{"id":5386,"date":"2026-05-26T09:42:40","date_gmt":"2026-05-26T09:42:40","guid":{"rendered":"https:\/\/laexome.com\/collagen-tripeptides-improve-skin-hydration-elasticity\/"},"modified":"2026-08-21T09:27:56","modified_gmt":"2026-08-21T09:27:56","slug":"%e8%83%b6%e5%8e%9f%e8%9b%8b%e7%99%bd%e4%b8%89%e8%82%bd%e6%9c%89%e5%8a%a9%e4%ba%8e%e6%94%b9%e5%96%84%e8%82%8c%e8%82%a4%e6%b0%b4%e5%88%86%e4%b8%8e%e5%bc%b9%e6%80%a7","status":"publish","type":"post","link":"https:\/\/laexome.com\/zh-hans\/%e8%83%b6%e5%8e%9f%e8%9b%8b%e7%99%bd%e4%b8%89%e8%82%bd%e6%9c%89%e5%8a%a9%e4%ba%8e%e6%94%b9%e5%96%84%e8%82%8c%e8%82%a4%e6%b0%b4%e5%88%86%e4%b8%8e%e5%bc%b9%e6%80%a7\/","title":{"rendered":"\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u6709\u52a9\u4e8e\u6539\u5584\u808c\u80a4\u6c34\u5206\u4e0e\u5f39\u6027"},"content":{"rendered":"<section id=\"s2\">\n<section id=\"sec5\">\n<h1>\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u5bf9\u76ae\u80a4\u7684\u4f5c\u7528<\/h1>\n<p><strong>\u5f15\u8a00\uff1a<\/strong><br \/>\n\u867d\u7136\u80f6\u539f\u86cb\u767d\u4ee5\u591a\u79cd\u5f62\u5f0f\u5e7f\u6cdb\u5e94\u7528\u4e8e\u62a4\u80a4\u4ea7\u54c1\u4e2d\uff0c\u4f5c\u4e3a\u4e00\u79cd\u529f\u80fd\u6027\u6210\u5206\uff0c\u4f46\u53e3\u670d\u8865\u5145\u80f6\u539f\u86cb\u767d\u4e09\u80bd\uff08CTP\uff09\u5bf9\u4eba\u4f53\u76ae\u80a4\u7684\u5177\u4f53\u4f5c\u7528\u4ecd\u6709\u5f85\u8fdb\u4e00\u6b65\u7814\u7a76\u3002\u6b64\u5916\uff0c\u76ee\u524d\u5173\u4e8e\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u79ef\u6781\u4f5c\u7528\u7684\u7814\u7a76\uff0c\u5927\u591a\u672a\u5145\u5206\u8003\u8651\u5929\u6c14\u548c\u6c14\u5019\u6761\u4ef6\u5bf9\u76ae\u80a4\u72b6\u6001\u7684\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u9488\u5bf9\u4e2d\u5e74\u5973\u6027\u5f00\u5c55\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u53e3\u670d\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u5bf9\u76ae\u80a4\u72b6\u6001\u7684\u5f71\u54cd\uff0c\u5e76\u8fdb\u4e00\u6b65\u7ed3\u5408\u6e29\u5ea6\u3001\u6e7f\u5ea6\u53ca\u7d2b\u5916\u7ebfA\uff08UVA\uff09\u7b49\u6c14\u5019\u56e0\u7d20\u8fdb\u884c\u5206\u6790\u3002<\/p>\n<p><strong>\u6750\u6599\u4e0e\u65b9\u6cd5\uff1a<\/strong><br \/>\n\u672c\u7814\u7a76\u91c7\u7528\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u5171\u7eb3\u516584\u540d\u5e74\u9f84\u572840\u81f360\u5c81\u7684\u5973\u6027\u53d7\u8bd5\u8005\u3002\u53d7\u8bd5\u8005\u968f\u673a\u5206\u4e3a\u5b89\u6170\u5242\u7ec4\u548c\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u7ec4\uff0c\u8fde\u7eed12\u5468\u6bcf\u65e5\u670d\u7528\u5b89\u6170\u5242\u62161,000 mg\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u3002\u6240\u4f7f\u7528\u7684\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u6765\u6e90\u4e8e\u5c3c\u7f57\u7f57\u975e\u9c7c\uff08<em>Nile Tilapia<\/em>\uff09\u9c7c\u76ae\uff0c\u901a\u8fc7\u4f7f\u7528\u6765\u6e90\u4e8e\u975e\u81f4\u75c5\u6027\u82bd\u5b62\u6746\u83cc\u5c5e\uff08<em>Bacillus<\/em>\uff09\u7ec6\u83cc\u7684\u80f6\u539f\u9176\u8fdb\u884c\u9176\u89e3\u5236\u5907\u3002<\/p>\n<p>\u7814\u7a76\u4eba\u5458\u5206\u522b\u5728\u7814\u7a76\u5f00\u59cb\u65f6\u3001\u5e72\u98846\u5468\u540e\u53ca12\u5468\u540e\uff0c\u5bf9\u53d7\u8bd5\u8005\u7684<strong>\u76ae\u80a4\u6c34\u5206\u3001\u76b1\u7eb9\u53ca\u76ae\u80a4\u5f39\u6027<\/strong>\u8fdb\u884c\u8bc4\u4f30\u3002\u540c\u65f6\uff0c\u6839\u636e\u5f53\u5730\u6c14\u8c61\u90e8\u95e8\u63d0\u4f9b\u7684\u5929\u6c14\u6570\u636e\uff0c\u5bf9\u8bc4\u4f30\u671f\u95f4\u7684\u6e29\u5ea6\u3001\u6e7f\u5ea6\u53ca\u7d2b\u5916\u7ebfA\uff08UVA\uff09\u66b4\u9732\u7b49\u73af\u5883\u56e0\u7d20\u8fdb\u884c\u8c03\u6574\uff0c\u4ee5\u964d\u4f4e\u5929\u6c14\u53d8\u5316\u5bf9\u7814\u7a76\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/p>\n<p><strong>\u7814\u7a76\u7ed3\u679c\uff1a<\/strong><br \/>\n\u572882\u540d\u5b8c\u6210\u76f8\u5173\u8bc4\u4f30\u7684\u53d7\u8bd5\u8005\u4e2d\uff0c\u5171\u670974\u540d\u5b8c\u6210\u4e86\u6574\u4e2a\u8bd5\u9a8c\uff0c\u4e14\u672a\u51fa\u73b0\u660e\u663e\u4e0d\u826f\u53cd\u5e94\u3002\u4e0e\u5bf9\u7167\u7ec4\u76f8\u6bd4\uff0c\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u7ec4\u5728\u8fde\u7eed\u670d\u752812\u5468\u540e\uff0c\u7ecf\u76ae\u6c34\u5206\u6d41\u5931\uff08TEWL\uff09\u660e\u663e\u51cf\u5c11\uff08<em>P<\/em> &lt; 0.05\uff09\u3002<\/p>\n<p>\u572812\u5468\u65f6\uff0c\u5373\u4f7f\u8fdb\u4e00\u6b65\u6821\u6b63\u5f53\u5730\u7684\u6e7f\u5ea6\u3001\u6e29\u5ea6\u53caUVA\u7b49\u73af\u5883\u56e0\u7d20\uff0c\u4e24\u7ec4\u4e4b\u95f4\u7684TEWL\u5dee\u5f02\u4ecd\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff1a\u6821\u6b63\u6e7f\u5ea6\u548c\u6e29\u5ea6\u540e\uff0c<em>P<\/em> = 0.024\uff1b\u6821\u6b63UVA\u540e\uff0c<em>P<\/em> = 0.032\uff1b\u540c\u65f6\u6821\u6b63\u6e29\u5ea6\u3001\u9ad8\u6e29\u53caUVA\u540e\uff0c<em>P<\/em> = 0.031\u3002<\/p>\n<p>\u5728\u76ae\u80a4\u6c34\u5206\u65b9\u9762\uff0c\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u7ec4\u7684\u6539\u5584\u7a0b\u5ea6\u4e5f\u4f18\u4e8e\u5bf9\u7167\u7ec4\u3002\u4e9a\u7ec4\u5206\u6790\u663e\u793a\uff0c<strong>50<\/strong><strong>\u5c81\u4ee5\u4e0b\u53d7\u8bd5\u8005\u5728\u8fde\u7eed\u670d\u7528\u80f6\u539f\u86cb\u767d\u4e09\u80bd<\/strong><strong>12<\/strong><strong>\u5468\u540e\uff0c\u5176\u4e3b\u89c2\u76ae\u80a4\u6539\u5584\u8bc4\u4ef7\u95ee\u5377\u4e2d\u7684\u603b\u8bc4\u5206\u53ca\u76ae\u80a4\u6c34\u5206\u8bc4\u5206\u5747\u51fa\u73b0\u663e\u8457\u6539\u5584\u3002<\/strong><\/p>\n<p>\u6574\u4f53\u800c\u8a00\uff0c\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u4e24\u7ec4\u5747\u672a\u62a5\u544a\u660e\u663e\u7684\u4e0d\u826f\u53cd\u5e94\u3002<\/p>\n<p><strong>\u8ba8\u8bba\uff1a<\/strong><br \/>\n\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c<strong>\u53e3\u670d\u6765\u6e90\u4e8e\u5c3c\u7f57\u7f57\u975e\u9c7c\uff08<\/strong><em>Oreochromis niloticus<\/em><strong>\uff09\u9c7c\u76ae\u7684\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u6709\u52a9\u4e8e\u51cf\u5c11\u4e2d\u5e74\u5973\u6027\u7684\u76ae\u80a4\u6c34\u5206\u6d41\u5931\u3002<\/strong><\/p>\n<p><strong>\u4e34\u5e8a\u8bd5\u9a8c\u6ce8\u518c\uff1a<\/strong><br \/>\nClinicalTrials.gov\uff0c\u6ce8\u518c\u53f7\uff1a<strong>NCT03505684<\/strong><\/p>\n<p><strong>\u5173\u952e\u8bcd\uff1a<\/strong><br \/>\n\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u3001\u76ae\u80a4\u6c34\u5206\u3001\u76ae\u80a4\u5f39\u6027\u3001\u76ae\u80a4\u76b1\u7eb9\u3001\u4e2d\u5e74\u5973\u6027\u3001\u6c14\u5019\u56e0\u7d20<\/p>\n<p>&nbsp;<\/p>\n<p><strong><em>\u00a0<\/em><\/strong><\/p>\n<h2>\u5f15\u8a00<\/h2>\n<p>\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u76ae\u80a4\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u548c\u5f39\u6027\u86cb\u767d\u7ea4\u7ef4\u4f1a\u9010\u6e10\u51cf\u5c11\uff0c\u76ae\u80a4\u4e5f\u4f1a\u968f\u4e4b\u51fa\u73b0\u8001\u5316\u8ff9\u8c61\uff0c\u5982\u7ec6\u7eb9\u3001\u76b1\u7eb9\u7b49\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u8868\u76ae\u548c\u771f\u76ae\u4e2d\u7684\u7cd6\u80fa\u805a\u7cd6\uff08GAGs\uff09\u542b\u91cf\u4e5f\u4f1a\u4e0b\u964d\uff0c\u4f7f\u76ae\u80a4\u4fdd\u6301\u6c34\u5206\u7684\u80fd\u529b\u51cf\u5f31\uff0c\u66f4\u5bb9\u6613\u51fa\u73b0\u5e72\u71e5\u3002\u80f6\u539f\u86cb\u767d\u662f\u76ae\u80a4\u771f\u76ae\u5c42\u7ec6\u80de\u5916\u57fa\u8d28\u7684\u91cd\u8981\u7ed3\u6784\u6210\u5206\uff0c\u5728\u6b63\u5e38\u4eba\u4f53\u76ae\u80a4\u771f\u76ae\u5c42\u5e72\u91cd\u4e2d\u5360\u6bd4\u8d85\u8fc770%\u3002<\/p>\n<p>\u968f\u7740\u5bf9\u53e3\u670d\u751f\u7269\u6d3b\u6027\u6210\u5206\u4e0e\u76ae\u80a4\u72b6\u6001\u4e4b\u95f4\u5173\u7cfb\u7684\u7814\u7a76\u4e0d\u65ad\u6df1\u5165\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u8425\u517b\u8865\u5145\u5242\u88ab\u7528\u4e8e\u652f\u6301\u76ae\u80a4\u5065\u5eb7\u3002\u4f8b\u5982\uff0c\u4e00\u4e9b\u5177\u6709\u6297\u6c27\u5316\u4f5c\u7528\u7684\u8425\u517b\u6210\u5206\u53ef\u4ee5\u901a\u8fc7\u4f53\u5185\u4fe1\u53f7\u901a\u8def\u5f71\u54cd\u76ae\u80a4\uff1b\u90e8\u5206\u6210\u5206\u5728\u6d88\u5316\u8fc7\u7a0b\u4e2d\u8fd8\u53ef\u4ee5\u7ecf\u8fc7\u80c3\u80a0\u9053\u3001\u7a7f\u8fc7\u80a0\u9053\u5c4f\u969c\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u5e76\u968f\u7740\u8840\u6db2\u8fd0\u8f93\u5230\u8fbe\u76ae\u80a4\u3002\u8840\u6db2\u6301\u7eed\u4e3a\u76ae\u80a4\u53ca\u5176\u4e0d\u540c\u7ec4\u7ec7\u63d0\u4f9b\u8425\u517b\uff0c\u5305\u62ec\u8868\u76ae\u3001\u771f\u76ae\u3001\u76ae\u4e0b\u8102\u80aa\u548c\u76ae\u8102\u7b49\u3002<\/p>\n<p>\u80f6\u539f\u86cb\u767d\u51ed\u501f\u5176\u826f\u597d\u7684\u751f\u7269\u5b66\u7279\u6027\u548c\u529f\u80fd\u7279\u6027\uff0c\u5df2\u5e7f\u6cdb\u5e94\u7528\u4e8e\u98df\u54c1\u3001\u7f8e\u5bb9\u53ca\u533b\u836f\u7b49\u9886\u57df\u3002\u5176\u4e2d\uff0c\u6765\u6e90\u4e8e\u6d77\u6d0b\u9c7c\u7c7b\u7684\u80f6\u539f\u86cb\u767d\u80bd\u4e5f\u88ab\u5e7f\u6cdb\u7814\u7a76\uff0c\u5e76\u88ab\u4f5c\u4e3a\u4e00\u79cd\u81b3\u98df\u8865\u5145\u6210\u5206\u3002<\/p>\n<p>\u80f6\u539f\u86cb\u767d\u5177\u6709\u72ec\u7279\u7684\u4e09\u87ba\u65cb\u7ed3\u6784\uff0c\u5176\u57fa\u672c\u7ed3\u6784\u53ef\u8868\u793a\u4e3a\uff08Gly-X-Y\uff09n\uff0c\u5176\u4e2dX\u548cY\u901a\u5e38\u4e3b\u8981\u7531\u812f\u6c28\u9178\uff08Pro\uff09\u548c\u7f9f\u812f\u6c28\u9178\uff08Hyp\uff09\u7ec4\u6210\u3002\u6444\u5165\u80f6\u539f\u86cb\u767d\u540e\uff0c\u5176\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u80bd\u4f1a\u5728\u6d88\u5316\u8fc7\u7a0b\u4e2d\u8fdb\u4e00\u6b65\u5206\u89e3\u3002\u5176\u4e2d\uff0cGly-Pro-Hyp\u7b49\u80f6\u539f\u86cb\u767d\u6765\u6e90\u7684\u5c0f\u5206\u5b50\u80bd\u5177\u6709\u8f83\u597d\u7684\u7a33\u5b9a\u6027\uff0c\u53ef\u5728\u80c3\u80a0\u9053\u73af\u5883\u4e2d\u4fdd\u6301\u4e00\u5b9a\u7684\u5b8c\u6574\u6027\uff0c\u5e76\u901a\u8fc7\u80a0\u9053\u88ab\u5438\u6536\u8fdb\u5165\u4f53\u5185\u3002<\/p>\n<p>\u7814\u7a76\u53d1\u73b0\uff0c\u4e0e\u5206\u5b50\u91cf\u8f83\u9ad8\u7684\u80f6\u539f\u86cb\u767d\u80bd\u76f8\u6bd4\uff0c\u6444\u5165\u4f4e\u5206\u5b50\u91cf\u80f6\u539f\u86cb\u767d\u6c34\u89e3\u7269\u6216\u80f6\u539f\u86cb\u767d\u4e09\u80bd\uff08CTP\uff09\u540e\uff0c\u8840\u6db2\u4e2d\u7684Gly-Pro-Hyp\u6c34\u5e73\u66f4\u9ad8\u3002\u6b64\u5916\uff0c\u7814\u7a76\u8fd8\u53d1\u73b0\uff0cGly-Pro-Hyp\u548cPro-Hyp\u5728\u80c3\u80a0\u6db2\u53ca\u8840\u6d46\u4e2d\u5177\u6709\u8f83\u597d\u7684\u7a33\u5b9a\u6027\uff0c\u4e0d\u6613\u88ab\u80c3\u9178\u3001\u6d88\u5316\u9176\u53ca\u8840\u6d46\u4e2d\u7684\u76f8\u5173\u9176\u5feb\u901f\u5206\u89e3\u3002\u8fd9\u4e9b\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u5177\u6709\u8f83\u597d\u7684\u6d88\u5316\u7a33\u5b9a\u6027\u548c\u80a0\u9053\u5438\u6536\u7279\u6027\uff0c\u56e0\u6b64\u53e3\u670d\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u53ef\u80fd\u662f\u4e00\u79cd\u6709\u6548\u8865\u5145\u751f\u7269\u6d3b\u6027\u80f6\u539f\u86cb\u767d\u80bd\u7684\u65b9\u5f0f\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u5173\u4e8e\u80f6\u539f\u86cb\u767d\u4e09\u80bd\uff08CTP\uff09\u5bf9\u76ae\u80a4\u7684\u6f5c\u5728\u76ca\u5904\u5df2\u6709\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8bc1\u636e\u3002\u6b64\u524d\u7684\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u53d1\u73b0\uff0c\u53e3\u670d\u4f4e\u5206\u5b50\u91cf\u80f6\u539f\u86cb\u767d\u80bd\uff08LMWCP\uff09\u80fd\u591f\u6539\u5584\u4e2d\u5e74\u5973\u6027\u7684\u76ae\u80a4\u6c34\u5206\u3001\u5f39\u6027\u53ca\u76b1\u7eb9\u72b6\u51b5\u3002<\/p>\n<p>\u4e0d\u8fc7\uff0c\u5728\u8bc4\u4f30\u76ae\u80a4\u72b6\u6001\u65f6\uff0c\u6d4b\u8bd5\u7ed3\u679c\u4e5f\u53ef\u80fd\u53d7\u5230\u73af\u5883\u56e0\u7d20\u5f71\u54cd\uff0c\u4f8b\u5982\u6d4b\u8bd5\u671f\u95f4\u7684\u6e29\u5ea6\u3001\u6e7f\u5ea6\u4ee5\u53ca\u7d2b\u5916\u7ebfA\uff08UVA\uff09\u66b4\u9732\u7b49\u3002\u7531\u4e8e\u6c14\u5019\u548c\u5b63\u8282\u53d8\u5316\u53ef\u80fd\u5bf9\u76ae\u80a4\u72b6\u6001\u4ea7\u751f\u5f71\u54cd\uff0c\u56e0\u6b64\uff0c\u5728\u8bc4\u4f30\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u5bf9\u76ae\u80a4\u7684\u4f5c\u7528\u65f6\uff0c\u540c\u65f6\u8003\u8651\u8fd9\u4e9b\u73af\u5883\u56e0\u7d20\uff0c\u53ef\u4ee5\u4f7f\u7814\u7a76\u7ed3\u679c\u66f4\u52a0\u5168\u9762\u3002<\/p>\n<p>\u57fa\u4e8e\u6b64\uff0c\u672c\u9879\u968f\u673a\u3001\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30\uff1a<strong>\u53e3\u670d\u6765\u6e90\u4e8e\u5c3c\u7f57\u7f57\u975e\u9c7c\u9c7c\u76ae\u7684\u80f6\u539f\u86cb\u767d\u4e09\u80bd\uff08<\/strong><strong>CTP<\/strong><strong>\uff09\uff0c\u5728\u6821\u6b63\u6d4b\u8bd5\u671f\u95f4\u7684\u6e29\u5ea6\u3001\u6e7f\u5ea6\u53ca<\/strong><strong>UVA<\/strong><strong>\u7b49\u5929\u6c14\u56e0\u7d20\u540e\uff0c\u662f\u5426\u4ecd\u80fd\u591f\u6539\u5584\u4e2d\u5e74\u5973\u6027\u7684\u76ae\u80a4\u72b6\u6001\u3002<\/strong><\/p>\n<p>&nbsp;<\/p>\n<h2>\u6750\u6599\u4e0e\u65b9\u6cd5<\/h2>\n<h3>\u7814\u7a76\u8bbe\u8ba1\u4e0e\u4f26\u7406<\/h3>\n<p>\u672c\u7814\u7a76\u91c7\u7528<strong>\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u3001\u53cc\u76f2\u4e34\u5e8a\u8bd5\u9a8c<\/strong>\u8bbe\u8ba1\u3002\u6240\u6709\u53d7\u8bd5\u8005\u5728\u53c2\u52a0\u7814\u7a76\u524d\u5747\u7b7e\u7f72\u4e86\u77e5\u60c5\u540c\u610f\u4e66\u3002\u7814\u7a76\u6309\u7167\u300a\u8d6b\u5c14\u8f9b\u57fa\u5ba3\u8a00\u300b\u7684\u76f8\u5173\u539f\u5219\u5f00\u5c55\uff0c\u7814\u7a76\u65b9\u6848\u7ecf\u97e9\u56fd\u91dc\u5c71\u56fd\u7acb\u5927\u5b66\u6768\u5c71\u533b\u9662\u673a\u6784\u5ba1\u67e5\u59d4\u5458\u4f1a\uff08IRB\uff09\u4f26\u7406\u59d4\u5458\u4f1a\u6279\u51c6\uff08IRB\u7f16\u53f7\uff1a02-2017-033\uff0c\u6279\u51c6\u65e5\u671f\uff1a2017\u5e7411\u67086\u65e5\uff09\u3002\u672c\u9879\u4e34\u5e8a\u8bd5\u9a8c\u5df2\u5728 ClinicalTrials.gov \u6ce8\u518c\uff08\u6ce8\u518c\u53f7\uff1aNCT03505684\uff0c\u6ce8\u518c\u65e5\u671f\uff1a2018\u5e744\u670823\u65e5\uff09\u3002<\/p>\n<h3>\u7814\u7a76\u53c2\u4e0e\u8005<\/h3>\n<p>\u7814\u7a76\u4eba\u5458\u901a\u8fc7\u97e9\u56fd\u6768\u5c71\u5e02\u4e00\u5bb6\u4e09\u7ea7\u533b\u9662\u53d1\u5e03\u62db\u52df\u5e7f\u544a\uff0c\u62db\u52df\u8eab\u4f53\u72b6\u51b5\u826f\u597d\u7684\u53d7\u8bd5\u8005\u3002\u7b26\u5408\u6761\u4ef6\u7684\u53d7\u8bd5\u8005\u5e74\u9f84\u4e3a40\u81f360\u5c81\uff0c\u5e76\u901a\u8fc7Tewameter\u68c0\u6d4b\uff0c\u7ecf\u76ae\u6c34\u5206\u6d41\u5931\uff08TEWL\uff09\u503c\u22654\u3002\u6b64\u5916\uff0c\u53d7\u8bd5\u8005\u9700\u5728\u5165\u7ec4\u524d4\u5468\u5f00\u59cb\u4f7f\u7528\u4e0e\u7814\u7a76\u671f\u95f4\u76f8\u540c\u7684\u62a4\u80a4\u4ea7\u54c1\uff08\u5305\u62ec\u5916\u7528\u62a4\u80a4\u4ea7\u54c1\u548c\u53e3\u670d\u8865\u5145\u5242\uff09\uff0c\u5e76\u5728\u4e3a\u671f12\u5468\u7684\u7814\u7a76\u671f\u95f4\u4e0d\u5f97\u63a5\u53d7\u5176\u4ed6\u76ae\u80a4\u62a4\u7406\u6216\u7f8e\u5bb9\u6cbb\u7597\u3002<\/p>\n<p>\u4e3b\u8981\u6392\u9664\u6807\u51c6\u5305\u62ec\uff1a\u5165\u7ec4\u524d3\u4e2a\u6708\u5185\u4f7f\u7528\u8fc7\u53ef\u80fd\u5f71\u54cd\u76ae\u80a4\u72b6\u6001\u7684\u836f\u7269\u6216\u8865\u5145\u5242\uff0c\u5305\u62ec\u7ef4A\u9178\u7c7b\u3001\u7c7b\u56fa\u9187\u53ca\u5176\u4ed6\u6fc0\u7d20\u7c7b\u4ea7\u54c1\uff1b\u6709\u76ae\u80a4\u654f\u611f\u3001\u8fc7\u654f\u53cd\u5e94\u6216\u65e5\u5149\u8fc7\u654f\u53f2\uff1b\u5165\u7ec4\u524d6\u4e2a\u6708\u5185\u63a5\u53d7\u8fc7\u76ae\u80a4\u6539\u5584\u7c7b\u6cbb\u7597\uff1b\u8fc7\u91cf\u996e\u9152\uff1b\u5165\u7ec4\u524d3\u4e2a\u6708\u5185\u505c\u6b62\u5438\u70df\uff1b\u8840\u538b\u3001\u8840\u7cd6\u6216\u80c3\u80a0\u9053\u75c7\u72b6\u63a7\u5236\u4e0d\u4f73\uff1b\u8840\u6e05\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u6216\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u6c34\u5e73&gt;80 mg\/dL\uff0c\u6216\u808c\u9150\uff08Cr\uff09\u6c34\u5e73&gt;1.5 mg\/dL\uff1b\u5904\u4e8e\u598a\u5a20\u671f\u6216\u54fa\u4e73\u671f\uff1b\u5bf9\u7814\u7a76\u6210\u5206\u4e2d\u7684\u4efb\u4f55\u6210\u5206\u8fc7\u654f\uff1b\u4ee5\u53ca\u9884\u8ba1\u5728\u7814\u7a76\u671f\u95f4\u642c\u79bb\u7814\u7a76\u6240\u5728\u5730\u3002\u6b64\u5916\uff0c\u51fa\u4e8e\u5b89\u5168\u8003\u8651\uff0c\u7814\u7a76\u5f00\u59cb\u524d6\u4e2a\u6708\u5185\u88ab\u8bca\u65ad\u60a3\u6709\u5fc3\u8840\u7ba1\u75be\u75c5\u6216\u764c\u75c7\u7684\u53d7\u8bd5\u8005\u4e5f\u88ab\u6392\u9664\u5728\u5916\u3002<\/p>\n<p>\u5982\u53d7\u8bd5\u8005\u8fde\u7eed5\u5929\u672a\u670d\u7528\u7814\u7a76\u4ea7\u54c1\u6216\u5b89\u6170\u5242\u3001\u672a\u6309\u8981\u6c42\u53c2\u52a0\u968f\u8bbf\u8bc4\u4f30\u3001\u670d\u7528\u4f9d\u4ece\u6027\u4f4e\u4e8e80%\u3001\u8fc7\u91cf\u996e\u9152\u6216\u8fc7\u5ea6\u65e5\u6652\uff0c\u6216\u5728\u7814\u7a76\u671f\u95f4\u642c\u79bb\u7814\u7a76\u6240\u5728\u5730\uff0c\u5219\u89c6\u4e3a\u9000\u51fa\u6216\u7ec8\u6b62\u53c2\u4e0e\u7814\u7a76\uff0c\u5e76\u4e0d\u7eb3\u5165\u6700\u7ec8\u7684\u65b9\u6848\u5206\u6790\u3002\u7814\u7a76\u4eba\u5458\u5728\u6bcf\u6b21\u8bbf\u89c6\u65f6\u901a\u8fc7\u6e05\u70b9\u5269\u4f59\u80f6\u56ca\u6570\u91cf\u6765\u8bc4\u4f30\u53d7\u8bd5\u8005\u7684\u670d\u7528\u4f9d\u4ece\u6027\u3002\u5171\u670911\u540d\u53d7\u8bd5\u8005\u7b26\u5408\u6392\u9664\u6807\u51c6\uff0c\u53e6\u67093\u540d\u53d7\u8bd5\u8005\u4e3b\u52a8\u653e\u5f03\u53c2\u4e0e\u3002<\/p>\n<h3>\u968f\u673a\u5206\u7ec4<\/h3>\n<p>\u5171\u670998\u540d\u53d7\u8bd5\u8005\u63a5\u53d7\u7b5b\u9009\uff0c\u5176\u4e2d84\u540d\uff0885.7%\uff09\u5728\u5b8c\u6210\u57fa\u7ebf\u68c0\u6d4b\u540e\u6700\u7ec8\u5165\u7ec4\u3002\u53d7\u8bd5\u8005\u91c7\u7528\u533a\u7ec4\u968f\u673a\u6cd5\uff0c\u901a\u8fc7\u968f\u673a\u7f16\u53f7\u5206\u914d\u81f3<strong>\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u7ec4\uff08\u5e72\u9884\u7ec4\uff0c<\/strong><strong>IG<\/strong><strong>\uff09\u6216\u5b89\u6170\u5242\u7ec4\uff08\u5bf9\u7167\u7ec4\uff0c<\/strong><strong>CG<\/strong><strong>\uff09<\/strong>\uff0c\u5e76\u5728\u5165\u7ec4\u65f6\u83b7\u5f97\u76f8\u5e94\u7684\u7814\u7a76\u7f16\u53f7\u3002<\/p>\n<p>\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u7ec4\uff08IG\uff0c<em>n<\/em> = 42\uff09\u6bcf\u65e5\u670d\u75281,000 mg\u80f6\u539f\u86cb\u767d\u4e09\u80bd\u8865\u5145\u5242\uff08\u6bcf\u7c92\u80f6\u56ca\u542b250 mg\uff09\uff1b\u5b89\u6170\u5242\u7ec4\uff08CG\uff0c<em>n<\/em> = 42\uff09\u6bcf\u65e5\u670d\u7528\u5b89\u6170\u5242\uff08\u89c1\u56fe1\uff09\u3002\u968f\u673a\u5206\u7ec4\u7f16\u7801\u7531\u4e13\u4e1a\u7edf\u8ba1\u4eba\u5458\u4f7f\u7528 nQuery Advisor 7.0 \u8f6f\u4ef6\u751f\u6210\u3002\u8d1f\u8d23\u5224\u65ad\u53d7\u8bd5\u8005\u662f\u5426\u7b26\u5408\u7814\u7a76\u6761\u4ef6\u53ca\u8fdb\u884c\u5404\u9879\u68c0\u6d4b\u7684\u7814\u7a76\u4eba\u5458\uff0c\u5728\u6574\u4e2a\u7814\u7a76\u8fc7\u7a0b\u4e2d\u5747\u4e0d\u77e5\u9053\u53d7\u8bd5\u8005\u7684\u5177\u4f53\u5206\u7ec4\u60c5\u51b5\uff0c\u4ee5\u5c3d\u53ef\u80fd\u51cf\u5c11\u4eba\u4e3a\u56e0\u7d20\u5bf9\u7814\u7a76\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u6bcf\u4f4d\u53d7\u8bd5\u8005\u5171\u9700\u5230\u7814\u7a76\u4e2d\u5fc3\u8fdb\u884c4\u6b21\u8bbf\u89c6\uff1a<strong>\u7b2c<\/strong><strong>1<\/strong><strong>\u6b21<\/strong>\u4e3a\u7b5b\u9009\uff1b<strong>\u7b2c<\/strong><strong>2<\/strong><strong>\u6b21<\/strong>\u8fdb\u884c\u968f\u673a\u5206\u7ec4\u5e76\u5f00\u59cb\u670d\u7528\u7814\u7a76\u4ea7\u54c1\uff1b<strong>\u7b2c<\/strong><strong>3<\/strong><strong>\u6b21<\/strong>\u4e3a\u5e72\u98846\u5468\u540e\u7684\u8bc4\u4f30\uff1b<strong>\u7b2c<\/strong><strong>4<\/strong><strong>\u6b21<\/strong>\u4e3a\u5e72\u988412\u5468\u540e\u7684\u6700\u7ec8\u8bc4\u4f30\u3002<\/p>\n<p><strong><em>\u56fe<\/em><\/strong><strong><em>1<\/em><\/strong><em>\uff1a\u7814\u7a76\u53c2\u4e0e\u8005\u62db\u52df\u3001\u968f\u673a\u5206\u7ec4\u53ca\u968f\u8bbf\u6d41\u7a0b\u56fe\u3002<\/em><\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone wp-image-3092 size-full\" src=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001.jpg\" alt=\"\" width=\"767\" height=\"523\" srcset=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001.jpg 767w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001-300x205.jpg 300w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0001-600x409.jpg 600w\" sizes=\"(max-width: 767px) 100vw, 767px\" \/><\/p>\n<p><em>CONSORT <\/em><em>\u4e34\u5e8a\u8bd5\u9a8c\u6d41\u7a0b\u56fe<\/em><\/p>\n<section id=\"s2\">\n<section id=\"sec6\">\n<h2>\u8bd5\u9a8c\u4ea7\u54c1\u4e0e\u5b89\u6170\u5242<\/h2>\n<p>\u80f6\u539f\u4e09\u80bd\uff08CTP\uff09\u7531\u5c3c\u7f57\u7f57\u975e\u9c7c\uff08<em>Oreochromis niloticus<\/em>\uff09\u9c7c\u76ae\u5236\u5907\u800c\u6210\uff0c\u91c7\u7528\u6765\u81ea\u975e\u81f4\u75c5\u6027\u82bd\u5b62\u6746\u83cc\u5c5e\uff08<em>Bacillus<\/em>\uff09\u7ec6\u83cc\u7684\u80f6\u539f\u9176\u8fdb\u884c\u9176\u89e3\uff08Collagen-Tripep20S\uff1bAmicogen Inc.\uff0c\u97e9\u56fd\u5e86\u5c1a\u5357\u9053\u664b\u5dde\u5e02\uff09\u3002CTP\u7684\u603b\u5e73\u5747\u5206\u5b50\u91cf\u4e3a500 Da\uff0c\u5176\u4e2d\u80f6\u539f\u4e09\u80bd\uff08CTP\uff09\u542b\u91cf\u4e3a20%\uff0c\u5305\u62ec3.2%\u7684 Gly\u2013Pro\u2013Hyp\u3002\u7814\u7a76\u5df2\u8bc1\u5b9e\uff0cGly\u2013Pro\u2013Hyp \u5728\u4f53\u5185\u5177\u6709\u826f\u597d\u7684\u7a33\u5b9a\u6027\u548c\u751f\u7269\u5229\u7528\u5ea6[14,15]\u3002\u6b64\u5916\uff0c\u52a8\u7269\u7ec4\u7ec7\u5b66\u7814\u7a76\u663e\u793a\uff0cGly\u2013Pro\u2013Hyp \u53ef\u901a\u8fc7\u4fc3\u8fdb\u76f8\u5173\u57fa\u56e0\u53ca\u86cb\u767d\u8d28\u7684\u8868\u8fbe\uff0c\u5bf9\u76ae\u80a4\u4fdd\u6e7f\u4ea7\u751f\u79ef\u6781\u4f5c\u7528[16]\u3002<\/p>\n<p>\u672c\u7814\u7a76\u4e2dCTP\u7684\u4f7f\u7528\u5242\u91cf\uff0c\u662f\u6839\u636e\u65e2\u5f80\u52a8\u7269\u5b9e\u9a8c\u7ed3\u679c\u786e\u5b9a\u7684\u3002\u7814\u7a76\u663e\u793a\uff0c\u6bcf\u65e5\u6444\u5165CTP\uff08333 mg\/kg\uff09\u7684\u5b9e\u9a8c\u5c0f\u9f20\uff0c\u5176\u76ae\u80a4\u6c34\u5206\u548c\u76b1\u7eb9\u72b6\u51b5\u5747\u5f97\u5230\u663e\u8457\u6539\u5584\uff0c\u4e14\u672a\u89c2\u5bdf\u5230\u4e0d\u826f\u53cd\u5e94[17,18]\u3002\u56e0\u6b64\uff0c\u6839\u636e\u5065\u5eb7\u6210\u4eba\u9996\u6b21\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u6700\u5927\u5b89\u5168\u8d77\u59cb\u5242\u91cf\u7684\u4f30\u7b97\u6307\u5bfc\uff0c\u5bf9\u4e8e\u5e73\u5747\u4f53\u91cd60 kg\u7684\u6210\u5e74\u4eba\uff0c\u6bcf\u65e5\u6444\u51651,000 mg\u80f6\u539f\u86cb\u767d\u6c34\u89e3\u7269\u88ab\u8ba4\u4e3a\u662f\u5408\u9002\u7684\u5242\u91cf[19]\u3002\u6b64\u5916\uff0c\u4e0e\u672c\u7814\u7a76\u7c7b\u4f3c\u7684\u5176\u4ed6\u7814\u7a76\u4e2d\uff0c\u53d7\u8bd5\u8005\u6bcf\u65e5\u6444\u5165\u7684\u80f6\u539f\u86cb\u767d\u5242\u91cf\u4e3a1.0\u20133.0 g[15,20\u201322]\u3002<\/p>\n<p>CTP\u7ec4\u53d7\u8bd5\u8005\u8fde\u7eed12\u5468\u6bcf\u5929\u670d\u75284\u7c92\u80f6\u56ca\uff0c\u6bcf\u7c92\u542b250 mg CTP\uff0c\u5206\u522b\u4e8e\u65e9\u665a\u5404\u670d\u75282\u7c92\uff0c\u6bcf\u65e5\u603b\u6444\u5165\u91cf\u4e3a1,000 mg\u3002\u5b89\u6170\u5242\u7ec4\u6309\u7167\u76f8\u540c\u7684\u670d\u7528\u65b9\u5f0f\u548c\u65f6\u95f4\u63a5\u53d7\u5b89\u6170\u5242\u3002\u5b89\u6170\u5242\u7531170 mg\uff0868.2%\uff09\u9ea6\u82bd\u7cca\u7cbe\u548c80 mg\uff0831.8%\uff09\u7cca\u7cbe\u7ec4\u6210\u3002\u524d\u671f\u7814\u7a76\u5df2\u5bf9\u8be5\u4ea7\u54c1\u8fdb\u5165\u4eba\u4f53\u540e\u7684\u4e09\u80bd\u8840\u6d46\u6d53\u5ea6\u53ca\u5176\u53d8\u5316\u8fc7\u7a0b\u8fdb\u884c\u4e86\u68c0\u6d4b[14]\u3002<\/p>\n<h2>\u529f\u6548\u8bc4\u4ef7<\/h2>\n<p>\u6bcf\u6b21\u8fdb\u884c\u76ae\u80a4\u72b6\u6001\u68c0\u6d4b\u524d\uff0c\u53d7\u8bd5\u8005\u5747\u9700\u5728\u6e29\u5ea6\u548c\u6e7f\u5ea6\u53d7\u5230\u63a7\u5236\u7684\u76f8\u540c\u73af\u5883\u4e2d\u9759\u575030\u5206\u949f\uff0c\u5ba4\u5185\u6e29\u5ea6\u4fdd\u6301\u572823 \u00b1 1\u00b0C\uff0c\u76f8\u5bf9\u6e7f\u5ea6\u4fdd\u6301\u572845 \u00b1 5%\u3002<\/p>\n<p>\u672c\u7814\u7a76\u7684\u4e3b\u8981\u529f\u6548\u6307\u6807\u4e3a\u8fde\u7eed\u4f7f\u7528CTP\u6216\u5b89\u6170\u52426\u5468\u53ca12\u5468\u540e\uff0c\u7ecf\u76ae\u5931\u6c34\uff08TEWL\uff09\u76f8\u8f83\u4e8e\u57fa\u7ebf\u7684\u53d8\u5316\u3002\u6b21\u8981\u8bc4\u4ef7\u6307\u6807\u5305\u62ec\u76ae\u80a4\u6c34\u5206\u3001\u76ae\u80a4\u5f39\u6027\u3001\u76ae\u80a4\u76b1\u7eb9\uff0c\u4ee5\u53ca\u53d7\u8bd5\u8005\u5bf9\u81ea\u8eab\u76ae\u80a4\u72b6\u6001\u6539\u5584\u60c5\u51b5\u7684\u4e3b\u89c2\u8bc4\u4ef7\uff0c\u5e76\u5728\u6bcf\u6b21\u968f\u8bbf\u65f6\u8fdb\u884c\u8bc4\u4f30\u3002<\/p>\n<h3>\u76ae\u80a4\u7ecf\u76ae\u5931\u6c34<\/h3>\n<p>\u4f7f\u7528\u84b8\u53d1\u6d4b\u91cf\u4eea\uff08Tewameter TM300\uff1bCourage + Khazaka Electronic GmbH\uff0c\u5fb7\u56fd\u79d1\u9686\uff09\u5bf9\u524d\u81c2\u8098\u7a9d\u4e0b\u65b9\u7ea610 cm\u8303\u56f4\u5185\u7684\u76ae\u80a4\u8fdb\u884c3\u6b21\u6d4b\u91cf[23]\u3002\u6700\u7ec8\u5206\u6790\u91c7\u75283\u6b21\u6d4b\u91cf\u7ed3\u679c\u7684\u5e73\u5747\u503c\u3002<\/p>\n<h3>\u76ae\u80a4\u6c34\u5206<\/h3>\n<p>\u4f7f\u7528\u89d2\u8d28\u5c42\u6c34\u5206\u6d4b\u8bd5\u4eea\uff08Corneometer CM 825\uff1bCourage + Khazaka Electronic GmbH\uff0c\u5fb7\u56fd\u79d1\u9686\uff09\uff0c\u901a\u8fc7\u7535\u5bb9\u6cd5\u6d4b\u91cf\u989d\u5934\u8868\u76ae\u5916\u5c42\u2014\u2014\u89d2\u8d28\u5c42\u7684\u6c34\u5206\u542b\u91cf[24]\u3002\u6bcf\u4e2a\u68c0\u6d4b\u65f6\u95f4\u70b9\uff0c\u5728\u989d\u5934\u6d4b\u8bd5\u533a\u57df\u7684\u4e0d\u540c\u4f4d\u7f6e\u81f3\u5c11\u8fdb\u884c5\u6b21\u6d4b\u91cf\uff0c\u5e76\u53bb\u9664\u6700\u9ad8\u503c\u548c\u6700\u4f4e\u503c\u540e\uff0c\u53d6\u5176\u4e2d3\u4e2a\u6570\u503c\u7684\u5e73\u5747\u503c\u8fdb\u884c\u5206\u6790\u3002<\/p>\n<h3>\u76ae\u80a4\u5f39\u6027<\/h3>\n<p>\u4f7f\u7528\u76ae\u80a4\u5f39\u6027\u6d4b\u8bd5\u4eea\uff08Cutometer MPA 580\uff1bCourage + Khazaka Electronic GmbH\uff0c\u5fb7\u56fd\u79d1\u9686\uff09\u8bc4\u4f30\u76ae\u80a4\u5f39\u6027[24]\u3002\u6bcf\u6b21\u6d4b\u91cf\u65f6\uff0c\u5bf9\u524d\u81c2\u6d4b\u8bd5\u533a\u57df\u76843\u4e2a\u4e0d\u540c\u4f4d\u7f6e\u8fdb\u884c\u68c0\u6d4b\uff0c\u5e76\u53d6\u5e73\u5747\u503c\u4f5c\u4e3a\u6700\u7ec8\u7ed3\u679c\u3002<\/p>\n<h3>\u76ae\u80a4\u76b1\u7eb9<\/h3>\n<p>\u4f7f\u7528\u76ae\u80a4\u76b1\u7eb9\u6210\u50cf\u5206\u6790\u4eea\uff08Skin-Visiometer SV 600\uff1bCourage + Khazaka Electronic GmbH\uff0c\u5fb7\u56fd\u79d1\u9686\uff09\u5bf9\u53cc\u4fa7\u773c\u89d2\u9c7c\u5c3e\u7eb9\u533a\u57df\u8fdb\u884c\u6d4b\u91cf[25]\u3002\u7531\u4e0d\u77e5\u9053\u53d7\u8bd5\u8005\u5206\u7ec4\u60c5\u51b5\u7684\u76ae\u80a4\u79d1\u533b\u751f\uff0c\u6839\u636e\u5168\u7403\u5149\u8001\u5316\u8bc4\u5206\u7cfb\u7edf\u5bf9\u76ae\u80a4\u76b1\u7eb9\u53ca\u5149\u8001\u5316\u7a0b\u5ea6\u8fdb\u884c\u89c6\u89c9\u8bc4\u5206[25]\u3002<\/p>\n<h3>\u95ee\u5377\u8c03\u67e5<\/h3>\n<p>\u5728\u4f7f\u7528\u4ea7\u54c16\u5468\u548c12\u5468\u540e\uff0c\u53d7\u8bd5\u8005\u586b\u5199\u95ee\u5377\uff0c\u5bf9\u4e00\u6bb5\u65f6\u95f4\u5185\u81ea\u8eab\u76ae\u80a4\u72b6\u6001\u7684\u6539\u5584\u60c5\u51b5\u8fdb\u884c\u4e3b\u89c2\u8bc4\u4ef7\u3002\u8bc4\u4ef7\u91c7\u75285\u7ea7\u674e\u514b\u7279\u91cf\u8868\uff1a<\/p>\n<p>1 = \u660e\u663e\u53d8\u5dee<br \/>\n2 = \u53d8\u5dee<br \/>\n3 = \u65e0\u660e\u663e\u53d8\u5316<br \/>\n4 = \u6709\u6240\u6539\u5584<br \/>\n5 = \u660e\u663e\u6539\u5584<\/p>\n<p>\u6b64\u5916\uff0c\u53d7\u8bd5\u8005\u8fd8\u9700\u62a5\u544a\u4f7f\u7528\u7814\u7a76\u8865\u5145\u5242\u671f\u95f4\u51fa\u73b0\u7684\u4efb\u4f55\u4e0d\u9002\u4f53\u9a8c\u3002<\/p>\n<h2>\u5b89\u5168\u6027\u8bc4\u4ef7<\/h2>\n<p>\u53d7\u8bd5\u8005\u4f11\u606f10\u5206\u949f\u540e\u4fdd\u6301\u5750\u59ff\uff0c\u4f7f\u7528BP-203 RV II\u8840\u538b\u8ba1\uff08Colin Corp.\uff0c\u65e5\u672c\u7231\u77e5\u53bf\uff09\u6d4b\u91cf\u8840\u538b\u548c\u5fc3\u73873\u6b21\uff0c\u5e76\u8bb0\u5f55\u5e73\u5747\u503c\u3002\u53d7\u8bd5\u8005\u7a7f\u7740\u8f7b\u4fbf\u670d\u88c5\u3001\u4e0d\u7a7f\u978b\uff0c\u4f7f\u7528\u7535\u5b50\u4f53\u91cd\u79e4\u548c\u8eab\u9ad8\u6d4b\u91cf\u4eea\uff08BSM370\uff1bBiospace Co. Ltd.\uff0c\u97e9\u56fd\u9996\u5c14\uff09\u6d4b\u91cf\u4f53\u91cd\u548c\u8eab\u9ad8\u3002<\/p>\n<p>\u53d7\u8bd5\u8005\u5728\u7981\u98df4\u5c0f\u65f6\u540e\uff0c\u4e8e\u57fa\u7ebf\u4ee5\u53ca\u5f00\u59cb\u7814\u7a76\u540e\u7684\u7b2c6\u5468\u548c\u7b2c12\u5468\u91c7\u96c6\u8840\u6db2\u6837\u672c\u3002\u4f7f\u7528TBA200FR\u751f\u5316\u5206\u6790\u4eea\uff08Toshiba Co. Ltd.\uff0c\u65e5\u672c\u4e1c\u4eac\uff09\u68c0\u6d4b\u8840\u6e05\u5929\u95e8\u51ac\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08AST\uff09\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f6c\u79fb\u9176\uff08ALT\uff09\u3001\u603b\u80c6\u7ea2\u7d20\u3001\u8840\u7cd6\u548c\u808c\u9150\uff08Cr\uff09\u6c34\u5e73\u3002<\/p>\n<p>\u7814\u7a76\u671f\u95f4\u6301\u7eed\u8bb0\u5f55\u53d7\u8bd5\u8005\u51fa\u73b0\u7684\u5176\u4ed6\u4e0d\u826f\u4e8b\u4ef6\u6216\u65e0\u6cd5\u9884\u671f\u7684\u8fc7\u654f\u53cd\u5e94\u3002<\/p>\n<h2>\u6c14\u5019\u6570\u636e<\/h2>\n<p>\u7814\u7a76\u671f\u95f4\uff0c\u6240\u6709\u53d7\u8bd5\u8005\u5747\u5c45\u4f4f\u5728\u5e86\u5c1a\u7701\u548c\u91dc\u5c71\u5730\u533a\u3002\u7814\u7a76\u56e2\u961f\u4ece\u5f53\u5730\u6c14\u8c61\u90e8\u95e8\u83b7\u53d6\u4e86\u53d7\u8bd5\u8005\u6574\u4e2a\u7814\u7a76\u671f\u95f4\uff081\u6708\u81f310\u6708\uff09\u7684\u6e29\u5ea6\u3001\u6e7f\u5ea6\u548cUVA\uff08\u7d2b\u5916\u7ebfA\uff09\u6570\u636e\uff0c\u7528\u4e8e\u5206\u6790\u6c14\u5019\u56e0\u7d20\u5bf9\u76ae\u80a4\u68c0\u6d4b\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/p>\n<h2>\u7edf\u8ba1\u5b66\u5206\u6790<\/h2>\n<p>\u4f7f\u7528nQuery Advisor 7.0\u8f6f\u4ef6\uff08\u7231\u5c14\u5170\u79d1\u514b\uff09\u8ba1\u7b97\u7814\u7a76\u6240\u9700\u7684\u6837\u672c\u91cf\u3002\u6837\u672c\u91cf\u8ba1\u7b97\u53c2\u8003Choi\u7b49\u4eba\u7684\u7814\u7a76[21]\uff0c\u8be5\u7814\u7a76\u8bc4\u4f30\u4e86CTP\u8865\u5145\u5242\u5bf9\u76ae\u80a4\u72b6\u6001\u7684\u5f71\u54cd\u3002\u6839\u636e\u4e3b\u8981\u8bc4\u4ef7\u6307\u6807TEWL\u7684\u7ed3\u679c\uff0c\u5728\u6807\u51c6\u5dee\u4e3a5.0\u3001\u663e\u8457\u6027\u6c34\u5e73\uff08\u03b1\uff09\u4e3a5%\u7684\u60c5\u51b5\u4e0b\uff0c\u4e3a\u8fbe\u523080%\u7684\u7edf\u8ba1\u6548\u80fd\u3001\u68c0\u6d4b\u52303.53\u7684\u5e73\u5747TEWL\u5dee\u5f02\uff0c\u6bcf\u7ec4\u9884\u8ba1\u9700\u898134\u540d\u53d7\u8bd5\u8005\u3002\u8003\u8651\u5230\u7ea620%\u7684\u53d7\u8bd5\u8005\u53ef\u80fd\u4e2d\u9014\u9000\u51fa\uff0c\u6700\u7ec8\u5c06\u6837\u672c\u91cf\u8c03\u6574\u4e3a\u6bcf\u7ec442\u4eba\u3002<\/p>\n<p>\u4e3b\u8981\u5206\u6790\u91c7\u7528\u610f\u5411\u6027\u5206\u6790\uff08ITT\uff09\uff0c\u7528\u4e8e\u6bd4\u8f83\u4e24\u7ec4\u53d7\u8bd5\u8005\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e76\u901a\u8fc7\u591a\u91cd\u63d2\u8865\u6cd5\u5904\u7406\u7f3a\u5931\u6570\u636e\uff08n = 84\uff09\u3002\u540c\u65f6\u8fdb\u884c\u7b26\u5408\u65b9\u6848\u5206\u6790\uff08PP\uff09\uff08n = 71\uff09\uff0c\u4ee5\u8fdb\u4e00\u6b65\u8bc4\u4f30\u8865\u5145CTP\u7684\u5b9e\u9645\u6548\u679c\u3002<\/p>\n<p>\u91c7\u7528Shapiro\u2013Wilk\u68c0\u9a8c\u8bc4\u4f30\u6570\u636e\u662f\u5426\u7b26\u5408\u6b63\u6001\u5206\u5e03\u3002\u4e24\u7ec4\u4e4b\u95f4\u57fa\u7ebf\u7279\u5f81\u4ee5\u53ca\u7b2c6\u5468\u548c\u7b2c12\u5468\u7684\u53d8\u5316\u6bd4\u8f83\uff0c\u5bf9\u4e8e\u8fde\u7eed\u53d8\u91cf\u91c7\u7528\u72ec\u7acb\u6837\u672c<em>t<\/em>\u68c0\u9a8c\uff1b\u5bf9\u4e8e\u4e0d\u7b26\u5408\u6b63\u6001\u5206\u5e03\u7684\u6570\u636e\uff0c\u5219\u91c7\u7528Mann\u2013Whitney U\u68c0\u9a8c\u3002\u5206\u7c7b\u53d8\u91cf\u91c7\u7528\u5361\u65b9\u68c0\u9a8c\u3002<\/p>\n<p>\u7ec4\u5185\u524d\u540e\u53d8\u5316\u91c7\u7528\u914d\u5bf9<em>t<\/em>\u68c0\u9a8c\uff1b\u5bf9\u4e8e\u4e0d\u7b26\u5408\u6b63\u6001\u5206\u5e03\u7684\u6570\u636e\uff0c\u5219\u91c7\u7528Wilcoxon\u7b26\u53f7\u79e9\u68c0\u9a8c\u3002\u6b64\u5916\uff0c\u6839\u636e\u53d7\u8bd5\u8005\u5e74\u9f84\u8fdb\u884c\u4e9a\u7ec4\u5206\u6790\u3002<\/p>\n<p>\u91c7\u7528\u91cd\u590d\u6d4b\u91cf\u534f\u65b9\u5dee\u5206\u6790\uff0c\u5bf9\u4e24\u7ec4\u4e4b\u95f4\u7684\u7ed3\u679c\u8fdb\u884c\u6bd4\u8f83\uff0c\u5e76\u5bf9\u68c0\u6d4b\u5f53\u5929\u7684\u6e29\u5ea6\u3001\u6e7f\u5ea6\u548cUVA\u6c34\u5e73\u8fdb\u884c\u6821\u6b63\uff0c\u4ee5\u51cf\u5c11\u5929\u6c14\u6761\u4ef6\u5bf9\u68c0\u6d4b\u7ed3\u679c\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u5f53<em>P<\/em> &lt; 0.05\u65f6\uff0c\u8ba4\u4e3a\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002\u6240\u6709\u7edf\u8ba1\u5206\u6790\u5747\u4f7f\u7528SPSS Statistics for Windows 22.0\u7248\uff08IBM Corp.\uff0c\u7f8e\u56fd\u7ebd\u7ea6\u5dde\u963f\u8499\u514b\uff09\u5b8c\u6210\u3002<\/p>\n<p>&nbsp;<\/p>\n<h2>\u7814\u7a76\u7ed3\u679c<\/h2>\n<h3>CONSORT\uff08\u8bd5\u9a8c\u62a5\u544a\u7edf\u4e00\u6807\u51c6\uff09\u6d41\u7a0b\u56fe\u53ca\u53d7\u8bd5\u8005\u57fa\u7ebf\u7279\u5f81<\/h3>\n<p>\u672c\u968f\u673a\u5bf9\u7167\u5e72\u9884\u8bd5\u9a8c\u7684\u53d7\u8bd5\u8005\u62db\u52df\u3001\u7b5b\u9009\u3001\u5206\u7ec4\u53ca\u968f\u8bbf\u6d41\u7a0b\u6309\u7167CONSORT\uff08\u8bd5\u9a8c\u62a5\u544a\u7edf\u4e00\u6807\u51c6\uff09\u89c4\u8303\u8fdb\u884c\uff0c\u5e76\u4ee5\u6d41\u7a0b\u56fe\u5f62\u5f0f\u5c55\u793a\uff08\u56fe1\uff09[26]\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6700\u7ec8\u5bf984\u540d\u5e74\u9f84\u572840\u201360\u5c81\u7684\u53d7\u8bd5\u8005\u8fdb\u884c\u4e86\u7edf\u8ba1\u5206\u6790\u3002CTP\u5e72\u9884\u7ec4\uff08IG\uff0c<em>n<\/em> = 42\uff09\u7684\u5e73\u5747\u5e74\u9f84\u4e3a48.0 \u00b1 5.9\u5c81\uff0c\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff08CG\uff0c<em>n<\/em> = 42\uff09\u7684\u5e73\u5747\u5e74\u9f84\u4e3a49.9 \u00b1 6.5\u5c81\u3002<\/p>\n<p>CTP\u5e72\u9884\u7ec4\u67094\u540d\u53d7\u8bd5\u8005\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u67093\u540d\u53d7\u8bd5\u8005\u56e0\u4e2a\u4eba\u539f\u56e0\u4e3b\u52a8\u9000\u51fa\u7814\u7a76\uff0c\u5176\u9000\u51fa\u539f\u56e0\u4e0e\u672c\u8bd5\u9a8c\u65e0\u5173\u3002\u6b64\u5916\uff0c\u67093\u540d\u53d7\u8bd5\u8005\uff08CTP\u5e72\u9884\u7ec42\u540d\u3001\u5b89\u6170\u5242\u5bf9\u7167\u7ec41\u540d\uff09\u56e0\u8fdd\u53cd\u7814\u7a76\u65b9\u6848\u800c\u88ab\u6392\u9664\u3002\u4e0a\u8ff010\u540d\u53d7\u8bd5\u8005\u7684\u57fa\u672c\u7279\u5f81\u4e0e\u5b8c\u6210\u7814\u7a76\u7684\u5176\u4ed6\u53d7\u8bd5\u8005\u603b\u4f53\u76f8\u8fd1\u3002<\/p>\n<p>CTP\u5e72\u9884\u7ec4\u548c\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u7684\u53d7\u8bd5\u8005\u4f9d\u4ece\u7387\u5747\u8d85\u8fc788%\u3002\u56e0\u6b64\uff0c\u610f\u5411\u6027\u5206\u6790\uff08ITT\uff09\u4eba\u7fa4\u4e3a84\u4eba\uff0c\u7b26\u5408\u65b9\u6848\u5206\u6790\uff08PP\uff09\u4eba\u7fa4\u4e3a71\u4eba\u3002<\/p>\n<p>\u7814\u7a76\u5f00\u59cb\u65f6\uff0c\u4e24\u7ec4\u53d7\u8bd5\u8005\u5728\u5e74\u9f84\u3001\u4f53\u91cd\u3001\u996e\u9152\u60c5\u51b5\u548c\u5438\u70df\u60c5\u51b5\u7b49\u65b9\u9762\u5747\u672a\u53d1\u73b0\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u7684\u5dee\u5f02\uff08\u88681\uff09\u3002\u6574\u4e2a\u7814\u7a76\u8fc7\u7a0b\u4e2d\uff0c\u53cc\u76f2\u8bd5\u9a8c\u8bbe\u8ba1\u5747\u5f97\u5230\u826f\u597d\u6267\u884c\u3002<\/p>\n<p><strong>\u6ce8\uff1a<\/strong> CG\uff0c\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff1bIG\uff0c\u80f6\u539f\u4e09\u80bd\u5e72\u9884\u7ec4\u3002\u996e\u9152\u5b9a\u4e49\u4e3a\u5e73\u5747\u6bcf\u5468\u996e\u9152\u8d85\u8fc72\u6b21\uff0c\u4e14\u6bcf\u6b21\u996e\u9152\u91cf\u8fbe\u5230\u6216\u8d85\u8fc75\u676f\u3002\u6570\u636e\u4ee5\u5e73\u5747\u503c \u00b1 \u6807\u51c6\u5dee\u6216\u4eba\u6570\uff08\u767e\u5206\u6bd4\uff09\u8868\u793a\u3002\u91c7\u7528Shapiro\u2013Wilk\u68c0\u9a8c\u8bc4\u4f30\u6570\u636e\u662f\u5426\u7b26\u5408\u6b63\u6001\u5206\u5e03\uff1b\u5e74\u9f84\u548c\u4f53\u91cd\u91c7\u7528Mann\u2013Whitney U\u68c0\u9a8c\uff0c\u8eab\u9ad8\u91c7\u7528\u72ec\u7acb\u6837\u672c<em>t<\/em>\u68c0\u9a8c\uff0c\u996e\u9152\u60c5\u51b5\u91c7\u7528\u5361\u65b9\u68c0\u9a8c\u3002<\/p>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<p>&nbsp;<\/p>\n<table style=\"width: 100%; border-collapse: collapse; font-family: 'Lora', serif; color: #222;\">\n<caption style=\"caption-side: top; text-align: left; padding-bottom: 10px;\"><em>\u8868<\/em><em>1. <\/em><em>\u7814\u7a76\u53d7\u8bd5\u8005\u7684\u57fa\u7ebf\u7279\u5f81<\/em><\/caption>\n<thead>\n<tr>\n<th style=\"border-top: 1px solid #333; border-bottom: 1px solid #333; padding: 12px; text-align: left;\" rowspan=\"2\"><\/th>\n<th style=\"border-top: 1px solid #333; border-bottom: 1px solid #333; padding: 12px; text-align: center;\" colspan=\"3\">Intention to treat population<\/th>\n<th style=\"border-top: 1px solid #333; border-bottom: 1px solid #333; padding: 12px; text-align: center;\" colspan=\"3\">Per protocol population<\/th>\n<\/tr>\n<tr>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">CG (<em>n<\/em> = 41)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">IG (<em>n<\/em> = 41)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\"><em>P<\/em><\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">CG (<em>n<\/em> = 38)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\">IG (<em>n<\/em> = 36)<\/th>\n<th style=\"border-bottom: 1px solid #333; padding: 10px; text-align: center;\"><em>P<\/em><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Age (years)<\/td>\n<td style=\"padding: 12px; text-align: center;\">49.9 \u00b1 6.5<\/td>\n<td style=\"padding: 12px; text-align: center;\">48.0 \u00b1 5.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.176<\/td>\n<td style=\"padding: 12px; text-align: center;\">49.5 \u00b1 6.4<\/td>\n<td style=\"padding: 12px; text-align: center;\">47.9 \u00b1 6.0<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.303<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Weight (kg)<\/td>\n<td style=\"padding: 12px; text-align: center;\">56.7 \u00b1 6.8<\/td>\n<td style=\"padding: 12px; text-align: center;\">57.4 \u00b1 8.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.813<\/td>\n<td style=\"padding: 12px; text-align: center;\">56.4 \u00b1 7.0<\/td>\n<td style=\"padding: 12px; text-align: center;\">57.1 \u00b1 9.2<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.864<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Height (cm)<\/td>\n<td style=\"padding: 12px; text-align: center;\">157.9 \u00b1 5.7<\/td>\n<td style=\"padding: 12px; text-align: center;\">157.6 \u00b1 4.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.807<\/td>\n<td style=\"padding: 12px; text-align: center;\">158.1 \u00b1 5.7<\/td>\n<td style=\"padding: 12px; text-align: center;\">157.5 \u00b1 4.9<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.614<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left;\">Alcohol drinking (%)<\/td>\n<td style=\"padding: 12px; text-align: center;\">2 (4.8)<\/td>\n<td style=\"padding: 12px; text-align: center;\">4 (9.8)<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.396<\/td>\n<td style=\"padding: 12px; text-align: center;\">2 (5.3)<\/td>\n<td style=\"padding: 12px; text-align: center;\">3 (8.3)<\/td>\n<td style=\"padding: 12px; text-align: center;\">0.599<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; text-align: left; border-bottom: 1px solid #333;\">Smoker (%)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">\u2013<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">0 (0)<\/td>\n<td style=\"padding: 12px; text-align: center; border-bottom: 1px solid #333;\">\u2013<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><em>CG<\/em><em>\uff1a\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff1bIG<\/em><em>\uff1a\u80f6\u539f\u4e09\u80bd\u5e72\u9884\u7ec4\u3002\u996e\u9152\u5b9a\u4e49\u4e3a\u5e73\u5747\u6bcf\u5468\u996e\u9152\u8d85\u8fc72<\/em><em>\u6b21\uff0c\u4e14\u6bcf\u6b21\u996e\u9152\u91cf\u8fbe\u5230\u6216\u8d85\u8fc75<\/em><em>\u676f\u3002\u6570\u636e\u4ee5\u5e73\u5747\u503c \u00b1 <\/em><em>\u6807\u51c6\u5dee\u6216\u4eba\u6570\uff08\u767e\u5206\u6bd4\uff09\u8868\u793a\u3002\u91c7\u7528Shapiro\u2013Wilk<\/em><em>\u68c0\u9a8c\u8bc4\u4f30\u6570\u636e\u662f\u5426\u7b26\u5408\u6b63\u6001\u5206\u5e03\uff1b\u5e74\u9f84\u548c\u4f53\u91cd\u91c7\u7528Mann\u2013Whitney U<\/em><em>\u68c0\u9a8c\uff0c\u8eab\u9ad8\u91c7\u7528\u72ec\u7acb\u6837\u672ct<\/em><em>\u68c0\u9a8c\uff0c\u996e\u9152\u60c5\u51b5\u91c7\u7528\u5361\u65b9\u68c0\u9a8c\u3002<\/em><\/p>\n<p>&nbsp;<\/p>\n<h3 class=\"pmc_sec_title\">\u76ae\u80a4\u72b6\u6001\u7684\u53d8\u5316<br \/>\n\u76ae\u80a4\u6307\u6807<\/h3>\n<section id=\"sec19\">\u7ecf\u8fc76\u5468\u548c12\u5468\u7684\u8bd5\u9a8c\u540e\uff0c\u4e24\u7ec4\u53d7\u8bd5\u8005\u7684\u7ecf\u76ae\u6c34\u5206\u6d41\u5931\uff08TEWL\uff09\u5747\u6709\u6240\u4e0b\u964d\uff0c\u5176\u4e2d\u80f6\u539f\u4e09\u80bd\u5e72\u9884\u7ec4\uff08IG\uff09\u7684\u4e0b\u964d\u5e45\u5ea6\u5927\u4e8e\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff08CG\uff09\uff08\u88682\uff09\u3002<\/p>\n<p>\u5728\u7b2c12\u5468\u65f6\uff0c\u5373\u4f7f\u8fdb\u4e00\u6b65\u5bf9\u7814\u7a76\u5730\u533a\u7684\u6e7f\u5ea6\u3001\u6e29\u5ea6\u548cUVA\uff08\u7d2b\u5916\u7ebfA\uff09\u66b4\u9732\u60c5\u51b5\u8fdb\u884c\u6821\u6b63\uff0c\u4e24\u7ec4\u4e4b\u95f4\u7684TEWL\u5dee\u5f02\u4ecd\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff1a\u6821\u6b63\u6e7f\u5ea6\u548c\u6e29\u5ea6\u540e\uff0c<em>P<\/em> = 0.024\uff1b\u6821\u6b63UVA\u540e\uff0c<em>P<\/em> = 0.032\uff1b\u540c\u65f6\u6821\u6b63\u6e29\u5ea6\u3001\u9ad8\u6e29\u548cUVA\u540e\uff0c<em>P<\/em> = 0.031\uff08\u56fe2\uff09\u3002<\/p>\n<p>\u5728\u76ae\u80a4\u6c34\u5206\u65b9\u9762\uff0c\u80f6\u539f\u4e09\u80bd\u5e72\u9884\u7ec4\u7684\u6539\u5584\u7a0b\u5ea6\u9ad8\u4e8e\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff0c\u4f46\u4e24\u7ec4\u76f8\u8f83\u4e8e\u57fa\u7ebf\u7684\u53d8\u5316\u5dee\u5f02\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08\u56fe2\uff09\u3002<\/p>\n<p>\u5728\u5bf9\u7814\u7a76\u5730\u533a\u7684\u6e7f\u5ea6\u3001\u6e29\u5ea6\u548cUVA\u8fdb\u884c\u6821\u6b63\u540e\uff0c50\u5c81\u4ee5\u4e0a\u53d7\u8bd5\u8005\u4e2d\uff0c\u80f6\u539f\u4e09\u80bd\u5e72\u9884\u7ec4\u4e0e\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u4e4b\u95f4\u7684TEWL\u4ecd\u5b58\u5728\u663e\u8457\u5dee\u5f02\uff08\u88683\uff09\u3002<\/p>\n<p><em>\u6570\u636e\u4ee5\u5e73\u5747\u503c \u00b1 <\/em><em>\u6807\u51c6\u5dee\uff08SD<\/em><em>\uff09\u8868\u793a\u3002<\/em><\/p>\n<p><em>a\uff1a\u914d\u5bf9 t \u68c0\u9a8c\u3002<br \/>\nb\uff1a\u72ec\u7acb\u6837\u672c t \u68c0\u9a8c\u3002<br \/>\nc\uff1a\u91cd\u590d\u6d4b\u91cf\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u6821\u6b63\u6e29\u5ea6\u548c\u6e7f\u5ea6\u3002<br \/>\nd\uff1a\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u6821\u6b63UVA\uff08\u7d2b\u5916\u7ebfA\uff09\u3002<br \/>\ne\uff1a\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u6821\u6b63\u6e29\u5ea6\u3001\u9ad8\u6e29\u548cUVA\uff08\u7d2b\u5916\u7ebfA\uff09\u3002<\/em><\/p>\n<\/section>\n<h5 class=\"obj_head\">\u56fe2.<\/h5>\n<p><img decoding=\"async\" class=\"alignnone wp-image-3093 size-full\" src=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002.jpg\" alt=\"\" width=\"630\" height=\"1019\" srcset=\"https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002.jpg 630w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002-185x300.jpg 185w, https:\/\/laexome.com\/wp-content\/uploads\/2026\/05\/fmed-07-608903-g0002-600x970.jpg 600w\" sizes=\"(max-width: 630px) 100vw, 630px\" \/><\/p>\n<p><em>\u63a5\u53d7\u80f6\u539f\u4e09\u80bd\u6216\u5b89\u6170\u5242\u7684\u53d7\u8bd5\u8005\u76ae\u80a4\u6307\u6807\u53d8\u5316\u3002<\/em><strong><em>(A)<\/em><\/strong> <em>\u7ecf\u76ae\u6c34\u5206\u6d41\u5931\uff08<\/em><em>TEWL<\/em><em>\uff09\u7684\u53d8\u5316\u3002<\/em><strong><em>(B)<\/em><\/strong> <em>\u76ae\u80a4\u6c34\u5206\u7684\u53d8\u5316\u3002\u4e0e\u57fa\u7ebf\u503c\u76f8\u6bd4\uff0c\u914d\u5bf9 <\/em><em>t<\/em> <em>\u68c0\u9a8c\u663e\u793a\uff1a<\/em><em>P<\/em><em> &lt; 0.05<\/em><em>\uff0c<\/em><em>P &lt; 0.01<\/em><em>\uff1b\u5e72\u9884\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u4e4b\u95f4\u7684\u6bd4\u8f83\u91c7\u7528\u72ec\u7acb\u6837\u672c<\/em><em> t <\/em><em>\u68c0\u9a8c\uff0c<\/em><em>P &lt; 0.05<\/em><em>\u3002<\/em><\/p>\n<p>&nbsp;<\/p>\n<style>\n.study-table-wrap {<br \/>    width: 100%;<br \/>    overflow-x: auto;<br \/>    -webkit-overflow-scrolling: touch;<br \/>    margin: 24px 0;<br \/>}<\/p>\n<p>.study-table {<br \/>    width: 100%;<br \/>    min-width: 1200px;<br \/>    border-collapse: collapse;<br \/>    font-family: 'Lora', serif;<br \/>    color: #222;<br \/>    line-height: 1.45;<br \/>}<\/p>\n<p>.study-table th,<br \/>.study-table td {<br \/>    padding: 10px 12px;<br \/>    border-bottom: 1px solid #dcdcdc;<br \/>    vertical-align: middle;<br \/>}<\/p>\n<p>.study-table thead th {<br \/>    text-align: center;<br \/>    font-weight: 700;<br \/>    border-top: 1px solid #333;<br \/>    border-bottom: 1px solid #333;<br \/>}<\/p>\n<p>.study-table tbody td {<br \/>    text-align: center;<br \/>}<\/p>\n<p>.study-table tbody td:first-child {<br \/>    text-align: left;<br \/>    white-space: nowrap;<br \/>}<\/p>\n<p>.study-section td {<br \/>    background: #f7f7f7;<br \/>    font-weight: 700;<br \/>    text-align: left !important;<br \/>    border-top: 1px solid #333;<br \/>}<\/p>\n<p>@media screen and (max-width: 767px) {<br \/>    .study-table {<br \/>        font-size: 12px;<br \/>        min-width: 1050px;<br \/>    }<\/p>\n<p>    .study-table th,<br \/>    .study-table td {<br \/>        padding: 7px 8px;<br \/>    }<br \/>}<br \/><\/style>\n<div class=\"study-table-wrap\">\n<table class=\"study-table\">\n<thead>\n<tr>\n<th rowspan=\"2\">Variable<\/th>\n<th colspan=\"2\">Observed values<\/th>\n<th colspan=\"7\">Changes from baseline<\/th>\n<\/tr>\n<tr>\n<th>IG (<em>n<\/em> = 14)<\/th>\n<th>CG (<em>n<\/em> = 19)<\/th>\n<th>IG (<em>n<\/em> = 14)<\/th>\n<th><em>P<\/em><sup>a,b<\/sup><\/th>\n<th>CG (<em>n<\/em> = 19)<\/th>\n<th><em>P<\/em><sup>a,b<\/sup><\/th>\n<th><em>P<\/em><sup>c,d<\/sup><\/th>\n<th><em>P<\/em><sup>e<\/sup><\/th>\n<th><em>P<\/em><sup>f<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody><!-- Transepidermal water loss --><\/p>\n<tr class=\"study-section\">\n<td colspan=\"10\">Transepidermal water loss (g\/m<sup>2<\/sup>\/h)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>6.60 \u00b1 2.64<\/td>\n<td>5.54 \u00b1 1.61<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>4.53 \u00b1 1.25<\/td>\n<td>3.97 \u00b1 0.97<\/td>\n<td>\u22122.07 \u00b1 2.20<\/td>\n<td>0.003<sup>a<\/sup><\/td>\n<td>\u22121.57 \u00b1 2.19<\/td>\n<td>0.002<sup>a<\/sup><\/td>\n<td>0.413<sup>c<\/sup><\/td>\n<td>0.152<\/td>\n<td>0.294<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>5.39 \u00b1 1.87<\/td>\n<td>5.16 \u00b1 1.12<\/td>\n<td>\u22121.21 \u00b1 2.00<\/td>\n<td>0.056<sup>a<\/sup><\/td>\n<td>\u22120.39 \u00b1 1.89<\/td>\n<td>0.657<sup>a<\/sup><\/td>\n<td>0.209<sup>c<\/sup><\/td>\n<td>0.034<\/td>\n<td>0.040<\/td>\n<\/tr>\n<p><!-- Skin hydration --><\/p>\n<tr class=\"study-section\">\n<td colspan=\"10\">Skin hydration (A.U.)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>192.39 \u00b1 24.09<\/td>\n<td>195.89 \u00b1 25.70<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>203.90 \u00b1 21.82<\/td>\n<td>192.92 \u00b1 27.34<\/td>\n<td>11.50 \u00b1 19.57<\/td>\n<td>0.047<sup>b<\/sup><\/td>\n<td>\u22122.97 \u00b1 21.56<\/td>\n<td>0.555<sup>b<\/sup><\/td>\n<td>0.057<sup>d<\/sup><\/td>\n<td>0.043<\/td>\n<td>0.046<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>212.55 \u00b1 19.33<\/td>\n<td>212.42 \u00b1 16.51<\/td>\n<td>20.16 \u00b1 21.55<\/td>\n<td>0.004<sup>b<\/sup><\/td>\n<td>16.53 \u00b1 22.70<\/td>\n<td>0.005<sup>b<\/sup><\/td>\n<td>0.646<sup>d<\/sup><\/td>\n<td>0.622<\/td>\n<td>0.639<\/td>\n<\/tr>\n<p><!-- Skin elasticity --><\/p>\n<tr class=\"study-section\">\n<td colspan=\"10\">Skin elasticity (mm)<\/td>\n<\/tr>\n<tr>\n<td>Baseline<\/td>\n<td>0.40 \u00b1 0.11<\/td>\n<td>0.39 \u00b1 0.10<\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>At 6 weeks<\/td>\n<td>0.38 \u00b1 0.12<\/td>\n<td>0.37 \u00b1 0.09<\/td>\n<td>\u22120.03 \u00b1 0.13<\/td>\n<td>0.485<sup>b<\/sup><\/td>\n<td>\u22120.03 \u00b1 0.07<\/td>\n<td>0.124<sup>b<\/sup><\/td>\n<td>0.986<sup>d<\/sup><\/td>\n<td>0.931<\/td>\n<td>0.720<\/td>\n<\/tr>\n<tr>\n<td>At 12 weeks<\/td>\n<td>0.35 \u00b1 0.11<\/td>\n<td>0.37 \u00b1 0.10<\/td>\n<td>\u22120.05 \u00b1 0.10<\/td>\n<td>0.079<sup>b<\/sup><\/td>\n<td>\u22120.02 \u00b1 0.07<\/td>\n<td>0.208<sup>b<\/sup><\/td>\n<td>0.316<sup>d<\/sup><\/td>\n<td>0.316<\/td>\n<td>0.330<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p><em>\u6570\u636e\u4ee5\u5e73\u5747\u503c \u00b1 <\/em><em>\u6807\u51c6\u5dee\uff08SD<\/em><em>\uff09\u8868\u793a\u3002<\/em><\/p>\n<p><em>a<\/em><em>\uff1aWilcoxon<\/em><em>\u7b26\u53f7\u79e9\u68c0\u9a8c\u3002<br \/>\nb<\/em><em>\uff1a\u914d\u5bf9 t <\/em><em>\u68c0\u9a8c\u3002<br \/>\nc<\/em><em>\uff1aMann\u2013Whitney U<\/em><em>\u68c0\u9a8c\u3002<br \/>\nd<\/em><em>\uff1a\u72ec\u7acb\u6837\u672c t <\/em><em>\u68c0\u9a8c\u3002<br \/>\ne<\/em><em>\uff1a\u91cd\u590d\u6d4b\u91cf\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA<\/em><em>\uff09\uff0c\u6821\u6b63UVA<\/em><em>\uff08\u7d2b\u5916\u7ebfA<\/em><em>\uff09\u3002<br \/>\nf<\/em><em>\uff1a\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA<\/em><em>\uff09\uff0c\u6821\u6b63\u6e29\u5ea6\u3001\u9ad8\u6e29\u548cUVA<\/em><em>\uff08\u7d2b\u5916\u7ebfA<\/em><em>\uff09\u3002<\/em><\/p>\n<h4 class=\"pmc_sec_title\">\u53d7\u8bd5\u8005\u81ea\u6211\u8bc4\u4ef7<\/h4>\n<p>\u4e24\u7ec4\u53d7\u8bd5\u8005\u5747\u8868\u793a\uff0c\u968f\u7740\u4f7f\u7528\u65f6\u95f4\u7684\u589e\u52a0\uff0c\u76ae\u80a4\u72b6\u6001\u6709\u4e00\u5b9a\u7a0b\u5ea6\u7684\u6539\u5584\uff0c\u4f46\u4e24\u7ec4\u4e4b\u95f4\u7684\u5dee\u5f02\u672a\u8fbe\u5230\u7edf\u8ba1\u5b66\u663e\u8457\u6027\uff08\u88684\uff09\u3002<\/p>\n<p>\u8fde\u7eed\u53e3\u670d\u8865\u5145\u524212\u5468\u540e\uff0c\u4e24\u7ec4\u53d7\u8bd5\u8005\u5747\u672a\u62a5\u544a\u51fa\u73b0\u660e\u663e\u7684\u76ae\u80a4\u4e0d\u9002\u611f\uff08\u88684\uff09\u3002<\/p>\n<p>\u5728\u4e9a\u7ec4\u5206\u6790\u4e2d\uff0c50\u5c81\u4ee5\u4e0b\u53d7\u8bd5\u8005\u8fde\u7eed\u670d\u7528CTP 12\u5468\u540e\uff0c\u5728\u76ae\u80a4\u6539\u5584\u4e3b\u89c2\u8bc4\u4ef7\u95ee\u5377\u7684<strong>\u603b\u8bc4\u5206\u548c\u76ae\u80a4\u6c34\u5206\u8bc4\u5206<\/strong>\u65b9\u9762\u5747\u8868\u73b0\u51fa\u663e\u8457\u6539\u5584\uff08<em>P<\/em> &lt; 0.05\uff0c\u6570\u636e\u672a\u663e\u793a\uff09\u3002\u6b64\u5916\uff0c50\u5c81\u4ee5\u4e0a\u53d7\u8bd5\u8005\u670d\u7528CTP 6\u5468\u540e\uff0c<strong>\u76ae\u80a4\u7d27\u81f4\u5ea6<\/strong>\u8f83\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\u663e\u8457\u6539\u5584\uff08<em>P<\/em> &lt; 0.05\uff0c\u6570\u636e\u672a\u663e\u793a\uff09\u3002<\/p>\n<p>&nbsp;<\/p>\n<style>\n.skin-study-table-wrap {<br \/>    width: 100%;<br \/>    overflow-x: auto;<br \/>    -webkit-overflow-scrolling: touch;<br \/>    margin: 24px 0;<br \/>}<\/p>\n<p>.skin-study-table {<br \/>    width: 100%;<br \/>    min-width: 1150px;<br \/>    border-collapse: collapse;<br \/>    font-family: 'Lora', serif;<br \/>    color: #222;<br \/>    line-height: 1.45;<br \/>}<\/p>\n<p>.skin-study-table th,<br \/>.skin-study-table td {<br \/>    padding: 10px 12px;<br \/>    border-bottom: 1px solid #dddddd;<br \/>    vertical-align: middle;<br \/>}<\/p>\n<p>.skin-study-table thead th {<br \/>    text-align: center;<br \/>    font-weight: 700;<br \/>    border-top: 1px solid #333;<br \/>    border-bottom: 1px solid #333;<br \/>}<\/p>\n<p>.skin-study-table tbody td {<br \/>    text-align: center;<br \/>}<\/p>\n<p>.skin-study-table tbody td:first-child {<br \/>    text-align: left;<br \/>    white-space: nowrap;<br \/>    font-weight: 500;<br \/>}<\/p>\n<p>@media screen and (max-width: 767px) {<\/p>\n<p>    .skin-study-table {<br \/>        font-size: 12px;<br \/>        min-width: 1000px;<br \/>    }<\/p>\n<p>    .skin-study-table th,<br \/>    .skin-study-table td {<br \/>        padding: 7px 8px;<br \/>    }<br \/>}<br \/><\/style>\n<div class=\"skin-study-table-wrap\">\n<table class=\"skin-study-table\">\n<thead>\n<tr>\n<th rowspan=\"2\">Variable<\/th>\n<th colspan=\"4\">Intervention group (<em>n<\/em> = 36)<\/th>\n<th colspan=\"6\">Control group (<em>n<\/em> = 38)<\/th>\n<\/tr>\n<tr>\n<th>6 week<\/th>\n<th>12 week<\/th>\n<th>\u0394<\/th>\n<th>P<sup>a<\/sup><\/th>\n<th>6 week<\/th>\n<th>12 week<\/th>\n<th>\u0394<\/th>\n<th>P<sup>a<\/sup><\/th>\n<th>P<sup>b<\/sup><\/th>\n<th>P<sup>c<\/sup><\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Total score<\/td>\n<td>35.22 \u00b1 3.4<\/td>\n<td>35.75 \u00b1 3.6<\/td>\n<td>0.53 \u00b1 2.7<\/td>\n<td>0.256<\/td>\n<td>34.87 \u00b1 4.1<\/td>\n<td>35.45 \u00b1 4.4<\/td>\n<td>0.58 \u00b1 4.8<\/td>\n<td>0.461<\/td>\n<td>0.748<\/td>\n<td>0.719<\/td>\n<\/tr>\n<tr>\n<td>Hydration<\/td>\n<td>3.42 \u00b1 0.6<\/td>\n<td>3.50 \u00b1 0.6<\/td>\n<td>0.08 \u00b1 0.6<\/td>\n<td>0.373<\/td>\n<td>3.37 \u00b1 0.6<\/td>\n<td>3.50 \u00b1 0.7<\/td>\n<td>0.13 \u00b1 0.8<\/td>\n<td>0.303<\/td>\n<td>1.000<\/td>\n<td>0.969<\/td>\n<\/tr>\n<tr>\n<td>Smoothness<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>3.53 \u00b1 0.6<\/td>\n<td>0.17 \u00b1 0.6<\/td>\n<td>0.083<\/td>\n<td>3.34 \u00b1 0.7<\/td>\n<td>3.53 \u00b1 0.7<\/td>\n<td>0.18 \u00b1 0.8<\/td>\n<td>0.147<\/td>\n<td>0.992<\/td>\n<td>0.911<\/td>\n<\/tr>\n<tr>\n<td>Roughness<\/td>\n<td>3.28 \u00b1 0.6<\/td>\n<td>3.47 \u00b1 0.7<\/td>\n<td>0.19 \u00b1 0.6<\/td>\n<td>0.070<\/td>\n<td>3.42 \u00b1 0.6<\/td>\n<td>3.47 \u00b1 0.7<\/td>\n<td>0.05 \u00b1 0.9<\/td>\n<td>0.711<\/td>\n<td>0.993<\/td>\n<td>0.959<\/td>\n<\/tr>\n<tr>\n<td>Glowing<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>0.00 \u00b1 0.5<\/td>\n<td>1.000<\/td>\n<td>3.26 \u00b1 0.7<\/td>\n<td>3.32 \u00b1 0.7<\/td>\n<td>0.05 \u00b1 0.7<\/td>\n<td>0.644<\/td>\n<td>0.766<\/td>\n<td>0.843<\/td>\n<\/tr>\n<tr>\n<td>Elasticity<\/td>\n<td>3.39 \u00b1 0.6<\/td>\n<td>3.36 \u00b1 0.5<\/td>\n<td>\u22120.03 \u00b1 0.5<\/td>\n<td>0.744<\/td>\n<td>3.34 \u00b1 0.6<\/td>\n<td>3.32 \u00b1 0.7<\/td>\n<td>\u22120.03 \u00b1 0.8<\/td>\n<td>0.845<\/td>\n<td>0.749<\/td>\n<td>0.756<\/td>\n<\/tr>\n<tr>\n<td>Wrinkles<\/td>\n<td>3.31 \u00b1 0.5<\/td>\n<td>3.25 \u00b1 0.4<\/td>\n<td>\u22120.06 \u00b1 0.5<\/td>\n<td>0.487<\/td>\n<td>3.16 \u00b1 0.5<\/td>\n<td>3.29 \u00b1 0.6<\/td>\n<td>0.13 \u00b1 0.6<\/td>\n<td>0.169<\/td>\n<td>0.739<\/td>\n<td>0.914<\/td>\n<\/tr>\n<tr>\n<td>Itching<\/td>\n<td>2.97 \u00b1 0.3<\/td>\n<td>2.97 \u00b1 0.6<\/td>\n<td>0.00 \u00b1 0.6<\/td>\n<td>1.000<\/td>\n<td>2.97 \u00b1 0.4<\/td>\n<td>2.97 \u00b1 0.6<\/td>\n<td>0.00 \u00b1 0.8<\/td>\n<td>1.000<\/td>\n<td>0.992<\/td>\n<td>0.923<\/td>\n<\/tr>\n<tr>\n<td>Aching<\/td>\n<td>3.00 \u00b1 0.0<\/td>\n<td>3.00 \u00b1 0.0<\/td>\n<td>0.00 \u00b1 0.0<\/td>\n<td>\u2013<\/td>\n<td>3.00 \u00b1 0.4<\/td>\n<td>2.95 \u00b1 0.4<\/td>\n<td>\u22120.05 \u00b1 0.6<\/td>\n<td>0.571<\/td>\n<td>0.422<\/td>\n<td>0.382<\/td>\n<\/tr>\n<tr>\n<td>Burning<\/td>\n<td>2.94 \u00b1 0.3<\/td>\n<td>3.00 \u00b1 0.2<\/td>\n<td>0.06 \u00b1 0.2<\/td>\n<td>0.160<\/td>\n<td>3.00 \u00b1 0.4<\/td>\n<td>3.03 \u00b1 0.4<\/td>\n<td>0.03 \u00b1 0.6<\/td>\n<td>0.785<\/td>\n<td>0.746<\/td>\n<td>0.827<\/td>\n<\/tr>\n<tr>\n<td>Stinging<\/td>\n<td>2.97 \u00b1 0.4<\/td>\n<td>3.00 \u00b1 0.4<\/td>\n<td>0.03 \u00b1 0.3<\/td>\n<td>0.571<\/td>\n<td>2.89 \u00b1 0.3<\/td>\n<td>2.92 \u00b1 0.4<\/td>\n<td>0.03 \u00b1 0.5<\/td>\n<td>0.734<\/td>\n<td>0.383<\/td>\n<td>0.366<\/td>\n<\/tr>\n<tr>\n<td>Tightness<\/td>\n<td>3.22 \u00b1 0.6<\/td>\n<td>3.31 \u00b1 0.5<\/td>\n<td>0.08 \u00b1 0.4<\/td>\n<td>0.263<\/td>\n<td>3.11 \u00b1 0.5<\/td>\n<td>3.16 \u00b1 0.6<\/td>\n<td>0.05 \u00b1 0.6<\/td>\n<td>0.600<\/td>\n<td>0.282<\/td>\n<td>0.300<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u6570\u636e\u4ee5\u5e73\u5747\u503c \u00b1 \u6807\u51c6\u5dee\uff08SD\uff09\u8868\u793a\u3002<\/p>\n<p>a\uff1a\u914d\u5bf9 <em>t<\/em> \u68c0\u9a8c\u3002<br \/>\nb\uff1a\u72ec\u7acb\u6837\u672c <em>t<\/em> \u68c0\u9a8c\uff0c\u7528\u4e8e\u6bd4\u8f83\u7b2c6\u5468\u81f3\u7b2c12\u5468\u671f\u95f4\u7684\u53d8\u5316\u3002<br \/>\nc\uff1a\u91cd\u590d\u6d4b\u91cf\u534f\u65b9\u5dee\u5206\u6790\uff08ANCOVA\uff09\uff0c\u6821\u6b63\u6e29\u5ea6\u3001\u6e7f\u5ea6\u548cUVA\uff08\u7d2b\u5916\u7ebfA\uff09\u3002<\/p>\n<section id=\"s3\">\n<section id=\"sec21\"><\/section>\n<\/section>\n<section id=\"conf1\">\n<h3>\u5b89\u5168\u6027<\/h3>\n<p>\u5927\u591a\u6570\u53d7\u8bd5\u8005\u5747\u987a\u5229\u5b8c\u6210\u4e86\u6574\u4e2a\u7814\u7a76\u8fc7\u7a0b\uff0c\u672a\u51fa\u73b0\u660e\u663e\u4e0d\u826f\u53cd\u5e94\u3002\u5b89\u6170\u5242\u5bf9\u7167\u7ec4\uff08CG\uff09\u4e2d\u67091\u540d\u53d7\u8bd5\u8005\u62a5\u544a\u51fa\u73b0\u53e3\u5e72\u75c7\u72b6\uff0c\u4f46\u65e0\u6cd5\u786e\u5b9a\u8be5\u75c7\u72b6\u662f\u5426\u4e0e\u670d\u7528CTP\u6709\u5173\u3002<\/p>\n<p>\u7814\u7a76\u671f\u95f4\uff0c\u4e24\u7ec4\u53d7\u8bd5\u8005\u7684\u809d\u9176\u3001\u808c\u9150\u548c\u8840\u7cd6\u6c34\u5e73\u5747\u672a\u51fa\u73b0\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u53d8\u5316\u3002\u540c\u65f6\uff0c\u5728\u6574\u4e2a\u7814\u7a76\u671f\u95f4\uff0c\u4e24\u7ec4\u4e4b\u95f4\u4e0a\u8ff0\u6307\u6807\u4e5f\u672a\u53d1\u73b0\u660e\u663e\u5dee\u5f02\u3002<\/p>\n<h3>\u8ba8\u8bba<\/h3>\n<p>\u5c3d\u7ba1\u80f6\u539f\u86cb\u767d\u4e09\u80bd\uff08CTP\uff09\u957f\u671f\u4ee5\u6765\u4e00\u76f4\u662f\u5907\u53d7\u5173\u6ce8\u7684\u53e3\u670d\u7f8e\u5bb9\u8865\u5145\u6210\u5206\u4e4b\u4e00\uff0c\u4f46\u76ee\u524d\u9488\u5bf9\u5176\u5bf9\u4eba\u4f53\u76ae\u80a4\u4f5c\u7528\u7684\u4e34\u5e8a\u8bc1\u636e\u4ecd\u76f8\u5bf9\u6709\u9650\u3002\u672c\u9879\u4e34\u5e8a\u8bd5\u9a8c\u65e8\u5728\u8bc4\u4f30CTP\u5bf9\u591a\u9879\u76ae\u80a4\u6307\u6807\u7684\u6709\u6548\u6027\u3001\u5b89\u5168\u6027\u53ca\u8010\u53d7\u6027\u3002\u7814\u7a76\u7ed3\u679c\u663e\u793a\uff0c\u4e2d\u5e74\u5973\u6027\u6bcf\u65e5\u53e3\u670d1,000 mg CTP\u3001\u6301\u7eed12\u5468\u540e\uff0c\u7ecf\u8868\u76ae\u5931\u6c34\uff08TEWL\uff09\u6709\u6240\u964d\u4f4e\uff0c\u4e14\u6574\u4f53\u8010\u53d7\u6027\u826f\u597d\u3002\u76ae\u80a4\u72b6\u6001\u4f1a\u53d7\u5230\u5e74\u9f84\u3001\u6027\u522b\u3001\u6d4b\u8bd5\u90e8\u4f4d\u3001\u751f\u6d3b\u65b9\u5f0f\u4ee5\u53ca\u76ae\u80a4\u81ea\u8eab\u751f\u7406\u72b6\u51b5\u7b49\u591a\u79cd\u56e0\u7d20\u7684\u5f71\u54cd [27]\u3002\u4e0e\u5e72\u71e5\u7684\u79cb\u51ac\u5b63\u8282\u76f8\u6bd4\uff0c\u6625\u590f\u5b63\u8282\u7684\u76ae\u80a4\u4fdd\u6e7f\u72b6\u6001\u548c\u7d2b\u5916\u7ebf\u66b4\u9732\u901a\u5e38\u66f4\u9ad8 [28]\u3002UVA\u80fd\u591f\u6df1\u5165\u76ae\u80a4\uff0c\u5e76\u53ef\u80fd\u5bf9\u76ae\u80a4\u8840\u7ba1\u53ca\u771f\u76ae\u5185\u7ec6\u80de\u9020\u6210\u5f71\u54cd [29\u201331]\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u5bf9\u53d7\u8bd5\u8005\u6240\u5904\u5730\u533a\u7684\u5916\u90e8\u6c14\u5019\u56e0\u7d20\u8fdb\u884c\u4e86\u6821\u6b63\uff0c\u4ee5\u66f4\u51c6\u786e\u5730\u8bc4\u4f30\u53e3\u670dCTP\u5bf9\u76ae\u80a4\u7684\u4f5c\u7528\u3002\u7ed3\u679c\u663e\u793a\uff0c\u5728\u5bf9\u53d7\u8bd5\u8005\u5c45\u4f4f\u5730\u533a\u7684\u6e7f\u5ea6\u3001\u6e29\u5ea6\u548cUVA\u7b49\u56e0\u7d20\u8fdb\u884c\u6821\u6b63\u540e\uff0cCTP\u7ec4\u4e0e\u5bf9\u7167\u7ec4\u4e4b\u95f4\u7684TEWL\u5dee\u5f02\u4ecd\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\u3002<\/p>\n<p>\u968f\u7740\u5e74\u9f84\u589e\u957f\uff0c\u76ae\u80a4\u539a\u5ea6\u53ca\u8868\u76ae\u7ec6\u80de\u6570\u91cf\u4f1a\u9010\u6e10\u51cf\u5c11\uff0c\u540c\u65f6\u771f\u76ae\u4e2d\u7684\u80f6\u539f\u86cb\u767d\u542b\u91cf\u4e5f\u4f1a\u4e0b\u964d [2,3]\u3002\u4e0e\u5e74\u8f7b\u5973\u6027\u76f8\u6bd4\uff0c\u4e2d\u5e74\u5973\u6027\u7684\u76ae\u80a4\u8001\u5316\u8fc7\u7a0b\u53ef\u80fd\u66f4\u52a0\u660e\u663e\uff0c\u56e0\u4e3a\u96cc\u6fc0\u7d20\u6c34\u5e73\u4e0b\u964d\u4f1a\u76f4\u63a5\u5f71\u54cd\u8868\u76ae\u72b6\u6001 [32]\u3002\u6b64\u5916\uff0c\u8bb8\u591a\u4e2d\u5e74\u5973\u6027\u5bf9\u9762\u90e8\u5916\u89c2\u53ca\u53ef\u89c1\u7684\u808c\u80a4\u8001\u5316\u95ee\u9898\u8f83\u4e3a\u5173\u6ce8\uff0c\u8fd9\u4e5f\u4f53\u73b0\u5728\u5176\u5bf9\u62a4\u80a4\u4ea7\u54c1\u53ca\u7f8e\u5bb9\u62a4\u7406\u7684\u6295\u5165\u4e0d\u65ad\u589e\u52a0 [33]\u3002\u56e0\u6b64\uff0c\u672c\u7814\u7a76\u9009\u62e9\u4e2d\u5e74\u5973\u6027\u4f5c\u4e3a\u7814\u7a76\u5bf9\u8c61\u5177\u6709\u4e00\u5b9a\u7684\u4e34\u5e8a\u610f\u4e49\uff0c\u56e0\u4e3a\u4e0e\u7537\u6027\u6216\u5e74\u8f7b\u5973\u6027\u76f8\u6bd4\uff0c\u8fd9\u4e00\u4eba\u7fa4\u53ef\u80fd\u66f4\u5bb9\u6613\u4ece\u80f6\u539f\u86cb\u767d\u8865\u5145\u4e2d\u83b7\u76ca\u3002<\/p>\n<p>\u80f6\u539f\u86cb\u767d\u53d1\u6325\u76ae\u80a4\u4f5c\u7528\u7684\u751f\u7269\u5b66\u673a\u5236\uff0c\u53ef\u80fd\u4e0e\u5176\u5bf9\u771f\u76ae\u7ec4\u7ec7\u7684\u4f5c\u7528\u6709\u5173 [34]\u3002\u7136\u800c\uff0c\u7531\u4e8e\u80f6\u539f\u86cb\u767d\u5206\u5b50\u8f83\u5927\uff0c\u5728\u80c3\u80a0\u9053\u4e2d\u901a\u5e38\u96be\u4ee5\u76f4\u63a5\u5206\u89e3\u4e3a\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5f62\u5f0f\uff0c\u56e0\u6b64\u5982\u4f55\u4f7f\u80f6\u539f\u86cb\u767d\u4ee5\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u5f62\u5f0f\u88ab\u4eba\u4f53\u5438\u6536\uff0c\u5e76\u5230\u8fbe\u76f8\u5e94\u7ec4\u7ec7\u53d1\u6325\u4f5c\u7528\uff0c\u5728\u4e34\u5e8a\u7814\u7a76\u4e2d\u4ecd\u5177\u6709\u4e00\u5b9a\u6311\u6218 [35]\u3002\u8fd9\u4e5f\u662f\u5c3d\u7ba1\u80f6\u539f\u86cb\u767d\u5e7f\u6cdb\u5e94\u7528\u4e8e\u76ae\u80a4\u5065\u5eb7\u7c7b\u8425\u517b\u8865\u5145\u4ea7\u54c1\uff0c\u4f46\u76ee\u524d\u5173\u4e8e\u5176\u6539\u5584\u76ae\u80a4\u72b6\u6001\u7684\u4e34\u5e8a\u8bc1\u636e\u4ecd\u76f8\u5bf9\u6709\u9650\u7684\u539f\u56e0\u4e4b\u4e00 [4,21,36]\u3002\u4e3a\u4e86\u63d0\u9ad8\u80f6\u539f\u86cb\u767d\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u76ee\u524d\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5f00\u59cb\u91c7\u7528\u4f4e\u5206\u5b50\u91cf\u80f6\u539f\u80bd\u3002\u7531\u4e8e\u5206\u5b50\u66f4\u5c0f\uff0c\u8fd9\u7c7b\u80f6\u539f\u80bd\u53ef\u80fd\u66f4\u5bb9\u6613\u8010\u53d7\u80c3\u80a0\u9053\u53ca\u8840\u6db2\u4e2d\u7684\u9176\u4f5c\u7528\uff0c\u5e76\u901a\u8fc7\u80a0\u9053\u4e0a\u76ae\u7ec6\u80de\u819c\u88ab\u4eba\u4f53\u5438\u6536 [15]\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6240\u4f7f\u7528\u7684CTP\u4e2d\u542b\u67093.2%\u7684Gly-Pro-Hyp\uff08\u4e09\u80bd\uff1a\u7518\u6c28\u9178-\u812f\u6c28\u9178-\u7f9f\u812f\u6c28\u9178\uff09\u3002\u8fd9\u4e00\u7ed3\u6784\u662f\u80f6\u539f\u86cb\u767d\u6765\u6e90\u80bd\u4e2d\u7684\u91cd\u8981\u6d3b\u6027\u6210\u5206 [37]\u3002\u836f\u4ee3\u52a8\u529b\u5b66\u7814\u7a76\u663e\u793a\uff0c\u7531Gly-Pro-Hyp\u4ea7\u751f\u7684Pro-Hyp\uff08\u4e8c\u80bd\uff1a\u812f\u6c28\u9178-\u7f9f\u812f\u6c28\u9178\uff09\u5728\u53e3\u670d\u540e\u80fd\u591f\u4ee5\u8f83\u9ad8\u6d53\u5ea6\u5b58\u5728\u4e8e\u4eba\u4f53\u8840\u6db2\u4e2d\uff0c\u5e76\u6301\u7eed\u6570\u5c0f\u65f6 [35,38]\u3002\u52a8\u7269\u7814\u7a76\u4e5f\u53d1\u73b0\uff0c\u53e3\u670d\u540e\uff0c\u6807\u8bb0\u7684Pro-Hyp\u80fd\u591f\u8f83\u5feb\u5230\u8fbe\u76ae\u80a4\u548c\u9aa8\u7ec4\u7ec7 [39]\u3002\u53e6\u4e00\u9879\u8fd1\u671f\u52a8\u7269\u7814\u7a76\u663e\u793a\uff0c\u53e3\u670d\u80f6\u539f\u80bd\u540e\uff0c\u5176\u4e2d\u7684Pro-Hyp\u88ab\u5438\u6536\uff0c\u5e76\u53ef\u80fd\u5e2e\u52a9\u51cf\u8f7bUVB\u8bf1\u5bfc\u7684\u76ae\u80a4\u8001\u5316 [40]\u3002\u6b64\u5916\uff0c\u4e00\u9879\u4e34\u5e8a\u7814\u7a76\u5728\u53d7\u8bd5\u8005\u6444\u5165\u80f6\u539f\u86cb\u767d\u6c34\u89e3\u7269\u540e\uff0c\u5728\u5c3f\u6db2\u4e2d\u68c0\u6d4b\u5230\u4e86Pro-Hyp\uff0c\u8fd9\u63d0\u793a\u8fd9\u4e9b\u80f6\u539f\u6765\u6e90\u80bd\u5177\u6709\u76f8\u5bf9\u8f83\u597d\u7684\u7a33\u5b9a\u6027\uff0c\u4e0d\u6613\u88ab\u8840\u6db2\u4e2d\u7684\u80bd\u9176\u8fc5\u901f\u5206\u89e3\uff0c\u5e76\u53ef\u80fd\u5230\u8fbe\u76ae\u80a4\u7ec4\u7ec7 [13,41]\u3002\u4e00\u4e9b\u4f53\u5916\u7814\u7a76\u8fdb\u4e00\u6b65\u53d1\u73b0\uff0cPro-Hyp\u4f5c\u7528\u4e8e\u76ae\u80a4\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u540e\uff0c\u53ef\u4ee5\u4fc3\u8fdb\u7ec6\u80de\u589e\u6b96\uff0c\u5e76\u4fc3\u8fdb\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u7684\u8d8b\u5316\u4f5c\u7528 [34]\u3002\u540c\u65f6\uff0cPro-Hyp\u8fd8\u53ef\u80fd\u4fc3\u8fdb\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4ea7\u751f\u900f\u660e\u8d28\u9178 [42]\u3002\u8fd9\u4e9b\u4f5c\u7528\u5bf9\u4e8e\u7ef4\u6301\u76ae\u80a4\u5065\u5eb7\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u672c\u7814\u7a76\u89c2\u5bdf\u5230\u53e3\u670dCTP\u540e\u76ae\u80a4\u76f8\u5173\u6307\u6807\u6709\u6240\u6539\u5584\uff0c\u4e5f\u8fdb\u4e00\u6b65\u63d0\u793aCTP\u4e2d\u7684Gly-Pro-Hyp\u548cPro-Hyp\u53ef\u80fd\u5177\u6709\u8f83\u597d\u7684\u5438\u6536\u6027\uff0c\u5e76\u80fd\u591f\u53d1\u6325\u4e00\u5b9a\u7684\u751f\u7269\u6d3b\u6027\u3002<\/p>\n<p>\u76ee\u524d\uff0c\u5927\u591a\u6570\u5173\u4e8eCTP\u7684\u4e34\u5e8a\u7814\u7a76\u5747\u62a5\u544a\u4e86\u53e3\u670dCTP\u540e\u76ae\u80a4\u6574\u4f53\u72b6\u6001\u6709\u6240\u6539\u5584 [4,15,36,43\u201345]\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u7814\u7a76\u6240\u4f7f\u7528\u7684\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u901a\u5e38\u8fd8\u542b\u6709\u5176\u4ed6\u80fd\u591f\u4fc3\u8fdb\u80f6\u539f\u86cb\u767d\u751f\u6210\u6216\u51cf\u5c11\u80f6\u539f\u86cb\u767d\u964d\u89e3\u7684\u6210\u5206\uff0c\u4f8b\u5982\u7ef4\u751f\u7d20\u6216\u77ff\u7269\u8d28\u7b49\u6297\u6c27\u5316\u6210\u5206 [46]\u3002\u56e0\u6b64\uff0c\u76ae\u80a4\u5f39\u6027\u7684\u6539\u5584\u53ef\u80fd\u4e0d\u4ec5\u4e0e\u80f6\u539f\u86cb\u767d\u6d3b\u6027\u80bd\u6709\u5173\uff0c\u4e5f\u53ef\u80fd\u53d7\u5230\u8fd9\u4e9b\u6297\u6c27\u5316\u6210\u5206\u7684\u5f71\u54cd\u3002\u7531\u4e8e\u8fd9\u4e9b\u6210\u5206\u672c\u8eab\u5177\u6709\u660e\u786e\u7684\u62a4\u80a4\u4f5c\u7528\uff0c\u5e76\u5df2\u5f97\u5230\u5e7f\u6cdb\u7814\u7a76 [47]\uff0c\u56e0\u6b64\uff0c\u65e2\u5f80\u7814\u7a76\u5c1a\u4e0d\u80fd\u5b8c\u5168\u786e\u5b9aCTP\u672c\u8eab\u5bf9\u76ae\u80a4\u72b6\u6001\u7684\u5177\u4f53\u4f5c\u7528\u53ca\u6539\u5584\u7a0b\u5ea6\u3002\u672c\u7814\u7a76\u5219\u4ec5\u5728\u8bd5\u9a8c\u7ec4\u4e2d\u4f7f\u7528CTP\u8865\u5145\u5242\uff0c\u4ee5\u66f4\u52a0\u9488\u5bf9\u6027\u5730\u8bc4\u4f30CTP\u672c\u8eab\u5bf9\u76ae\u80a4\u7684\u5f71\u54cd\u3002<\/p>\n<p>\u4eceCTP\u7684\u5177\u4f53\u7ec4\u6210\u6765\u770b\uff0c\u8fd1\u671f\u4e00\u9879\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u4e0e\u672c\u7814\u7a76\u5177\u6709\u8f83\u9ad8\u7684\u53ef\u6bd4\u6027 [15]\u3002\u8be5\u7814\u7a76\u5c06\u6bcf\u65e5\u6444\u51651,000 mg\u4f4e\u5206\u5b50\u91cf\u80f6\u539f\u80bd\uff08LMWCP\uff0c\u542b\u8d85\u8fc715%\u7684\u4e09\u80bd\uff0c\u5176\u4e2d\u5305\u62ec3%\u7684Gly-Pro-Hyp\uff09\u53ca100 mg\u7ef4\u751f\u7d20C\u7684\u53d7\u8bd5\u8005\uff0c\u4e0e\u4ec5\u6444\u5165100 mg\u7ef4\u751f\u7d20C\u7684\u5b89\u6170\u5242\u7ec4\u8fdb\u884c\u6bd4\u8f83\u3002\u7814\u7a76\u53d1\u73b0\uff0c40\u201360\u5c81\u5973\u6027\u8fde\u7eed12\u5468\u53e3\u670d\u4f4e\u5206\u5b50\u91cf\u80f6\u539f\u80bd\u540e\uff0c\u76ae\u80a4\u6c34\u5206\u3001\u5f39\u6027\u53ca\u76b1\u7eb9\u72b6\u51b5\u5747\u6709\u6240\u6539\u5584\u3002\u7136\u800c\uff0c\u8fd9\u4e9b\u79ef\u6781\u7ed3\u679c\u53ef\u80fd\u90e8\u5206\u53d7\u5230\u6d4b\u8bd5\u671f\u95f4\u4e0d\u540c\u5929\u6c14\u6761\u4ef6\u7684\u5f71\u54cd\u3002\u8be5\u7814\u7a76\u4ece2\u6708\uff08\u51ac\u5b63\uff0c\u4f4e\u6e7f\u5ea6\u53ca\u4f4e\u6e29\uff09\u6301\u7eed\u81f36\u6708\uff08\u590f\u5b63\uff0c\u9ad8\u6e7f\u5ea6\u53ca\u9ad8\u6e29\uff09\uff0c\u4e24\u4e2a\u6d4b\u8bd5\u65f6\u95f4\u70b9\u7684\u6c14\u5019\u6761\u4ef6\u5b58\u5728\u660e\u663e\u5dee\u5f02\u3002\u867d\u7136\u7814\u7a76\u4eba\u5458\u5728\u6d4b\u8bd5\u524d\u8ba9\u53d7\u8bd5\u8005\u5728\u6052\u6e29\uff0822\u201324\u00b0C\uff09\u3001\u6052\u6e7f\uff0840\u201360%\uff09\u7684\u623f\u95f4\u5185\u9759\u7f6e30\u5206\u949f\uff0c\u4ee5\u5c3d\u91cf\u6392\u9664\u73af\u5883\u56e0\u7d20\u5bf9\u76ae\u80a4\u72b6\u6001\u7684\u5f71\u54cd\uff0c\u4f46\u53d7\u8bd5\u8005\u5728\u4e24\u4e2a\u4e0d\u540c\u65f6\u95f4\u70b9\u8fdb\u884c\u6d4b\u8bd5\u65f6\uff0c\u5176\u76ae\u80a4\u72b6\u6001\u4ecd\u53ef\u80fd\u53d7\u5230\u6574\u4f53\u5b63\u8282\u53ca\u5929\u6c14\u6761\u4ef6\u7684\u5f71\u54cd\u3002\u73af\u5883\u4e2d\u7684\u6e7f\u5ea6\u3001\u6e29\u5ea6\u548cUVA\u5747\u4f1a\u5f71\u54cd\u76ae\u80a4\u5c4f\u969c\u529f\u80fd [31]\u3002\u4f8b\u5982\uff0c\u4f4e\u6e29\u548c\u4f4e\u6e7f\u5ea6\u7b49\u6c14\u5019\u56e0\u7d20\u53ef\u80fd\u52a0\u901f\u76ae\u80a4\u6c34\u5206\u6d41\u5931\uff0c\u5e76\u589e\u52a0\u76ae\u80a4\u5e72\u71e5\u548c\u76ae\u708e\u7684\u98ce\u9669 [31]\u3002<\/p>\n<p>\u56e0\u6b64\uff0c\u5bf9\u4e8e\u8bc4\u4f30\u76ae\u80a4\u72b6\u6001\u53d8\u5316\u7684\u4e34\u5e8a\u7814\u7a76\u800c\u8a00\uff0c\u7814\u7a76\u6240\u5728\u5730\u7684\u5b63\u8282\u53d8\u5316\u5e94\u4f5c\u4e3a\u91cd\u8981\u7684\u5f71\u54cd\u56e0\u7d20\u7eb3\u5165\u5206\u6790\u3002\u4e3a\u4e86\u5c3d\u53ef\u80fd\u6392\u9664\u5929\u6c14\u6761\u4ef6\u5bf9\u76ae\u80a4\u72b6\u6001\u7684\u5f71\u54cd\uff0c\u672c\u7814\u7a76\u5728\u5206\u6790\u53d7\u8bd5\u8005\u8fde\u7eed12\u5468\u53e3\u670dCTP\u540e\u7684\u76ae\u80a4\u6307\u6807\u53d8\u5316\u65f6\uff0c\u5bf9\u7814\u7a76\u671f\u95f4\u53d7\u8bd5\u8005\u5c45\u4f4f\u5730\u533a\u7684\u6e7f\u5ea6\u3001\u6e29\u5ea6\u548cUVA\u8fdb\u884c\u4e86\u6821\u6b63\u3002\u7531\u4e8e\u5e73\u5747\u6e7f\u5ea6\u3001\u6e29\u5ea6\u53caUVA\u6570\u636e\u5747\u6765\u81ea\u5f53\u5730\u6c14\u8c61\u90e8\u95e8\uff0c\u56e0\u6b64\u6240\u4f7f\u7528\u7684\u73af\u5883\u6570\u636e\u5177\u6709\u8f83\u597d\u7684\u53ef\u9760\u6027\u548c\u51c6\u786e\u6027\u3002\u5bf9\u5929\u6c14\u56e0\u7d20\u8fdb\u884c\u6821\u6b63\uff0c\u53ef\u80fd\u90e8\u5206\u89e3\u91ca\u4e86\u4e3a\u4ec0\u4e48\u672c\u7814\u7a76\u53d7\u8bd5\u8005\u76ae\u80a4\u6307\u6807\u7684\u6539\u5584\u5e45\u5ea6\u4f4e\u4e8e\u6b64\u524d\u7814\u7a76\u4e2d\u7684\u53d7\u8bd5\u8005 [15]\u3002\u6b64\u5916\uff0c\u6211\u4eec\u63a8\u6d4b\uff0c\u672c\u7814\u7a76\u5b89\u6170\u5242\u7ec4\u76ae\u80a4\u72b6\u6001\u7684\u660e\u663e\u6539\u5584\uff0c\u4e5f\u53ef\u80fd\u4e0e\u5b63\u8282\u53d8\u5316\u6709\u5173\u3002\u5728\u672c\u7814\u7a76\u5f00\u5c55\u4e4b\u524d\uff0c\u5df2\u6709\u591a\u9879\u7814\u7a76\u62a5\u9053\u4e86CTP\u5bf9\u76ae\u80a4\u5065\u5eb7\u7684\u79ef\u6781\u4f5c\u7528 [4,15,36,43\u201345]\u3002\u4f46\u6b64\u524d\u7684\u7814\u7a76\u5e76\u672a\u5145\u5206\u8003\u8651\u6c14\u5019\u56e0\u7d20\uff0c\u800c\u8fd9\u4e5f\u662f\u672c\u7814\u7a76\u4e0e\u65e2\u5f80\u7814\u7a76\u7684\u91cd\u8981\u533a\u522b\u4e4b\u4e00\u3002<\/p>\n<p>\u4e0e\u9646\u751f\u52a8\u7269\u6765\u6e90\u7684\u80f6\u539f\u80bd\u76f8\u6bd4\uff0c\u9c7c\u7c7b\u901a\u5e38\u662f\u8f83\u4e3a\u7406\u60f3\u7684\u80f6\u539f\u86cb\u767d\u6765\u6e90\u4e4b\u4e00\uff0c\u8fd9\u53ef\u80fd\u4e0e\u9c7c\u7c7b\u6240\u5904\u7684\u4f4e\u6e29\u548c\u9ad8\u76d0\u73af\u5883\u6709\u5173\u3002\u9c7c\u6e90\u80f6\u539f\u86cb\u767d\u5177\u6709\u72ec\u7279\u7684\u6c28\u57fa\u9178\u7ec4\u6210\u53ca\u751f\u7269\u5b66\u7279\u6027\uff0c\u5e76\u88ab\u7814\u7a76\u5176\u6297\u6c27\u5316\u3001\u6539\u5584\u76ae\u80a4\u8001\u5316\u4ee5\u53ca\u8c03\u8282\u8102\u80aa\u79ef\u7d2f\u7b49\u6f5c\u5728\u4f5c\u7528 [10,36,48]\u3002Ohara\u7b49\u4eba [49]\u6bd4\u8f83\u4e86\u4e0d\u540c\u6765\u6e90\u7684I\u578b\u80f6\u539f\u86cb\u767d\uff08\u9c7c\u6e90\u548c\u732a\u6e90\uff09\u7ecf\u6c34\u89e3\u540e\u5f62\u6210\u7684\u660e\u80f6\u80bd\u8fdb\u5165\u4eba\u4f53\u8840\u6db2\u7684\u60c5\u51b5\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5728\u6e38\u79bb\u7f9f\u812f\u6c28\u9178\uff08Hyp\uff09\u7684\u5f62\u5f0f\u4e0b\uff0c\u9c7c\u6e90\u660e\u80f6\u6c34\u89e3\u7269\u7684\u5438\u6536\u7a0b\u5ea6\u9ad8\u4e8e\u732a\u6e90\u660e\u80f6\u6c34\u89e3\u7269\uff0c\u8fd9\u63d0\u793a\u9c7c\u6e90\u4f4e\u5206\u5b50\u80f6\u539f\u86cb\u767d\u53ef\u80fd\u5177\u6709\u8f83\u597d\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u5e76\u53ef\u80fd\u6709\u5229\u4e8e\u76ae\u80a4\u5065\u5eb7\u3002\u6b64\u5916\uff0c\u4e0e\u54fa\u4e73\u52a8\u7269\u6765\u6e90\u7684\u80f6\u539f\u86cb\u767d\u76f8\u6bd4\uff0c\u6d77\u6d0b\u6765\u6e90\u80f6\u539f\u86cb\u767d\u7684\u5e94\u7528\u6b63\u5728\u5feb\u901f\u589e\u957f\uff0c\u8fd9\u4e0e\u5176\u72ec\u7279\u4f18\u52bf\u6709\u5173\uff0c\u4f8b\u5982\u75be\u75c5\u4f20\u64ad\u98ce\u9669\u8f83\u4f4e\u3001\u4e0d\u53d7\u5b97\u6559\u996e\u98df\u9650\u5236\u3001\u751f\u4ea7\u6210\u672c\u76f8\u5bf9\u8f83\u4f4e\u3001\u5206\u5b50\u91cf\u8f83\u5c0f\u3001\u751f\u7269\u76f8\u5bb9\u6027\u8f83\u597d\uff0c\u4ee5\u53ca\u66f4\u5bb9\u6613\u88ab\u4eba\u4f53\u5438\u6536\u7b49\u3002<\/p>\n<p>\u4e3a\u4e86\u63d0\u9ad8\u6d3b\u6027\u80bd\u7684\u751f\u7269\u5229\u7528\u5ea6\uff0c\u672c\u7814\u7a76\u6240\u4f7f\u7528\u7684CTP\u91c7\u7528\u7f57\u975e\u9c7c\uff08<em>Tilapia<\/em>\uff09\u9c7c\u76ae\u4f5c\u4e3a\u539f\u6599\uff0c\u5e76\u901a\u8fc7\u4f7f\u7528\u6765\u6e90\u4e8e\u975e\u81f4\u75c5\u6027\u82bd\u5b62\u6746\u83cc\u5c5e\uff08<em>Bacillus<\/em>\uff09\u7ec6\u83cc\u7684\u80f6\u539f\u9176\u8fdb\u884c\u9176\u89e3\u5236\u5907\u3002\u52a8\u7269\u7814\u7a76\u663e\u793a\uff0c\u4e0e\u9ad8\u5206\u5b50\u91cf\u80f6\u539f\u80bd\u76f8\u6bd4\uff0c\u53e3\u670d\u8be5CTP\u540e\uff0c\u5176\u4e2d\u7684Gly-Pro-Hyp\u548cPro-Hyp\u80fd\u591f\u66f4\u597d\u5730\u88ab\u5927\u9f20\u5438\u6536\uff0c\u5e76\u8fbe\u5230\u66f4\u9ad8\u7684\u8840\u6d46\u6d53\u5ea6\uff1b\u540c\u65f6\uff0cGly-Pro-Hyp\u548cPro-Hyp\u5728\u80c3\u80a0\u6db2\u53ca\u5927\u9f20\u8840\u6d46\u4e2d\u5177\u6709\u8f83\u597d\u7684\u7a33\u5b9a\u6027\uff0cGly-Pro-Hyp\u8fd8\u80fd\u591f\u901a\u8fc7\u80a0\u9053\u7ec6\u80de\u5c42\u88ab\u8f6c\u8fd0 [14]\u3002\u6b64\u5916\uff0c\u53e6\u4e00\u9879\u8f83\u65b0\u7684\u7ec4\u7ec7\u5b66\u7814\u7a76\u901a\u8fc7\u89c2\u5bdf\u5c0f\u9f20\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u7684\u8868\u8fbe\uff0c\u8fdb\u4e00\u6b65\u8bc4\u4f30\u4e86\u53e3\u670d\u8be5CTP\u4ea7\u54c1\u5bf9\u76ae\u80a4\u6c34\u5206\u72b6\u6001\u7684\u5f71\u54cd [28]\u3002\u7814\u7a76\u53d1\u73b0\uff0cCTP\u4f5c\u7528\u540e\uff0c\u4eba\u771f\u76ae\u6210\u7ea4\u7ef4\u7ec6\u80de\u4e2d\u795e\u7ecf\u9170\u80fa\u6fc0\u9176\u3001\u900f\u660e\u8d28\u9178\u3001\u80f6\u539f\u86cb\u767d1A\u53ca\u900f\u660e\u8d28\u9178\u5408\u6210\u9176-2\uff08HAS2\uff09\u7684\u8868\u8fbe\u589e\u52a0\uff0c\u800c\u900f\u660e\u8d28\u9178\u9176-1\uff08HYAL1\uff09\u548cCD44\u7684\u8868\u8fbe\u964d\u4f4e\u3002\u540c\u65f6\uff0c\u7814\u7a76\u8fd8\u89c2\u5bdf\u5230\u7ecf\u8868\u76ae\u5931\u6c34\uff08TEWL\uff09\u3001\u6293\u6320\u884c\u4e3a\u3001HYAL1\u3001\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF-\u03b1\uff09\u53ca\u767d\u7ec6\u80de\u4ecb\u7d20-6\uff08IL-6\uff09\u6c34\u5e73\u4e0b\u964d\uff0c\u800c\u76ae\u80a4\u542b\u6c34\u91cf\u53caHAS2\u6c34\u5e73\u589e\u52a0\u3002\u8fd9\u4e9b\u7ed3\u679c\u63d0\u793a\uff0c\u672c\u7814\u7a76\u6240\u4f7f\u7528\u7684CTP\u4ea7\u54c1\u53ef\u80fd\u6709\u52a9\u4e8e\u6539\u5584\u76ae\u80a4\u6c34\u5206\u72b6\u6001\uff0c\u5e76\u5177\u6709\u4f5c\u4e3a\u76ae\u80a4\u4fdd\u6e7f\u6210\u5206\u7684\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002\u9c7c\u7c7b\u56e0\u5176\u8425\u517b\u4ef7\u503c\u53ca\u8f83\u4f4e\u7684\u70ed\u91cf\u6444\u5165\u800c\u8d8a\u6765\u8d8a\u53d7\u5230\u6d88\u8d39\u8005\u7684\u6b22\u8fce\uff0c\u65e0\u8bba\u751f\u9c9c\u8fd8\u662f\u719f\u98df\u5747\u5f97\u5230\u5e7f\u6cdb\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u76ee\u524d\u4e5f\u6709\u5927\u91cf\u9c7c\u76ae\u4f5c\u4e3a\u52a0\u5de5\u526f\u4ea7\u54c1\u88ab\u4e22\u5f03\u3002\u4ece\u73af\u5883\u53ef\u6301\u7eed\u6027\u7684\u89d2\u5ea6\u6765\u770b\uff0c\u5bf9\u9c7c\u76ae\u7b49\u526f\u4ea7\u54c1\u8fdb\u884c\u66f4\u5145\u5206\u7684\u5229\u7528\u5177\u6709\u4e00\u5b9a\u610f\u4e49\u3002<\/p>\n<p>\u672c\u7814\u7a76\u4ecd\u5b58\u5728\u4e00\u4e9b\u5c40\u9650\u6027\u3002\u9996\u5148\uff0c\u672c\u7814\u7a76\u4ec5\u5728\u5355\u4e00\u7814\u7a76\u4e2d\u5fc3\u5f00\u5c55\uff0c\u4e14\u53d7\u8bd5\u8005\u5168\u90e8\u4e3a\u5973\u6027\uff0c\u56e0\u6b64\u7814\u7a76\u7ed3\u679c\u80fd\u5426\u63a8\u5e7f\u81f3\u66f4\u5e7f\u6cdb\u7684\u4eba\u7fa4\u4ecd\u9700\u8fdb\u4e00\u6b65\u9a8c\u8bc1\u3002\u5176\u6b21\uff0c\u7531\u4e8e\u6837\u672c\u91cf\u8f83\u5c0f\u3001\u7814\u7a76\u5468\u671f\u8f83\u77ed\uff0c\u5c3d\u7ba1\u4e24\u7ec4\u4e4b\u95f4\u7684\u5dee\u5f02\u5177\u6709\u7edf\u8ba1\u5b66\u610f\u4e49\uff0c\u4f46\u80f6\u539f\u86cb\u767d\u5bf9\u76ae\u80a4\u76f8\u5173\u6307\u6807\u7684\u5b9e\u9645\u6539\u5584\u5e45\u5ea6\u76f8\u5bf9\u6709\u9650\u3002\u6b64\u5916\uff0c\u7814\u7a76\u7ed3\u679c\u5e76\u4e0d\u80fd\u5b8c\u5168\u9002\u7528\u4e8e\u6240\u6709\u4e0d\u540c\u7684\u6c14\u5019\u73af\u5883\u3002\u6700\u540e\uff0c\u4e3a\u4e86\u786e\u4fdd\u968f\u673a\u53cc\u76f2\u8bd5\u9a8c\u4e2d\u4e24\u7ec4\u53d7\u8bd5\u8005\u5728\u5473\u9053\u3001\u989c\u8272\u548c\u53e3\u611f\u7b49\u65b9\u9762\u4fdd\u6301\u4e00\u81f4\uff0c\u672c\u7814\u7a76\u91c7\u7528\u80f6\u56ca\u5f62\u5f0f\u7684\u80f6\u539f\u86cb\u767d\u8865\u5145\u5242\u3002\u7136\u800c\uff0c\u5df2\u6709\u7814\u7a76\u8ba4\u4e3a\uff0c\u4e0e\u56fa\u4f53\u8865\u5145\u5242\u76f8\u6bd4\uff0c\u6db2\u4f53\u80f6\u539f\u86cb\u767d\u53ef\u80fd\u66f4\u5feb\u3001\u66f4\u5145\u5206\u5730\u8fdb\u5165\u8840\u6db2\u5faa\u73af\uff0c\u5e76\u7f29\u77ed\u86cb\u767d\u8d28\u7684\u6d88\u5316\u65f6\u95f4\u3002\u5c3d\u7ba1\u5b58\u5728\u4e0a\u8ff0\u5c40\u9650\uff0c\u672c\u7814\u7a76\u4ecd\u5177\u6709\u4e00\u5b9a\u4ef7\u503c\u3002\u9996\u5148\uff0c\u636e\u7814\u7a76\u4f5c\u8005\u6240\u77e5\uff0c\u8fd9\u662f\u9996\u9879\u5728\u8bc4\u4f30CTP\u5bf9\u76ae\u80a4\u72b6\u6001\u5f71\u54cd\u65f6\uff0c\u6839\u636e\u53d7\u8bd5\u8005\u7814\u7a76\u671f\u95f4\u5c45\u4f4f\u5730\u533a\u7684\u5929\u6c14\u6761\u4ef6\u8fdb\u884c\u6821\u6b63\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u5e76\u91c7\u7528\u5f53\u5730\u6c14\u8c61\u90e8\u95e8\u63d0\u4f9b\u7684\u51c6\u786e\u73af\u5883\u6570\u636e\u3002\u672c\u7814\u7a76\u91c7\u7528\u4e25\u683c\u7684\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u8bbe\u8ba1\uff0c\u5e76\u5236\u5b9a\u4e86\u660e\u786e\u7684\u7eb3\u5165\u53ca\u6392\u9664\u6807\u51c6\u3002\u540c\u65f6\uff0c\u76ae\u80a4\u76f8\u5173\u6307\u6807\u5747\u901a\u8fc7\u53ef\u9760\u7684\u5b9a\u91cf\u68c0\u6d4b\u65b9\u6cd5\u8fdb\u884c\u5ba2\u89c2\u8bc4\u4f30\u3002<\/p>\n<p>\u7efc\u4e0a\uff0c\u672c\u9879\u968f\u673a\u3001\u5b89\u6170\u5242\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u8868\u660e\uff0c\u53e3\u670dCTP\u5177\u6709\u826f\u597d\u7684\u8010\u53d7\u6027\uff0c\u5e76\u6709\u52a9\u4e8e\u51cf\u5c11\u4e2d\u5e74\u5973\u6027\u7684\u76ae\u80a4\u6c34\u5206\u6d41\u5931\u3002\u672c\u7814\u7a76\u540c\u65f6\u521d\u6b65\u63ed\u793a\u4e86\u53d7\u8bd5\u8005\u5c45\u4f4f\u5730\u533a\u7684\u6e29\u5ea6\u3001\u6e7f\u5ea6\u548cUVA\u7b49\u6c14\u5019\u56e0\u7d20\u53ef\u80fd\u5bf9\u4eba\u4f53\u76ae\u80a4\u72b6\u6001\u4ea7\u751f\u5f71\u54cd\u3002\u56e0\u6b64\uff0c\u672a\u6765\u5728\u5f00\u5c55\u76f8\u5173\u4eba\u7fa4\u7684\u76ae\u80a4\u5065\u5eb7\u4e34\u5e8a\u7814\u7a76\u65f6\uff0c\u5c24\u5176\u662f\u5728\u5177\u6709\u660e\u663e\u56db\u5b63\u53d8\u5316\u7684\u5730\u533a\uff0c\u5e94\u5c06\u5929\u6c14\u53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<strong>Amicogen Inc. 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