>>8 <\/em><\/strong>\u5468<\/em><\/strong><\/li>\n
            • \u77ed\u671f\u8865\u5145\uff1a<\/em><\/strong><8 <\/em><\/strong>\u5468<\/em><\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div>\n
              \n
              \n

              3.3.2 \u4e9a\u7ec4\u5206\u6790\u2014\u2014\u808c\u80a4\u5f39\u6027\u90e8\u5206<\/h3>\n

              \u6b64\u5916\uff0c\u7814\u7a76\u56e2\u961f\u9488\u5bf9\u80f6\u539f\u86cb\u767d\u6765\u6e90\u3001\u808c\u80a4\u5f39\u6027\u6d4b\u91cf\u6307\u6807\u4ee5\u53ca\u8865\u5145\u65f6\u95f4<\/strong>\u8fdb\u884c\u4e86\u4e09\u9879\u4e9a\u7ec4\u5206\u6790\uff0c\u4ee5\u8fdb\u4e00\u6b65\u8bc4\u4f30\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09\u5bf9\u808c\u80a4\u5f39\u6027\u7684\u5f71\u54cd\u3002<\/p>\n

              \u5728\u80f6\u539f\u86cb\u767d\u6765\u6e90<\/strong>\u65b9\u9762\uff0c\u4e0d\u540c\u6765\u6e90\u7684 HC \u5bf9\u808c\u80a4\u5f39\u6027\u7684\u5f71\u54cd\u5e76\u672a\u53d1\u73b0\u663e\u8457\u5dee\u5f02\uff08p = 0.21<\/strong>\uff09\uff0c\u5177\u4f53\u7ed3\u679c\u89c1\u56fe 7\u3002<\/p>\n

              \u5728\u808c\u80a4\u5f39\u6027\u6d4b\u91cf\u6307\u6807<\/strong>\u65b9\u9762\uff0c\u7814\u7a76\u91c7\u7528\u4e86\u4e0d\u540c\u7684\u5f39\u6027\u53c2\u6570\u8fdb\u884c\u8bc4\u4f30\uff0c\u5305\u62ec\uff1a<\/p>\n

                \n
              • R2<\/strong>\uff1a\u603b\u4f53\u5f39\u6027\uff08<\/strong>Gross Elasticity<\/strong>\uff09<\/strong><\/li>\n
              • R5<\/strong>\uff1a\u51c0\u5f39\u6027\uff08<\/strong>Net Elasticity<\/strong>\uff09<\/strong><\/li>\n
              • R7<\/strong>\uff1a\u5f39\u6027\u90e8\u5206\uff08<\/strong>Elastic Portion<\/strong>\uff09<\/strong><\/li>\n
              • \u4ee5\u53ca\u901a\u8fc7 **Cutometer\uff08\u76ae\u80a4\u5f39\u6027\u6d4b\u8bd5\u4eea\uff09**\u6d4b\u91cf\u7684\u5176\u4ed6\u5f39\u6027\u6307\u6807\u3002<\/li>\n<\/ul>\n

                \u4e0d\u540c\u6d4b\u91cf\u6307\u6807\u4e4b\u95f4\u7684\u7ed3\u679c\u4e5f\u672a\u53d1\u73b0\u663e\u8457\u5dee\u5f02\uff08p = 0.06<\/strong>\uff09\uff0c\u5177\u4f53\u7ed3\u679c\u89c1\u56fe 8\u3002<\/p>\n

                \u5728\u8865\u5145\u65f6\u95f4<\/strong>\u65b9\u9762\uff0c\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c\u8865\u5145 6 <\/strong>\u5468<\/strong>\u7684 HC \u5bf9\u808c\u80a4\u5f39\u6027\u672a\u663e\u793a\u51fa\u660e\u663e\u7684\u79ef\u6781\u5f71\u54cd\uff08p = 0.05<\/strong>\uff09\uff0c\u5177\u4f53\u7ed3\u679c\u89c1\u56fe 9\u3002<\/p>\n

                \u8fdb\u4e00\u6b65\u6bd4\u8f83\u53d1\u73b0\uff0c\u957f\u671f\u8865\u5145\uff08<\/strong>>8 <\/strong>\u5468\uff09\u7684\u6548\u679c\u4f18\u4e8e\u77ed\u671f\u8865\u5145\uff08<\/strong><8 <\/strong>\u5468\uff09<\/strong>\uff1a<\/p>\n

                  \n
                • **\u957f\u671f\u8865\u5145\uff08>8 \u5468\uff09\uff1a**\u6548\u5e94\u91cf 0.73\uff0895% CI\uff1a0.41\u20131.06\uff09<\/li>\n
                • **\u77ed\u671f\u8865\u5145\uff08<8 \u5468\uff09\uff1a**\u6548\u5e94\u91cf 0.67\uff0895% CI\uff1a0.33\u20131.00\uff09<\/li>\n<\/ul>\n

                  \u76f8\u5173\u4e9a\u7ec4\u5206\u6790\u7ed3\u679c\u89c1\u56fe 10\u3002<\/p>\n

                  \u603b\u4f53\u6765\u770b\uff0c\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u5bf9\u808c\u80a4\u5f39\u6027\u7684\u5f71\u54cd\u53ef\u80fd\u4e0e\u8865\u5145\u65f6\u95f4\u6709\u5173\u3002\u76f8\u6bd4\u77ed\u671f\u8865\u5145\uff0c\u6301\u7eed\u8d85\u8fc7 8 \u5468\u7684\u957f\u671f\u8865\u5145\u5448\u73b0\u51fa\u66f4\u6709\u5229\u7684\u6548\u679c\uff0c\u4f46\u4e0d\u540c\u80f6\u539f\u86cb\u767d\u6765\u6e90\u4e4b\u95f4\u5e76\u672a\u89c2\u5bdf\u5230\u663e\u8457\u5dee\u5f02\u3002<\/p><\/div>\n

                  \n
                  \"\"<\/div>\n<\/div>\n
                  \n
                  \n
                  \n
                  \n

                  \u56fe<\/em><\/strong> 7. <\/em><\/strong>\u4e0d\u540c\u6765\u6e90\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em><\/strong>HC<\/em><\/strong>\uff09\u5bf9\u808c\u80a4\u5f39\u6027\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/strong><\/p>\n

                  \u672c\u56fe\u6bd4\u8f83\u4e86\u9c7c\u6e90\u3001\u725b\u6e90\u3001\u9e21\u6e90\u3001\u732a\u6e90\u53ca\u6765\u6e90\u4e0d\u660e\u7684\u6c34\u89e3\u80f6\u539f\u86cb\u767d<\/strong>\u8865\u5145\u7ec4\u4e0e\u5b89\u6170\u5242\u7ec4\u5728\u808c\u80a4\u5f39\u6027\u65b9\u9762\u7684\u5dee\u5f02\u3002<\/em><\/p>\n<\/div>\n<\/div>\n

                  \n
                  \"\"<\/div>\n<\/div>\n
                  \n
                  \n

                  \u56fe<\/em> 8. <\/em>\u4e0d\u540c\u808c\u80a4\u5f39\u6027\u6d4b\u91cf\u6307\u6807\u5bf9\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em>HC<\/em>\uff09\u6548\u679c\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/p>\n<\/div>\n

                  \n
                  \"\"<\/div>\n
                  \n
                  \n

                  \u56fe 9. <\/em>\u4e0d\u540c\u8865\u5145\u5468\u671f\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC<\/em>\uff09\u5bf9\u808c\u80a4\u5f39\u6027\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/p>\n

                  \u672c\u56fe\u6bd4\u8f83\u4e86 2<\/em>\u30014<\/em>\u30016<\/em>\u30018 <\/em>\u548c 12 <\/em>\u5468\u8865\u5145\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u540e\uff0c\u808c\u80a4\u5f39\u6027\u76f8\u5173\u6307\u6807\u7684\u53d8\u5316\u3002<\/em><\/p>\n<\/div>\n

                  \"\"<\/div>\n
                  \n
                  \n
                  \n
                  \n
                  \n
                  \n

                  \u56fe<\/em><\/strong> 10. <\/em><\/strong>\u957f\u671f\u4e0e\u77ed\u671f\u8865\u5145\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/em><\/strong>HC<\/em><\/strong>\uff09\u5bf9\u808c\u80a4\u5f39\u6027\u5f71\u54cd\u7684\u4e9a\u7ec4\u5206\u6790\u68ee\u6797\u56fe\u3002<\/em><\/strong><\/p>\n

                  \u5176\u4e2d\uff1a<\/em><\/p>\n

                    \n
                  • \u957f\u671f\u8865\u5145\uff1a<\/em><\/strong>>8 <\/em><\/strong>\u5468<\/em><\/strong><\/li>\n
                  • \u77ed\u671f\u8865\u5145\uff1a<\/em><\/strong><8 <\/em><\/strong>\u5468<\/em><\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n
                    \n

                    3.4 \u504f\u501a\u98ce\u9669<\/h3>\n

                    \u5728\u8fdb\u884c\u7cfb\u7edf\u7efc\u8ff0\u548c\u835f\u8403\u5206\u6790\u65f6\uff0c\u9664\u4e86\u6c47\u603b\u7814\u7a76\u7ed3\u679c\u5916\uff0c\u8fd8\u9700\u8981\u8bc4\u4f30\u7eb3\u5165\u7814\u7a76\u7684\u8d28\u91cf\u4ee5\u53ca\u53ef\u80fd\u5b58\u5728\u7684\u504f\u501a<\/strong>\uff0c\u4ee5\u5224\u65ad\u7814\u7a76\u7ed3\u679c\u7684\u53ef\u9760\u7a0b\u5ea6\u3002<\/p>\n

                    \u5e38\u7528\u7684\u8bc4\u4f30\u65b9\u6cd5\u4e4b\u4e00\u662f\u504f\u501a\u98ce\u9669\uff08<\/strong>Risk of Bias<\/strong>\uff0c<\/strong>RoB<\/strong>\uff09\u8bc4\u4f30<\/strong>\u3002RoB \u4e3b\u8981\u8003\u5bdf\u7814\u7a76\u8fc7\u7a0b\u4e2d\u53ef\u80fd\u5f71\u54cd\u7ed3\u679c\u51c6\u786e\u6027\u7684\u591a\u4e2a\u65b9\u9762\uff0c\u4f8b\u5982\u968f\u673a\u5206\u7ec4\u8fc7\u7a0b\u3001\u5e72\u9884\u5b9e\u65bd\u8fc7\u7a0b\u3001\u7ed3\u679c\u6570\u636e\u662f\u5426\u5b8c\u6574\uff0c\u4ee5\u53ca\u662f\u5426\u5b58\u5728\u9009\u62e9\u6027\u62a5\u544a\u7814\u7a76\u7ed3\u679c<\/strong>\u7b49\u3002<\/p>\n

                    \u7814\u7a76\u4eba\u5458\u4f1a\u6839\u636e\u9884\u5148\u8bbe\u5b9a\u7684\u6807\u51c6\uff0c\u5bf9\u5404\u4e2a\u65b9\u9762\u8fdb\u884c\u8bc4\u4f30\uff0c\u5e76\u7efc\u5408\u5224\u65ad\u6bcf\u9879\u7814\u7a76\u5b58\u5728\u7684\u504f\u501a\u98ce\u9669\u3002\u901a\u8fc7 RoB \u8bc4\u4f30\uff0c\u53ef\u4ee5\u66f4\u52a0\u5ba2\u89c2\u5730\u5224\u65ad\u7814\u7a76\u8bbe\u8ba1\u3001\u5b9e\u65bd\u53ca\u7ed3\u679c\u62a5\u544a\u7684\u53ef\u9760\u6027\uff0c\u5e76\u4e3a\u7cfb\u7edf\u7efc\u8ff0\u548c\u835f\u8403\u5206\u6790\u5224\u65ad\u7814\u7a76\u662f\u5426\u9002\u5408\u7eb3\u5165\u63d0\u4f9b\u4f9d\u636e\u3002<\/p>\n

                    \u5728\u672c\u9879\u7814\u7a76\u4e2d\uff0c\u5bf9\u7eb3\u5165\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u8fdb\u884c\u8bc4\u4f30\u540e\u53d1\u73b0\uff1a<\/p>\n

                      \n
                    • 1 <\/strong>\u9879\u7814\u7a76<\/strong>\u5b58\u5728\u4e0e\u968f\u673a\u5206\u7ec4\u8fc7\u7a0b<\/strong>\u76f8\u5173\u7684\u504f\u501a\u98ce\u9669\uff1b<\/li>\n
                    • 7 <\/strong>\u9879\u7814\u7a76<\/strong>\u5b58\u5728\u4e0e\u5b9e\u9645\u5b9e\u65bd\u7684\u5e72\u9884\u63aa\u65bd\u504f\u79bb\u9884\u8bbe\u65b9\u6848<\/strong>\u76f8\u5173\u7684\u504f\u501a\u98ce\u9669\uff1b<\/li>\n
                    • 13 <\/strong>\u9879\u7814\u7a76<\/strong>\u5b58\u5728\u7ed3\u679c\u6570\u636e\u7f3a\u5931<\/strong>\u76f8\u5173\u7684\u504f\u501a\u98ce\u9669\uff1b<\/li>\n
                    • 2 <\/strong>\u9879\u7814\u7a76<\/strong>\u5b58\u5728\u9009\u62e9\u6027\u62a5\u544a\u7814\u7a76\u7ed3\u679c<\/strong>\u76f8\u5173\u7684\u504f\u501a\u98ce\u9669\u3002<\/li>\n<\/ul>\n

                      \u7eb3\u5165\u7814\u7a76\u7684\u5177\u4f53\u504f\u501a\u98ce\u9669\u8bc4\u4f30\u7ed3\u679c\u8be6\u89c1\u56fe<\/strong> 11<\/strong>\u3002<\/p>\n

                      \u7b80\u5355\u6765\u8bf4\uff0c\u504f\u501a\u98ce\u9669\u8bc4\u4f30\u662f\u4e3a\u4e86\u5224\u65ad\u4e00\u9879\u7814\u7a76\u7684\u7ed3\u679c\u662f\u5426\u53ef\u80fd\u53d7\u5230\u7814\u7a76\u8bbe\u8ba1\u3001\u5b9e\u65bd\u8fc7\u7a0b\u6216\u6570\u636e\u5b8c\u6574\u6027\u7b49\u56e0\u7d20\u7684\u5f71\u54cd\uff0c\u4ece\u800c\u5e2e\u52a9\u7814\u7a76\u4eba\u5458\u66f4\u5ba2\u89c2\u5730\u89e3\u8bfb\u835f\u8403\u5206\u6790\u7ed3\u679c\u3002<\/h3>\n<\/section>\n<\/div>\n
                      \n
                      \"\"<\/div>\n
                      \n
                      \n
                      \n
                      \n
                      \n
                      \n
                      \n

                      \u56fe<\/em><\/strong> 11. <\/em><\/strong>\u7eb3\u5165\u7814\u7a76\u7684\u504f\u501a\u98ce\u9669\u8bc4\u4f30\u7ed3\u679c\u3002<\/em><\/strong><\/p>\n

                      \u6ce8\uff1a<\/em><\/strong><\/p>\n

                        \n
                      • D1<\/em><\/strong>\uff1a\u968f\u673a\u5206\u7ec4\u8fc7\u7a0b<\/em><\/strong><\/li>\n
                      • D2<\/em><\/strong>\uff1a\u504f\u79bb\u9884\u8bbe\u5e72\u9884\u63aa\u65bd<\/em><\/strong><\/li>\n
                      • D3<\/em><\/strong>\uff1a\u7ed3\u679c\u6570\u636e\u7f3a\u5931<\/em><\/strong><\/li>\n
                      • D4<\/em><\/strong>\uff1a\u7ed3\u679c\u6d4b\u91cf<\/em><\/strong><\/li>\n
                      • D5<\/em><\/strong>\uff1a\u7ed3\u679c\u62a5\u544a\u7684\u9009\u62e9<\/em><\/strong><\/li>\n<\/ul>\n

                        \u00a0<\/em><\/strong><\/p>\n

                        4. \u7814\u7a76\u8ba8\u8bba<\/h3>\n

                        \u4e3a\u8bc4\u4f30\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u5bf9\u76ae\u80a4\u8001\u5316\u7684\u5f71\u54cd\uff0c\u672c\u7814\u7a76\u5206\u6790\u4e86 26<\/strong>\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08<\/strong>RCTs<\/strong>\uff09<\/strong>\uff0c\u91cd\u70b9\u8bc4\u4f30\u53e3\u670d\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u5bf9\u76ae\u80a4\u6c34\u5206\u548c\u76ae\u80a4\u5f39\u6027<\/strong>\u7684\u5f71\u54cd\u3002\u8fd9\u4e24\u9879\u6307\u6807\u5747\u88ab\u5e7f\u6cdb\u7528\u4e8e\u8bc4\u4ef7\u76ae\u80a4\u8001\u5316\u72b6\u6001\u3002<\/p>\n

                        \u7814\u7a76\u4e2d\u7684\u8bd5\u9a8c\u5206\u522b\u5bf9\u8138\u988a\u3001\u524d\u81c2\u548c\u989d\u5934\u7b49\u4e0d\u540c\u90e8\u4f4d\u7684\u76ae\u80a4\u6c34\u5206\u548c\u5f39\u6027\u8fdb\u884c\u4e86\u6d4b\u91cf\u3002\u7efc\u5408\u5206\u6790\u7ed3\u679c\u663e\u793a\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u80fd\u591f\u6539\u5584\u76ae\u80a4\u6c34\u5206\u548c\u76ae\u80a4\u5f39\u6027<\/strong>\u3002<\/p>\n

                        \u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u7814\u7a76\u53d1\u73b0\uff0c\u6301\u7eed\u8865\u5145\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/strong>HC<\/strong>\uff09<\/strong>8<\/strong>\u5468\u6216\u66f4\u957f\u65f6\u95f4\u540e\uff0c\u5176\u6539\u5584\u76ae\u80a4\u6c34\u5206\u548c\u5f39\u6027\u7684\u6548\u679c\u66f4\u4e3a\u660e\u663e\uff0c\u5e76\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\u3002<\/strong><\/p>\n

                        \u6838\u5fc3\u7ed3\u8bba\uff1a<\/strong>
                        \n26\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u7684Meta\u5206\u6790\u8868\u660e\uff0c\u53e3\u670d\u6c34\u89e3\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u4e0e\u76ae\u80a4\u6c34\u5206\u548c\u5f39\u6027\u7684\u6539\u5584<\/strong>\u76f8\u5173\uff0c\u800c\u6301\u7eed<\/strong>8<\/strong>\u5468\u6216\u4ee5\u4e0a\u7684\u8865\u5145\u53ef\u80fd\u5e26\u6765\u66f4\u660e\u663e\u7684\u76ae\u80a4\u6539\u5584\u6548\u679c<\/strong>\u3002<\/p>\n

                        4.1. \u76ae\u80a4\u6c34\u5206<\/h3>\n

                        \u900f\u660e\u8d28\u9178\u662f\u7ef4\u6301\u76ae\u80a4\u6c34\u5206\u7684\u91cd\u8981\u6210\u5206\uff0c\u5c5e\u4e8e\u4e00\u79cd\u5177\u6709\u8f83\u5f3a\u9501\u6c34\u80fd\u529b\u7684\u7cd6\u80fa\u805a\u7cd6\uff0c\u80fd\u591f\u5e2e\u52a9\u76ae\u80a4\u4fdd\u6301\u6c34\u5206\u3002\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u8868\u76ae\u4e2d\u7684\u900f\u660e\u8d28\u9178\u4f1a\u9010\u6e10\u51cf\u5c11\uff0c\u8fd9\u4e5f\u662f\u76ae\u80a4\u8001\u5316\u8fc7\u7a0b\u4e2d\u8f83\u4e3a\u660e\u663e\u7684\u7ec4\u7ec7\u5b66\u53d8\u5316\u4e4b\u4e00\u3002\u7814\u7a76\u8868\u660e\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u6c34\u89e3\u7269\u5bcc\u542b\u812f\u6c28\u9178\u548c\u7f9f\u812f\u6c28\u9178\uff0c\u6709\u52a9\u4e8e\u4fc3\u8fdb\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u751f\u6210\u900f\u660e\u8d28\u9178\u3002<\/p>\n

                        \u672c\u7814\u7a76\u53d1\u73b0\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u80fd\u591f\u6539\u5584\u76ae\u80a4\u6c34\u5206<\/strong>\uff0c\u8fd9\u4e00\u7ed3\u679c\u4e0e\u65e2\u5f80\u7814\u7a76\u4e00\u81f4\u3002Cao\u7b49\u4eba\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u6444\u5165\u80f6\u539f\u86cb\u767d\u80bd\uff08CPs\uff09\u7684\u5c0f\u9f20\u76ae\u80a4\u6c34\u5206\u542b\u91cf\u663e\u8457\u63d0\u9ad8\uff08p<\/em> < 0.05\uff09\u3002Sun\u7b49\u4eba\u7684\u7814\u7a76\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u5355\u72ec\u8865\u5145\u80f6\u539f\u86cb\u767d\u5bf9\u6539\u5584\u76ae\u80a4\u6c34\u5206\u5177\u6709\u660e\u663e\u6548\u679c\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u5176\u6807\u51c6\u5316\u5e73\u5747\u5dee\uff08SMD\uff09\u4e3a0.77\uff0895% CI\uff1a0.60\u20130.94\uff0cp<\/em> < 0.00001\uff09\u3002<\/p>\n

                        \u672c\u7814\u7a76\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0c\u9c7c\u6e90\u80f6\u539f\u86cb\u767d\u5728\u6539\u5584\u76ae\u80a4\u6c34\u5206\u65b9\u9762\u8868\u73b0\u8f83\u4e3a\u7a81\u51fa<\/strong>\u3002\u65e2\u5f80\u7814\u7a76\u663e\u793a\uff0c\u9c7c\u76ae\u6765\u6e90\u7684\u80f6\u539f\u86cb\u767d\u4e0e\u54fa\u4e73\u52a8\u7269\u6765\u6e90\u7684\u80f6\u539f\u86cb\u767d\u5728\u6c28\u57fa\u9178\u7ec4\u6210\u65b9\u9762\u5b58\u5728\u4e00\u5b9a\u5dee\u5f02\u3002\u53e6\u4e00\u9879\u7814\u7a76\u4f30\u7b97\uff0c\u9c7c\u76ae\u3001\u9c7c\u9aa8\u548c\u9c7c\u9ccd\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u63d0\u53d6\u7387\u5206\u522b\u7ea6\u4e3a50%\u300140%\u548c36.4%\u3002\u503c\u5f97\u6ce8\u610f\u7684\u662f\uff0c\u6d77\u6d0b\u80f6\u539f\u86cb\u767d\u53ca\u80f6\u539f\u86cb\u767d\u80bd\u5177\u6709\u8f83\u9ad8\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u540c\u65f6\u8868\u73b0\u51fa\u826f\u597d\u7684\u5e94\u7528\u6f5c\u529b\u548c\u5b89\u5168\u6027<\/strong>\u3002<\/p>\n

                        \u5bf9\u4e8e\u9e21\u6e90\u80f6\u539f\u86cb\u767d\uff0c\u672c\u7814\u7a76\u4e2d\u4ec5\u6709Schwartz\uff082019\uff09\u7684\u4e00\u9879\u7814\u7a76\u8fdb\u884c\u4e86\u76f8\u5173\u8bc4\u4ef7\uff0c\u56e0\u6b64\u76ee\u524d\u53ef\u53c2\u8003\u7684\u4eba\u4f53\u7814\u7a76\u76f8\u5bf9\u6709\u9650\u3002\u4e0d\u8fc7\uff0cCao\u7b49\u4eba\u7684\u52a8\u7269\u7814\u7a76\u53d1\u73b0\uff0c\u6444\u5165\u6765\u6e90\u4e8e\u9e21\u9aa8\u7684\u80f6\u539f\u86cb\u767d\u80bd\u540e\uff0c\u5c0f\u9f20\u76ae\u80a4\u6c34\u5206\u542b\u91cf\u663e\u8457\u9ad8\u4e8e\u5bf9\u7167\u7ec4\uff08p<\/em> < 0.05\uff09\u3002\u6b64\u5916\uff0cSchwartz\u7b49\u4eba\u7684\u4eba\u4f53\u7814\u7a76\u4e2d\uff0c\u53c2\u4e0e\u8005\u6bcf\u65e5\u6444\u51651 g\u6765\u6e90\u4e8e\u6c34\u89e3\u9e21\u80f8\u9aa8\u8f6f\u9aa8<\/strong>\u7684\u80f6\u539f\u86cb\u767d\uff0c\u6301\u7eed12\u5468\u540e\uff0c\u7b2c<\/strong>6<\/strong>\u81f3\u7b2c<\/strong>12<\/strong>\u5468\u671f\u95f4\u76ae\u80a4\u6c34\u5206\u663e\u8457\u63d0\u9ad8<\/strong>12.5%<\/strong>\uff08p<\/em> = 0.003\uff09\u3002<\/p>\n

                        \u9700\u8981\u6ce8\u610f\u7684\u662f\uff0c\u7531\u4e8e\u90e8\u5206\u7814\u7a76\u57fa\u4e8e\u52a8\u7269\u5b9e\u9a8c\uff0c\u4e14\u4e0d\u540c\u4eba\u4f53\u7814\u7a76\u4e2d\u7684\u53d7\u8bd5\u8005\u7279\u5f81\u5b58\u5728\u5dee\u5f02\uff0c\u56e0\u6b64\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u662f\u5426\u80fd\u591f\u5b8c\u5168\u9002\u7528\u4e8e\u66f4\u5e7f\u6cdb\u7684\u4eba\u7fa4\uff0c\u4ecd\u9700\u8981\u66f4\u591a\u7814\u7a76\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n

                        4.2. \u76ae\u80a4\u5f39\u6027<\/h3>\n

                        I\u578b\u80f6\u539f\u86cb\u767d\u662f\u76ae\u80a4\u4e2d\u6700\u4e3b\u8981\u7684\u80f6\u539f\u86cb\u767d\u7c7b\u578b\uff0c\u7ea6\u5360\u76ae\u80a4\u80f6\u539f\u86cb\u767d\u603b\u91cf\u768490%\uff0c\u5728\u7ef4\u6301\u76ae\u80a4\u7684\u7ed3\u6784\u3001\u5b8c\u6574\u6027\u548c\u652f\u6491\u529b\u65b9\u9762\u53d1\u6325\u7740\u91cd\u8981\u4f5c\u7528\u3002\u76ae\u80a4\u7684\u5f39\u6027\u548c\u97e7\u6027\u5219\u4e3b\u8981\u4e0e\u5f39\u6027\u7ea4\u7ef4\u7f51\u7edc\u6709\u5173\uff0c\u8be5\u7f51\u7edc\u7531\u5f39\u6027\u86cb\u767d\u3001\u5fae\u539f\u7ea4\u7ef4\u7b49\u591a\u79cd\u86cb\u767d\u8d28\u6784\u6210\u3002\u76ae\u80a4\u5f39\u6027\u53d6\u51b3\u4e8e\u8fd9\u4e00\u590d\u6742\u7f51\u7edc\u7684\u6574\u4f53\u529f\u80fd\uff0c\u5176\u5f62\u6210\u548c\u7ef4\u6301\u53d7\u5230\u591a\u79cd\u56e0\u7d20\u7684\u5f71\u54cd\u3002<\/p>\n

                        \u4e00\u9879\u7814\u7a76\u53d1\u73b0\uff0c\u6444\u5165\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09\u540e\uff0c\u53ef\u8c03\u8282\u591a\u79cd\u4e0e\u76ae\u80a4\u7ec4\u7ec7\u548c\u751f\u957f\u56e0\u5b50\u76f8\u5173\u7684\u86cb\u767d\u8d28\u6c34\u5e73\uff0c\u540c\u65f6\u589e\u52a0I\u578b\u80f6\u539f\u86cb\u767dmRNA\u53ca\u86cb\u767d\u8d28\u7684\u8868\u8fbe\u3002\u8fd9\u4e9b\u53d8\u5316\u53ef\u80fd\u6709\u52a9\u4e8e\u7ef4\u6301\u76ae\u80a4\u7ed3\u6784\uff0c\u5e76\u6539\u5584\u76ae\u80a4\u5f39\u6027\u3002<\/p>\n

                        \u672c\u7814\u7a76\u53d1\u73b0\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u80fd\u591f\u6539\u5584\u76ae\u80a4\u5f39\u6027<\/strong>\uff0c\u8fd9\u4e00\u7ed3\u679c\u4e0e\u65e2\u5f80\u7814\u7a76\u57fa\u672c\u4e00\u81f4\u3002De Luca\u7b49\u4eba\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u6444\u5165\u6d77\u6d0b\u80f6\u539f\u86cb\u767d\u80bd\u540e\uff0c\u53d7\u8bd5\u8005\u7684\u76ae\u80a4\u5f39\u6027\u663e\u8457\u6539\u5584\uff08p<\/em> < 0.0001\uff09\u3002<\/p>\n

                        Maia Campos\u7b49\u4eba\u7684\u7814\u7a76\u663e\u793a\uff0c\u4e0e\u57fa\u7ebf\u53ca\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u8fde\u7eed\u53e3\u670d\u80f6\u539f\u86cb\u767d90\u5929\u540e\uff0c\u53d7\u8bd5\u8005\u773c\u5468\u533a\u57df\u7684\u51c0\u5f39\u6027<\/strong>\u51fa\u73b0\u663e\u8457\u6539\u5584\u3002<\/p>\n

                        Lee\u7b49\u4eba\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8fde\u7eed\u53e3\u670d\u80f6\u539f\u86cb\u767d12\u5468\u540e\uff0c\u76ae\u80a4\u8868\u9762\u5f39\u6027\u6307\u6807R2\u663e\u8457\u63d0\u9ad8\uff0c\u7531\u4f7f\u7528\u524d\u7684 0.66 \u00b1 0.05<\/strong> \u63d0\u9ad8\u81f312\u5468\u540e\u7684 0.75 \u00b1 0.04<\/strong>\uff08p<\/em> < 0.05\uff09\u3002<\/p>\n

                        \u6b64\u5916\uff0cSone\u7b49\u4eba\uff082018\uff09\u7684\u52a8\u7269\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u81ea\u7136\u8870\u8001\u7684\u5c0f\u9f20\u4e2d\uff0c\u53e3\u670d\u725b\u9aa8\u6765\u6e90\u7684\u80f6\u539f\u86cb\u767d\u80bd<\/strong>\u80fd\u591f\u589e\u52a0\u76ae\u80a4\u80f6\u539f\u86cb\u767d\u542b\u91cf\uff0c\u5e76\u6539\u5584I\u578b\u4e0eIII\u578b\u80f6\u539f\u86cb\u767d\u7684\u6bd4\u4f8b\uff0c\u4ece\u800c\u6709\u52a9\u4e8e\u6539\u5584\u56e0\u5e74\u9f84\u589e\u957f\u800c\u4ea7\u751f\u7684\u76ae\u80a4\u677e\u5f1b\u3002\u7814\u7a76\u8fd8\u63d0\u793a\uff0c\u80f6\u539f\u86cb\u767d\u80bd\u53ef\u80fd\u6709\u52a9\u4e8e\u589e\u5f3a\u673a\u4f53\u7684\u6297\u6c27\u5316\u80fd\u529b\uff0c\u800c\u812f\u6c28\u9178\u7684\u6444\u5165\u4e5f\u53ef\u80fd\u5bf9\u6539\u5584\u8001\u9f84\u76ae\u80a4\u5f39\u6027\u4ea7\u751f\u79ef\u6781\u4f5c\u7528\u3002<\/p>\n

                        \u5728\u7eb3\u5165\u672c\u7814\u7a76\u7684\u5404\u9879\u7814\u7a76\u4e2d\uff0cYoon\u7b49\u4eba\u7684\u7814\u7a76\u663e\u793a\uff0c\u8fde\u7eed\u53e3\u670d\u80f6\u539f\u86cb\u767d<\/strong>12<\/strong>\u5468\u540e\uff0c\u76ae\u80a4\u5f39\u6027\u7684\u6539\u5584\u6548\u679c\u8f83\u5176\u4ed6\u8865\u5145\u5468\u671f\u66f4\u4e3a\u660e\u663e<\/strong>\uff0c\u6548\u5e94\u503c\u4e3a3.25\uff0895% CI\uff1a2.33\u20134.18\uff09\u3002\u8fd9\u4e00\u7ed3\u679c\u4e0e\u53e6\u4e00\u9879\u5f00\u653e\u6027\u3001\u76f2\u6cd5\u3001\u975e\u5bf9\u7167\u7814\u7a76\u7684\u7ed3\u679c\u76f8\u7b26\uff0c\u8be5\u7814\u7a76\u53d1\u73b0\uff0c\u8fde\u7eed\u6444\u5165\u53e3\u670d\u80f6\u539f\u86cb\u767d3\u4e2a\u6708\u540e\uff0c\u76ae\u80a4\u5f39\u6027\u63d0\u9ad8\u4e86 38.31%<\/strong>\u3002<\/p>\n

                        \u53e6\u4e00\u9879\u52a8\u7269\u7814\u7a76\u901a\u8fc7D-\u534a\u4e73\u7cd6\u8054\u5408\u7d2b\u5916\u7ebf\u7167\u5c04\u5efa\u7acb\u76ae\u80a4\u8870\u8001\u6a21\u578b\u3002\u7ed3\u679c\u663e\u793a\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u80bd\u540e\uff0c\u5c0f\u9f20\u76ae\u80a4\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u548c\u5f39\u6027\u86cb\u767d\u542b\u91cf\u5747\u6709\u6240\u589e\u52a0<\/strong>\u3002<\/p>\n

                        \u603b\u4f53\u800c\u8a00\uff0c\u73b0\u6709\u7814\u7a76\u8868\u660e\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u8865\u5145\u53ef\u80fd\u6709\u52a9\u4e8e\u6539\u5584\u76ae\u80a4\u5f39\u6027\uff0c\u4e14\u6301\u7eed\u8865\u5145\u8f83\u957f\u65f6\u95f4\u53ef\u80fd\u83b7\u5f97\u66f4\u660e\u663e\u7684\u6548\u679c<\/strong>\u3002\u4e0d\u8fc7\uff0c\u76ee\u524d\u7814\u7a76\u4ecd\u5b58\u5728\u4e00\u5b9a\u5c40\u9650\u6027\u3002\u4e0d\u540c\u7814\u7a76\u6240\u4f7f\u7528\u7684\u80f6\u539f\u86cb\u767d\u6765\u6e90\u3001\u5242\u91cf\u3001\u5f62\u5f0f\u53ca\u8865\u5145\u5468\u671f\u5b58\u5728\u5dee\u5f02\uff0c\u56e0\u6b64\u7814\u7a76\u7ed3\u679c\u4e4b\u95f4\u8f83\u96be\u8fdb\u884c\u76f4\u63a5\u6bd4\u8f83\u3002\u6b64\u5916\uff0c\u90e8\u5206\u7814\u7a76\u7684\u53d7\u8bd5\u8005\u6570\u91cf\u8f83\u5c11\uff0c\u90e8\u5206\u4eba\u4f53\u7814\u7a76\u5bf9\u76ae\u80a4\u5f39\u6027\u7684\u8bc4\u4ef7\u4e5f\u5b58\u5728\u4e00\u5b9a\u7684\u4e3b\u89c2\u6027\u3002\u52a8\u7269\u5b9e\u9a8c\u7684\u7ed3\u679c\u540c\u6837\u4e0d\u80fd\u5b8c\u5168\u4ee3\u8868\u4eba\u4f53\u4e2d\u7684\u5b9e\u9645\u6548\u679c\uff0c\u56e0\u6b64\u4ecd\u9700\u8981\u66f4\u591a\u5927\u6837\u672c\u3001\u957f\u671f\u7684\u4eba\u4f53\u4e34\u5e8a\u7814\u7a76\u8fdb\u884c\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002<\/p>\n

                        4.3. \u4f5c\u7528\u673a\u5236<\/h3>\n

                        \u4e0e\u5b8c\u6574\u86cb\u767d\u8d28\u76f8\u6bd4\uff0c\u86cb\u767d\u8d28\u6c34\u89e3\u7269\u66f4\u5bb9\u6613\u88ab\u4eba\u4f53\u6d88\u5316\u548c\u5438\u6536<\/strong>\uff0c\u6444\u5165\u540e\u80fd\u591f\u589e\u52a0\u4f53\u5185\u6c28\u57fa\u9178\u7684\u91ca\u653e\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u53e3\u670d\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08HC\uff09\u540e\uff0c\u4eba\u4f53\u548c\u5c0f\u9f20\u8840\u6db2\u4e2d\u7684 Gly-Pro-Hyp<\/strong>\uff08\u7518\u6c28\u9178<\/strong>–<\/strong>\u812f\u6c28\u9178<\/strong>–<\/strong>\u7f9f\u812f\u6c28\u9178\uff09<\/strong> \u6c34\u5e73\u4f1a\u77ed\u6682\u5347\u9ad8\uff0c\u540c\u65f6\uff0c\u5176\u4ed6\u80f6\u539f\u86cb\u767d\u80bd\u4e5f\u80fd\u591f\u88ab\u8fd0\u8f93\u81f3\u76ae\u80a4\u7ec4\u7ec7\u3002<\/p>\n

                        Kamiyama\u7b49\u4eba\u4ee5 Gly-Pro-Hyp<\/strong> \u4f5c\u4e3a\u793a\u8e2a\u7269\uff0c\u5e76\u4e0e\u6807\u8bb0\u7684\u812f\u6c28\u9178\u8fdb\u884c\u6bd4\u8f83\uff0c\u7814\u7a76\u5176\u5728\u5927\u9f20\u4f53\u5185\u7684\u5438\u6536\u548c\u5206\u5e03\u60c5\u51b5\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6444\u5165Gly-Pro-Hyp\u540e\uff0c\u968f\u7740\u65f6\u95f4\u63a8\u79fb\uff0c\u5927\u90e8\u5206\u793a\u8e2a\u7269\u4ece\u5176\u4ed6\u5668\u5b98\u4e2d\u9010\u6e10\u6d88\u5931\uff0c\u800c\u76ae\u80a4\u7ec4\u7ec7\u4e2d\u4ecd\u53ef\u68c0\u6d4b\u5230\u8f83\u9ad8\u6c34\u5e73\uff1b\u5728\u6444\u51656\u5c0f\u65f6\u540e\uff0c\u76ae\u80a4\u4e2d\u7684\u76f8\u5173\u4fe1\u53f7\u7ea6\u4e3a70%\u3002<\/p>\n

                        \u53e6\u4e00\u9879\u7c7b\u4f3c\u7814\u7a76\u53d1\u73b0\uff0c\u5355\u6b21\u6444\u5165Gly-Pro-Hyp\u540e\uff0c\u572824\u5c0f\u65f6\u5185\uff0c\u9aa8\u9abc\u3001\u76ae\u80a4\u7b49\u7ed3\u7f14\u7ec4\u7ec7\u4e2d\u4ecd\u53ef\u68c0\u6d4b\u5230\u76f8\u5173\u793a\u8e2a\u4fe1\u53f7<\/strong>\u3002<\/p>\n

                        \u8fd9\u4e9b\u7814\u7a76\u63d0\u793a\uff0c\u80f6\u539f\u86cb\u767d\u7ecf\u8fc7\u6c34\u89e3\u540e\u5f62\u6210\u7684\u5c0f\u5206\u5b50\u80bd\u66f4\u5bb9\u6613\u88ab\u4eba\u4f53\u5438\u6536\uff0c\u5176\u4e2d\u90e8\u5206\u80f6\u539f\u86cb\u767d\u80bd\u53ca\u5176\u76f8\u5173\u6c28\u57fa\u9178\u53ef\u80fd\u8fdb\u5165\u76ae\u80a4\u7ec4\u7ec7\uff0c\u4ece\u800c\u4e3a\u76ae\u80a4\u80f6\u539f\u86cb\u767d\u53ca\u76f8\u5173\u7ed3\u6784\u7684\u7ef4\u6301\u63d0\u4f9b\u8425\u517b\u57fa\u7840\u3002<\/p>\n

                        4.4. \u654f\u611f\u6027\u5206\u6790<\/h3>\n

                        \u672c\u7814\u7a76\u4e2d\u7684\u4e24\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff08RCT\uff09\u2014\u2014Campos\u7b49\u4eba\u7684\u7814\u7a76\u548cChoi\u7b49\u4eba\u7684\u7814\u7a76\u2014\u2014\u5747\u663e\u793a\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u5bf9\u6539\u5584\u76ae\u80a4\u5f39\u6027\u5177\u6709\u8f83\u4e3a\u660e\u663e\u7684\u79ef\u6781\u4f5c\u7528<\/strong>\u3002<\/p>\n

                        Campos\uff082015\uff09\u7684\u7814\u7a76\u4f7f\u7528\u4e86\u542b\u670910 g<\/strong>\u80f6\u539f\u86cb\u767d\u3001\u7ef4\u751f\u7d20<\/strong>A<\/strong>\u3001<\/strong>C<\/strong>\u3001<\/strong>E<\/strong>\u53ca\u950c<\/strong>\u7b49\u6210\u5206\u7684\u590d\u5408\u914d\u65b9\u3002\u56e0\u6b64\uff0c\u8be5\u7814\u7a76\u89c2\u5bdf\u5230\u7684\u6539\u5584\u6548\u679c\u53ef\u80fd\u4e0d\u4ec5\u6765\u81ea\u80f6\u539f\u86cb\u767d\u672c\u8eab\uff0c\u4e5f\u53ef\u80fd\u4e0e\u7ef4\u751f\u7d20\u548c\u77ff\u7269\u8d28\u7b49\u6210\u5206\u7684\u534f\u540c\u4f5c\u7528\u6709\u5173\u3002<\/p>\n

                        \u5df2\u6709\u7814\u7a76\u663e\u793a\uff0c\u7ef4\u751f\u7d20<\/strong>C<\/strong>\u6709\u52a9\u4e8e\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u751f\u6210\uff0c\u5e76\u652f\u6301\u5f39\u6027\u5fae\u539f\u7ea4\u7ef4\u7684\u5f62\u6210<\/strong>\uff1b\u7ef4\u751f\u7d20A\u5219\u6709\u52a9\u4e8e\u7ef4\u6301\u76ae\u80a4\u8868\u5c42\u7ec6\u80de\u7684\u6b63\u5e38\u72b6\u6001\uff0c\u5e76\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u53ca\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u751f\u6210\u3002<\/p>\n

                        \u53e6\u4e00\u65b9\u9762\uff0cChoi\uff082014\uff09\u7684\u7814\u7a76\u53d7\u8bd5\u8005\u5e74\u9f84\u4e3a30\u201348\u5c81\uff0c\u76f8\u8f83\u4e8e\u5176\u4ed6\u7eb3\u5165\u7814\u7a76\u4e2d\u7684\u53d7\u8bd5\u8005\u6574\u4f53\u5e74\u9f84\u66f4\u4f4e\u3002\u56e0\u6b64\uff0c\u5176\u7814\u7a76\u7ed3\u679c\u53ef\u80fd\u53d7\u5230\u5e74\u9f84\u56e0\u7d20\u5f71\u54cd\u3002\u4f8b\u5982\uff0c\u5e74\u8f7b\u4eba\u901a\u5e38\u5177\u6709\u66f4\u597d\u7684\u6574\u4f53\u5065\u5eb7\u72b6\u51b5\uff0c\u5e74\u9f84\u76f8\u5173\u7684\u76ae\u80a4\u7ed3\u6784\u53d8\u5316\u4e5f\u53ef\u80fd\u76f8\u5bf9\u8f83\u5c11\uff0c\u8fd9\u53ef\u80fd\u662f\u8be5\u7814\u7a76\u5448\u73b0\u8f83\u660e\u663e\u6548\u679c\u7684\u539f\u56e0\u4e4b\u4e00\u3002<\/p>\n

                        \u5df2\u6709\u4e34\u5e8a\u7814\u7a76\u8868\u660e\uff0c\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u76ae\u80a4\u57fa\u5e95\u819c\u7684\u7ec4\u6210\u4f1a\u53d1\u751f\u53d8\u5316\uff0c\u90e8\u5206\u80f6\u539f\u86cb\u767d\u76f8\u5173\u6210\u5206\u7684\u6c34\u5e73\u4e5f\u4f1a\u9010\u6e10\u4e0b\u964d<\/strong>\u3002<\/p>\n

                        \u56e0\u6b64\uff0c\u672c\u7814\u7a76\u8fdb\u4e00\u6b65\u8fdb\u884c\u4e86\u654f\u611f\u6027\u5206\u6790\uff0c\u4ee5\u8bc4\u4f30\u4e0a\u8ff0\u4e24\u9879\u7814\u7a76\u5bf9\u6574\u4f53\u7ed3\u679c\u7684\u5f71\u54cd\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u6392\u9664\u8fd9\u4e9b\u7814\u7a76\u540e\uff0c\u6574\u4f53\u7ed3\u8bba\u6ca1\u6709\u53d1\u751f\u663e\u8457\u53d8\u5316\uff0c\u53e3\u670d\u80f6\u539f\u86cb\u767d\u5bf9\u76ae\u80a4\u5f39\u6027\u7684\u79ef\u6781\u4f5c\u7528\u4ecd\u7136\u5b58\u5728<\/strong>\u3002<\/p>\n

                        4.5. \u7814\u7a76\u5c40\u9650\u6027<\/h3>\n

                        \u672c\u7814\u7a76\u4ecd\u5b58\u5728\u4e00\u4e9b\u5c40\u9650\u6027\u3002<\/p>\n

                        \u9996\u5148\uff0c\u7eb3\u5165\u7814\u7a76\u6240\u4f7f\u7528\u7684\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u5728\u5242\u91cf\u3001\u7ec4\u6210\u3001\u5f62\u5f0f\u53ca\u6d4b\u91cf\u5355\u4f4d<\/strong>\u7b49\u65b9\u9762\u5b58\u5728\u5dee\u5f02\uff0c\u56e0\u6b64\u4e0d\u540c\u7814\u7a76\u4e4b\u95f4\u5b58\u5728\u4e00\u5b9a\u7684\u5f02\u8d28\u6027\uff0c\u53ef\u80fd\u5f71\u54cd\u7ed3\u679c\u7684\u76f4\u63a5\u6bd4\u8f83\u3002<\/p>\n

                        \u5176\u6b21\uff0c\u90e8\u5206\u7814\u7a76\u7684\u53d7\u8bd5\u8005\u6570\u91cf\u8f83\u5c11\uff0c\u90e8\u5206\u7814\u7a76\u7684\u6837\u672c\u91cf\u751a\u81f3\u4f4e\u4e8e40\u4eba\u3002\u8f83\u5c0f\u7684\u6837\u672c\u91cf\u53ef\u80fd\u589e\u52a0\u7814\u7a76\u7ed3\u679c\u51fa\u73b0\u504f\u501a\u7684\u53ef\u80fd\u6027<\/strong>\uff0c\u56e0\u6b64\u9700\u8981\u8c28\u614e\u89e3\u8bfb\u76f8\u5173\u7ed3\u679c\u3002<\/p>\n

                        \u6b64\u5916\uff0c\u672c\u7814\u7a76\u672a\u5145\u5206\u7eb3\u5165\u53d7\u8bd5\u8005\u7684\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20<\/strong>\u3002\u4f8b\u5982\uff0c\u996e\u98df\u4e60\u60ef\u3001\u8fd0\u52a8\u3001\u7761\u7720\u53ca\u65e5\u5e38\u62a4\u80a4\u7b49\u56e0\u7d20\u90fd\u53ef\u80fd\u5f71\u54cd\u76ae\u80a4\u72b6\u6001\u3002\u5982\u679c\u53d7\u8bd5\u8005\u672c\u8eab\u5177\u6709\u8f83\u5065\u5eb7\u7684\u751f\u6d3b\u65b9\u5f0f\uff0c\u80f6\u539f\u86cb\u767d\u8865\u5145\u5bf9\u76ae\u80a4\u5916\u89c2\u7684\u6539\u5584\u53ef\u80fd\u4f1a\u66f4\u52a0\u660e\u663e\u3002<\/p>\n

                        \u56e0\u6b64\uff0c\u672a\u6765\u4ecd\u9700\u8981\u5f00\u5c55\u6837\u672c\u91cf\u66f4\u5927\u3001\u7814\u7a76\u5468\u671f\u66f4\u957f\u3001\u8bbe\u8ba1\u66f4\u52a0\u89c4\u8303\u7684\u4eba\u4f53\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff0c\u4ee5\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u53e3\u670d\u80f6\u539f\u86cb\u767d\u5bf9\u76ae\u80a4\u6c34\u5206\u3001\u5f39\u6027\u53ca\u6574\u4f53\u76ae\u80a4\u72b6\u6001\u7684\u957f\u671f\u5f71\u54cd\u3002<\/p>\n

                        5. \u7ed3\u8bba<\/h2>\n

                        \u672c\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u8865\u5145\u6c34\u89e3\u80f6\u539f\u86cb\u767d\uff08<\/strong>HC<\/strong>\uff09\u6709\u52a9\u4e8e\u6539\u5584\u76ae\u80a4\u6c34\u5206\u548c\u5f39\u6027<\/strong>\u3002\u6b64\u5916\uff0c\u4e0e\u77ed\u671f\u8865\u5145\u76f8\u6bd4\uff0c\u957f\u671f\u8865\u5145\u80f6\u539f\u86cb\u767d\u5bf9\u6539\u5584\u76ae\u80a4\u6c34\u5206\u548c\u5f39\u6027\u7684\u6548\u679c\u66f4\u4e3a\u660e\u663e<\/strong>\u3002<\/p>\n

                        \u4e0d\u8fc7\uff0c\u76ee\u524d\u4ecd\u9700\u8981\u5f00\u5c55\u66f4\u5927\u89c4\u6a21\u3001\u8bbe\u8ba1\u66f4\u4e25\u8c28\u7684\u968f\u673a\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\uff0c\u4ee5\u8fdb\u4e00\u6b65\u8bc4\u4f30\u53e3\u670d\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u6240\u5e26\u6765\u7684\u4e34\u5e8a\u83b7\u76ca\u3002<\/p>\n

                         <\/p>\n

                        \u8865\u5145\u6750\u6599<\/h2>\n

                        \u4ee5\u4e0b\u8865\u5145\u8d44\u6599\u53ef\u4f9b\u4e0b\u8f7d\uff1a<\/p>\n

                          \n
                        • \u56feS1<\/strong>\uff1a\u76ae\u80a4\u5f39\u6027\u654f\u611f\u6027\u5206\u6790<\/strong><\/li>\n
                        • \u56feS2<\/strong>\uff1a\u76ae\u80a4\u6c34\u5206\u654f\u611f\u6027\u5206\u6790<\/strong><\/li>\n<\/ul>\n

                          \u4f5c\u8005\u8d21\u732e<\/h2>\n
                            \n
                          • \u7814\u7a76\u6784\u601d\uff08Conceptualization<\/strong>\uff09\uff1a<\/strong> S.-Y.P.<\/li>\n
                          • \u6570\u636e\u6574\u7406\uff08Data curation<\/strong>\uff09\uff1a<\/strong> S.-Y.P.\u3001Y.-N.K.<\/li>\n
                          • \u7edf\u8ba1\u5206\u6790\uff08Formal analysis<\/strong>\uff09\uff1a<\/strong> S.-Y.P.\u3001C.C.<\/li>\n
                          • \u7ecf\u8d39\u83b7\u53d6\uff08Funding acquisition<\/strong>\uff09\uff1a<\/strong> Y.-L.H.<\/li>\n
                          • \u7814\u7a76\u5b9e\u65bd\uff08Investigation<\/strong>\uff09\uff1a<\/strong> C.C.<\/li>\n
                          • \u7814\u7a76\u65b9\u6cd5\u8bbe\u8ba1\uff08Methodology<\/strong>\uff09\uff1a<\/strong> S.-Y.P.\u3001Y.-L.H.\u3001C.-M.P.\u3001C.C.<\/li>\n
                          • \u9879\u76ee\u7ba1\u7406\uff08Project administration<\/strong>\uff09\uff1a<\/strong> C.-M.P.\u3001Y.-N.K.\u3001K.-H.C.\u3001C.C.<\/li>\n
                          • \u8f6f\u4ef6\u652f\u6301\uff08Software<\/strong>\uff09\uff1a<\/strong> C.-M.P.\u3001Y.-N.K.\u3001C.C.<\/li>\n
                          • \u7814\u7a76\u76d1\u7763\uff08Supervision<\/strong>\uff09\uff1a<\/strong> C.C.\u3001C.-M.P.<\/li>\n
                          • \u7ed3\u679c\u9a8c\u8bc1\uff08Validation<\/strong>\uff09\uff1a<\/strong> S.-Y.P.\u3001Y.-L.H.\u3001C.-M.P.\u3001C.C.<\/li>\n
                          • \u53ef\u89c6\u5316\uff08Visualization<\/strong>\uff09\uff1a<\/strong> S.-Y.P.<\/li>\n
                          • \u8bba\u6587\u521d\u7a3f\u64b0\u5199\uff08Writing\u2014original draft<\/strong>\uff09\uff1a<\/strong> S.-Y.P.\u3001C.-M.P.\u3001Y.-L.H.<\/li>\n
                          • \u8bba\u6587\u5ba1\u9605\u4e0e\u7f16\u8f91\uff08Writing\u2014review & editing<\/strong>\uff09\uff1a<\/strong> K.D.H.\u3001K.-H.C.\u3001C.C.<\/li>\n<\/ul>\n

                            \u6240\u6709\u4f5c\u8005\u5747\u5df2\u9605\u8bfb\u5e76\u540c\u610f\u6700\u7ec8\u53d1\u8868\u7684\u8bba\u6587\u7248\u672c\u3002<\/p>\n

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                             <\/p>\n

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                             <\/p>\n

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                            \u4f5c\u8005\u58f0\u660e\uff0c\u4e0d\u5b58\u5728\u5229\u76ca\u51b2\u7a81<\/strong>\u3002<\/p>\n

                            \u7814\u7a76\u8d44\u52a9\u65b9\u672a\u53c2\u4e0e\u672c\u7814\u7a76\u7684\u8bbe\u8ba1\u3001\u6570\u636e\u6536\u96c6\u3001\u6570\u636e\u5206\u6790\u3001\u7ed3\u679c\u89e3\u8bfb\u3001\u8bba\u6587\u64b0\u5199\u6216\u6700\u7ec8\u53d1\u8868\u51b3\u5b9a\u3002<\/p>\n<\/div>\n<\/div>\n<\/section>\n<\/section>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

                            2023 \u5e74\u7814\u7a76\uff1a\u57fa\u4e8e 26 \u9879\u968f\u673a\u5bf9\u7167 […]<\/p>\n","protected":false},"author":1,"featured_media":5368,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[83],"tags":[],"class_list":["post-5354","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"_links":{"self":[{"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/posts\/5354","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=5354"}],"version-history":[{"count":2,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/posts\/5354\/revisions"}],"predecessor-version":[{"id":5385,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/posts\/5354\/revisions\/5385"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/media\/5368"}],"wp:attachment":[{"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=5354"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/categories?post=5354"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/laexome.com\/zh-hans\/wp-json\/wp\/v2\/tags?post=5354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}